3qtm - Revision history

OCA at 05:35, 15 June 2022

OCA — Wed, 15 Jun 2022 05:35:40 GMT

←Older revision		Revision as of 05:35, 15 June 2022
Line 1:		Line 1:

	==Structure of S. pombe nuclear import adaptor Nro1 (Space group P21)==		==Structure of S. pombe nuclear import adaptor Nro1 (Space group P21)==
-	<StructureSection load='3qtm' size='340' side='right' caption='[[3qtm]], [[Resolution\|resolution]] 2.15Å' scene=''>	+	<StructureSection load='3qtm' size='340' side='right'caption='[[3qtm]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qtm]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QTM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3QTM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qtm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QTM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QTM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qtn\|3qtn]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3qtn\|3qtn]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPCC4B3.07 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 CBS 356])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPCC4B3.07 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 CBS 356])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3qtm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qtm OCA], [~~http~~://pdbe.org/3qtm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3qtm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3qtm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3qtm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qtm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qtm OCA], [https://pdbe.org/3qtm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qtm RCSB], [https://www.ebi.ac.uk/pdbsum/3qtm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qtm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ETT1_SCHPO ETT1_SCHPO]] Required for correct translation termination (By similarity). Positive regulator of the stability of the N-terminal transcription factor domain (Sre1N) of sre1 which is released from the membrane and enters the nucleus to activate hypoxic gene expression. Acts also as a direct inhibitor of ofd1. Functions probably by inhibiting the ability of the ofd1 to accelerate Sre1N degradation in absence of oxygen.<ref>PMID:15116432</ref> <ref>PMID:19158663</ref>	+	[[https://www.uniprot.org/uniprot/ETT1_SCHPO ETT1_SCHPO]] Required for correct translation termination (By similarity). Positive regulator of the stability of the N-terminal transcription factor domain (Sre1N) of sre1 which is released from the membrane and enters the nucleus to activate hypoxic gene expression. Acts also as a direct inhibitor of ofd1. Functions probably by inhibiting the ability of the ofd1 to accelerate Sre1N degradation in absence of oxygen.<ref>PMID:15116432</ref> <ref>PMID:19158663</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Cbs 356]]		[[Category: Cbs 356]]
		+	[[Category: Large Structures]]
	[[Category: Graille, M]]		[[Category: Graille, M]]
	[[Category: Henri, J]]		[[Category: Henri, J]]

OCA at 05:54, 3 January 2018

OCA — Wed, 03 Jan 2018 05:54:22 GMT

←Older revision		Revision as of 05:54, 3 January 2018
Line 1:		Line 1:

-	==~~Crystal structure~~ of ~~Nro1/Ett1 protein from~~ S. pombe (~~High resolution~~)==	+	==Structure of S. pombe nuclear import adaptor Nro1 (Space group P21)==
	<StructureSection load='3qtm' size='340' side='right' caption='[[3qtm]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='3qtm' size='340' side='right' caption='[[3qtm]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 02:36, 5 August 2016

OCA — Fri, 05 Aug 2016 02:36:16 GMT

←Older revision		Revision as of 02:36, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of Nro1/Ett1 protein from S. pombe (High resolution)==		==Crystal structure of Nro1/Ett1 protein from S. pombe (High resolution)==
	<StructureSection load='3qtm' size='340' side='right' caption='[[3qtm]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='3qtm' size='340' side='right' caption='[[3qtm]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qtm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Schizosaccharomyces_pombe Schizosaccharomyces pombe~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QTM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QTM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qtm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QTM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QTM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qtn\|3qtn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qtn\|3qtn]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPCC4B3.07 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 ~~Schizosaccharomyces pombe~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPCC4B3.07 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 CBS 356])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qtm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qtm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qtm RCSB], [http://www.ebi.ac.uk/pdbsum/3qtm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qtm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qtm OCA], [http://pdbe.org/3qtm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qtm RCSB], [http://www.ebi.ac.uk/pdbsum/3qtm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qtm ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ETT1_SCHPO ETT1_SCHPO]] Required for correct translation termination (By similarity). Positive regulator of the stability of the N-terminal transcription factor domain (Sre1N) of sre1 which is released from the membrane and enters the nucleus to activate hypoxic gene expression. Acts also as a direct inhibitor of ofd1. Functions probably by inhibiting the ability of the ofd1 to accelerate Sre1N degradation in absence of oxygen.<ref>PMID:15116432</ref> <ref>PMID:19158663</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3qtm" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Schizosaccharomyces pombe~~]]	+	[[Category: Cbs 356]]
	[[Category: Graille, M]]		[[Category: Graille, M]]
	[[Category: Henri, J]]		[[Category: Henri, J]]

