3qy7 - Revision history

OCA at 10:50, 21 February 2024

OCA — Wed, 21 Feb 2024 10:50:43 GMT

←Older revision		Revision as of 10:50, 21 February 2024
Line 3:		Line 3:
	<StructureSection load='3qy7' size='340' side='right'caption='[[3qy7]], [[Resolution\|resolution]] 1.62Å' scene=''>		<StructureSection load='3qy7' size='340' side='right'caption='[[3qy7]], [[Resolution\|resolution]] 1.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qy7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"vibrio_subtilis"_ehrenberg_1835 "vibrio~~ subtilis~~" ehrenberg 1835~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QY7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QY7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qy7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QY7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QY7 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.62Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[3qy6\|3qy6]], [[3qy8\|3qy8]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>BSU36240, ywqE ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1423~~ "~~Vibrio subtilis~~" ~~Ehrenberg 1835])~~<~~/td~~></tr>	+
-	<~~tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qy7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qy7 OCA], [https://pdbe.org/3qy7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qy7 RCSB], [https://www.ebi.ac.uk/pdbsum/3qy7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qy7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qy7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qy7 OCA], [https://pdbe.org/3qy7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qy7 RCSB], [https://www.ebi.ac.uk/pdbsum/3qy7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qy7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/YWQE_BACSU YWQE_BACSU]] Dephosphorylates the phosphotyrosine-containing proteins YwqD, YwqF and Ssb.<ref>PMID:16549871</ref>	+	[https://www.uniprot.org/uniprot/YWQE_BACSU YWQE_BACSU] Dephosphorylates the phosphotyrosine-containing proteins YwqD, YwqF and Ssb.<ref>PMID:16549871</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Unique metal-dependent protein tyrosine phosphatases that belong to the polymerase and histindinol phosphatase (PHP) family are present in Gram-positive bacteria. They are distinct from the Cys-based, low-molecular-weight phosphotyrosine protein phosphatases (LMPTPs). Two representative members of the PHP family tyrosine phosphatases are YwqE from Bacillus subtilis and CpsB from Streptococcus pneumoniae. YwqE is involved in polysaccharide biosynthesis, bacterial DNA metabolism, and DNA damage response in B. subtilis. CpsB regulates capsular polysaccharide biosynthesis via tyrosine dephosphorylation of CpsD, its cognate tyrosine kinase, in S. pneumoniae. To gain insights into the active site and possible conformational changes of the metal-dependent tyrosine phosphatases from Gram-positive bacteria, we have determined the crystal structures of B. subtilis YwqE (in both the apo form and the phosphate-bound form) and S. pneumoniae CpsB (in the sulfate-bound form). Comparisons of the three structures reveal conformational plasticity of two active site loops. Furthermore, in both structures of the phosphate-bound YwqE and the sulfate-bound CpsB, the phosphate (or sulfate) ion is bound to a cluster of three metal ions in the active site, thus providing insight into the pre-catalytic state.	+
-		+
-	Crystal structures of YwqE from Bacillus subtilis and CpsB from Streptococcus pneumoniae, unique metal-dependent tyrosine phosphatases.,Kim HS, Lee SJ, Yoon HJ, An DR, Kim DJ, Kim SJ, Suh SW J Struct Biol. 2011 May 14. PMID:21605684<ref>PMID:21605684</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3qy7" style="background-color:#fffaf0;"></div~~>	+

	==See Also==		==See Also==
Line 28:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Vibrio~~ subtilis ~~ehrenberg 1835~~]]	+	[[Category: Bacillus subtilis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Protein-tyrosine-phosphatase]]~~	+	[[Category: An DR]]
-	[[Category: An~~, D R~~]]	+	[[Category: Kim DJ]]
-	[[Category: Kim~~, D J~~]]	+	[[Category: Kim HS]]
-	[[Category: Kim~~, H S~~]]	+	[[Category: Kim S-J]]
-	[[Category: Kim, S J]]	+	[[Category: Lee SJ]]
-	[[Category: Lee~~, S J~~]]	+	[[Category: Suh SW]]
-	[[Category: Suh~~, S W~~]]	+	[[Category: Yoon HJ]]
-	[[Category: Yoon~~, H J]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Phosphatase]]~~	+
-	~~[[Category: Tim barrel~~]]	+

