3qnb - Revision history

OCA at 11:52, 14 March 2024

OCA — Thu, 14 Mar 2024 11:52:02 GMT

←Older revision		Revision as of 11:52, 14 March 2024
Line 10:		Line 10:
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/Q7BNC2_ECOLX Q7BNC2_ECOLX]		[https://www.uniprot.org/uniprot/Q7BNC2_ECOLX Q7BNC2_ECOLX]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Class D beta-lactamases with carbapenemase activity are emerging as carbapenem-resistance determinants in gram-negative bacterial pathogens, mostly Acinetobacter baumannii and Klebsiella pneumoniae. Carbapenemase activity is an unusual feature among class D beta-lactamases, and the structural elements responsible for this activity remain unclear. Based on structural and molecular dynamics data, we previously hypothesized a potential role of the residues located in the short-loop connecting strands beta5 and beta6 (the beta5-beta6 loop) in conferring the carbapenemase activity of the OXA-48 enzyme. In this work, the narrow-spectrum OXA-10 class D beta-lactamase, which is unable to hydrolyze carbapenems, was used as a model to investigate the possibility of evolving carbapenemase activity by replacement of the beta5-beta6 loop with those present in three different lineages of class D carbapenemases (OXA-23, OXA-24, and OXA-48). Biological assays and kinetic measurements showed that all three OXA-10-derived hybrids acquired significant carbapenemase activity. Structural analysis of the OXA-10loop24 and OXA-10loop48 hybrids revealed no significant changes in the molecular fold of the enzyme, except for the orientation of the substituted beta5-beta6 loops, which was reminiscent of that found in their parental enzymes. These results demonstrate the crucial role of the beta5-beta6 loop in the carbapenemase activity of class D beta-lactamases, and provide previously unexplored insights into the mechanism by which these enzymes can evolve carbapenemase activity.
-
-	Evolution to carbapenem-hydrolyzing activity in noncarbapenemase class D beta-lactamase OXA-10 by rational protein design.,De Luca F, Benvenuti M, Carboni F, Pozzi C, Rossolini GM, Mangani S, Docquier JD Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18424-9. Epub 2011 Oct 31. PMID:22042844<ref>PMID:22042844</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3qnb" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:13, 6 December 2023

OCA — Wed, 06 Dec 2023 08:13:30 GMT

←Older revision		Revision as of 08:13, 6 December 2023
Line 3:		Line 3:
	<StructureSection load='3qnb' size='340' side='right'caption='[[3qnb]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='3qnb' size='340' side='right'caption='[[3qnb]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qnb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Escherichia_coli_dh5[alpha]~~ Escherichia coli ~~dh5[alpha]~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QNB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QNB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qnb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_DH5alpha Escherichia coli DH5alpha]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QNB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QNB FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=EDO:1,2~~-~~ETHANEDIOL'>EDO</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.95Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~KCX~~:~~LYSINE+NZ~~-~~CARBOXYLIC+ACID~~'>~~KCX~~</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;~~'>~~[[3qnc\|3qnc]]~~</~~div~~><~~/td></tr>~~	+
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b></td><td class="sblockDat">blaOXA-10(loop24) ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=668369 Escherichia coli DH5[alpha]])</td></tr>~~	+
-	~~<tr id='activity~~'>~~<td class="sblockLbl"><b>Activity:~~</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qnb OCA], [https://pdbe.org/3qnb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qnb RCSB], [https://www.ebi.ac.uk/pdbsum/3qnb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qnb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qnb OCA], [https://pdbe.org/3qnb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qnb RCSB], [https://www.ebi.ac.uk/pdbsum/3qnb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qnb ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q7BNC2_ECOLX Q7BNC2_ECOLX]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Beta-lactamase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Benvenuti, M]]	+	[[Category: Benvenuti M]]
-	[[Category: Carboni, F]]	+	[[Category: Carboni F]]
-	[[Category: ~~Docquier, J D~~]]	+	[[Category: De Luca F]]
-	[[Category: ~~Luca, F De~~]]	+	[[Category: Docquier JD]]
-	[[Category: Mangani, S]]	+	[[Category: Mangani S]]
-	[[Category: Pozzi, C]]	+	[[Category: Pozzi C]]
-	[[Category: Rossolini~~, G M]]~~	+	[[Category: Rossolini GM]]
-	~~[[Category: Antibiotic resistance]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydrolysis of amide bond of beta-lactam compound~~]]	+

