3r06 - Revision history

OCA at 05:43, 15 June 2022

OCA — Wed, 15 Jun 2022 05:43:24 GMT

←Older revision		Revision as of 05:43, 15 June 2022
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	==Crystal structure of anti-mouse CD3epsilon antibody 2C11 Fab fragment==		==Crystal structure of anti-mouse CD3epsilon antibody 2C11 Fab fragment==
-	<StructureSection load='3r06' size='340' side='right' caption='[[3r06]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='3r06' size='340' side='right'caption='[[3r06]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3r06]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Armenian_hamster Armenian hamster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R06 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3R06 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3r06]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Armenian_hamster Armenian hamster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R06 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3R06 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3r08\|3r08]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3r08\|3r08]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3r06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r06 OCA], [~~http~~://pdbe.org/3r06 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3r06 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3r06 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3r06 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3r06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r06 OCA], [https://pdbe.org/3r06 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3r06 RCSB], [https://www.ebi.ac.uk/pdbsum/3r06 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3r06 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	==See Also==		==See Also==
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[Sandbox 20009\|Sandbox 20009]]
		+	*[[3D structures of non-human antibody\|3D structures of non-human antibody]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Armenian hamster]]		[[Category: Armenian hamster]]
		+	[[Category: Large Structures]]
	[[Category: Shore, D A]]		[[Category: Shore, D A]]
	[[Category: Wilson, I A]]		[[Category: Wilson, I A]]

OCA at 10:06, 13 February 2019

OCA — Wed, 13 Feb 2019 10:06:43 GMT

←Older revision		Revision as of 10:06, 13 February 2019
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	==See Also==		==See Also==
-	*[[3D structures ~~of antibody~~\|3D structures ~~of antibody~~]]	+	*[[Antibody 3D structures\|Antibody 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:17, 5 August 2016

OCA — Fri, 05 Aug 2016 09:17:34 GMT

←Older revision		Revision as of 09:17, 5 August 2016
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		+
	==Crystal structure of anti-mouse CD3epsilon antibody 2C11 Fab fragment==		==Crystal structure of anti-mouse CD3epsilon antibody 2C11 Fab fragment==
	<StructureSection load='3r06' size='340' side='right' caption='[[3r06]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3r06' size='340' side='right' caption='[[3r06]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3r06]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Cricetulus_migratorius Cricetulus migratorius~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R06 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3R06 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3r06]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Armenian_hamster Armenian hamster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R06 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3R06 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3r08\|3r08]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3r08\|3r08]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3r06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r06 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3r06 RCSB], [http://www.ebi.ac.uk/pdbsum/3r06 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3r06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r06 OCA], [http://pdbe.org/3r06 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3r06 RCSB], [http://www.ebi.ac.uk/pdbsum/3r06 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3r06 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3r06" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[~~Antibody~~\|~~Antibody~~]]	+	*[[3D structures of antibody\|3D structures of antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cricetulus migratorius~~]]	+	[[Category: Armenian hamster]]
	[[Category: Shore, D A]]		[[Category: Shore, D A]]
	[[Category: Wilson, I A]]		[[Category: Wilson, I A]]

OCA at 10:12, 19 December 2014

OCA — Fri, 19 Dec 2014 10:12:02 GMT

←Older revision		Revision as of 10:12, 19 December 2014
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-	~~{{STRUCTURE_3r06\| PDB=3r06 \| SCENE= }}~~	+	==Crystal structure of anti-mouse CD3epsilon antibody 2C11 Fab fragment==
-	===Crystal structure of anti-mouse CD3epsilon antibody 2C11 Fab fragment===	+	<StructureSection load='3r06' size='340' side='right' caption='[[3r06]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~{{ABSTRACT_PUBMED_22262845}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3r06]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Cricetulus_migratorius Cricetulus migratorius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R06 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3R06 FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3r08\|3r08]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3r06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r06 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3r06 RCSB], [http://www.ebi.ac.uk/pdbsum/3r06 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Native and non-native ligands of the T cell receptor (TCR), including antibodies, have been proposed to induce signaling in T cells via intra- or intersubunit conformational rearrangements within the extracellular regions of TCR complexes. We have investigated whether any signatures can be found for such postulated structural changes during TCR triggering induced by antibodies, using crystallographic and mutagenesis-based approaches. The crystal structure of murine CD3epsilon complexed with the mitogenic anti-CD3epsilon antibody 2C11 enabled the first direct structural comparisons of antibody-liganded and unliganded forms of CD3epsilon from a single species, which revealed that antibody binding does not induce any substantial rearrangements within CD3epsilon. Saturation mutagenesis of surface-exposed CD3epsilon residues, coupled with assays of antibody-induced signaling by the mutated complexes, suggests a new configuration for the complex within which CD3epsilon is highly exposed and reveals that no large new CD3epsilon interfaces are required to form during antibody-induced signaling. The TCR complex therefore appears to be a structure that is capable of initiating intracellular signaling in T cells without substantial structural rearrangements within or between the component subunits. Our findings raise the possibility that signaling by native ligands might also be initiated in the absence of large structural rearrangements in the receptor.

