3qug - Revision history

OCA at 17:15, 1 November 2023

OCA — Wed, 01 Nov 2023 17:15:08 GMT

←Older revision		Revision as of 17:15, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3qug' size='340' side='right'caption='[[3qug]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='3qug' size='340' side='right'caption='[[3qug]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qug]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Staam Staam~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QUG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qug]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_Mu50 Staphylococcus aureus subsp. aureus Mu50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QUG FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GIX:PROTOPORPHYRIN+IX+CONTAINING+GA'>GIX</scene>~~, ~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[3quh\|3quh]]~~</~~div~~><~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GIX:PROTOPORPHYRIN+IX+CONTAINING+GA'>GIX</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">harA, isdH, IsdH-NEAT3, sasI, SAV1731 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=158878 STAAM])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qug OCA], [https://pdbe.org/3qug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qug RCSB], [https://www.ebi.ac.uk/pdbsum/3qug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qug ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qug OCA], [https://pdbe.org/3qug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qug RCSB], [https://www.ebi.ac.uk/pdbsum/3qug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qug ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ISDH_STAAM ISDH_STAAM]] Binds human plasma haptoglobin-hemoglobin complexes, haptoglobin and hemoglobin. Binds haptoglobin-hemoglobin complexes with significantly higher affinity than haptoglobin alone (By similarity).	+	[https://www.uniprot.org/uniprot/ISDH_STAAM ISDH_STAAM] Binds human plasma haptoglobin-hemoglobin complexes, haptoglobin and hemoglobin. Binds haptoglobin-hemoglobin complexes with significantly higher affinity than haptoglobin alone (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Staam~~]]	+	[[Category: Staphylococcus aureus subsp. aureus Mu50]]
-	[[Category: Caaveiro~~, J M.M~~]]	+	[[Category: Caaveiro JMM]]
-	[[Category: Moriwaki, Y]]	+	[[Category: Moriwaki Y]]
-	[[Category: Tsumoto, K]]	+	[[Category: Tsumoto K]]
-	~~[[Category: Cell wall]]~~	+
-	~~[[Category: Gallium]]~~	+
-	~~[[Category: Heme]]~~	+
-	~~[[Category: Heme binding]]~~	+
-	~~[[Category: Heme transport]]~~	+
-	~~[[Category: Heme-binding protein]]~~	+
-	~~[[Category: Hemin]]~~	+
-	~~[[Category: Metal selectivity]]~~	+
-	~~[[Category: Metalloporphyrin]]~~	+
-	~~[[Category: Neat domain]]~~	+
-	~~[[Category: Ppix]]~~	+
-	~~[[Category: Protoporphyrin ix~~]]	+

OCA at 05:36, 15 June 2022

OCA — Wed, 15 Jun 2022 05:36:39 GMT

←Older revision		Revision as of 05:36, 15 June 2022
Line 1:		Line 1:

	==Structure of heme transport protein IsdH-NEAT3 from S. aureus in complex with Gallium-porphyrin==		==Structure of heme transport protein IsdH-NEAT3 from S. aureus in complex with Gallium-porphyrin==
-	<StructureSection load='3qug' size='340' side='right' caption='[[3qug]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='3qug' size='340' side='right'caption='[[3qug]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qug]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Staam Staam]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QUG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3QUG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qug]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staam Staam]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QUG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GIX:PROTOPORPHYRIN+IX+CONTAINING+GA'>GIX</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GIX:PROTOPORPHYRIN+IX+CONTAINING+GA'>GIX</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3quh\|3quh]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3quh\|3quh]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">harA, isdH, IsdH-NEAT3, sasI, SAV1731 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=158878 STAAM])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">harA, isdH, IsdH-NEAT3, sasI, SAV1731 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=158878 STAAM])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3qug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qug OCA], [~~http~~://pdbe.org/3qug PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3qug RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3qug PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3qug ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qug OCA], [https://pdbe.org/3qug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qug RCSB], [https://www.ebi.ac.uk/pdbsum/3qug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qug ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ISDH_STAAM ISDH_STAAM]] Binds human plasma haptoglobin-hemoglobin complexes, haptoglobin and hemoglobin. Binds haptoglobin-hemoglobin complexes with significantly higher affinity than haptoglobin alone (By similarity).	+	[[https://www.uniprot.org/uniprot/ISDH_STAAM ISDH_STAAM]] Binds human plasma haptoglobin-hemoglobin complexes, haptoglobin and hemoglobin. Binds haptoglobin-hemoglobin complexes with significantly higher affinity than haptoglobin alone (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Staam]]		[[Category: Staam]]
	[[Category: Caaveiro, J M.M]]		[[Category: Caaveiro, J M.M]]