OCA at 06:15, 8 June 2022

OCA — Wed, 08 Jun 2022 06:15:49 GMT

←Older revision		Revision as of 06:15, 8 June 2022
Line 1:		Line 1:

	==Crystal Structure of an Engineered OXA-10 Variant with Carbapenemase Activity, OXA-10loop24==		==Crystal Structure of an Engineered OXA-10 Variant with Carbapenemase Activity, OXA-10loop24==
-	<StructureSection load='3qnb' size='340' side='right' caption='[[3qnb]], [[Resolution\|resolution]] 1.95Å' scene=''>	+	<StructureSection load='3qnb' size='340' side='right'caption='[[3qnb]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qnb]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Escherichia_coli_dh5[alpha] Escherichia coli dh5[alpha]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QNB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3QNB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qnb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_dh5[alpha] Escherichia coli dh5[alpha]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QNB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QNB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qnc\|3qnc]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3qnc\|3qnc]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">blaOXA-10(loop24) ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=668369 Escherichia coli DH5[alpha]])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">blaOXA-10(loop24) ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=668369 Escherichia coli DH5[alpha]])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3qnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qnb OCA], [~~http~~://pdbe.org/3qnb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3qnb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3qnb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3qnb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qnb OCA], [https://pdbe.org/3qnb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qnb RCSB], [https://www.ebi.ac.uk/pdbsum/3qnb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qnb ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
		+	[[Category: Large Structures]]
	[[Category: Benvenuti, M]]		[[Category: Benvenuti, M]]
	[[Category: Carboni, F]]		[[Category: Carboni, F]]

OCA at 15:04, 5 August 2016

OCA — Fri, 05 Aug 2016 15:04:12 GMT

←Older revision		Revision as of 15:04, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of an Engineered OXA-10 Variant with Carbapenemase Activity, OXA-10loop24==		==Crystal Structure of an Engineered OXA-10 Variant with Carbapenemase Activity, OXA-10loop24==
	<StructureSection load='3qnb' size='340' side='right' caption='[[3qnb]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='3qnb' size='340' side='right' caption='[[3qnb]], [[Resolution\|resolution]] 1.95Å' scene=''>
Line 8:		Line 9:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">blaOXA-10(loop24) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=668369 Escherichia coli DH5[alpha]])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">blaOXA-10(loop24) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=668369 Escherichia coli DH5[alpha]])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qnb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qnb RCSB], [http://www.ebi.ac.uk/pdbsum/3qnb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qnb OCA], [http://pdbe.org/3qnb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qnb RCSB], [http://www.ebi.ac.uk/pdbsum/3qnb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qnb ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3qnb" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:45, 19 December 2014

