3r1g - Revision history

OCA at 05:45, 15 June 2022

OCA — Wed, 15 Jun 2022 05:45:02 GMT

←Older revision		Revision as of 05:45, 15 June 2022
Line 1:		Line 1:

	==Structure Basis of Allosteric Inhibition of BACE1 by an Exosite-Binding Antibody==		==Structure Basis of Allosteric Inhibition of BACE1 by an Exosite-Binding Antibody==
-	<StructureSection load='3r1g' size='340' side='right' caption='[[3r1g]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='3r1g' size='340' side='right'caption='[[3r1g]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3r1g]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human] and [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R1G OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3R1G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3r1g]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R1G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3R1G FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3r1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r1g OCA], [~~http~~://pdbe.org/3r1g PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3r1g RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3r1g PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3r1g ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3r1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r1g OCA], [https://pdbe.org/3r1g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3r1g RCSB], [https://www.ebi.ac.uk/pdbsum/3r1g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3r1g ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>	+	[[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Beta secretase\|Beta secretase]]	+	*[[Beta secretase 3D structures\|Beta secretase 3D structures]]
-	*[[3D structures ~~of monoclonal antibody~~\|3D structures ~~of monoclonal antibody~~]]	+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 29:		Line 29:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
	[[Category: Chen, Y]]		[[Category: Chen, Y]]

OCA at 07:59, 5 August 2016

OCA — Fri, 05 Aug 2016 07:59:51 GMT

←Older revision		Revision as of 07:59, 5 August 2016
Line 1:		Line 1:
		+
	==Structure Basis of Allosteric Inhibition of BACE1 by an Exosite-Binding Antibody==		==Structure Basis of Allosteric Inhibition of BACE1 by an Exosite-Binding Antibody==
	<StructureSection load='3r1g' size='340' side='right' caption='[[3r1g]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='3r1g' size='340' side='right' caption='[[3r1g]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3r1g]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R1G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3R1G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3r1g]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R1G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3R1G FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3r1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r1g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3r1g RCSB], [http://www.ebi.ac.uk/pdbsum/3r1g PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3r1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r1g OCA], [http://pdbe.org/3r1g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3r1g RCSB], [http://www.ebi.ac.uk/pdbsum/3r1g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3r1g ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3r1g" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Beta secretase\|Beta secretase]]		*[[Beta secretase\|Beta secretase]]
-	*[[~~Monoclonal Antibody~~\|~~Monoclonal Antibody~~]]	+	*[[3D structures of monoclonal antibody\|3D structures of monoclonal antibody]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Human]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
	[[Category: Chen, Y]]		[[Category: Chen, Y]]

OCA at 00:30, 25 December 2014

OCA — Thu, 25 Dec 2014 00:30:00 GMT

←Older revision		Revision as of 00:30, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3r1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r1g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3r1g RCSB], [http://www.ebi.ac.uk/pdbsum/3r1g PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3r1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r1g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3r1g RCSB], [http://www.ebi.ac.uk/pdbsum/3r1g PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 10:41, 9 December 2014

OCA — Tue, 09 Dec 2014 10:41:42 GMT

←Older revision		Revision as of 10:41, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3r1g.~~png~~\|~~left\|200px~~]]	+	==Structure Basis of Allosteric Inhibition of BACE1 by an Exosite-Binding Antibody==
		+	<StructureSection load='3r1g' size='340' side='right' caption='[[3r1g]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3r1g]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R1G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3R1G FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3r1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r1g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3r1g RCSB], [http://www.ebi.ac.uk/pdbsum/3r1g PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Reducing production of amyloid-beta (Abeta) peptide by direct inhibition of the enzymes that process amyloid precursor protein (APP) is a central therapeutic strategy for treating Alzheimer's disease. However, small-molecule inhibitors of the beta-secretase (BACE1) and gamma-secretase APP processing enzymes have shown a lack of target selectivity and poor penetrance of the blood-brain barrier (BBB). Here, we have developed a high-affinity, phage-derived human antibody that targets BACE1 (anti-BACE1) and is anti-amyloidogenic. Anti-BACE1 reduces endogenous BACE1 activity and Abeta production in human cell lines expressing APP and in cultured primary neurons. Anti-BACE1 is highly selective and does not inhibit the related enzymes BACE2 or cathepsin D. Competitive binding assays and x-ray crystallography indicate that anti-BACE1 binds noncompetitively to an exosite on BACE1 and not to the catalytic site. Systemic dosing of mice and nonhuman primates with anti-BACE1 resulted in sustained reductions in peripheral Abeta peptide concentrations. Anti-BACE1 also reduces central nervous system Abeta concentrations in mouse and monkey, consistent with a measurable uptake of antibody across the BBB. Thus, BACE1 can be targeted in a highly selective manner through passive immunization with anti-BACE1, providing a potential approach for treating Alzheimer's disease. Nevertheless, therapeutic success with anti-BACE1 will depend on improving antibody uptake into the brain.