-	~~==About this Structure==~~	+	T cell receptors are structures capable of initiating signaling in the absence of large conformational rearrangements.,Fernandes RA, Shore DA, Vuong MT, Yu C, Zhu X, Pereira-Lopes S, Brouwer H, Fennelly JA, Jessup CM, Evans EJ, Wilson IA, Davis SJ J Biol Chem. 2012 Apr 13;287(16):13324-35. doi: 10.1074/jbc.M111.332783. Epub, 2012 Jan 19. PMID:22262845<ref>PMID:22262845</ref>
-	~~[[3r06]] is a 8 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org~~/~~wiki/Cricetulus_migratorius Cricetulus migratorius]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=3R06 OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Antibody\|Antibody]]		*[[Antibody\|Antibody]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:022262845</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Cricetulus migratorius]]		[[Category: Cricetulus migratorius]]
-	[[Category: Shore, D A.]]	+	[[Category: Shore, D A]]
-	[[Category: Wilson, I A.]]	+	[[Category: Wilson, I A]]
-	[[Category: Zhu, X.]]	+	[[Category: Zhu, X]]
	[[Category: Anti-cd3epsilon]]		[[Category: Anti-cd3epsilon]]
	[[Category: Antibody]]		[[Category: Antibody]]

OCA at 04:05, 12 September 2013

OCA — Thu, 12 Sep 2013 04:05:57 GMT

←Older revision		Revision as of 04:05, 12 September 2013
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-	[[Image:3r06.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3r06", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3r06\| PDB=3r06 \| SCENE= }}		{{STRUCTURE_3r06\| PDB=3r06 \| SCENE= }}
-
	===Crystal structure of anti-mouse CD3epsilon antibody 2C11 Fab fragment===		===Crystal structure of anti-mouse CD3epsilon antibody 2C11 Fab fragment===
-		+	{{ABSTRACT_PUBMED_22262845}}

	==About this Structure==		==About this Structure==
	[[3r06]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Cricetulus_migratorius Cricetulus migratorius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R06 OCA].		[[3r06]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Cricetulus_migratorius Cricetulus migratorius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R06 OCA].
		+
		+	==See Also==
		+	*[[Antibody\|Antibody]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022262845</ref><references group="xtra"/><references/>
	[[Category: Cricetulus migratorius]]		[[Category: Cricetulus migratorius]]
	[[Category: Shore, D A.]]		[[Category: Shore, D A.]]

OCA at 07:27, 1 February 2012

OCA — Wed, 01 Feb 2012 07:27:50 GMT

←Older revision		Revision as of 07:27, 1 February 2012
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-	[[Image:3r06.~~jpg~~\|left\|200px]]	+	[[Image:3r06.png\|left\|200px]]

	<!--		<!--

OCA at 06:42, 25 January 2012

OCA — Wed, 25 Jan 2012 06:42:25 GMT

←Older revision		Revision as of 06:42, 25 January 2012
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-	~~'''Unreleased structure'''~~	+	[[Image:3r06.jpg\|left\|200px]]

-	The ~~entry 3r06~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3r06", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3r06\| PDB=3r06 \| SCENE= }}

-	~~Authors: Shore, D.A., Zhu, X., Wilson, I.A.~~	+	===Crystal structure of anti-mouse CD3epsilon antibody 2C11 Fab fragment===

-	~~Description: Crystal~~ structure ~~of anti~~-~~mouse CD3epsilon antibody 2C11 Fab fragment~~	+
		+	==About this Structure==
		+	[[3r06]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Cricetulus_migratorius Cricetulus migratorius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R06 OCA].
		+	[[Category: Cricetulus migratorius]]
		+	[[Category: Shore, D A.]]
		+	[[Category: Wilson, I A.]]
		+	[[Category: Zhu, X.]]
		+	[[Category: Anti-cd3epsilon]]
		+	[[Category: Antibody]]
		+	[[Category: Immune system]]
		+	[[Category: Signalling]]
		+	[[Category: T-cell receptor]]

OCA at 16:14, 22 June 2011

OCA — Wed, 22 Jun 2011 16:14:02 GMT

←Older revision		Revision as of 16:14, 22 June 2011
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3r06 is ON HOLD	+	The entry 3r06 is ON HOLD until Paper Publication

	Authors: Shore, D.A., Zhu, X., Wilson, I.A.		Authors: Shore, D.A., Zhu, X., Wilson, I.A.

	Description: Crystal structure of anti-mouse CD3epsilon antibody 2C11 Fab fragment		Description: Crystal structure of anti-mouse CD3epsilon antibody 2C11 Fab fragment

OCA: Protected "3r06" [edit=sysop:move=sysop]

OCA — Wed, 16 Mar 2011 08:06:46 GMT

Protected "3r06" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:06, 16 March 2011

OCA: New page: '''Unreleased structure''' The entry 3r06 is ON HOLD Authors: Shore, D.A., Zhu, X., Wilson, I.A. Description: Crystal structure of anti-mouse CD3epsilon antibody 2C11 Fab fragment

OCA — Wed, 16 Mar 2011 08:06:45 GMT

New page: '''Unreleased structure''' The entry 3r06 is ON HOLD Authors: Shore, D.A., Zhu, X., Wilson, I.A. Description: Crystal structure of anti-mouse CD3epsilon antibody 2C11 Fab fragment

New page

'''Unreleased structure'''

The entry 3r06 is ON HOLD

Authors: Shore, D.A., Zhu, X., Wilson, I.A.

Description: Crystal structure of anti-mouse CD3epsilon antibody 2C11 Fab fragment