3qrl - Revision history

OCA at 10:49, 21 February 2024

OCA — Wed, 21 Feb 2024 10:49:28 GMT

←Older revision		Revision as of 10:49, 21 February 2024
Line 3:		Line 3:
	<StructureSection load='3qrl' size='340' side='right'caption='[[3qrl]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='3qrl' size='340' side='right'caption='[[3qrl]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qrl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QRL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QRL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qrl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QRL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QRL FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~ANC1, CST10, SWP29, TAF14, TAF30, TFG3, YPL129W ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qrl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qrl OCA], [https://pdbe.org/3qrl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qrl RCSB], [https://www.ebi.ac.uk/pdbsum/3qrl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qrl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qrl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qrl OCA], [https://pdbe.org/3qrl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qrl RCSB], [https://www.ebi.ac.uk/pdbsum/3qrl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qrl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TAF14_YEAST TAF14_YEAST]] Functions as a component of the DNA-binding general transcription factor complex TFIID, the RNA polymerase II associated general transcription factor complex TFIIF, and the chromatin-remodeling complex SWI/SNF. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. TFIIF is essential for the initiation of transcription by RNA polymerase II. TFIIF functions include the recruitment of RNA polymerase II to the promoter bound DNA-TBP-TFIIB complex, decreasing the affinity of RNA polymerase II for non-specific DNA, allowing for the subsequent recruitment of TFIIE and TFIIH, and facilitating RNA polymerase II elongation. The TAF14 subunit has stimulatory activity. Component of the SWI/SNF complex, an ATP-dependent chromatin-remodeling complex, is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors. Component of the histone acetyltransferase NuA3 complex, that acetylates Lys-14 of histone H3. Recruitment of NuA3 to nucleosomes requires methylated histone H3. In conjunction with the FACT complex, NuA3 may be involved in transcriptional regulation.<ref>PMID:9618449</ref> <ref>PMID:10788514</ref> <ref>PMID:12138208</ref> <ref>PMID:12516863</ref> <ref>PMID:12672490</ref> <ref>PMID:17157260</ref>	+	[https://www.uniprot.org/uniprot/TAF14_YEAST TAF14_YEAST] Functions as a component of the DNA-binding general transcription factor complex TFIID, the RNA polymerase II associated general transcription factor complex TFIIF, and the chromatin-remodeling complex SWI/SNF. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. TFIIF is essential for the initiation of transcription by RNA polymerase II. TFIIF functions include the recruitment of RNA polymerase II to the promoter bound DNA-TBP-TFIIB complex, decreasing the affinity of RNA polymerase II for non-specific DNA, allowing for the subsequent recruitment of TFIIE and TFIIH, and facilitating RNA polymerase II elongation. The TAF14 subunit has stimulatory activity. Component of the SWI/SNF complex, an ATP-dependent chromatin-remodeling complex, is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors. Component of the histone acetyltransferase NuA3 complex, that acetylates Lys-14 of histone H3. Recruitment of NuA3 to nucleosomes requires methylated histone H3. In conjunction with the FACT complex, NuA3 may be involved in transcriptional regulation.<ref>PMID:9618449</ref> <ref>PMID:10788514</ref> <ref>PMID:12138208</ref> <ref>PMID:12516863</ref> <ref>PMID:12672490</ref> <ref>PMID:17157260</ref>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Simpson, P J~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: ~~Warren, A J~~]]	+	[[Category: Simpson PJ]]
-	[[Category: ~~Ig fold]]~~	+	[[Category: Warren AJ]]
-	~~[[Category: Nuclear protein]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Yeats domain~~]]	+

OCA at 06:21, 8 June 2022

OCA — Wed, 08 Jun 2022 06:21:08 GMT

←Older revision		Revision as of 06:21, 8 June 2022
Line 1:		Line 1:

	==Crystal Structure of the Taf14 YEATS domain==		==Crystal Structure of the Taf14 YEATS domain==
-	<StructureSection load='3qrl' size='340' side='right' caption='[[3qrl]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='3qrl' size='340' side='right'caption='[[3qrl]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qrl]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QRL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3QRL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qrl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QRL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QRL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ANC1, CST10, SWP29, TAF14, TAF30, TFG3, YPL129W ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ANC1, CST10, SWP29, TAF14, TAF30, TFG3, YPL129W ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3qrl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qrl OCA], [~~http~~://pdbe.org/3qrl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3qrl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3qrl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3qrl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qrl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qrl OCA], [https://pdbe.org/3qrl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qrl RCSB], [https://www.ebi.ac.uk/pdbsum/3qrl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qrl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TAF14_YEAST TAF14_YEAST]] Functions as a component of the DNA-binding general transcription factor complex TFIID, the RNA polymerase II associated general transcription factor complex TFIIF, and the chromatin-remodeling complex SWI/SNF. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. TFIIF is essential for the initiation of transcription by RNA polymerase II. TFIIF functions include the recruitment of RNA polymerase II to the promoter bound DNA-TBP-TFIIB complex, decreasing the affinity of RNA polymerase II for non-specific DNA, allowing for the subsequent recruitment of TFIIE and TFIIH, and facilitating RNA polymerase II elongation. The TAF14 subunit has stimulatory activity. Component of the SWI/SNF complex, an ATP-dependent chromatin-remodeling complex, is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors. Component of the histone acetyltransferase NuA3 complex, that acetylates Lys-14 of histone H3. Recruitment of NuA3 to nucleosomes requires methylated histone H3. In conjunction with the FACT complex, NuA3 may be involved in transcriptional regulation.<ref>PMID:9618449</ref> <ref>PMID:10788514</ref> <ref>PMID:12138208</ref> <ref>PMID:12516863</ref> <ref>PMID:12672490</ref> <ref>PMID:17157260</ref>	+	[[https://www.uniprot.org/uniprot/TAF14_YEAST TAF14_YEAST]] Functions as a component of the DNA-binding general transcription factor complex TFIID, the RNA polymerase II associated general transcription factor complex TFIIF, and the chromatin-remodeling complex SWI/SNF. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. TFIIF is essential for the initiation of transcription by RNA polymerase II. TFIIF functions include the recruitment of RNA polymerase II to the promoter bound DNA-TBP-TFIIB complex, decreasing the affinity of RNA polymerase II for non-specific DNA, allowing for the subsequent recruitment of TFIIE and TFIIH, and facilitating RNA polymerase II elongation. The TAF14 subunit has stimulatory activity. Component of the SWI/SNF complex, an ATP-dependent chromatin-remodeling complex, is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors. Component of the histone acetyltransferase NuA3 complex, that acetylates Lys-14 of histone H3. Recruitment of NuA3 to nucleosomes requires methylated histone H3. In conjunction with the FACT complex, NuA3 may be involved in transcriptional regulation.<ref>PMID:9618449</ref> <ref>PMID:10788514</ref> <ref>PMID:12138208</ref> <ref>PMID:12516863</ref> <ref>PMID:12672490</ref> <ref>PMID:17157260</ref>
	== References ==		== References ==
	<references/>		<references/>
Line 15:		Line 15:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Simpson, P J]]		[[Category: Simpson, P J]]
	[[Category: Warren, A J]]		[[Category: Warren, A J]]

OCA at 10:08, 5 August 2016

OCA — Fri, 05 Aug 2016 10:08:19 GMT

←Older revision		Revision as of 10:08, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of the Taf14 YEATS domain==		==Crystal Structure of the Taf14 YEATS domain==
	<StructureSection load='3qrl' size='340' side='right' caption='[[3qrl]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='3qrl' size='340' side='right' caption='[[3qrl]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qrl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QRL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QRL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qrl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QRL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QRL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ANC1, CST10, SWP29, TAF14, TAF30, TFG3, YPL129W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ANC1, CST10, SWP29, TAF14, TAF30, TFG3, YPL129W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qrl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qrl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qrl RCSB], [http://www.ebi.ac.uk/pdbsum/3qrl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qrl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qrl OCA], [http://pdbe.org/3qrl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qrl RCSB], [http://www.ebi.ac.uk/pdbsum/3qrl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qrl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Atcc 18824]]
	[[Category: Simpson, P J]]		[[Category: Simpson, P J]]
	[[Category: Warren, A J]]		[[Category: Warren, A J]]

OCA at 17:55, 25 December 2014

OCA — Thu, 25 Dec 2014 17:55:57 GMT

←Older revision		Revision as of 17:55, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3qrl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QRL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QRL FirstGlance]. <br>		<table><tr><td colspan='2'>[[3qrl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QRL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QRL FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ANC1, CST10, SWP29, TAF14, TAF30, TFG3, YPL129W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ANC1, CST10, SWP29, TAF14, TAF30, TFG3, YPL129W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qrl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qrl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qrl RCSB], [http://www.ebi.ac.uk/pdbsum/3qrl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qrl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qrl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qrl RCSB], [http://www.ebi.ac.uk/pdbsum/3qrl PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TAF14_YEAST TAF14_YEAST]] Functions as a component of the DNA-binding general transcription factor complex TFIID, the RNA polymerase II associated general transcription factor complex TFIIF, and the chromatin-remodeling complex SWI/SNF. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. TFIIF is essential for the initiation of transcription by RNA polymerase II. TFIIF functions include the recruitment of RNA polymerase II to the promoter bound DNA-TBP-TFIIB complex, decreasing the affinity of RNA polymerase II for non-specific DNA, allowing for the subsequent recruitment of TFIIE and TFIIH, and facilitating RNA polymerase II elongation. The TAF14 subunit has stimulatory activity. Component of the SWI/SNF complex, an ATP-dependent chromatin-remodeling complex, is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors. Component of the histone acetyltransferase NuA3 complex, that acetylates Lys-14 of histone H3. Recruitment of NuA3 to nucleosomes requires methylated histone H3. In conjunction with the FACT complex, NuA3 may be involved in transcriptional regulation.<ref>PMID:9618449</ref> <ref>PMID:10788514</ref> <ref>PMID:12138208</ref> <ref>PMID:12516863</ref> <ref>PMID:12672490</ref> <ref>PMID:17157260</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Simpson, P J.]]	+	[[Category: Simpson, P J]]
-	[[Category: Warren, A J.]]	+	[[Category: Warren, A J]]
	[[Category: Ig fold]]		[[Category: Ig fold]]
	[[Category: Nuclear protein]]		[[Category: Nuclear protein]]
	[[Category: Nucleus]]		[[Category: Nucleus]]
	[[Category: Yeats domain]]		[[Category: Yeats domain]]