OCA at 05:41, 15 June 2022

OCA — Wed, 15 Jun 2022 05:41:11 GMT

←Older revision		Revision as of 05:41, 15 June 2022
Line 1:		Line 1:

	==Crystal structures of YwqE from Bacillus subtilis and CpsB from Streptococcus pneumoniae, unique metal-dependent tyrosine phosphatases==		==Crystal structures of YwqE from Bacillus subtilis and CpsB from Streptococcus pneumoniae, unique metal-dependent tyrosine phosphatases==
-	<StructureSection load='3qy7' size='340' side='right' caption='[[3qy7]], [[Resolution\|resolution]] 1.62Å' scene=''>	+	<StructureSection load='3qy7' size='340' side='right'caption='[[3qy7]], [[Resolution\|resolution]] 1.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qy7]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"~~bacillus_globigii~~"~~_migula_1900~~ "~~bacillus globigii~~" ~~migula 1900~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QY7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3QY7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qy7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QY7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QY7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qy6\|3qy6]], [[3qy8\|3qy8]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3qy6\|3qy6]], [[3qy8\|3qy8]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BSU36240, ywqE ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "~~Bacillus globigii~~" ~~Migula 1900~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BSU36240, ywqE ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3qy7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qy7 OCA], [~~http~~://pdbe.org/3qy7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3qy7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3qy7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3qy7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qy7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qy7 OCA], [https://pdbe.org/3qy7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qy7 RCSB], [https://www.ebi.ac.uk/pdbsum/3qy7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qy7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/YWQE_BACSU YWQE_BACSU]] Dephosphorylates the phosphotyrosine-containing proteins YwqD, YwqF and Ssb.<ref>PMID:16549871</ref>	+	[[https://www.uniprot.org/uniprot/YWQE_BACSU YWQE_BACSU]] Dephosphorylates the phosphotyrosine-containing proteins YwqD, YwqF and Ssb.<ref>PMID:16549871</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:

	==See Also==		==See Also==
-	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]	+	*[[Tyrosine phosphatase 3D structures\|Tyrosine phosphatase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus globigii migula 1900~~]]	+	[[Category: Vibrio subtilis ehrenberg 1835]]
		+	[[Category: Large Structures]]
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]
	[[Category: An, D R]]		[[Category: An, D R]]

OCA at 19:44, 5 August 2016

OCA — Fri, 05 Aug 2016 19:44:09 GMT

←Older revision		Revision as of 19:44, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structures of YwqE from Bacillus subtilis and CpsB from Streptococcus pneumoniae, unique metal-dependent tyrosine phosphatases==		==Crystal structures of YwqE from Bacillus subtilis and CpsB from Streptococcus pneumoniae, unique metal-dependent tyrosine phosphatases==
	<StructureSection load='3qy7' size='340' side='right' caption='[[3qy7]], [[Resolution\|resolution]] 1.62Å' scene=''>		<StructureSection load='3qy7' size='340' side='right' caption='[[3qy7]], [[Resolution\|resolution]] 1.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qy7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_subtilis Bacillus subtilis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QY7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QY7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qy7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_globigii"_migula_1900 "bacillus globigii" migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QY7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QY7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qy6\|3qy6]], [[3qy8\|3qy8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qy6\|3qy6]], [[3qy8\|3qy8]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BSU36240, ywqE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus ~~subtilis~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BSU36240, ywqE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Bacillus globigii" Migula 1900])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qy7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qy7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qy7 RCSB], [http://www.ebi.ac.uk/pdbsum/3qy7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qy7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qy7 OCA], [http://pdbe.org/3qy7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qy7 RCSB], [http://www.ebi.ac.uk/pdbsum/3qy7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qy7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3qy7" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus ~~subtilis~~]]	+	[[Category: Bacillus globigii migula 1900]]
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]
	[[Category: An, D R]]		[[Category: An, D R]]

