3qzt - Revision history

OCA at 12:04, 14 March 2024

OCA — Thu, 14 Mar 2024 12:04:17 GMT

←Older revision		Revision as of 12:04, 14 March 2024
Line 10:		Line 10:
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/BPTF_HUMAN BPTF_HUMAN] Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.		[https://www.uniprot.org/uniprot/BPTF_HUMAN BPTF_HUMAN] Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Little is known about how combinations of histone marks are interpreted at the level of nucleosomes. The second PHD finger of human BPTF is known to specifically recognize histone H3 when methylated on lysine 4 (H3K4me2/3). Here, we examine how additional heterotypic modifications influence BPTF binding. Using peptide surrogates, three acetyllysine ligands are indentified for a PHD-adjacent bromodomain in BPTF via systematic screening and biophysical characterization. Although the bromodomain displays limited discrimination among the three possible acetyllysines at the peptide level, marked selectivity is observed for only one of these sites, H4K16ac, in combination with H3K4me3 at the mononucleosome level. In support, these two histone marks constitute a unique trans-histone modification pattern that unambiguously resides within a single nucleosomal unit in human cells, and this module colocalizes with these marks in the genome. Together, our data call attention to nucleosomal patterning of covalent marks in dictating critical chromatin associations.
-
-	Recognition of a Mononucleosomal Histone Modification Pattern by BPTF via Multivalent Interactions.,Ruthenburg AJ, Li H, Milne TA, Dewell S, McGinty RK, Yuen M, Ueberheide B, Dou Y, Muir TW, Patel DJ, Allis CD Cell. 2011 May 27;145(5):692-706. Epub 2011 May 19. PMID:21596426<ref>PMID:21596426</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3qzt" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Histone 3D structures\|Histone 3D structures]]		*[[Histone 3D structures\|Histone 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:13, 6 December 2023

OCA — Wed, 06 Dec 2023 08:13:51 GMT

←Older revision		Revision as of 08:13, 6 December 2023
Line 3:		Line 3:
	<StructureSection load='3qzt' size='340' side='right'caption='[[3qzt]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='3qzt' size='340' side='right'caption='[[3qzt]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qzt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QZT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qzt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QZT FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;~~'>~~[[3qzs\|3qzs]], [[3qzv\|3qzv]]~~</~~div~~>~~</td></tr>~~	+
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BPTF, FAC1, FALZ ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qzt OCA], [https://pdbe.org/3qzt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qzt RCSB], [https://www.ebi.ac.uk/pdbsum/3qzt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qzt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qzt OCA], [https://pdbe.org/3qzt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qzt RCSB], [https://www.ebi.ac.uk/pdbsum/3qzt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qzt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/BPTF_HUMAN BPTF_HUMAN]] Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.	+	[https://www.uniprot.org/uniprot/BPTF_HUMAN BPTF_HUMAN] Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Li, H~~]]	+	[[Category: Xenopus laevis]]
-	[[Category: ~~Patel, D J~~]]	+	[[Category: Li H]]
-	[[Category: ~~Ruthenburg, A J~~]]	+	[[Category: Patel DJ]]
-	[[Category: ~~All alpha helix]]~~	+	[[Category: Ruthenburg AJ]]
-	~~[[Category: Histone h4]]~~	+
-	~~[[Category: Nuclear]]~~	+
-	~~[[Category: Protein-peptide complex]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription-nuclear protein complex~~]]	+

OCA at 05:42, 15 June 2022

OCA — Wed, 15 Jun 2022 05:42:58 GMT

←Older revision		Revision as of 05:42, 15 June 2022
Line 1:		Line 1:

	==Crystal Structure of BPTF bromo in complex with histone H4K16ac - Form II==		==Crystal Structure of BPTF bromo in complex with histone H4K16ac - Form II==
-	<StructureSection load='3qzt' size='340' side='right' caption='[[3qzt]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='3qzt' size='340' side='right'caption='[[3qzt]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qzt]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QZT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3QZT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qzt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QZT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qzs\|3qzs]], [[3qzv\|3qzv]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3qzs\|3qzs]], [[3qzv\|3qzv]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BPTF, FAC1, FALZ ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BPTF, FAC1, FALZ ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3qzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qzt OCA], [~~http~~://pdbe.org/3qzt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3qzt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3qzt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3qzt ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qzt OCA], [https://pdbe.org/3qzt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qzt RCSB], [https://www.ebi.ac.uk/pdbsum/3qzt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qzt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BPTF_HUMAN BPTF_HUMAN]] Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.	+	[[https://www.uniprot.org/uniprot/BPTF_HUMAN BPTF_HUMAN]] Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:

	==See Also==		==See Also==
-	*[[Histone\|Histone]]	+	*[[Histone 3D structures\|Histone 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Li, H]]		[[Category: Li, H]]
	[[Category: Patel, D J]]		[[Category: Patel, D J]]

OCA at 16:50, 5 August 2016

OCA — Fri, 05 Aug 2016 16:50:16 GMT

←Older revision		Revision as of 16:50, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of BPTF bromo in complex with histone H4K16ac - Form II==		==Crystal Structure of BPTF bromo in complex with histone H4K16ac - Form II==
	<StructureSection load='3qzt' size='340' side='right' caption='[[3qzt]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='3qzt' size='340' side='right' caption='[[3qzt]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qzt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QZT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QZT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qzt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QZT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QZT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qzs\|3qzs]], [[3qzv\|3qzv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qzs\|3qzs]], [[3qzv\|3qzv]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BPTF, FAC1, FALZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BPTF, FAC1, FALZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qzt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qzt RCSB], [http://www.ebi.ac.uk/pdbsum/3qzt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qzt OCA], [http://pdbe.org/3qzt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qzt RCSB], [http://www.ebi.ac.uk/pdbsum/3qzt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qzt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3qzt" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Li, H]]		[[Category: Li, H]]
	[[Category: Patel, D J]]		[[Category: Patel, D J]]

OCA at 20:25, 25 December 2014

OCA — Thu, 25 Dec 2014 20:25:32 GMT

←Older revision		Revision as of 20:25, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qzt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qzt RCSB], [http://www.ebi.ac.uk/pdbsum/3qzt PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qzt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qzt RCSB], [http://www.ebi.ac.uk/pdbsum/3qzt PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BPTF_HUMAN BPTF_HUMAN]] Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:18, 9 December 2014

OCA — Tue, 09 Dec 2014 12:18:33 GMT

←Older revision		Revision as of 12:18, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3qzt.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal Structure of BPTF bromo in complex with histone H4K16ac - Form II==
		+	<StructureSection load='3qzt' size='340' side='right' caption='[[3qzt]], [[Resolution\|resolution]] 1.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3qzt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QZT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QZT FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qzs\|3qzs]], [[3qzv\|3qzv]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BPTF, FAC1, FALZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qzt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qzt RCSB], [http://www.ebi.ac.uk/pdbsum/3qzt PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Little is known about how combinations of histone marks are interpreted at the level of nucleosomes. The second PHD finger of human BPTF is known to specifically recognize histone H3 when methylated on lysine 4 (H3K4me2/3). Here, we examine how additional heterotypic modifications influence BPTF binding. Using peptide surrogates, three acetyllysine ligands are indentified for a PHD-adjacent bromodomain in BPTF via systematic screening and biophysical characterization. Although the bromodomain displays limited discrimination among the three possible acetyllysines at the peptide level, marked selectivity is observed for only one of these sites, H4K16ac, in combination with H3K4me3 at the mononucleosome level. In support, these two histone marks constitute a unique trans-histone modification pattern that unambiguously resides within a single nucleosomal unit in human cells, and this module colocalizes with these marks in the genome. Together, our data call attention to nucleosomal patterning of covalent marks in dictating critical chromatin associations.