OCA at 05:28, 4 June 2014

OCA — Wed, 04 Jun 2014 05:28:10 GMT

←Older revision		Revision as of 05:28, 4 June 2014
Line 1:		Line 1:
-	~~[[Image:3qrl.jpg\|left\|200px]]~~	+	==Crystal Structure of the Taf14 YEATS domain==
-		+	<StructureSection load='3qrl' size='340' side='right' caption='[[3qrl]], [[Resolution\|resolution]] 1.70Å' scene=''>
-	~~<!--~~	+	== Structural highlights ==
-	~~The line below this paragraph, containing "STRUCTURE_3qrl", creates the "Structure Box" on the page.~~	+	<table><tr><td colspan='2'>[[3qrl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QRL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QRL FirstGlance]. <br>
-	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene><br>
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ANC1, CST10, SWP29, TAF14, TAF30, TFG3, YPL129W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
-	~~or leave the SCENE parameter empty for the default display.~~	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qrl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qrl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qrl RCSB], [http://www.ebi.ac.uk/pdbsum/3qrl PDBsum]</span></td></tr>
-	~~-->~~	+	<table>
-	~~{{STRUCTURE_3qrl\| PDB=3qrl \| SCENE= }}~~	+	__TOC__
-		+	</StructureSection>
-	===Crystal Structure of the Taf14 YEATS domain===	+
-		+
-		+
-	==~~About this Structure~~==	+
-	[[3qrl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QRL OCA].	+
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Simpson, P J.]]		[[Category: Simpson, P J.]]

OCA at 08:56, 29 February 2012

OCA — Wed, 29 Feb 2012 08:56:20 GMT

←Older revision		Revision as of 08:56, 29 February 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3qrl.jpg\|left\|200px]]

-	The ~~entry 3qrl~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3qrl", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3qrl\| PDB=3qrl \| SCENE= }}

-	~~Authors: Simpson, P.J., Warren, A.J.~~	+	===Crystal Structure of the Taf14 YEATS domain===

-	~~Description: Crystal~~ Structure ~~of the Taf14 YEATS~~ domain	+
		+	==About this Structure==
		+	[[3qrl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QRL OCA].
		+	[[Category: Saccharomyces cerevisiae]]
		+	[[Category: Simpson, P J.]]
		+	[[Category: Warren, A J.]]
		+	[[Category: Ig fold]]
		+	[[Category: Nuclear protein]]
		+	[[Category: Nucleus]]
		+	[[Category: Yeats domain]]

OCA at 05:02, 25 May 2011

OCA — Wed, 25 May 2011 05:02:07 GMT

←Older revision		Revision as of 05:02, 25 May 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3qrl is ON HOLD	+	The entry 3qrl is ON HOLD until Paper Publication

	Authors: Simpson, P.J., Warren, A.J.		Authors: Simpson, P.J., Warren, A.J.

	Description: Crystal Structure of the Taf14 YEATS domain		Description: Crystal Structure of the Taf14 YEATS domain

OCA: Protected "3qrl" [edit=sysop:move=sysop]

OCA — Wed, 02 Mar 2011 06:42:18 GMT

Protected "3qrl" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:42, 2 March 2011

OCA: New page: '''Unreleased structure''' The entry 3qrl is ON HOLD Authors: Simpson, P.J., Warren, A.J. Description: Crystal Structure of the Taf14 YEATS domain

OCA — Wed, 02 Mar 2011 06:42:17 GMT

New page: '''Unreleased structure''' The entry 3qrl is ON HOLD Authors: Simpson, P.J., Warren, A.J. Description: Crystal Structure of the Taf14 YEATS domain

New page

'''Unreleased structure'''

The entry 3qrl is ON HOLD

Authors: Simpson, P.J., Warren, A.J.

Description: Crystal Structure of the Taf14 YEATS domain