3qrq - Revision history

OCA at 10:49, 21 February 2024

OCA — Wed, 21 Feb 2024 10:49:40 GMT

←Older revision		Revision as of 10:49, 21 February 2024
Line 3:		Line 3:
	<StructureSection load='3qrq' size='340' side='right'caption='[[3qrq]], [[Resolution\|resolution]] 3.19Å' scene=''>		<StructureSection load='3qrq' size='340' side='right'caption='[[3qrq]], [[Resolution\|resolution]] 3.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qrq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Thet8 Thet8~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QRQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QRQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qrq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QRQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QRQ FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3qrp\|3qrp]], [[3qrr\|3qrr]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.194Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">TTHB1192, TTHB192 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=300852 THET8])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qrq OCA], [https://pdbe.org/3qrq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qrq RCSB], [https://www.ebi.ac.uk/pdbsum/3qrq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qrq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qrq OCA], [https://pdbe.org/3qrq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qrq RCSB], [https://www.ebi.ac.uk/pdbsum/3qrq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qrq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CAS6_THET8 CAS6_THET8]] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). This enzyme processes pre-crRNA into individual crRNA units, but may not actually undergo enzyme turnover, retaining the crRNA product (PubMed:21572442). Generates a 2',3'-cyclic phosphodiester.<ref>PMID:21572442</ref> <ref>PMID:21572444</ref>	+	[https://www.uniprot.org/uniprot/CAS6_THET8 CAS6_THET8] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). This enzyme processes pre-crRNA into individual crRNA units, but may not actually undergo enzyme turnover, retaining the crRNA product (PubMed:21572442). Generates a 2',3'-cyclic phosphodiester.<ref>PMID:21572442</ref> <ref>PMID:21572444</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	In bacteria and archaea, small RNAs derived from clustered, regularly interspaced, short palindromic repeat (CRISPR) loci are involved in an adaptable and heritable gene-silencing pathway. Resistance to phage infection is conferred by the incorporation of short invading DNA sequences into the genome as CRISPR spacer elements separated by short repeat sequences. Processing of long primary transcripts (pre-crRNAs) containing these repeats by an RNA endonuclease generates the mature effector RNAs that interfere with phage gene expression. Here we describe structural and functional analyses of the Thermus thermophilus CRISPR Cse3 endonuclease. High-resolution X-ray structures of Cse3 bound to repeat RNAs model both the pre- and post-cleavage complexes associated with processing the pre-crRNA. These structures establish the molecular basis of a specific CRISPR RNA recognition and suggest the mechanism for generation of effector RNAs responsible for gene silencing.	+
-		+
-	Recognition and maturation of effector RNAs in a CRISPR interference pathway.,Gesner EM, Schellenberg MJ, Garside EL, George MM, Macmillan AM Nat Struct Mol Biol. 2011 May 15. PMID:21572444<ref>PMID:21572444</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3qrq" style="background-color:#fffaf0;"></div~~>	+

	==See Also==		==See Also==
Line 28:		Line 18:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Thet8~~]]	+	[[Category: Thermus thermophilus HB8]]
-	[[Category: Garside~~, E L~~]]	+	[[Category: Garside EL]]
-	[[Category: Gesner~~, E G~~]]	+	[[Category: Gesner EG]]
-	[[Category: MacMillan~~, A M~~]]	+	[[Category: MacMillan AM]]
-	[[Category: Schellenberg~~, M J]]~~	+	[[Category: Schellenberg MJ]]
-	~~[[Category: Protein-rna complex]]~~	+
-	~~[[Category: Ramp domain]]~~	+
-	~~[[Category: Rna binding protein-rna complex~~]]	+

OCA at 06:21, 8 June 2022

OCA — Wed, 08 Jun 2022 06:21:19 GMT

←Older revision		Revision as of 06:21, 8 June 2022
Line 1:		Line 1:

	==Structure of Thermus Thermophilus Cse3 bound to an RNA representing a pre-cleavage complex==		==Structure of Thermus Thermophilus Cse3 bound to an RNA representing a pre-cleavage complex==
-	<StructureSection load='3qrq' size='340' side='right' caption='[[3qrq]], [[Resolution\|resolution]] 3.19Å' scene=''>	+	<StructureSection load='3qrq' size='340' side='right'caption='[[3qrq]], [[Resolution\|resolution]] 3.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qrq]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QRQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3QRQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qrq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QRQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QRQ FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qrp\|3qrp]], [[3qrr\|3qrr]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3qrp\|3qrp]], [[3qrr\|3qrr]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TTHB1192, TTHB192 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 THET8])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TTHB1192, TTHB192 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 THET8])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3qrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qrq OCA], [~~http~~://pdbe.org/3qrq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3qrq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3qrq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3qrq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qrq OCA], [https://pdbe.org/3qrq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qrq RCSB], [https://www.ebi.ac.uk/pdbsum/3qrq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qrq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CAS6_THET8 CAS6_THET8]] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). This enzyme processes pre-crRNA into individual crRNA units, but may not actually undergo enzyme turnover, retaining the crRNA product (PubMed:21572442). Generates a 2',3'-cyclic phosphodiester.<ref>PMID:21572442</ref> <ref>PMID:21572444</ref>	+	[[https://www.uniprot.org/uniprot/CAS6_THET8 CAS6_THET8]] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). This enzyme processes pre-crRNA into individual crRNA units, but may not actually undergo enzyme turnover, retaining the crRNA product (PubMed:21572442). Generates a 2',3'-cyclic phosphodiester.<ref>PMID:21572442</ref> <ref>PMID:21572444</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 3qrq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3qrq" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[CRISPR type I-E (Cascade)\|CRISPR type I-E (Cascade)]]
		+	*[[Endonuclease 3D structures\|Endonuclease 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Thet8]]		[[Category: Thet8]]
	[[Category: Garside, E L]]		[[Category: Garside, E L]]

OCA at 19:33, 24 January 2018

OCA — Wed, 24 Jan 2018 19:33:35 GMT

←Older revision		Revision as of 19:33, 24 January 2018
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 3qrq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3qrq" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Endonuclease\|Endonuclease]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Thet8]]		[[Category: Thet8]]
-	[[Category: E L~~., Garside~~]]	+	[[Category: Garside, E L]]
	[[Category: Gesner, E G]]		[[Category: Gesner, E G]]
	[[Category: MacMillan, A M]]		[[Category: MacMillan, A M]]

OCA at 04:10, 5 August 2016

OCA — Fri, 05 Aug 2016 04:10:17 GMT

←Older revision		Revision as of 04:10, 5 August 2016
Line 1:		Line 1:
		+
	==Structure of Thermus Thermophilus Cse3 bound to an RNA representing a pre-cleavage complex==		==Structure of Thermus Thermophilus Cse3 bound to an RNA representing a pre-cleavage complex==
	<StructureSection load='3qrq' size='340' side='right' caption='[[3qrq]], [[Resolution\|resolution]] 3.19Å' scene=''>		<StructureSection load='3qrq' size='340' side='right' caption='[[3qrq]], [[Resolution\|resolution]] 3.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qrq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Thermus_thermophilus_hb8 Thermus thermophilus hb8~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QRQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QRQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qrq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QRQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QRQ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qrp\|3qrp]], [[3qrr\|3qrr]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qrp\|3qrp]], [[3qrr\|3qrr]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TTHB1192, TTHB192 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 ~~Thermus thermophilus HB8~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TTHB1192, TTHB192 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 THET8])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qrq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qrq RCSB], [http://www.ebi.ac.uk/pdbsum/3qrq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qrq OCA], [http://pdbe.org/3qrq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qrq RCSB], [http://www.ebi.ac.uk/pdbsum/3qrq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qrq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~Q53WG9_THET8 Q53WG9_THET8~~]] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). ~~Processes~~ pre-crRNA into individual crRNA units, but may not actually undergo enzyme turnover, retaining the crRNA product. Generates a 2',3'-cyclic phosphodiester.<ref>PMID:21572442</ref> <ref>PMID:21572444</ref>	+	[[http://www.uniprot.org/uniprot/CAS6_THET8 CAS6_THET8]] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). This enzyme processes pre-crRNA into individual crRNA units, but may not actually undergo enzyme turnover, retaining the crRNA product (PubMed:21572442). Generates a 2',3'-cyclic phosphodiester.<ref>PMID:21572442</ref> <ref>PMID:21572444</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3qrq" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Thermus thermophilus hb8~~]]	+	[[Category: Thet8]]
	[[Category: E L., Garside]]		[[Category: E L., Garside]]
	[[Category: Gesner, E G]]		[[Category: Gesner, E G]]

