3qyt - Revision history

OCA at 17:15, 1 November 2023

OCA — Wed, 01 Nov 2023 17:15:28 GMT

←Older revision		Revision as of 17:15, 1 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3qyt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QYT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QYT FirstGlance]. <br>		<table><tr><td colspan='2'>[[3qyt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QYT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QYT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2hav\|2hav]], [[4h0w\|4h0w]]</div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qyt OCA], [https://pdbe.org/3qyt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qyt RCSB], [https://www.ebi.ac.uk/pdbsum/3qyt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qyt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qyt OCA], [https://pdbe.org/3qyt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qyt RCSB], [https://www.ebi.ac.uk/pdbsum/3qyt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qyt ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[https://omim.org/entry/209300 209300]]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref> <ref>PMID:15466165</ref>	+	[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[https://omim.org/entry/209300 209300]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref> <ref>PMID:15466165</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.	+	[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hao, Q]]	+	[[Category: Hao Q]]
-	[[Category: Sun, H]]	+	[[Category: Sun H]]
-	[[Category: Wang, M]]	+	[[Category: Wang M]]
-	[[Category: Yang, N]]	+	[[Category: Yang N]]
-	[[Category: Zhang, H]]	+	[[Category: Zhang H]]
-	~~[[Category: Diferric]]~~	+
-	~~[[Category: Human transferrin]]~~	+
-	~~[[Category: Intermediate]]~~	+
-	~~[[Category: Iron transporter]]~~	+
-	~~[[Category: Metal transport~~]]	+

OCA at 05:41, 15 June 2022

OCA — Wed, 15 Jun 2022 05:41:49 GMT

←Older revision		Revision as of 05:41, 15 June 2022
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	<StructureSection load='3qyt' size='340' side='right'caption='[[3qyt]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='3qyt' size='340' side='right'caption='[[3qyt]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qyt]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QYT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3QYT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qyt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QYT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QYT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hav\|2hav]], [[4h0w\|4h0w]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2hav\|2hav]], [[4h0w\|4h0w]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3qyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qyt OCA], [~~http~~://pdbe.org/3qyt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3qyt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3qyt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3qyt ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qyt OCA], [https://pdbe.org/3qyt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qyt RCSB], [https://www.ebi.ac.uk/pdbsum/3qyt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qyt ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[~~http~~://omim.org/entry/209300 209300]]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref> <ref>PMID:15466165</ref>	+	[[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[https://omim.org/entry/209300 209300]]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref> <ref>PMID:15466165</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.	+	[[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	==See Also==		==See Also==
	*[[Transferrin\|Transferrin]]		*[[Transferrin\|Transferrin]]
		+	*[[Transferrin 3D structures\|Transferrin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:14, 14 August 2019

OCA — Wed, 14 Aug 2019 18:14:43 GMT

←Older revision		Revision as of 18:14, 14 August 2019
Line 1:		Line 1:

	==Diferric bound human serum transferrin==		==Diferric bound human serum transferrin==
-	<StructureSection load='3qyt' size='340' side='right' caption='[[3qyt]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='3qyt' size='340' side='right'caption='[[3qyt]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3qyt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QYT FirstGlance]. <br>		<table><tr><td colspan='2'>[[3qyt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QYT FirstGlance]. <br>
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 3qyt" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3qyt" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Transferrin\|Transferrin]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
	[[Category: Hao, Q]]		[[Category: Hao, Q]]
	[[Category: Sun, H]]		[[Category: Sun, H]]

OCA at 09:20, 8 November 2017

OCA — Wed, 08 Nov 2017 09:20:24 GMT

←Older revision		Revision as of 09:20, 8 November 2017
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 3qyt" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3qyt" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Transferrin\|Transferrin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:24, 5 August 2016

OCA — Fri, 05 Aug 2016 15:24:54 GMT

←Older revision		Revision as of 15:24, 5 August 2016
Line 1:		Line 1:
		+
	==Diferric bound human serum transferrin==		==Diferric bound human serum transferrin==
	<StructureSection load='3qyt' size='340' side='right' caption='[[3qyt]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='3qyt' size='340' side='right' caption='[[3qyt]], [[Resolution\|resolution]] 2.80Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hav\|2hav]], [[4h0w\|4h0w]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hav\|2hav]], [[4h0w\|4h0w]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qyt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qyt RCSB], [http://www.ebi.ac.uk/pdbsum/3qyt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qyt OCA], [http://pdbe.org/3qyt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qyt RCSB], [http://www.ebi.ac.uk/pdbsum/3qyt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qyt ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3qyt" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 11:03, 19 December 2014

OCA — Fri, 19 Dec 2014 11:03:10 GMT

←Older revision		Revision as of 11:03, 19 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3qyt\| PDB~~=3qyt \| ~~SCENE~~= }}	+	==Diferric bound human serum transferrin==
-	===~~Diferric bound human serum transferrin~~===	+	<StructureSection load='3qyt' size='340' side='right' caption='[[3qyt]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23256035}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3qyt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QYT FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hav\|2hav]], [[4h0w\|4h0w]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qyt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qyt RCSB], [http://www.ebi.ac.uk/pdbsum/3qyt PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[http://omim.org/entry/209300 209300]]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref> <ref>PMID:15466165</ref>		[[http://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[http://omim.org/entry/209300 209300]]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref> <ref>PMID:15466165</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human serum transferrin (hTF) binds Fe(III) tightly but reversibly, and delivers it to cells via a receptor-mediated endocytosis process. The metal-binding and release result in significant conformational changes of the protein. Here, we report the crystal structures of diferric-hTF (Fe(N)Fe(C)-hTF) and bismuth-bound hTF (Bi(N)Fe(C)-hTF) at 2.8 and 2.4 A resolutions respectively. Notably, the N-lobes of both structures exhibit unique "partially-opened" conformations between those of the apo-hTF and holo-hTF. Fe(III) and Bi(III) in the N-lobe coordinate to, besides anions, only two (Tyr95 and Tyr188) and one (Tyr188) tyrosine residues, respectively, in contrast to four residues in the holo-hTF. The C-lobe of both structures are fully closed with iron coordinating to four residues and a carbonate. The structures of hTF observed here represent key conformers captured in the dynamic nature of the transferrin family proteins and provide a structural basis for understanding the mechanism of metal uptake and release in transferrin families.

