3qs1 - Revision history

OCA at 06:21, 8 June 2022

OCA — Wed, 08 Jun 2022 06:21:40 GMT

←Older revision		Revision as of 06:21, 8 June 2022
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	==Crystal structure of KNI-10006 complex of Plasmepsin I (PMI) from Plasmodium falciparum==		==Crystal structure of KNI-10006 complex of Plasmepsin I (PMI) from Plasmodium falciparum==
-	<StructureSection load='3qs1' size='340' side='right' caption='[[3qs1]], [[Resolution\|resolution]] 3.10Å' scene=''>	+	<StructureSection load='3qs1' size='340' side='right'caption='[[3qs1]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qs1]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QS1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3QS1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qs1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QS1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QS1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=006:(4R)-3-[(2S,3S)-3-{[(2,6-DIMETHYLPHENOXY)ACETYL]AMINO}-2-HYDROXY-4-PHENYLBUTANOYL]-N-[(1S,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YL]-5,5-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXAMIDE'>006</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=006:(4R)-3-[(2S,3S)-3-{[(2,6-DIMETHYLPHENOXY)ACETYL]AMINO}-2-HYDROXY-4-PHENYLBUTANOYL]-N-[(1S,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YL]-5,5-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXAMIDE'>006</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qrv\|3qrv]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3qrv\|3qrv]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PMI ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PMI ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Plasmepsin_I Plasmepsin I], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.38 3.4.23.38] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Plasmepsin_I Plasmepsin I], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.38 3.4.23.38] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3qs1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qs1 OCA], [~~http~~://pdbe.org/3qs1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3qs1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3qs1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3qs1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qs1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qs1 OCA], [https://pdbe.org/3qs1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qs1 RCSB], [https://www.ebi.ac.uk/pdbsum/3qs1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qs1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PLM1_PLAFA PLM1_PLAFA]] Participates in the digestion of the host hemoglobin. Initial cleavage at the hinge region of hemoglobin, than cleaves at other sites, leading to denaturation of the molecule and to further degradation.	+	[[https://www.uniprot.org/uniprot/PLM1_PLAFA PLM1_PLAFA]] Participates in the digestion of the host hemoglobin. Initial cleavage at the hinge region of hemoglobin, than cleaves at other sites, leading to denaturation of the molecule and to further degradation.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Plafa]]		[[Category: Plafa]]
	[[Category: Plasmepsin I]]		[[Category: Plasmepsin I]]

OCA at 06:32, 5 August 2016

OCA — Fri, 05 Aug 2016 06:32:47 GMT

←Older revision		Revision as of 06:32, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of KNI-10006 complex of Plasmepsin I (PMI) from Plasmodium falciparum==		==Crystal structure of KNI-10006 complex of Plasmepsin I (PMI) from Plasmodium falciparum==
	<StructureSection load='3qs1' size='340' side='right' caption='[[3qs1]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='3qs1' size='340' side='right' caption='[[3qs1]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qs1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Plasmodium_falciparum Plasmodium falciparum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QS1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QS1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qs1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QS1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QS1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=006:(4R)-3-[(2S,3S)-3-{[(2,6-DIMETHYLPHENOXY)ACETYL]AMINO}-2-HYDROXY-4-PHENYLBUTANOYL]-N-[(1S,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YL]-5,5-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXAMIDE'>006</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=006:(4R)-3-[(2S,3S)-3-{[(2,6-DIMETHYLPHENOXY)ACETYL]AMINO}-2-HYDROXY-4-PHENYLBUTANOYL]-N-[(1S,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YL]-5,5-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXAMIDE'>006</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qrv\|3qrv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qrv\|3qrv]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PMI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 ~~Plasmodium falciparum~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PMI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Plasmepsin_I Plasmepsin I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.38 3.4.23.38] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Plasmepsin_I Plasmepsin I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.38 3.4.23.38] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qs1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qs1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qs1 RCSB], [http://www.ebi.ac.uk/pdbsum/3qs1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qs1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qs1 OCA], [http://pdbe.org/3qs1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qs1 RCSB], [http://www.ebi.ac.uk/pdbsum/3qs1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qs1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3qs1" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Plafa]]
	[[Category: Plasmepsin I]]		[[Category: Plasmepsin I]]
-	[[Category: Plasmodium falciparum]]
	[[Category: Bhaumik, P]]		[[Category: Bhaumik, P]]
	[[Category: Gustchina, A]]		[[Category: Gustchina, A]]

