3qy9 - Revision history

OCA at 17:15, 1 November 2023

OCA — Wed, 01 Nov 2023 17:15:26 GMT

←Older revision		Revision as of 17:15, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3qy9' size='340' side='right'caption='[[3qy9]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3qy9' size='340' side='right'caption='[[3qy9]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qy9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Staac Staac~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QY9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QY9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qy9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_COL Staphylococcus aureus subsp. aureus COL]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QY9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QY9 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>~~, ~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~dapB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=93062 STAAC])</td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<~~tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>[https://en.wikipedia.org/wiki/4-hydroxy-tetrahydrodipicolinate_reductase 4-hydroxy-tetrahydrodipicolinate reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.1.8 1.17.1.8] </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qy9 OCA], [https://pdbe.org/3qy9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qy9 RCSB], [https://www.ebi.ac.uk/pdbsum/3qy9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qy9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qy9 OCA], [https://pdbe.org/3qy9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qy9 RCSB], [https://www.ebi.ac.uk/pdbsum/3qy9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qy9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DAPB_STAAC DAPB_STAAC]] Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.[HAMAP-Rule:MF_00102]	+	[https://www.uniprot.org/uniprot/DAPB_STAAC DAPB_STAAC] Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.[HAMAP-Rule:MF_00102]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: 4-hydroxy-tetrahydrodipicolinate reductase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Staac~~]]	+	[[Category: Staphylococcus aureus subsp. aureus COL]]
-	[[Category: Girish~~, T S~~]]	+	[[Category: Girish TS]]
-	[[Category: Gopal, B]]	+	[[Category: Gopal B]]
-	~~[[Category: Dihydrodipicolinate]]~~	+
-	~~[[Category: Nadh]]~~	+
-	~~[[Category: Nadph]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Reductase]]~~	+
-	~~[[Category: Rossmann fold~~]]	+

OCA at 05:41, 15 June 2022

OCA — Wed, 15 Jun 2022 05:41:13 GMT

←Older revision		Revision as of 05:41, 15 June 2022
Line 1:		Line 1:

	==The Crystal Structure of Dihydrodipicolinate reductase from Staphylococcus aureus==		==The Crystal Structure of Dihydrodipicolinate reductase from Staphylococcus aureus==
-	<StructureSection load='3qy9' size='340' side='right' caption='[[3qy9]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='3qy9' size='340' side='right'caption='[[3qy9]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qy9]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Staac Staac]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QY9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3QY9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qy9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staac Staac]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QY9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QY9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dapB ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93062 STAAC])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dapB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93062 STAAC])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/4-hydroxy-tetrahydrodipicolinate_reductase 4-hydroxy-tetrahydrodipicolinate reductase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.1.8 1.17.1.8] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/4-hydroxy-tetrahydrodipicolinate_reductase 4-hydroxy-tetrahydrodipicolinate reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.1.8 1.17.1.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3qy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qy9 OCA], [~~http~~://pdbe.org/3qy9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3qy9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3qy9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3qy9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qy9 OCA], [https://pdbe.org/3qy9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qy9 RCSB], [https://www.ebi.ac.uk/pdbsum/3qy9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qy9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DAPB_STAAC DAPB_STAAC]] Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.[HAMAP-Rule:MF_00102]	+	[[https://www.uniprot.org/uniprot/DAPB_STAAC DAPB_STAAC]] Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.[HAMAP-Rule:MF_00102]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: 4-hydroxy-tetrahydrodipicolinate reductase]]		[[Category: 4-hydroxy-tetrahydrodipicolinate reductase]]
		+	[[Category: Large Structures]]
	[[Category: Staac]]		[[Category: Staac]]
	[[Category: Girish, T S]]		[[Category: Girish, T S]]