OCA at 05:19, 25 December 2014

OCA — Thu, 25 Dec 2014 05:19:18 GMT

←Older revision		Revision as of 05:19, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qy7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qy7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qy7 RCSB], [http://www.ebi.ac.uk/pdbsum/3qy7 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qy7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qy7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qy7 RCSB], [http://www.ebi.ac.uk/pdbsum/3qy7 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/YWQE_BACSU YWQE_BACSU]] Dephosphorylates the phosphotyrosine-containing proteins YwqD, YwqF and Ssb.<ref>PMID:16549871</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:32, 9 December 2014

OCA — Tue, 09 Dec 2014 12:32:39 GMT

←Older revision		Revision as of 12:32, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3qy7.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structures of YwqE from Bacillus subtilis and CpsB from Streptococcus pneumoniae, unique metal-dependent tyrosine phosphatases==
		+	<StructureSection load='3qy7' size='340' side='right' caption='[[3qy7]], [[Resolution\|resolution]] 1.62Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3qy7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QY7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QY7 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qy6\|3qy6]], [[3qy8\|3qy8]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BSU36240, ywqE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qy7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qy7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qy7 RCSB], [http://www.ebi.ac.uk/pdbsum/3qy7 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Unique metal-dependent protein tyrosine phosphatases that belong to the polymerase and histindinol phosphatase (PHP) family are present in Gram-positive bacteria. They are distinct from the Cys-based, low-molecular-weight phosphotyrosine protein phosphatases (LMPTPs). Two representative members of the PHP family tyrosine phosphatases are YwqE from Bacillus subtilis and CpsB from Streptococcus pneumoniae. YwqE is involved in polysaccharide biosynthesis, bacterial DNA metabolism, and DNA damage response in B. subtilis. CpsB regulates capsular polysaccharide biosynthesis via tyrosine dephosphorylation of CpsD, its cognate tyrosine kinase, in S. pneumoniae. To gain insights into the active site and possible conformational changes of the metal-dependent tyrosine phosphatases from Gram-positive bacteria, we have determined the crystal structures of B. subtilis YwqE (in both the apo form and the phosphate-bound form) and S. pneumoniae CpsB (in the sulfate-bound form). Comparisons of the three structures reveal conformational plasticity of two active site loops. Furthermore, in both structures of the phosphate-bound YwqE and the sulfate-bound CpsB, the phosphate (or sulfate) ion is bound to a cluster of three metal ions in the active site, thus providing insight into the pre-catalytic state.

-	~~{{STRUCTURE_3qy7\| PDB=3qy7 \| SCENE= }}~~	+	Crystal structures of YwqE from Bacillus subtilis and CpsB from Streptococcus pneumoniae, unique metal-dependent tyrosine phosphatases.,Kim HS, Lee SJ, Yoon HJ, An DR, Kim DJ, Kim SJ, Suh SW J Struct Biol. 2011 May 14. PMID:21605684<ref>PMID:21605684</ref>

-	~~===Crystal structures of YwqE from Bacillus subtilis and CpsB from Streptococcus pneumoniae~~, ~~unique metal-dependent tyrosine phosphatases===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21605684}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3qy7]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bacillus_subtilis Bacillus subtilis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3QY7 OCA].~~	+

	==See Also==		==See Also==
	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]		*[[Tyrosine phosphatase\|Tyrosine phosphatase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021605684<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]
-	[[Category: An, D R.]]	+	[[Category: An, D R]]
-	[[Category: Kim, D J.]]	+	[[Category: Kim, D J]]
-	[[Category: Kim, H S.]]	+	[[Category: Kim, H S]]
-	[[Category: Kim, S J.]]	+	[[Category: Kim, S J]]
-	[[Category: Lee, S J.]]	+	[[Category: Lee, S J]]
-	[[Category: Suh, S W.]]	+	[[Category: Suh, S W]]
-	[[Category: Yoon, H J.]]	+	[[Category: Yoon, H J]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Phosphatase]]		[[Category: Phosphatase]]
	[[Category: Tim barrel]]		[[Category: Tim barrel]]

OCA at 13:05, 20 October 2012

OCA — Sat, 20 Oct 2012 13:05:52 GMT

←Older revision		Revision as of 13:05, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3qy7]] is a 1 chain structure ~~of [[Tyrosine phosphatase]]~~ with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QY7 OCA].	+	[[3qy7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QY7 OCA].