OCA at 23:53, 24 December 2014

OCA — Wed, 24 Dec 2014 23:53:13 GMT

←Older revision		Revision as of 23:53, 24 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qs1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qs1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qs1 RCSB], [http://www.ebi.ac.uk/pdbsum/3qs1 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qs1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qs1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qs1 RCSB], [http://www.ebi.ac.uk/pdbsum/3qs1 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PLM1_PLAFA PLM1_PLAFA]] Participates in the digestion of the host hemoglobin. Initial cleavage at the hinge region of hemoglobin, than cleaves at other sites, leading to denaturation of the molecule and to further degradation.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:19, 9 December 2014

OCA — Tue, 09 Dec 2014 12:19:25 GMT

←Older revision		Revision as of 12:19, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3qs1.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of KNI-10006 complex of Plasmepsin I (PMI) from Plasmodium falciparum==
		+	<StructureSection load='3qs1' size='340' side='right' caption='[[3qs1]], [[Resolution\|resolution]] 3.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3qs1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QS1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QS1 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=006:(4R)-3-[(2S,3S)-3-{[(2,6-DIMETHYLPHENOXY)ACETYL]AMINO}-2-HYDROXY-4-PHENYLBUTANOYL]-N-[(1S,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YL]-5,5-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXAMIDE'>006</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qrv\|3qrv]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PMI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 Plasmodium falciparum])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Plasmepsin_I Plasmepsin I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.38 3.4.23.38] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qs1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qs1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qs1 RCSB], [http://www.ebi.ac.uk/pdbsum/3qs1 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Plasmepsin I (PMI) is one of the four vacuolar pepsin-like proteases responsible for hemoglobin degradation by the malarial parasite Plasmodium falciparum, and the only one with no crystal structure reported to date. Due to substantial functional redundancy of these enzymes, lack of inhibition of even a single plasmepsin can defeat efforts in creating effective antiparasitic agents. We have now solved crystal structures of the recombinant PMI as apoenzyme and in complex with the potent peptidic inhibitor, KNI-10006, at the resolution of 2.4 and 3.1A, respectively. The apoenzyme crystallized in the orthorhombic space group P2(1)2(1)2(1) with two molecules in the asymmetric unit and the structure has been refined to the final R-factor of 20.7%. The KNI-10006 bound enzyme crystallized in the tetragonal space group P4(3) with four molecules in the asymmetric unit and the structure has been refined to the final R-factor of 21.1%. In the PMI-KNI-10006 complex, the inhibitors were bound identically to all four enzyme molecules, with the opposite directionality of the main chain of KNI-10006 relative to the direction of the enzyme substrates. Such a mode of binding of inhibitors containing an allophenylnorstatine-dimethylthioproline insert in the P1-P1' positions, previously reported in a complex with PMIV, demonstrates the importance of satisfying the requirements for the proper positioning of the functional groups in the mechanism-based inhibitors towards the catalytic machinery of aspartic proteases, as opposed to binding driven solely by the specificity of the individual enzymes. A comparison of the structure of the PMI-KNI-10006 complex with the structures of other vacuolar plasmepsins identified the important differences between them and may help in the design of specific inhibitors targeting the individual enzymes.

-	~~{{STRUCTURE_3qs1\| PDB=3qs1 \| SCENE= }}~~	+	Crystal structures of the free and inhibited forms of plasmepsin I (PMI) from Plasmodium falciparum.,Bhaumik P, Horimoto Y, Xiao H, Miura T, Hidaka K, Kiso Y, Wlodawer A, Yada RY, Gustchina A J Struct Biol. 2011 Apr 20. PMID:21521654<ref>PMID:21521654</ref>

-	~~===Crystal structure~~ of ~~KNI-10006 complex of Plasmepsin I (PMI) from Plasmodium falciparum===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21521654}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3qs1]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Plasmodium_falciparum Plasmodium falciparum]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3QS1 OCA].~~	+

	==See Also==		==See Also==
	*[[Plasmepsin\|Plasmepsin]]		*[[Plasmepsin\|Plasmepsin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021521654<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Plasmepsin I]]		[[Category: Plasmepsin I]]
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
-	[[Category: Bhaumik, P.]]	+	[[Category: Bhaumik, P]]
-	[[Category: Gustchina, A.]]	+	[[Category: Gustchina, A]]
-	[[Category: Wlodawer, A.]]	+	[[Category: Wlodawer, A]]
	[[Category: Aspartic protease]]		[[Category: Aspartic protease]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Kni]]		[[Category: Kni]]
	[[Category: Malaria]]		[[Category: Malaria]]

OCA at 10:24, 20 October 2012

OCA — Sat, 20 Oct 2012 10:24:03 GMT

←Older revision		Revision as of 10:24, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3qs1]] is a 4 chain structure ~~of [[Plasmepsin]]~~ with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QS1 OCA].	+	[[3qs1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QS1 OCA].