OCA at 07:54, 4 August 2016

OCA — Thu, 04 Aug 2016 07:54:33 GMT

←Older revision		Revision as of 07:54, 4 August 2016
Line 1:		Line 1:
		+
	==Structure of heme transport protein IsdH-NEAT3 from S. aureus in complex with Gallium-porphyrin==		==Structure of heme transport protein IsdH-NEAT3 from S. aureus in complex with Gallium-porphyrin==
	<StructureSection load='3qug' size='340' side='right' caption='[[3qug]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='3qug' size='340' side='right' caption='[[3qug]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qug]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Staphylococcus_aureus Staphylococcus aureus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QUG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QUG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qug]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staam Staam]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QUG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QUG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GIX:PROTOPORPHYRIN+IX+CONTAINING+GA'>GIX</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GIX:PROTOPORPHYRIN+IX+CONTAINING+GA'>GIX</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3quh\|3quh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3quh\|3quh]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">harA, isdH, IsdH-NEAT3, sasI, SAV1731 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~1280 Staphylococcus aureus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">harA, isdH, IsdH-NEAT3, sasI, SAV1731 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=158878 STAAM])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qug OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qug RCSB], [http://www.ebi.ac.uk/pdbsum/3qug PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qug OCA], [http://pdbe.org/3qug PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qug RCSB], [http://www.ebi.ac.uk/pdbsum/3qug PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qug ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3qug" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Haptoglobin receptor\|Haptoglobin receptor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Staphylococcus aureus~~]]	+	[[Category: Staam]]
	[[Category: Caaveiro, J M.M]]		[[Category: Caaveiro, J M.M]]
	[[Category: Moriwaki, Y]]		[[Category: Moriwaki, Y]]

OCA at 07:06, 25 December 2014

OCA — Thu, 25 Dec 2014 07:06:39 GMT

←Older revision		Revision as of 07:06, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3qug]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QUG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QUG FirstGlance]. <br>		<table><tr><td colspan='2'>[[3qug]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QUG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QUG FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GIX:PROTOPORPHYRIN+IX+CONTAINING+GA'>GIX</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GIX:PROTOPORPHYRIN+IX+CONTAINING+GA'>GIX</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3quh\|3quh]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3quh\|3quh]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">harA, isdH, IsdH-NEAT3, sasI, SAV1731 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">harA, isdH, IsdH-NEAT3, sasI, SAV1731 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qug OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qug RCSB], [http://www.ebi.ac.uk/pdbsum/3qug PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qug OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qug RCSB], [http://www.ebi.ac.uk/pdbsum/3qug PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ISDH_STAAM ISDH_STAAM]] Binds human plasma haptoglobin-hemoglobin complexes, haptoglobin and hemoglobin. Binds haptoglobin-hemoglobin complexes with significantly higher affinity than haptoglobin alone (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 16:
	Molecular basis of recognition of antibacterial porphyrins by heme-transporter IsdH-NEAT3 of Staphylococcus aureus.,Moriwaki Y, Caaveiro JM, Tanaka Y, Tsutsumi H, Hamachi I, Tsumoto K Biochemistry. 2011 Aug 30;50(34):7311-20. Epub 2011 Aug 4. PMID:21797259<ref>PMID:21797259</ref>		Molecular basis of recognition of antibacterial porphyrins by heme-transporter IsdH-NEAT3 of Staphylococcus aureus.,Moriwaki Y, Caaveiro JM, Tanaka Y, Tsutsumi H, Hamachi I, Tsumoto K Biochemistry. 2011 Aug 30;50(34):7311-20. Epub 2011 Aug 4. PMID:21797259<ref>PMID:21797259</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 21:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
-	[[Category: Caaveiro, J M.M.]]	+	[[Category: Caaveiro, J M.M]]
-	[[Category: Moriwaki, Y.]]	+	[[Category: Moriwaki, Y]]
-	[[Category: Tsumoto, K.]]	+	[[Category: Tsumoto, K]]
	[[Category: Cell wall]]		[[Category: Cell wall]]
	[[Category: Gallium]]		[[Category: Gallium]]