-	~~{{STRUCTURE_3qzt\| PDB=3qzt \| SCENE= }}~~	+	Recognition of a Mononucleosomal Histone Modification Pattern by BPTF via Multivalent Interactions.,Ruthenburg AJ, Li H, Milne TA, Dewell S, McGinty RK, Yuen M, Ueberheide B, Dou Y, Muir TW, Patel DJ, Allis CD Cell. 2011 May 27;145(5):692-706. Epub 2011 May 19. PMID:21596426<ref>PMID:21596426</ref>

-	~~===Crystal Structure~~ of ~~BPTF bromo in complex with histone H4K16ac - Form II===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21596426}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3qzt]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3QZT OCA].~~	+

	==See Also==		==See Also==
	*[[Histone\|Histone]]		*[[Histone\|Histone]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021596426<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Li, H.]]	+	[[Category: Li, H]]
-	[[Category: Patel, D J.]]	+	[[Category: Patel, D J]]
-	[[Category: Ruthenburg, A J.]]	+	[[Category: Ruthenburg, A J]]
	[[Category: All alpha helix]]		[[Category: All alpha helix]]
	[[Category: Histone h4]]		[[Category: Histone h4]]

OCA at 21:05, 20 October 2012

OCA — Sat, 20 Oct 2012 21:05:32 GMT

←Older revision		Revision as of 21:05, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3qzt]] is a 2 chain structure ~~of [[Histone]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QZT OCA].	+	[[3qzt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QZT OCA].

	==See Also==		==See Also==

OCA at 12:34, 27 July 2012

OCA — Fri, 27 Jul 2012 12:34:14 GMT

←Older revision		Revision as of 12:34, 27 July 2012
Line 1:		Line 1:
-	[[Image:3qzt.~~jpg~~\|left\|200px]]	+	[[Image:3qzt.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3qzt", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3qzt\| PDB=3qzt \| SCENE= }}		{{STRUCTURE_3qzt\| PDB=3qzt \| SCENE= }}

	===Crystal Structure of BPTF bromo in complex with histone H4K16ac - Form II===		===Crystal Structure of BPTF bromo in complex with histone H4K16ac - Form II===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21596426}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21596426 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21596426}}		{{ABSTRACT_PUBMED_21596426}}

	==About this Structure==		==About this Structure==
-	[[3qzt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QZT OCA].	+	[[3qzt]] is a 2 chain structure of [[Histone]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QZT OCA].
		+
		+	==See Also==
		+	*[[Histone\|Histone]]

	==Reference==		==Reference==

OCA at 05:36, 15 June 2011

OCA — Wed, 15 Jun 2011 05:36:12 GMT

←Older revision		Revision as of 05:36, 15 June 2011
Line 27:		Line 27:
	[[Category: Patel, D J.]]		[[Category: Patel, D J.]]
	[[Category: Ruthenburg, A J.]]		[[Category: Ruthenburg, A J.]]
		+	[[Category: All alpha helix]]
		+	[[Category: Histone h4]]
		+	[[Category: Nuclear]]
		+	[[Category: Protein-peptide complex]]
		+	[[Category: Transcription]]
		+	[[Category: Transcription-nuclear protein complex]]

OCA at 05:48, 1 June 2011

OCA — Wed, 01 Jun 2011 05:48:00 GMT

←Older revision		Revision as of 05:48, 1 June 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3qzt.jpg\|left\|200px]]

-	The ~~entry 3qzt~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3qzt", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3qzt\| PDB=3qzt \| SCENE= }}

-	~~Authors: Li, H., Ruthenburg, A.J., Patel, D.J.~~	+	===Crystal Structure of BPTF bromo in complex with histone H4K16ac - Form II===

-	~~Description~~: ~~Crystal~~ Structure ~~of BPTF bromo in complex~~ with ~~histone H4K16ac~~ -~~Form II~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21596426}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21596426 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21596426}}
		+
		+	==About this Structure==
		+	[[3qzt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QZT OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021596426</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Li, H.]]
		+	[[Category: Patel, D J.]]
		+	[[Category: Ruthenburg, A J.]]