OCA at 08:10, 4 August 2016

OCA — Thu, 04 Aug 2016 08:10:37 GMT

←Older revision		Revision as of 08:10, 4 August 2016
Line 1:		Line 1:
		+
	==The Crystal Structure of Dihydrodipicolinate reductase from Staphylococcus aureus==		==The Crystal Structure of Dihydrodipicolinate reductase from Staphylococcus aureus==
	<StructureSection load='3qy9' size='340' side='right' caption='[[3qy9]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3qy9' size='340' side='right' caption='[[3qy9]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qy9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Staphylococcus_aureus Staphylococcus aureus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QY9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qy9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staac Staac]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QY9 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dapB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~1280 Staphylococcus aureus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dapB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93062 STAAC])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~Dihydrodipicolinate_reductase Dihydrodipicolinate~~ reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.26 1.3.1.26] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-tetrahydrodipicolinate_reductase 4-hydroxy-tetrahydrodipicolinate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.1.8 1.17.1.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qy9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qy9 RCSB], [http://www.ebi.ac.uk/pdbsum/3qy9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qy9 OCA], [http://pdbe.org/3qy9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qy9 RCSB], [http://www.ebi.ac.uk/pdbsum/3qy9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qy9 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DAPB_STAAC DAPB_STAAC]] Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.[HAMAP-Rule:MF_00102]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 16:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3qy9" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Dihydrodipicolinate~~ reductase]]	+	[[Category: 4-hydroxy-tetrahydrodipicolinate reductase]]
-	[[Category: ~~Staphylococcus aureus~~]]	+	[[Category: Staac]]
	[[Category: Girish, T S]]		[[Category: Girish, T S]]
	[[Category: Gopal, B]]		[[Category: Gopal, B]]

OCA at 22:02, 3 January 2015

OCA — Sat, 03 Jan 2015 22:02:26 GMT

←Older revision		Revision as of 22:02, 3 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3qy9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QY9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3qy9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QY9 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dapB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dapB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrodipicolinate_reductase Dihydrodipicolinate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.26 1.3.1.26] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrodipicolinate_reductase Dihydrodipicolinate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.26 1.3.1.26] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qy9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qy9 RCSB], [http://www.ebi.ac.uk/pdbsum/3qy9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qy9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qy9 RCSB], [http://www.ebi.ac.uk/pdbsum/3qy9 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 14:
	Structure and nucleotide specificity of Staphylococcus aureus dihydrodipicolinate reductase (DapB).,Girish TS, Navratna V, Gopal B FEBS Lett. 2011 Aug 19;585(16):2561-7. Epub 2011 Jul 26. PMID:21803042<ref>PMID:21803042</ref>		Structure and nucleotide specificity of Staphylococcus aureus dihydrodipicolinate reductase (DapB).,Girish TS, Navratna V, Gopal B FEBS Lett. 2011 Aug 19;585(16):2561-7. Epub 2011 Jul 26. PMID:21803042<ref>PMID:21803042</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 22:		Line 22:
	[[Category: Dihydrodipicolinate reductase]]		[[Category: Dihydrodipicolinate reductase]]
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
-	[[Category: Girish, T S.]]	+	[[Category: Girish, T S]]
-	[[Category: Gopal, B.]]	+	[[Category: Gopal, B]]
	[[Category: Dihydrodipicolinate]]		[[Category: Dihydrodipicolinate]]
	[[Category: Nadh]]		[[Category: Nadh]]

OCA at 04:49, 5 June 2014

OCA — Thu, 05 Jun 2014 04:49:46 GMT

←Older revision		Revision as of 04:49, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3qy9.~~png~~\|~~left~~\|~~200px~~]]	+	==The Crystal Structure of Dihydrodipicolinate reductase from Staphylococcus aureus==
		+	<StructureSection load='3qy9' size='340' side='right' caption='[[3qy9]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3qy9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QY9 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dapB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrodipicolinate_reductase Dihydrodipicolinate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.26 1.3.1.26] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qy9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qy9 RCSB], [http://www.ebi.ac.uk/pdbsum/3qy9 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Lysine biosynthesis proceeds by the nucleotide-dependent reduction of dihydrodipicolinate (DHDP) to tetrahydrodipicolinate (THDP) by dihydrodipicolinate reductase (DHDPR). The S. aureus DHDPR structure reveals different conformational states of this enzyme even in the absence of a substrate or nucleotide-cofactor. Despite lacking a conserved basic residue essential for NADPH interaction, S. aureus DHDPR differs from other homologues as NADPH is a more preferred co-factor than NADH. The structure provides a rationale-Lys35 compensates for the co-factor site mutation. These observations are significant for bi-ligand inhibitor design that relies on ligand-induced conformational changes as well as co-factor specificity for this important drug target. STRUCTURED SUMMARY OF PROTEIN INTERACTIONS: DHDPRbindstoDHDPR by molecular sieving(View interaction). DHDPRbindstoDHDPR by dynamic light scattering(View interaction). DHDPRbindstoDHDPR by X-ray crystallography(View interaction).

