3qvn - Revision history

OCA at 12:00, 14 March 2024

OCA — Thu, 14 Mar 2024 12:00:23 GMT

←Older revision		Revision as of 12:00, 14 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3qvn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QVN FirstGlance]. <br>		<table><tr><td colspan='2'>[[3qvn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QVN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qvn OCA], [https://pdbe.org/3qvn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qvn RCSB], [https://www.ebi.ac.uk/pdbsum/3qvn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qvn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qvn OCA], [https://pdbe.org/3qvn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qvn RCSB], [https://www.ebi.ac.uk/pdbsum/3qvn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qvn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/Q96UT6_CANAX Q96UT6_CANAX] Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity).[RuleBase:RU000414]		[https://www.uniprot.org/uniprot/Q96UT6_CANAX Q96UT6_CANAX] Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity).[RuleBase:RU000414]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Human MnSOD is significantly more product-inhibited than bacterial MnSODs at high concentrations of superoxide (O(2)(-)). This behavior limits the amount of H(2)O(2) produced at high [O(2)(-)]; its desirability can be explained by the multiple roles of H(2)O(2) in mammalian cells, particularly its role in signaling. To investigate the mechanism of product inhibition in MnSOD, two yeast MnSODs, one from Saccharomyces cerevisiae mitochondria (ScMnSOD) and the other from Candida albicans cytosol (CaMnSODc), were isolated and characterized. ScMnSOD and CaMnSODc are similar in catalytic kinetics, spectroscopy, and redox chemistry, and they both rest predominantly in the reduced state (unlike most other MnSODs). At high [O(2)(-)], the dismutation efficiencies of the yeast MnSODs surpass those of human and bacterial MnSODs, due to very low level of product inhibition. Optical and parallel-mode electron paramagnetic resonance (EPR) spectra suggest the presence of two Mn(3+) species in yeast Mn(3+)SODs, including the well-characterized 5-coordinate Mn(3+) species and a 6-coordinate L-Mn(3+) species with hydroxide as the putative sixth ligand (L). The first and second coordination spheres of ScMnSOD are more similar to bacterial than to human MnSOD. Gln154, an H-bond donor to the Mn-coordinated solvent molecule, is slightly further away from Mn in yeast MnSODs, which may result in their unusual resting state. Mechanistically, the high efficiency of yeast MnSODs could be ascribed to putative translocation of an outer-sphere solvent molecule, which could destabilize the inhibited complex and enhance proton transfer from protein to peroxide. Our studies on yeast MnSODs indicate the unique nature of human MnSOD in that it predominantly undergoes the inhibited pathway at high [O(2)(-)].
-
-	Comparison of two yeast MnSODs: mitochondrial Saccharomyces cerevisiae versus cytosolic Candida albicans.,Sheng Y, Stich TA, Barnese K, Gralla EB, Cascio D, Britt RD, Cabelli DE, Valentine JS J Am Chem Soc. 2011 Dec 28;133(51):20878-89. Epub 2011 Nov 30. PMID:22077216<ref>PMID:22077216</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3qvn" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Superoxide dismutase 3D structures\|Superoxide dismutase 3D structures]]		*[[Superoxide dismutase 3D structures\|Superoxide dismutase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 04:30, 30 September 2022

OCA — Fri, 30 Sep 2022 04:30:31 GMT

←Older revision		Revision as of 04:30, 30 September 2022
Line 3:		Line 3:
	<StructureSection load='3qvn' size='340' side='right'caption='[[3qvn]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3qvn' size='340' side='right'caption='[[3qvn]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qvn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_11006_[[monilia_stellatoidea]] Atcc 11006 [[monilia stellatoidea]]~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QVN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qvn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QVN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CaJ7.0018, SOD3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 ATCC 11006 [[Monilia stellatoidea]]])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qvn OCA], [https://pdbe.org/3qvn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qvn RCSB], [https://www.ebi.ac.uk/pdbsum/3qvn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qvn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qvn OCA], [https://pdbe.org/3qvn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qvn RCSB], [https://www.ebi.ac.uk/pdbsum/3qvn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qvn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/Q96UT6_CANAX Q96UT6_CANAX]] Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity).[RuleBase:RU000414]	+	[https://www.uniprot.org/uniprot/Q96UT6_CANAX Q96UT6_CANAX] Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity).[RuleBase:RU000414]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Candida albicans]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cascio, D]]	+	[[Category: Cascio D]]
-	[[Category: Sheng, Y]]	+	[[Category: Sheng Y]]
-	[[Category: Valentine~~, J S]]~~	+	[[Category: Valentine JS]]
-	~~[[Category: Mn superoxide dismutase]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 05:38, 15 June 2022

OCA — Wed, 15 Jun 2022 05:38:15 GMT

←Older revision		Revision as of 05:38, 15 June 2022
Line 1:		Line 1:

	==Crystal Structure of cytosolic MnSOD3 from Candida albicans==		==Crystal Structure of cytosolic MnSOD3 from Candida albicans==
-	<StructureSection load='3qvn' size='340' side='right' caption='[[3qvn]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='3qvn' size='340' side='right'caption='[[3qvn]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qvn]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_11006_[[~~candida_stellatoidea~~]] Atcc 11006 [[~~candida~~ stellatoidea]]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3QVN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qvn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_11006_[[monilia_stellatoidea]] Atcc 11006 [[monilia stellatoidea]]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QVN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CaJ7.0018, SOD3 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 ATCC 11006 [[~~Candida~~ stellatoidea]]])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CaJ7.0018, SOD3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 ATCC 11006 [[Monilia stellatoidea]]])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3qvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qvn OCA], [~~http~~://pdbe.org/3qvn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3qvn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3qvn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3qvn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qvn OCA], [https://pdbe.org/3qvn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qvn RCSB], [https://www.ebi.ac.uk/pdbsum/3qvn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qvn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/Q96UT6_CANAX Q96UT6_CANAX]] Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity).[RuleBase:RU000414]	+	[[https://www.uniprot.org/uniprot/Q96UT6_CANAX Q96UT6_CANAX]] Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity).[RuleBase:RU000414]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Superoxide ~~Dismutase~~\|Superoxide ~~Dismutase~~]]	+	*[[Superoxide dismutase 3D structures\|Superoxide dismutase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Cascio, D]]		[[Category: Cascio, D]]
	[[Category: Sheng, Y]]		[[Category: Sheng, Y]]

OCA at 10:01, 4 August 2016

OCA — Thu, 04 Aug 2016 10:01:57 GMT

←Older revision		Revision as of 10:01, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of cytosolic MnSOD3 from Candida albicans==		==Crystal Structure of cytosolic MnSOD3 from Candida albicans==
	<StructureSection load='3qvn' size='340' side='right' caption='[[3qvn]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3qvn' size='340' side='right' caption='[[3qvn]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qvn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Candida_albicans Candida albicans~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QVN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qvn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_11006_[[candida_stellatoidea]] Atcc 11006 [[candida stellatoidea]]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QVN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CaJ7.0018, SOD3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 Candida ~~albicans~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CaJ7.0018, SOD3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 ATCC 11006 [[Candida stellatoidea]]])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qvn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qvn RCSB], [http://www.ebi.ac.uk/pdbsum/3qvn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qvn OCA], [http://pdbe.org/3qvn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qvn RCSB], [http://www.ebi.ac.uk/pdbsum/3qvn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qvn ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q96UT6_CANAX Q96UT6_CANAX]] Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity).[RuleBase:RU000414]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 15:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3qvn" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Superoxide Dismutase\|Superoxide Dismutase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Candida albicans]]
	[[Category: Cascio, D]]		[[Category: Cascio, D]]
	[[Category: Sheng, Y]]		[[Category: Sheng, Y]]

OCA at 21:28, 3 January 2015

OCA — Sat, 03 Jan 2015 21:28:18 GMT

←Older revision		Revision as of 21:28, 3 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3qvn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QVN FirstGlance]. <br>		<table><tr><td colspan='2'>[[3qvn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QVN FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CaJ7.0018, SOD3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 Candida albicans])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CaJ7.0018, SOD3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 Candida albicans])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qvn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qvn RCSB], [http://www.ebi.ac.uk/pdbsum/3qvn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qvn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qvn RCSB], [http://www.ebi.ac.uk/pdbsum/3qvn PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 13:		Line 13:
	Comparison of two yeast MnSODs: mitochondrial Saccharomyces cerevisiae versus cytosolic Candida albicans.,Sheng Y, Stich TA, Barnese K, Gralla EB, Cascio D, Britt RD, Cabelli DE, Valentine JS J Am Chem Soc. 2011 Dec 28;133(51):20878-89. Epub 2011 Nov 30. PMID:22077216<ref>PMID:22077216</ref>		Comparison of two yeast MnSODs: mitochondrial Saccharomyces cerevisiae versus cytosolic Candida albicans.,Sheng Y, Stich TA, Barnese K, Gralla EB, Cascio D, Britt RD, Cabelli DE, Valentine JS J Am Chem Soc. 2011 Dec 28;133(51):20878-89. Epub 2011 Nov 30. PMID:22077216<ref>PMID:22077216</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Candida albicans]]		[[Category: Candida albicans]]
-	[[Category: Cascio, D.]]	+	[[Category: Cascio, D]]
-	[[Category: Sheng, Y.]]	+	[[Category: Sheng, Y]]
-	[[Category: Valentine, J S.]]	+	[[Category: Valentine, J S]]
	[[Category: Mn superoxide dismutase]]		[[Category: Mn superoxide dismutase]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 04:49, 5 June 2014