OCA at 15:43, 25 December 2014

OCA — Thu, 25 Dec 2014 15:43:18 GMT

←Older revision		Revision as of 15:43, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qrq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qrq RCSB], [http://www.ebi.ac.uk/pdbsum/3qrq PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qrq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qrq RCSB], [http://www.ebi.ac.uk/pdbsum/3qrq PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q53WG9_THET8 Q53WG9_THET8]] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Processes pre-crRNA into individual crRNA units, but may not actually undergo enzyme turnover, retaining the crRNA product. Generates a 2',3'-cyclic phosphodiester.<ref>PMID:21572442</ref> <ref>PMID:21572444</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 15:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[Endonuclease\|Endonuclease]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:22, 19 December 2014

OCA — Fri, 19 Dec 2014 10:22:16 GMT

←Older revision		Revision as of 10:22, 19 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3qrq\| PDB=3qrq \| SCENE= }}~~	+	==Structure of Thermus Thermophilus Cse3 bound to an RNA representing a pre-cleavage complex==
-	===Structure of Thermus Thermophilus Cse3 bound to an RNA representing a pre-cleavage complex===	+	<StructureSection load='3qrq' size='340' side='right' caption='[[3qrq]], [[Resolution\|resolution]] 3.19Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21572444}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3qrq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus_hb8 Thermus thermophilus hb8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QRQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QRQ FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qrp\|3qrp]], [[3qrr\|3qrr]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TTHB1192, TTHB192 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 Thermus thermophilus HB8])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qrq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qrq RCSB], [http://www.ebi.ac.uk/pdbsum/3qrq PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In bacteria and archaea, small RNAs derived from clustered, regularly interspaced, short palindromic repeat (CRISPR) loci are involved in an adaptable and heritable gene-silencing pathway. Resistance to phage infection is conferred by the incorporation of short invading DNA sequences into the genome as CRISPR spacer elements separated by short repeat sequences. Processing of long primary transcripts (pre-crRNAs) containing these repeats by an RNA endonuclease generates the mature effector RNAs that interfere with phage gene expression. Here we describe structural and functional analyses of the Thermus thermophilus CRISPR Cse3 endonuclease. High-resolution X-ray structures of Cse3 bound to repeat RNAs model both the pre- and post-cleavage complexes associated with processing the pre-crRNA. These structures establish the molecular basis of a specific CRISPR RNA recognition and suggest the mechanism for generation of effector RNAs responsible for gene silencing.

-	~~==Function==~~	+	Recognition and maturation of effector RNAs in a CRISPR interference pathway.,Gesner EM, Schellenberg MJ, Garside EL, George MM, Macmillan AM Nat Struct Mol Biol. 2011 May 15. PMID:21572444<ref>PMID:21572444</ref>
-	[[http://www.uniprot.org/uniprot/Q53WG9_THET8 Q53WG9_THET8]] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and ~~conjugative plasmids).~~ CRISPR ~~clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids~~. ~~CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Processes pre-crRNA into individual crRNA units~~, ~~but may not actually undergo enzyme turnover~~, ~~retaining the crRNA product. Generates a 2'~~,~~3'-cyclic phosphodiester~~.~~<ref>~~PMID:~~21572442</ref>~~ <ref>PMID:21572444</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3qrq]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Thermus_thermophilus_hb8 Thermus thermophilus hb8]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3QRQ OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:021572444</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Thermus thermophilus hb8]]		[[Category: Thermus thermophilus hb8]]
-	[[Category: E L., Garside.]]	+	[[Category: E L., Garside]]
-	[[Category: Gesner, E G.]]	+	[[Category: Gesner, E G]]
-	[[Category: MacMillan, A M.]]	+	[[Category: MacMillan, A M]]
-	[[Category: Schellenberg, M J.]]	+	[[Category: Schellenberg, M J]]
	[[Category: Protein-rna complex]]		[[Category: Protein-rna complex]]
	[[Category: Ramp domain]]		[[Category: Ramp domain]]
	[[Category: Rna binding protein-rna complex]]		[[Category: Rna binding protein-rna complex]]