-	~~==Function==~~	+	Iron and bismuth bound human serum transferrin reveals a partially-opened conformation in the N-lobe.,Yang N, Zhang H, Wang M, Hao Q, Sun H Sci Rep. 2012;2:999. doi: 10.1038/srep00999. Epub 2012 Dec 19. PMID:23256035<ref>PMID:23256035</ref>
-	~~[[http://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions~~ in ~~association with~~ the ~~binding of an anion~~, ~~usually bicarbonate~~. ~~It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization~~. ~~Serum transferrin may also have a further role in stimulating cell proliferation~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3qyt]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3QYT OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:023256035</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Transferrin\|Transferrin]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Hao, Q.]]	+	[[Category: Hao, Q]]
-	[[Category: Sun, H.]]	+	[[Category: Sun, H]]
-	[[Category: Wang, M.]]	+	[[Category: Wang, M]]
-	[[Category: Yang, N.]]	+	[[Category: Yang, N]]
-	[[Category: Zhang, H.]]	+	[[Category: Zhang, H]]
	[[Category: Diferric]]		[[Category: Diferric]]
	[[Category: Human transferrin]]		[[Category: Human transferrin]]

OCA at 09:39, 19 June 2013

OCA — Wed, 19 Jun 2013 09:39:18 GMT

←Older revision		Revision as of 09:39, 19 June 2013
Line 1:		Line 1:
	{{STRUCTURE_3qyt\| PDB=3qyt \| SCENE= }}		{{STRUCTURE_3qyt\| PDB=3qyt \| SCENE= }}
	===Diferric bound human serum transferrin===		===Diferric bound human serum transferrin===
		+	{{ABSTRACT_PUBMED_23256035}}

	==Disease==		==Disease==
-	[[http://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[http://omim.org/entry/209300 209300]]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref><ref>PMID:15466165</ref>	+	[[http://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[http://omim.org/entry/209300 209300]]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref> <ref>PMID:15466165</ref>

	==Function==		==Function==
Line 12:		Line 13:

	==Reference==		==Reference==
-	<references group="xtra"/><references/>	+	<ref group="xtra">PMID:023256035</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hao, Q.]]		[[Category: Hao, Q.]]

OCA at 00:45, 25 March 2013

OCA — Mon, 25 Mar 2013 00:45:50 GMT

←Older revision		Revision as of 00:45, 25 March 2013
Line 1:		Line 1:
-	[[Image:3qyt.png\|left\|200px]]
-
	{{STRUCTURE_3qyt\| PDB=3qyt \| SCENE= }}		{{STRUCTURE_3qyt\| PDB=3qyt \| SCENE= }}
-
	===Diferric bound human serum transferrin===		===Diferric bound human serum transferrin===

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[http://omim.org/entry/209300 209300]]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref><ref>PMID:15466165</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.

	==About this Structure==		==About this Structure==
	[[3qyt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QYT OCA].		[[3qyt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QYT OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hao, Q.]]		[[Category: Hao, Q.]]

OCA at 08:09, 2 January 2013

OCA — Wed, 02 Jan 2013 08:09:26 GMT

←Older revision		Revision as of 08:09, 2 January 2013
Line 1:		Line 1:
-	[[Image:3qyt.~~jpg~~\|left\|200px]]	+	[[Image:3qyt.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3qyt", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3qyt\| PDB=3qyt \| SCENE= }}		{{STRUCTURE_3qyt\| PDB=3qyt \| SCENE= }}

Line 17:		Line 11:
	[[Category: Hao, Q.]]		[[Category: Hao, Q.]]
	[[Category: Sun, H.]]		[[Category: Sun, H.]]
		+	[[Category: Wang, M.]]
	[[Category: Yang, N.]]		[[Category: Yang, N.]]
	[[Category: Zhang, H.]]		[[Category: Zhang, H.]]

OCA at 06:42, 14 March 2012

OCA — Wed, 14 Mar 2012 06:42:07 GMT

←Older revision		Revision as of 06:42, 14 March 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3qyt.jpg\|left\|200px]]

-	The ~~entry 3qyt~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3qyt", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3qyt\| PDB=3qyt \| SCENE= }}

-	~~Authors: Yang, N., Zhang, H., Hao, Q., Sun, H.~~	+	===Diferric bound human serum transferrin===

-	~~Description~~: Diferric ~~bound human serum~~ transferrin	+
		+	==About this Structure==
		+	[[3qyt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QYT OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Hao, Q.]]
		+	[[Category: Sun, H.]]
		+	[[Category: Yang, N.]]
		+	[[Category: Zhang, H.]]
		+	[[Category: Diferric]]
		+	[[Category: Human transferrin]]
		+	[[Category: Intermediate]]
		+	[[Category: Iron transporter]]
		+	[[Category: Metal transport]]