OCA at 21:09, 3 January 2015

OCA — Sat, 03 Jan 2015 21:09:31 GMT

←Older revision		Revision as of 21:09, 3 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3qtm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QTM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QTM FirstGlance]. <br>		<table><tr><td colspan='2'>[[3qtm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QTM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QTM FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qtn\|3qtn]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qtn\|3qtn]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPCC4B3.07 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 Schizosaccharomyces pombe])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPCC4B3.07 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 Schizosaccharomyces pombe])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qtm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qtm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qtm RCSB], [http://www.ebi.ac.uk/pdbsum/3qtm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qtm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qtm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qtm RCSB], [http://www.ebi.ac.uk/pdbsum/3qtm PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 15:		Line 15:
	Structural and functional analysis of Nro1/Ett1: a protein involved in translation termination in S. cerevisiae and in O2-mediated gene control in S. pombe.,Rispal D, Henri J, van Tilbeurgh H, Graille M, Seraphin B RNA. 2011 Jul;17(7):1213-24. Epub 2011 May 24. PMID:21610214<ref>PMID:21610214</ref>		Structural and functional analysis of Nro1/Ett1: a protein involved in translation termination in S. cerevisiae and in O2-mediated gene control in S. pombe.,Rispal D, Henri J, van Tilbeurgh H, Graille M, Seraphin B RNA. 2011 Jul;17(7):1213-24. Epub 2011 May 24. PMID:21610214<ref>PMID:21610214</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Schizosaccharomyces pombe]]		[[Category: Schizosaccharomyces pombe]]
-	[[Category: Graille, M.]]	+	[[Category: Graille, M]]
-	[[Category: Henri, J.]]	+	[[Category: Henri, J]]
-	[[Category: Rispal, D.]]	+	[[Category: Rispal, D]]
-	[[Category: Seraphin, B.]]	+	[[Category: Seraphin, B]]
-	[[Category: Tilbeurgh, H van.]]	+	[[Category: Tilbeurgh, H van]]
	[[Category: Enhancer of translation termination]]		[[Category: Enhancer of translation termination]]
	[[Category: Tetratricopeptide repeat]]		[[Category: Tetratricopeptide repeat]]
	[[Category: Translation]]		[[Category: Translation]]

OCA at 04:41, 5 June 2014

OCA — Thu, 05 Jun 2014 04:41:01 GMT

←Older revision		Revision as of 04:41, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3qtm.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of Nro1/Ett1 protein from S. pombe (High resolution)==
		+	<StructureSection load='3qtm' size='340' side='right' caption='[[3qtm]], [[Resolution\|resolution]] 2.15Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3qtm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QTM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QTM FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qtn\|3qtn]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPCC4B3.07 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 Schizosaccharomyces pombe])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qtm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qtm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qtm RCSB], [http://www.ebi.ac.uk/pdbsum/3qtm PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In Saccharomyces cerevisiae, the putative 2-OG-Fe(II) dioxygenase Tpa1 and its partner Ett1 have been shown to impact mRNA decay and translation. Hence, inactivation of these factors was shown to influence stop codon read-though. In addition, Tpa1 represses, by an unknown mechanism, genes regulated by Hap1, a transcription factor involved in the response to levels of heme and O(2). The Schizosaccharomyces pombe orthologs of Tpa1 and Ett1, Ofd1, and its partner Nro1, respectively, have been shown to regulate the stability of the Sre1 transcription factor in response to oxygen levels. To gain insight into the function of Nro1/Ett1, we have solved the crystal structure of the S. pombe Nro1 protein deleted of its 54 N-terminal residues. Nro1 unexpectedly adopts a Tetratrico Peptide Repeat (TPR) fold, a motif often responsible for protein or peptide binding. Two ligands, a sulfate ion and an unknown molecule, interact with a cluster of highly conserved amino acids on the protein surface. Mutation of these residues demonstrates that these ligand binding sites are essential for Ett1 function in S. cerevisiae, as investigated by assaying for efficient translation termination.