OCA at 08:19, 8 May 2013

OCA — Wed, 08 May 2013 08:19:56 GMT

←Older revision		Revision as of 08:19, 8 May 2013
Line 1:		Line 1:
-	[[Image:3qrq.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3qrq", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3qrq\| PDB=3qrq \| SCENE= }}		{{STRUCTURE_3qrq\| PDB=3qrq \| SCENE= }}
-
	===Structure of Thermus Thermophilus Cse3 bound to an RNA representing a pre-cleavage complex===		===Structure of Thermus Thermophilus Cse3 bound to an RNA representing a pre-cleavage complex===
		+	{{ABSTRACT_PUBMED_21572444}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/Q53WG9_THET8 Q53WG9_THET8]] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Processes pre-crRNA into individual crRNA units, but may not actually undergo enzyme turnover, retaining the crRNA product. Generates a 2',3'-cyclic phosphodiester.<ref>PMID:21572442</ref> <ref>PMID:21572444</ref>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21572444}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~), ~~where 21572444~~ is the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_21572444}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:021572444</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021572444</ref><references group="xtra"/><references/>
	[[Category: Thermus thermophilus hb8]]		[[Category: Thermus thermophilus hb8]]
	[[Category: E L., Garside.]]		[[Category: E L., Garside.]]

OCA at 16:00, 22 June 2011

OCA — Wed, 22 Jun 2011 16:00:40 GMT

←Older revision		Revision as of 16:00, 22 June 2011
Line 1:		Line 1:
-	[[Image:3qrq.~~jpg~~\|left\|200px]]	+	[[Image:3qrq.png\|left\|200px]]

	<!--		<!--
Line 28:		Line 28:
	[[Category: MacMillan, A M.]]		[[Category: MacMillan, A M.]]
	[[Category: Schellenberg, M J.]]		[[Category: Schellenberg, M J.]]
		+	[[Category: Protein-rna complex]]
		+	[[Category: Ramp domain]]
		+	[[Category: Rna binding protein-rna complex]]

OCA at 05:38, 25 May 2011

OCA — Wed, 25 May 2011 05:38:50 GMT

←Older revision		Revision as of 05:38, 25 May 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3qrq.jpg\|left\|200px]]

-	The ~~entry 3qrq~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3qrq", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3qrq\| PDB=3qrq \| SCENE= }}

-	~~Authors: Schellenberg, M.J., Gesner, E.G., Garside E.L., MacMillan, A.M.~~	+	===Structure of Thermus Thermophilus Cse3 bound to an RNA representing a pre-cleavage complex===

-	~~Description~~: Structure ~~of Thermus Thermophilus Cse3 bound to an RNA representing~~ a ~~pre~~-~~cleavage complex~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21572444}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21572444 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21572444}}
		+
		+	==About this Structure==
		+	[[3qrq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus_hb8 Thermus thermophilus hb8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QRQ OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021572444</ref><references group="xtra"/>
		+	[[Category: Thermus thermophilus hb8]]
		+	[[Category: E L., Garside.]]
		+	[[Category: Gesner, E G.]]
		+	[[Category: MacMillan, A M.]]
		+	[[Category: Schellenberg, M J.]]

OCA at 05:10, 18 May 2011

OCA — Wed, 18 May 2011 05:10:36 GMT

←Older revision		Revision as of 05:10, 18 May 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3qrq is ON HOLD	+	The entry 3qrq is ON HOLD until Paper Publication

	Authors: Schellenberg, M.J., Gesner, E.G., Garside E.L., MacMillan, A.M.		Authors: Schellenberg, M.J., Gesner, E.G., Garside E.L., MacMillan, A.M.

	Description: Structure of Thermus Thermophilus Cse3 bound to an RNA representing a pre-cleavage complex		Description: Structure of Thermus Thermophilus Cse3 bound to an RNA representing a pre-cleavage complex