OCA at 04:40, 5 June 2014

OCA — Thu, 05 Jun 2014 04:40:47 GMT

←Older revision		Revision as of 04:40, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3qug.~~png~~\|~~left~~\|~~200px~~]]	+	==Structure of heme transport protein IsdH-NEAT3 from S. aureus in complex with Gallium-porphyrin==
		+	<StructureSection load='3qug' size='340' side='right' caption='[[3qug]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3qug]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QUG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QUG FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GIX:PROTOPORPHYRIN+IX+CONTAINING+GA'>GIX</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3quh\|3quh]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">harA, isdH, IsdH-NEAT3, sasI, SAV1731 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qug OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qug RCSB], [http://www.ebi.ac.uk/pdbsum/3qug PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Antibiotic resistance is increasingly seen as a serious problem that threatens public health and erodes our capacity to effectively combat disease. So-called non-iron metalloporhyrins have shown promising antibacterial properties against a number of pathogenic bacteria including Staphylococcus aureus. However, little is known about the molecular mechanism(s) of action of these compounds and in particular how they reach the interior of the bacterial cells. A popular hypothesis indicates that non-iron metalloporphyrins infiltrate into bacterial cells like a "Trojan horse" using heme transport systems. Iron-regulated surface determinant (Isd) is the best characterized heme transport system of S. aureus. Herein we studied the molecular mechanism by which the extracellular heme-receptor IsdH-NEAT3 of Isd recognizes antimicrobial metalloporphyrins. We found that potent antibacterial porphyrins Ga(III)-protoporphyrin IX (PPIX) and Mn(III)-PPIX closely mimicked the properties of the natural ligand heme, namely (i) stable binding to IsdH-NEAT3 with comparable affinities for the receptor, (ii) nearly undistinghuishable three-dimensional structure when complexed with IsdH-NEAT3, and (iii) similar transfer properties to a second receptor IsdA. On the contrary, weaker antibacterial porphyrins Mg(II)-PPIX, Zn(II)-PPIX, and Cu(II)-PPIX were not captured effectively by IsdH-NEAT3 under our experimental conditions and displayed lower affinities. Moreover, reduction of Fe(III)-PPIX to Fe(II)-PPIX with dithionite abrogated stable binding to receptor. These data revealed a clear connection between oxidation state of metal and effective attachment to IsdH-NEAT3. Also, the strong correlation between binding affinity and reported antimicrobial potency suggested that the Isd system may be used by these antibacterial compounds to gain access to the interior of the cells. We hope these results will increase our understanding of Isd system of S. aureus and highlight its biomedical potential to deliver new and more efficient antibacterial treatments.

-	<!--	+	Molecular basis of recognition of antibacterial porphyrins by heme-transporter IsdH-NEAT3 of Staphylococcus aureus.,Moriwaki Y, Caaveiro JM, Tanaka Y, Tsutsumi H, Hamachi I, Tsumoto K Biochemistry. 2011 Aug 30;50(34):7311-20. Epub 2011 Aug 4. PMID:21797259<ref>PMID:21797259</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3qug"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_3qug\| PDB=3qug \| SCENE= }}~~	+

-	~~===Structure~~ of ~~heme transport protein IsdH-NEAT3 from S. aureus in complex with Gallium-porphyrin===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21797259}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21797259 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_21797259}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3qug]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QUG OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021797259<~~/~~ref~~><~~ref group="xtra">PMID:018667422</ref><references group="xtra"~~/>	+
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Caaveiro, J M.M.]]		[[Category: Caaveiro, J M.M.]]

