3qzv - Revision history

OCA at 12:04, 14 March 2024

OCA — Thu, 14 Mar 2024 12:04:24 GMT

←Older revision		Revision as of 12:04, 14 March 2024
Line 10:		Line 10:
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/BPTF_HUMAN BPTF_HUMAN] Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.		[https://www.uniprot.org/uniprot/BPTF_HUMAN BPTF_HUMAN] Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Little is known about how combinations of histone marks are interpreted at the level of nucleosomes. The second PHD finger of human BPTF is known to specifically recognize histone H3 when methylated on lysine 4 (H3K4me2/3). Here, we examine how additional heterotypic modifications influence BPTF binding. Using peptide surrogates, three acetyllysine ligands are indentified for a PHD-adjacent bromodomain in BPTF via systematic screening and biophysical characterization. Although the bromodomain displays limited discrimination among the three possible acetyllysines at the peptide level, marked selectivity is observed for only one of these sites, H4K16ac, in combination with H3K4me3 at the mononucleosome level. In support, these two histone marks constitute a unique trans-histone modification pattern that unambiguously resides within a single nucleosomal unit in human cells, and this module colocalizes with these marks in the genome. Together, our data call attention to nucleosomal patterning of covalent marks in dictating critical chromatin associations.
-
-	Recognition of a Mononucleosomal Histone Modification Pattern by BPTF via Multivalent Interactions.,Ruthenburg AJ, Li H, Milne TA, Dewell S, McGinty RK, Yuen M, Ueberheide B, Dou Y, Muir TW, Patel DJ, Allis CD Cell. 2011 May 27;145(5):692-706. Epub 2011 May 19. PMID:21596426<ref>PMID:21596426</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3qzv" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:13, 6 December 2023

OCA — Wed, 06 Dec 2023 08:13:52 GMT

←Older revision		Revision as of 08:13, 6 December 2023
Line 3:		Line 3:
	<StructureSection load='3qzv' size='340' side='right'caption='[[3qzv]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3qzv' size='340' side='right'caption='[[3qzv]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qzv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QZV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QZV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qzv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QZV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QZV FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.999Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;~~'>~~[[3qzs\|3qzs]], [[3qzt\|3qzt]]~~</~~div~~>~~</td></tr>~~	+
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BPTF, FAC1, FALZ ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qzv OCA], [https://pdbe.org/3qzv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qzv RCSB], [https://www.ebi.ac.uk/pdbsum/3qzv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qzv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qzv OCA], [https://pdbe.org/3qzv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qzv RCSB], [https://www.ebi.ac.uk/pdbsum/3qzv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qzv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/BPTF_HUMAN BPTF_HUMAN]] Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.	+	[https://www.uniprot.org/uniprot/BPTF_HUMAN BPTF_HUMAN] Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Li, H~~]]	+	[[Category: Xenopus laevis]]
-	[[Category: ~~Patel, D J~~]]	+	[[Category: Li H]]
-	[[Category: ~~Ruthenburg, A J~~]]	+	[[Category: Patel DJ]]
-	[[Category: ~~Alpha helix bundle]]~~	+	[[Category: Ruthenburg AJ]]
-	~~[[Category: Histone h4]]~~	+
-	~~[[Category: Nuclear]]~~	+
-	~~[[Category: Protein-peptide complex]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription-nuclear protein complex]]~~	+
-	~~[[Category: Zinc finger~~]]	+

OCA at 05:43, 15 June 2022

OCA — Wed, 15 Jun 2022 05:43:05 GMT

←Older revision		Revision as of 05:43, 15 June 2022
Line 1:		Line 1:

	==Crystal Structure of BPTF PHD-linker-bromo in complex with histone H4K12ac peptide==		==Crystal Structure of BPTF PHD-linker-bromo in complex with histone H4K12ac peptide==
-	<StructureSection load='3qzv' size='340' side='right' caption='[[3qzv]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='3qzv' size='340' side='right'caption='[[3qzv]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qzv]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QZV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3QZV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qzv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QZV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QZV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qzs\|3qzs]], [[3qzt\|3qzt]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3qzs\|3qzs]], [[3qzt\|3qzt]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BPTF, FAC1, FALZ ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BPTF, FAC1, FALZ ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3qzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qzv OCA], [~~http~~://pdbe.org/3qzv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3qzv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3qzv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3qzv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qzv OCA], [https://pdbe.org/3qzv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qzv RCSB], [https://www.ebi.ac.uk/pdbsum/3qzv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qzv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BPTF_HUMAN BPTF_HUMAN]] Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.	+	[[https://www.uniprot.org/uniprot/BPTF_HUMAN BPTF_HUMAN]] Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Li, H]]		[[Category: Li, H]]
	[[Category: Patel, D J]]		[[Category: Patel, D J]]

OCA at 17:34, 4 August 2016

OCA — Thu, 04 Aug 2016 17:34:08 GMT

←Older revision		Revision as of 17:34, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of BPTF PHD-linker-bromo in complex with histone H4K12ac peptide==		==Crystal Structure of BPTF PHD-linker-bromo in complex with histone H4K12ac peptide==
	<StructureSection load='3qzv' size='340' side='right' caption='[[3qzv]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3qzv' size='340' side='right' caption='[[3qzv]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qzv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QZV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QZV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qzv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QZV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QZV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qzs\|3qzs]], [[3qzt\|3qzt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qzs\|3qzs]], [[3qzt\|3qzt]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BPTF, FAC1, FALZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BPTF, FAC1, FALZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qzv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qzv RCSB], [http://www.ebi.ac.uk/pdbsum/3qzv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qzv OCA], [http://pdbe.org/3qzv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qzv RCSB], [http://www.ebi.ac.uk/pdbsum/3qzv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qzv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3qzv" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Li, H]]		[[Category: Li, H]]
	[[Category: Patel, D J]]		[[Category: Patel, D J]]

OCA at 11:27, 25 December 2014

OCA — Thu, 25 Dec 2014 11:27:11 GMT

←Older revision		Revision as of 11:27, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qzv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qzv RCSB], [http://www.ebi.ac.uk/pdbsum/3qzv PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qzv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qzv RCSB], [http://www.ebi.ac.uk/pdbsum/3qzv PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BPTF_HUMAN BPTF_HUMAN]] Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 10:47, 19 December 2014

OCA — Fri, 19 Dec 2014 10:47:29 GMT

←Older revision		Revision as of 10:47, 19 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3qzv\| PDB=3qzv \| SCENE= }}~~	+	==Crystal Structure of BPTF PHD-linker-bromo in complex with histone H4K12ac peptide==
-	===Crystal Structure of BPTF PHD-linker-bromo in complex with histone H4K12ac peptide===	+	<StructureSection load='3qzv' size='340' side='right' caption='[[3qzv]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21596426}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3qzv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QZV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QZV FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qzs\|3qzs]], [[3qzt\|3qzt]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BPTF, FAC1, FALZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qzv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qzv RCSB], [http://www.ebi.ac.uk/pdbsum/3qzv PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Little is known about how combinations of histone marks are interpreted at the level of nucleosomes. The second PHD finger of human BPTF is known to specifically recognize histone H3 when methylated on lysine 4 (H3K4me2/3). Here, we examine how additional heterotypic modifications influence BPTF binding. Using peptide surrogates, three acetyllysine ligands are indentified for a PHD-adjacent bromodomain in BPTF via systematic screening and biophysical characterization. Although the bromodomain displays limited discrimination among the three possible acetyllysines at the peptide level, marked selectivity is observed for only one of these sites, H4K16ac, in combination with H3K4me3 at the mononucleosome level. In support, these two histone marks constitute a unique trans-histone modification pattern that unambiguously resides within a single nucleosomal unit in human cells, and this module colocalizes with these marks in the genome. Together, our data call attention to nucleosomal patterning of covalent marks in dictating critical chromatin associations.