-	~~<!--~~	+	Structure and nucleotide specificity of Staphylococcus aureus dihydrodipicolinate reductase (DapB).,Girish TS, Navratna V, Gopal B FEBS Lett. 2011 Aug 19;585(16):2561-7. Epub 2011 Jul 26. PMID:21803042<ref>PMID:21803042</ref>
-	~~The line below this paragraph, containing "STRUCTURE_3qy9", creates the "~~Structure ~~Box" on the page.~~	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet)~~	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded~~),	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_3qy9\| PDB=3qy9 \| SCENE= }}~~	+

-	~~===The Crystal Structure~~ of ~~Dihydrodipicolinate reductase from Staphylococcus aureus===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21803042}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21803042 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_21803042}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3qy9]] is a 4 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QY9 OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021803042<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Dihydrodipicolinate reductase]]		[[Category: Dihydrodipicolinate reductase]]
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]

OCA at 04:46, 28 September 2011

OCA — Wed, 28 Sep 2011 04:46:11 GMT

←Older revision		Revision as of 04:46, 28 September 2011
Line 1:		Line 1:
-	[[Image:3qy9.~~jpg~~\|left\|200px]]	+	[[Image:3qy9.png\|left\|200px]]

	<!--		<!--
Line 11:		Line 11:
	===The Crystal Structure of Dihydrodipicolinate reductase from Staphylococcus aureus===		===The Crystal Structure of Dihydrodipicolinate reductase from Staphylococcus aureus===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21803042}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21803042 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21803042}}

	==About this Structure==		==About this Structure==
	[[3qy9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QY9 OCA].		[[3qy9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QY9 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021803042</ref><references group="xtra"/>
	[[Category: Dihydrodipicolinate reductase]]		[[Category: Dihydrodipicolinate reductase]]
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]

OCA at 08:59, 3 August 2011

OCA — Wed, 03 Aug 2011 08:59:47 GMT

←Older revision		Revision as of 08:59, 3 August 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3qy9.jpg\|left\|200px]]

-	The ~~entry 3qy9~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3qy9", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3qy9\| PDB=3qy9 \| SCENE= }}

-	~~Authors: Girish, T.S., Gopal, B.~~	+	===The Crystal Structure of Dihydrodipicolinate reductase from Staphylococcus aureus===

-	~~Description: The Crystal~~ Structure of Dihydrodipicolinate reductase ~~from~~ Staphylococcus aureus	+
		+	==About this Structure==
		+	[[3qy9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QY9 OCA].
		+	[[Category: Dihydrodipicolinate reductase]]
		+	[[Category: Staphylococcus aureus]]
		+	[[Category: Girish, T S.]]
		+	[[Category: Gopal, B.]]
		+	[[Category: Dihydrodipicolinate]]
		+	[[Category: Nadh]]
		+	[[Category: Nadph]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Reductase]]
		+	[[Category: Rossmann fold]]

OCA at 05:11, 18 May 2011

OCA — Wed, 18 May 2011 05:11:05 GMT

←Older revision		Revision as of 05:11, 18 May 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3qy9 is ON HOLD	+	The entry 3qy9 is ON HOLD until Paper Publication

	Authors: Girish, T.S., Gopal, B.		Authors: Girish, T.S., Gopal, B.

	Description: The Crystal Structure of Dihydrodipicolinate reductase from Staphylococcus aureus		Description: The Crystal Structure of Dihydrodipicolinate reductase from Staphylococcus aureus

OCA at 07:46, 30 March 2011

OCA — Wed, 30 Mar 2011 07:46:16 GMT

←Older revision		Revision as of 07:46, 30 March 2011
Line 3:		Line 3:
	The entry 3qy9 is ON HOLD		The entry 3qy9 is ON HOLD

-	Authors: T.S. ~~Girish~~, B.~~Gopal~~	+	Authors: Girish, T.S., Gopal, B.

	Description: The Crystal Structure of Dihydrodipicolinate reductase from Staphylococcus aureus		Description: The Crystal Structure of Dihydrodipicolinate reductase from Staphylococcus aureus

OCA: Protected "3qy9" [edit=sysop:move=sysop]

OCA — Wed, 09 Mar 2011 06:10:59 GMT

Protected "3qy9" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:10, 9 March 2011