-	<!--	+	Structural and functional analysis of Nro1/Ett1: a protein involved in translation termination in S. cerevisiae and in O2-mediated gene control in S. pombe.,Rispal D, Henri J, van Tilbeurgh H, Graille M, Seraphin B RNA. 2011 Jul;17(7):1213-24. Epub 2011 May 24. PMID:21610214<ref>PMID:21610214</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3qtm"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_3qtm\| PDB=3qtm \| SCENE= }}~~	+

-	~~===Crystal structure of Nro1~~/~~Ett1 protein from S. pombe (High resolution)===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_21610214}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21610214 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_21610214}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3qtm]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QTM OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021610214<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Schizosaccharomyces pombe]]		[[Category: Schizosaccharomyces pombe]]
	[[Category: Graille, M.]]		[[Category: Graille, M.]]

OCA at 05:48, 14 March 2012

OCA — Wed, 14 Mar 2012 05:48:50 GMT

←Older revision		Revision as of 05:48, 14 March 2012
Line 1:		Line 1:
-	[[Image:3qtm.~~jpg~~\|left\|200px]]	+	[[Image:3qtm.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 9:
	{{STRUCTURE_3qtm\| PDB=3qtm \| SCENE= }}		{{STRUCTURE_3qtm\| PDB=3qtm \| SCENE= }}

-	===~~Structure~~ of ~~a yeast~~ protein===	+	===Crystal structure of Nro1/Ett1 protein from S. pombe (High resolution)===

OCA at 05:53, 21 September 2011

OCA — Wed, 21 Sep 2011 05:53:24 GMT

←Older revision		Revision as of 05:53, 21 September 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3qtm.jpg\|left\|200px]]

-	The ~~entry 3qtm~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3qtm", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3qtm\| PDB=3qtm \| SCENE= }}

-	~~Authors: Rispal, D., Henri, J., van Tilbeurgh, H., Graille, M., Seraphin, B.~~	+	===Structure of a yeast protein===

-	~~Description~~: Structure of a ~~yeast protein~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21610214}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21610214 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21610214}}
		+
		+	==About this Structure==
		+	[[3qtm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QTM OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021610214</ref><references group="xtra"/>
		+	[[Category: Schizosaccharomyces pombe]]
		+	[[Category: Graille, M.]]
		+	[[Category: Henri, J.]]
		+	[[Category: Rispal, D.]]
		+	[[Category: Seraphin, B.]]
		+	[[Category: Tilbeurgh, H van.]]
		+	[[Category: Enhancer of translation termination]]
		+	[[Category: Tetratricopeptide repeat]]
		+	[[Category: Translation]]

OCA at 07:45, 30 March 2011

OCA — Wed, 30 Mar 2011 07:45:30 GMT

←Older revision		Revision as of 07:45, 30 March 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3qtm is ON HOLD	+	The entry 3qtm is ON HOLD until Paper Publication

	Authors: Rispal, D., Henri, J., van Tilbeurgh, H., Graille, M., Seraphin, B.		Authors: Rispal, D., Henri, J., van Tilbeurgh, H., Graille, M., Seraphin, B.

	Description: Structure of a yeast protein		Description: Structure of a yeast protein

OCA: Protected "3qtm" [edit=sysop:move=sysop]

OCA — Wed, 02 Mar 2011 06:44:24 GMT

Protected "3qtm" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:44, 2 March 2011

OCA: New page: '''Unreleased structure''' The entry 3qtm is ON HOLD Authors: Rispal, D., Henri, J., van Tilbeurgh, H., Graille, M., Seraphin, B. Description: Structure of a yeast protein

OCA — Wed, 02 Mar 2011 06:44:23 GMT

New page: '''Unreleased structure''' The entry 3qtm is ON HOLD Authors: Rispal, D., Henri, J., van Tilbeurgh, H., Graille, M., Seraphin, B. Description: Structure of a yeast protein

New page

'''Unreleased structure'''

The entry 3qtm is ON HOLD

Authors: Rispal, D., Henri, J., van Tilbeurgh, H., Graille, M., Seraphin, B.

Description: Structure of a yeast protein