	==See Also==		==See Also==

OCA at 01:59, 26 July 2012

OCA — Thu, 26 Jul 2012 01:59:02 GMT

←Older revision		Revision as of 01:59, 26 July 2012
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	[[Image:3qs1.png\|left\|200px]]		[[Image:3qs1.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_3qs1\| PDB=3qs1 \| SCENE= }}		{{STRUCTURE_3qs1\| PDB=3qs1 \| SCENE= }}

	===Crystal structure of KNI-10006 complex of Plasmepsin I (PMI) from Plasmodium falciparum===		===Crystal structure of KNI-10006 complex of Plasmepsin I (PMI) from Plasmodium falciparum===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21521654}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21521654 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_21521654}}		{{ABSTRACT_PUBMED_21521654}}

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	==See Also==		==See Also==
-	*[[Plasmepsin]]	+	*[[Plasmepsin\|Plasmepsin]]

	==Reference==		==Reference==

OCA at 16:00, 22 June 2011

OCA — Wed, 22 Jun 2011 16:00:53 GMT

←Older revision		Revision as of 16:00, 22 June 2011
Line 1:		Line 1:
-	[[Image:3qs1.~~jpg~~\|left\|200px]]	+	[[Image:3qs1.png\|left\|200px]]

	<!--		<!--
Line 19:		Line 19:

	==About this Structure==		==About this Structure==
-	[[3qs1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QS1 OCA].	+	[[3qs1]] is a 4 chain structure of [[Plasmepsin]] with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QS1 OCA].
		+
		+	==See Also==
		+	*[[Plasmepsin]]

	==Reference==		==Reference==
Line 28:		Line 31:
	[[Category: Gustchina, A.]]		[[Category: Gustchina, A.]]
	[[Category: Wlodawer, A.]]		[[Category: Wlodawer, A.]]
		+	[[Category: Aspartic protease]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Kni]]
		+	[[Category: Malaria]]

OCA at 04:45, 12 May 2011

OCA — Thu, 12 May 2011 04:45:10 GMT

←Older revision		Revision as of 04:45, 12 May 2011
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-	~~'''Unreleased structure'''~~	+	[[Image:3qs1.jpg\|left\|200px]]

-	The ~~entry 3qs1~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3qs1", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3qs1\| PDB=3qs1 \| SCENE= }}

-	~~Authors: Bhaumik, P., Gustchina, A., Wlodawer, A.~~	+	===Crystal structure of KNI-10006 complex of Plasmepsin I (PMI) from Plasmodium falciparum===

-	~~Description~~: ~~Crystal~~ structure ~~of KNI~~-~~10006 complex of~~ Plasmepsin I ~~(PMI) from~~ Plasmodium falciparum	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21521654}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21521654 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21521654}}
		+
		+	==About this Structure==
		+	[[3qs1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QS1 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021521654</ref><references group="xtra"/>
		+	[[Category: Plasmepsin I]]
		+	[[Category: Plasmodium falciparum]]
		+	[[Category: Bhaumik, P.]]
		+	[[Category: Gustchina, A.]]
		+	[[Category: Wlodawer, A.]]

OCA at 04:55, 13 April 2011

OCA — Wed, 13 Apr 2011 04:55:49 GMT

←Older revision		Revision as of 04:55, 13 April 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3qs1 is ON HOLD	+	The entry 3qs1 is ON HOLD until Paper Publication

	Authors: Bhaumik, P., Gustchina, A., Wlodawer, A.		Authors: Bhaumik, P., Gustchina, A., Wlodawer, A.

	Description: Crystal structure of KNI-10006 complex of Plasmepsin I (PMI) from Plasmodium falciparum		Description: Crystal structure of KNI-10006 complex of Plasmepsin I (PMI) from Plasmodium falciparum

OCA at 08:37, 6 April 2011

OCA — Wed, 06 Apr 2011 08:37:10 GMT

←Older revision		Revision as of 08:37, 6 April 2011
Line 5:		Line 5:
	Authors: Bhaumik, P., Gustchina, A., Wlodawer, A.		Authors: Bhaumik, P., Gustchina, A., Wlodawer, A.

-	Description: Crystal structure of KNI-10006 complex of Plasmepsin I (PMI) from ~~<I>~~Plasmodium falciparum~~</i>~~	+	Description: Crystal structure of KNI-10006 complex of Plasmepsin I (PMI) from Plasmodium falciparum