OCA at 05:48, 15 February 2012

OCA — Wed, 15 Feb 2012 05:48:06 GMT

←Older revision		Revision as of 05:48, 15 February 2012
Line 1:		Line 1:
-	[[Image:3qug.~~jpg~~\|left\|200px]]	+	[[Image:3qug.png\|left\|200px]]

	<!--		<!--
Line 13:		Line 13:

	<!--		<!--
-	The line below this paragraph, {{~~ABSTRACT_PUBMED_18667422~~}}, adds the Publication Abstract to the page	+	The line below this paragraph, {{ABSTRACT_PUBMED_21797259}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where ~~18667422~~ is the PubMed ID number.	+	(as it appears on PubMed at http://www.pubmed.gov), where 21797259 is the PubMed ID number.
	-->		-->
-	{{~~ABSTRACT_PUBMED_18667422~~}}	+	{{ABSTRACT_PUBMED_21797259}}

	==About this Structure==		==About this Structure==
Line 22:		Line 22:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18667422~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021797259</ref><ref group="xtra">PMID:018667422</ref><references group="xtra"/>
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Caaveiro, J M.M.]]		[[Category: Caaveiro, J M.M.]]
	[[Category: Moriwaki, Y.]]		[[Category: Moriwaki, Y.]]
	[[Category: Tsumoto, K.]]		[[Category: Tsumoto, K.]]
		+	[[Category: Cell wall]]
		+	[[Category: Gallium]]
		+	[[Category: Heme]]
		+	[[Category: Heme binding]]
		+	[[Category: Heme transport]]
		+	[[Category: Heme-binding protein]]
		+	[[Category: Hemin]]
		+	[[Category: Metal selectivity]]
		+	[[Category: Metalloporphyrin]]
		+	[[Category: Neat domain]]
		+	[[Category: Ppix]]
		+	[[Category: Protoporphyrin ix]]

OCA at 08:17, 30 March 2011

OCA — Wed, 30 Mar 2011 08:17:59 GMT

←Older revision		Revision as of 08:17, 30 March 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3qug.jpg\|left\|200px]]

-	The ~~entry 3qug~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3qug", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3qug\| PDB=3qug \| SCENE= }}

-	~~Authors: Moriwaki, Y., Caaveiro, J.M.M., Tsumoto, K~~.	+	===Structure of heme transport protein IsdH-NEAT3 from S. aureus in complex with Gallium-porphyrin===

-	~~Description~~: ~~Structure of heme transport protein IsdH~~-~~NEAT3~~ from S. aureus ~~in complex with Gallium~~-~~porphyrin~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_18667422}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18667422 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18667422}}
		+
		+	==About this Structure==
		+	[[3qug]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QUG OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:18667422</ref><references group="xtra"/>
		+	[[Category: Staphylococcus aureus]]
		+	[[Category: Caaveiro, J M.M.]]
		+	[[Category: Moriwaki, Y.]]
		+	[[Category: Tsumoto, K.]]

OCA: Protected "3qug" [edit=sysop:move=sysop]

OCA — Wed, 02 Mar 2011 06:45:19 GMT

Protected "3qug" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:45, 2 March 2011

OCA: New page: '''Unreleased structure''' The entry 3qug is ON HOLD Authors: Moriwaki, Y., Caaveiro, J.M.M., Tsumoto, K. Description: Structure of heme transport protein IsdH-NEAT3 from S. aureus in ...

OCA — Wed, 02 Mar 2011 06:45:18 GMT

New page: '''Unreleased structure''' The entry 3qug is ON HOLD Authors: Moriwaki, Y., Caaveiro, J.M.M., Tsumoto, K. Description: Structure of heme transport protein IsdH-NEAT3 from S. aureus in ...

New page

'''Unreleased structure'''

The entry 3qug is ON HOLD

Authors: Moriwaki, Y., Caaveiro, J.M.M., Tsumoto, K.

Description: Structure of heme transport protein IsdH-NEAT3 from S. aureus in complex with Gallium-porphyrin