OCA — Thu, 05 Jun 2014 04:49:51 GMT

←Older revision		Revision as of 04:49, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3qvn.~~jpg~~\|~~left~~\|~~200px~~]]	+	==Crystal Structure of cytosolic MnSOD3 from Candida albicans==
		+	<StructureSection load='3qvn' size='340' side='right' caption='[[3qvn]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3qvn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QVN FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CaJ7.0018, SOD3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 Candida albicans])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qvn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qvn RCSB], [http://www.ebi.ac.uk/pdbsum/3qvn PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human MnSOD is significantly more product-inhibited than bacterial MnSODs at high concentrations of superoxide (O(2)(-)). This behavior limits the amount of H(2)O(2) produced at high [O(2)(-)]; its desirability can be explained by the multiple roles of H(2)O(2) in mammalian cells, particularly its role in signaling. To investigate the mechanism of product inhibition in MnSOD, two yeast MnSODs, one from Saccharomyces cerevisiae mitochondria (ScMnSOD) and the other from Candida albicans cytosol (CaMnSODc), were isolated and characterized. ScMnSOD and CaMnSODc are similar in catalytic kinetics, spectroscopy, and redox chemistry, and they both rest predominantly in the reduced state (unlike most other MnSODs). At high [O(2)(-)], the dismutation efficiencies of the yeast MnSODs surpass those of human and bacterial MnSODs, due to very low level of product inhibition. Optical and parallel-mode electron paramagnetic resonance (EPR) spectra suggest the presence of two Mn(3+) species in yeast Mn(3+)SODs, including the well-characterized 5-coordinate Mn(3+) species and a 6-coordinate L-Mn(3+) species with hydroxide as the putative sixth ligand (L). The first and second coordination spheres of ScMnSOD are more similar to bacterial than to human MnSOD. Gln154, an H-bond donor to the Mn-coordinated solvent molecule, is slightly further away from Mn in yeast MnSODs, which may result in their unusual resting state. Mechanistically, the high efficiency of yeast MnSODs could be ascribed to putative translocation of an outer-sphere solvent molecule, which could destabilize the inhibited complex and enhance proton transfer from protein to peroxide. Our studies on yeast MnSODs indicate the unique nature of human MnSOD in that it predominantly undergoes the inhibited pathway at high [O(2)(-)].

-	~~<!--~~	+	Comparison of two yeast MnSODs: mitochondrial Saccharomyces cerevisiae versus cytosolic Candida albicans.,Sheng Y, Stich TA, Barnese K, Gralla EB, Cascio D, Britt RD, Cabelli DE, Valentine JS J Am Chem Soc. 2011 Dec 28;133(51):20878-89. Epub 2011 Nov 30. PMID:22077216<ref>PMID:22077216</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3qvn"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_3qvn\| PDB=3qvn \| SCENE= }}~~	+

-	~~===Crystal Structure~~ of ~~cytosolic MnSOD3 from Candida albicans===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_22077216}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22077216 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_22077216}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3qvn]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVN OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022077216<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Candida albicans]]		[[Category: Candida albicans]]
	[[Category: Cascio, D.]]		[[Category: Cascio, D.]]

OCA at 06:27, 8 February 2012

OCA — Wed, 08 Feb 2012 06:27:15 GMT

←Older revision		Revision as of 06:27, 8 February 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3qvn.jpg\|left\|200px]]

-	The ~~entry 3qvn~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3qvn", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3qvn\| PDB=3qvn \| SCENE= }}

-	~~Authors: Sheng, Y., Cascio, D., Valentine, J.S.~~	+	===Crystal Structure of cytosolic MnSOD3 from Candida albicans===

-	~~Description~~: ~~Crystal~~ Structure ~~of cytosolic MnSOD3~~ from Candida albicans	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22077216}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22077216 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22077216}}
		+
		+	==About this Structure==
		+	[[3qvn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVN OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022077216</ref><references group="xtra"/>
		+	[[Category: Candida albicans]]
		+	[[Category: Cascio, D.]]
		+	[[Category: Sheng, Y.]]
		+	[[Category: Valentine, J S.]]
		+	[[Category: Mn superoxide dismutase]]
		+	[[Category: Oxidoreductase]]

OCA at 05:37, 29 June 2011

OCA — Wed, 29 Jun 2011 05:37:11 GMT

←Older revision		Revision as of 05:37, 29 June 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3qvn is ON HOLD	+	The entry 3qvn is ON HOLD until Paper Publication

	Authors: Sheng, Y., Cascio, D., Valentine, J.S.		Authors: Sheng, Y., Cascio, D., Valentine, J.S.

	Description: Crystal Structure of cytosolic MnSOD3 from Candida albicans		Description: Crystal Structure of cytosolic MnSOD3 from Candida albicans

OCA: Protected "3qvn" [edit=sysop:move=sysop]

OCA — Wed, 09 Mar 2011 06:08:12 GMT

Protected "3qvn" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:08, 9 March 2011

OCA: New page: '''Unreleased structure''' The entry 3qvn is ON HOLD Authors: Sheng, Y., Cascio, D., Valentine, J.S. Description: Crystal Structure of cytosolic MnSOD3 from Candida albicans

OCA — Wed, 09 Mar 2011 06:08:10 GMT

New page: '''Unreleased structure''' The entry 3qvn is ON HOLD Authors: Sheng, Y., Cascio, D., Valentine, J.S. Description: Crystal Structure of cytosolic MnSOD3 from Candida albicans

New page

'''Unreleased structure'''

The entry 3qvn is ON HOLD

Authors: Sheng, Y., Cascio, D., Valentine, J.S.

Description: Crystal Structure of cytosolic MnSOD3 from Candida albicans