OCA — Fri, 19 Dec 2014 10:45:58 GMT

←Older revision		Revision as of 10:45, 19 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3qnb\| PDB=3qnb \| SCENE= }}~~	+	==Crystal Structure of an Engineered OXA-10 Variant with Carbapenemase Activity, OXA-10loop24==
-	===Crystal Structure of an Engineered OXA-10 Variant with Carbapenemase Activity, OXA-10loop24===	+	<StructureSection load='3qnb' size='340' side='right' caption='[[3qnb]], [[Resolution\|resolution]] 1.95Å' scene=''>
-	~~{{ABSTRACT_PUBMED_22042844}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3qnb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_dh5[alpha] Escherichia coli dh5[alpha]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QNB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QNB FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qnc\|3qnc]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">blaOXA-10(loop24) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=668369 Escherichia coli DH5[alpha]])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qnb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qnb RCSB], [http://www.ebi.ac.uk/pdbsum/3qnb PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Class D beta-lactamases with carbapenemase activity are emerging as carbapenem-resistance determinants in gram-negative bacterial pathogens, mostly Acinetobacter baumannii and Klebsiella pneumoniae. Carbapenemase activity is an unusual feature among class D beta-lactamases, and the structural elements responsible for this activity remain unclear. Based on structural and molecular dynamics data, we previously hypothesized a potential role of the residues located in the short-loop connecting strands beta5 and beta6 (the beta5-beta6 loop) in conferring the carbapenemase activity of the OXA-48 enzyme. In this work, the narrow-spectrum OXA-10 class D beta-lactamase, which is unable to hydrolyze carbapenems, was used as a model to investigate the possibility of evolving carbapenemase activity by replacement of the beta5-beta6 loop with those present in three different lineages of class D carbapenemases (OXA-23, OXA-24, and OXA-48). Biological assays and kinetic measurements showed that all three OXA-10-derived hybrids acquired significant carbapenemase activity. Structural analysis of the OXA-10loop24 and OXA-10loop48 hybrids revealed no significant changes in the molecular fold of the enzyme, except for the orientation of the substituted beta5-beta6 loops, which was reminiscent of that found in their parental enzymes. These results demonstrate the crucial role of the beta5-beta6 loop in the carbapenemase activity of class D beta-lactamases, and provide previously unexplored insights into the mechanism by which these enzymes can evolve carbapenemase activity.

-	~~==About this Structure==~~	+	Evolution to carbapenem-hydrolyzing activity in noncarbapenemase class D beta-lactamase OXA-10 by rational protein design.,De Luca F, Benvenuti M, Carboni F, Pozzi C, Rossolini GM, Mangani S, Docquier JD Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18424-9. Epub 2011 Oct 31. PMID:22042844<ref>PMID:22042844</ref>
-	~~[[3qnb]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli_dh5[alpha] Escherichia coli dh5[alpha]]. Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=3QNB OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:022042844</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
-	[[Category: Benvenuti, M.]]	+	[[Category: Benvenuti, M]]
-	[[Category: Carboni, F.]]	+	[[Category: Carboni, F]]
-	[[Category: Docquier, J D.]]	+	[[Category: Docquier, J D]]
-	[[Category: Luca, F De.]]	+	[[Category: Luca, F De]]
-	[[Category: Mangani, S.]]	+	[[Category: Mangani, S]]
-	[[Category: Pozzi, C.]]	+	[[Category: Pozzi, C]]
-	[[Category: Rossolini, G M.]]	+	[[Category: Rossolini, G M]]
	[[Category: Antibiotic resistance]]		[[Category: Antibiotic resistance]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Hydrolysis of amide bond of beta-lactam compound]]		[[Category: Hydrolysis of amide bond of beta-lactam compound]]

OCA at 11:09, 24 July 2013

OCA — Wed, 24 Jul 2013 11:09:30 GMT

←Older revision		Revision as of 11:09, 24 July 2013
Line 1:		Line 1:
-	[[Image:3qnb.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3qnb", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_3qnb\| PDB=3qnb \| SCENE= }}		{{STRUCTURE_3qnb\| PDB=3qnb \| SCENE= }}
-
	===Crystal Structure of an Engineered OXA-10 Variant with Carbapenemase Activity, OXA-10loop24===		===Crystal Structure of an Engineered OXA-10 Variant with Carbapenemase Activity, OXA-10loop24===
		+	{{ABSTRACT_PUBMED_22042844}}

		+	==About this Structure==
		+	[[3qnb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_dh5[alpha] Escherichia coli dh5[alpha]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QNB OCA].