	==See Also==		==See Also==

OCA at 10:53, 26 July 2012

OCA — Thu, 26 Jul 2012 10:53:45 GMT

←Older revision		Revision as of 10:53, 26 July 2012
Line 1:		Line 1:
	[[Image:3qy7.png\|left\|200px]]		[[Image:3qy7.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3qy7", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3qy7\| PDB=3qy7 \| SCENE= }}		{{STRUCTURE_3qy7\| PDB=3qy7 \| SCENE= }}

	===Crystal structures of YwqE from Bacillus subtilis and CpsB from Streptococcus pneumoniae, unique metal-dependent tyrosine phosphatases===		===Crystal structures of YwqE from Bacillus subtilis and CpsB from Streptococcus pneumoniae, unique metal-dependent tyrosine phosphatases===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21605684}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21605684 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21605684}}		{{ABSTRACT_PUBMED_21605684}}

	==About this Structure==		==About this Structure==
-	[[3qy7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QY7 OCA].	+	[[3qy7]] is a 1 chain structure of [[Tyrosine phosphatase]] with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QY7 OCA].
		+
		+	==See Also==
		+	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]

	==Reference==		==Reference==

OCA at 06:42, 17 August 2011

OCA — Wed, 17 Aug 2011 06:42:08 GMT

←Older revision		Revision as of 06:42, 17 August 2011
Line 1:		Line 1:
-	[[Image:3qy7.~~jpg~~\|left\|200px]]	+	[[Image:3qy7.png\|left\|200px]]

	<!--		<!--
Line 32:		Line 32:
	[[Category: Suh, S W.]]		[[Category: Suh, S W.]]
	[[Category: Yoon, H J.]]		[[Category: Yoon, H J.]]
		+	[[Category: Hydrolase]]
		+	[[Category: Phosphatase]]
		+	[[Category: Tim barrel]]

OCA at 05:11, 8 June 2011

OCA — Wed, 08 Jun 2011 05:11:07 GMT

←Older revision		Revision as of 05:11, 8 June 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3qy7.jpg\|left\|200px]]

-	The ~~entry 3qy7~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3qy7", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3qy7\| PDB=3qy7 \| SCENE= }}

-	~~Authors: Kim~~, ~~H.S., Lee, S.J., Yoon, H.J., An, D.R., Kim, D.J., Kim, S.~~-~~J., Suh, S.W.~~	+	===Crystal structures of YwqE from Bacillus subtilis and CpsB from Streptococcus pneumoniae, unique metal-dependent tyrosine phosphatases===

-	~~Description~~: ~~Crystal structures of YwqE~~ from Bacillus subtilis ~~and CpsB~~ from ~~Streptococcus pneumoniae, unique metal~~-~~dependent~~ tyrosine ~~phosphatases~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21605684}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21605684 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21605684}}
		+
		+	==About this Structure==
		+	[[3qy7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QY7 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021605684</ref><references group="xtra"/>
		+	[[Category: Bacillus subtilis]]
		+	[[Category: Protein-tyrosine-phosphatase]]
		+	[[Category: An, D R.]]
		+	[[Category: Kim, D J.]]
		+	[[Category: Kim, H S.]]
		+	[[Category: Kim, S J.]]
		+	[[Category: Lee, S J.]]
		+	[[Category: Suh, S W.]]
		+	[[Category: Yoon, H J.]]

OCA at 06:47, 23 March 2011

OCA — Wed, 23 Mar 2011 06:47:37 GMT

←Older revision		Revision as of 06:47, 23 March 2011
Line 3:		Line 3:
	The entry 3qy7 is ON HOLD		The entry 3qy7 is ON HOLD

-	Authors: Kim, H.S. , Lee, S.J. , Yoon, H.J. , An, D.R. , Kim, D.J. , Kim, S-.J. , Suh, S.W.	+	Authors: Kim, H.S., Lee, S.J., Yoon, H.J., An, D.R., Kim, D.J., Kim, S.-J., Suh, S.W.

	Description: Crystal structures of YwqE from Bacillus subtilis and CpsB from Streptococcus pneumoniae, unique metal-dependent tyrosine phosphatases		Description: Crystal structures of YwqE from Bacillus subtilis and CpsB from Streptococcus pneumoniae, unique metal-dependent tyrosine phosphatases