-	~~==Function==~~	+	Recognition of a Mononucleosomal Histone Modification Pattern by BPTF via Multivalent Interactions.,Ruthenburg AJ, Li H, Milne TA, Dewell S, McGinty RK, Yuen M, Ueberheide B, Dou Y, Muir TW, Patel DJ, Allis CD Cell. 2011 May 27;145(5):692-706. Epub 2011 May 19. PMID:21596426<ref>PMID:21596426</ref>
-	~~[[http://www~~.~~uniprot~~.~~org/uniprot/BPTF_HUMAN BPTF_HUMAN]] Histone-binding component of NURF~~ (~~nucleosome-remodeling factor~~)~~, a complex which catalyzes ATP~~-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May ~~also regulate transcription through direct binding to DNA or transcription factors~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3qzv]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3QZV OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:021596426</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Li, H.]]	+	[[Category: Li, H]]
-	[[Category: Patel, D J.]]	+	[[Category: Patel, D J]]
-	[[Category: Ruthenburg, A J.]]	+	[[Category: Ruthenburg, A J]]
	[[Category: Alpha helix bundle]]		[[Category: Alpha helix bundle]]
	[[Category: Histone h4]]		[[Category: Histone h4]]

OCA at 07:50, 16 May 2013

OCA — Thu, 16 May 2013 07:50:23 GMT

←Older revision		Revision as of 07:50, 16 May 2013
Line 1:		Line 1:
-	[[Image:3qzv.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3qzv", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3qzv\| PDB=3qzv \| SCENE= }}		{{STRUCTURE_3qzv\| PDB=3qzv \| SCENE= }}
-
	===Crystal Structure of BPTF PHD-linker-bromo in complex with histone H4K12ac peptide===		===Crystal Structure of BPTF PHD-linker-bromo in complex with histone H4K12ac peptide===
		+	{{ABSTRACT_PUBMED_21596426}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/BPTF_HUMAN BPTF_HUMAN]] Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21596426}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~), ~~where 21596426 is the PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_21596426}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:021596426</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021596426</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Li, H.]]		[[Category: Li, H.]]

OCA at 05:28, 15 June 2011

OCA — Wed, 15 Jun 2011 05:28:20 GMT

←Older revision		Revision as of 05:28, 15 June 2011
Line 27:		Line 27:
	[[Category: Patel, D J.]]		[[Category: Patel, D J.]]
	[[Category: Ruthenburg, A J.]]		[[Category: Ruthenburg, A J.]]
		+	[[Category: Alpha helix bundle]]
		+	[[Category: Histone h4]]
		+	[[Category: Nuclear]]
		+	[[Category: Protein-peptide complex]]
		+	[[Category: Transcription]]
		+	[[Category: Transcription-nuclear protein complex]]
		+	[[Category: Zinc finger]]

OCA at 05:45, 1 June 2011

OCA — Wed, 01 Jun 2011 05:45:19 GMT

←Older revision		Revision as of 05:45, 1 June 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3qzv.jpg\|left\|200px]]

-	The ~~entry 3qzv~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3qzv", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3qzv\| PDB=3qzv \| SCENE= }}

-	~~Authors: Li, H., Ruthenburg, A.J., Patel, D.J.~~	+	===Crystal Structure of BPTF PHD-linker-bromo in complex with histone H4K12ac peptide===

-	~~Description~~: ~~Crystal Structure of BPTF PHD~~-~~linker~~-~~bromo in complex~~ with ~~histone H4K12ac peptide~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21596426}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21596426 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21596426}}
		+
		+	==About this Structure==
		+	[[3qzv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QZV OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021596426</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Li, H.]]
		+	[[Category: Patel, D J.]]
		+	[[Category: Ruthenburg, A J.]]

OCA: Protected "3qzv" [edit=sysop:move=sysop]

OCA — Wed, 16 Mar 2011 08:06:28 GMT

Protected "3qzv" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:06, 16 March 2011