-	==~~About this Structure~~==	+	==Reference==
-	~~[[3qnb]] is a 4 chain structure with sequence from [http~~://~~en.wikipedia.org~~/~~wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QNB OCA].~~	+	<ref group="xtra">PMID:022042844</ref><references group="xtra"/><references/>
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
-	[[Category: Escherichia coli]]
	[[Category: Benvenuti, M.]]		[[Category: Benvenuti, M.]]
	[[Category: Carboni, F.]]		[[Category: Carboni, F.]]

OCA at 08:34, 2 November 2011

OCA — Wed, 02 Nov 2011 08:34:17 GMT

←Older revision		Revision as of 08:34, 2 November 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3qnb.jpg\|left\|200px]]

-	The ~~entry 3qnb~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3qnb", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3qnb\| PDB=3qnb \| SCENE= }}

-	~~Authors: De Luca~~, ~~F., Benvenuti, M., Carboni, F., Pozzi, C., Rossolini, G.M., Mangani, S., Docquier, J.D.~~	+	===Crystal Structure of an Engineered OXA-10 Variant with Carbapenemase Activity, OXA-10loop24===

-	~~Description: Crystal~~ Structure ~~of an Engineered OXA-10 Variant~~ with ~~Carbapenemase Activity~~, ~~OXA~~-~~10loop24~~	+
		+	==About this Structure==
		+	[[3qnb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QNB OCA].
		+	[[Category: Beta-lactamase]]
		+	[[Category: Escherichia coli]]
		+	[[Category: Benvenuti, M.]]
		+	[[Category: Carboni, F.]]
		+	[[Category: Docquier, J D.]]
		+	[[Category: Luca, F De.]]
		+	[[Category: Mangani, S.]]
		+	[[Category: Pozzi, C.]]
		+	[[Category: Rossolini, G M.]]
		+	[[Category: Antibiotic resistance]]
		+	[[Category: Hydrolase]]
		+	[[Category: Hydrolysis of amide bond of beta-lactam compound]]

OCA at 06:44, 23 March 2011

OCA — Wed, 23 Mar 2011 06:44:53 GMT

←Older revision		Revision as of 06:44, 23 March 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3qnb is ON HOLD	+	The entry 3qnb is ON HOLD until Paper Publication

	Authors: De Luca, F., Benvenuti, M., Carboni, F., Pozzi, C., Rossolini, G.M., Mangani, S., Docquier, J.D.		Authors: De Luca, F., Benvenuti, M., Carboni, F., Pozzi, C., Rossolini, G.M., Mangani, S., Docquier, J.D.

	Description: Crystal Structure of an Engineered OXA-10 Variant with Carbapenemase Activity, OXA-10loop24		Description: Crystal Structure of an Engineered OXA-10 Variant with Carbapenemase Activity, OXA-10loop24

OCA: Protected "3qnb" [edit=sysop:move=sysop]

OCA — Wed, 16 Feb 2011 05:22:49 GMT

Protected "3qnb" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:22, 16 February 2011

OCA: New page: '''Unreleased structure''' The entry 3qnb is ON HOLD Authors: De Luca, F., Benvenuti, M., Carboni, F., Pozzi, C., Rossolini, G.M., Mangani, S., Docquier, J.D. Description: Crystal Stru...

OCA — Wed, 16 Feb 2011 05:22:49 GMT

New page: '''Unreleased structure''' The entry 3qnb is ON HOLD Authors: De Luca, F., Benvenuti, M., Carboni, F., Pozzi, C., Rossolini, G.M., Mangani, S., Docquier, J.D. Description: Crystal Stru...

New page

'''Unreleased structure'''

The entry 3qnb is ON HOLD

Authors: De Luca, F., Benvenuti, M., Carboni, F., Pozzi, C., Rossolini, G.M., Mangani, S., Docquier, J.D.

Description: Crystal Structure of an Engineered OXA-10 Variant with Carbapenemase Activity, OXA-10loop24