-	{~~{STRUCTURE_3r1g\| PDB=3r1g \| SCENE= }~~}	+	A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-{beta} Production in Vivo.,Atwal JK, Chen Y, Chiu C, Mortensen DL, Meilandt WJ, Liu Y, Heise CE, Hoyte K, Luk W, Lu Y, Peng K, Wu P, Rouge L, Zhang Y, Lazarus RA, Scearce-Levie K, Wang W, Wu Y, Tessier-Lavigne M, Watts RJ Sci Transl Med. 2011 May 25;3(84):84ra43. PMID:21613622<ref>PMID:21613622</ref>

-	~~===Structure Basis~~ of ~~Allosteric Inhibition of BACE1 by an Exosite-Binding Antibody===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21613622}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3r1g]] is a 3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3R1G OCA].~~	+

	==See Also==		==See Also==
-	*[[Antibody\|Antibody]]
	*[[Beta secretase\|Beta secretase]]		*[[Beta secretase\|Beta secretase]]
-		+	*[[Monoclonal Antibody\|Monoclonal Antibody]]
-	==~~Reference~~==	+	== References ==
-	<~~ref group="xtra">PMID:021613622<~~/~~ref~~><~~references group="xtra"~~/>	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
-	[[Category: Chen, Y.]]	+	[[Category: Chen, Y]]
-	[[Category: Chiu, C.]]	+	[[Category: Chiu, C]]
-	[[Category: Rouge, L.]]	+	[[Category: Rouge, L]]
-	[[Category: Wang, W.]]	+	[[Category: Wang, W]]
-	[[Category: Watts, R J.]]	+	[[Category: Watts, R J]]
-	[[Category: Wu, P.]]	+	[[Category: Wu, P]]
-	[[Category: Wu, Y.]]	+	[[Category: Wu, Y]]
	[[Category: Aspartal protease]]		[[Category: Aspartal protease]]
	[[Category: Protein binding]]		[[Category: Protein binding]]

OCA at 10:41, 20 October 2012

OCA — Sat, 20 Oct 2012 10:41:13 GMT

←Older revision		Revision as of 10:41, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3r1g]] is a 3 chain structure ~~of [[Antibody]] and [[Beta secretase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R1G OCA].	+	[[3r1g]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R1G OCA].

	==See Also==		==See Also==

OCA at 02:56, 26 July 2012

OCA — Thu, 26 Jul 2012 02:56:38 GMT

←Older revision		Revision as of 02:56, 26 July 2012
Line 1:		Line 1:
-	[[Image:3r1g.~~jpg~~\|left\|200px]]	+	[[Image:3r1g.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3r1g", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3r1g\| PDB=3r1g \| SCENE= }}		{{STRUCTURE_3r1g\| PDB=3r1g \| SCENE= }}

	===Structure Basis of Allosteric Inhibition of BACE1 by an Exosite-Binding Antibody===		===Structure Basis of Allosteric Inhibition of BACE1 by an Exosite-Binding Antibody===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21613622}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21613622 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21613622}}		{{ABSTRACT_PUBMED_21613622}}

	==About this Structure==		==About this Structure==
-	[[3r1g]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R1G OCA].	+	[[3r1g]] is a 3 chain structure of [[Antibody]] and [[Beta secretase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R1G OCA].
		+
		+	==See Also==
		+	*[[Antibody\|Antibody]]
		+	*[[Beta secretase\|Beta secretase]]

	==Reference==		==Reference==
Line 32:		Line 25:
	[[Category: Wu, P.]]		[[Category: Wu, P.]]
	[[Category: Wu, Y.]]		[[Category: Wu, Y.]]
		+	[[Category: Aspartal protease]]
		+	[[Category: Protein binding]]

OCA at 05:08, 8 June 2011

OCA — Wed, 08 Jun 2011 05:08:23 GMT

←Older revision		Revision as of 05:08, 8 June 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3r1g.jpg\|left\|200px]]

-	The ~~entry 3r1g~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3r1g", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3r1g\| PDB=3r1g \| SCENE= }}

-	~~Authors: Wang, W., Rouge, L., Wu, P., Chiu, C., Chen, Y., Wu, Y., Watts, R.J.~~	+	===Structure Basis of Allosteric Inhibition of BACE1 by an Exosite-Binding Antibody===

-	~~Description~~: Structure ~~Basis of Allosteric Inhibition of BACE1 by an Exosite~~-~~Binding Antibody~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21613622}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21613622 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21613622}}
		+
		+	==About this Structure==
		+	[[3r1g]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R1G OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021613622</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Memapsin 2]]
		+	[[Category: Chen, Y.]]
		+	[[Category: Chiu, C.]]
		+	[[Category: Rouge, L.]]
		+	[[Category: Wang, W.]]
		+	[[Category: Watts, R J.]]
		+	[[Category: Wu, P.]]
		+	[[Category: Wu, Y.]]

OCA at 06:48, 23 March 2011

OCA — Wed, 23 Mar 2011 06:48:45 GMT

←Older revision		Revision as of 06:48, 23 March 2011
Line 3:		Line 3:
	The entry 3r1g is ON HOLD		The entry 3r1g is ON HOLD

-	Authors: ~~Weiru~~ Wang, ~~Lionel~~ Rouge, ~~Ping~~ Wu, ~~Cecilia~~ Chiu, ~~Yongmei~~ Chen, ~~Yan~~ Wu, ~~Ryan J~~. Watts	+	Authors: Wang, W., Rouge, L., Wu, P., Chiu, C., Chen, Y., Wu, Y., Watts, R.J.

	Description: Structure Basis of Allosteric Inhibition of BACE1 by an Exosite-Binding Antibody		Description: Structure Basis of Allosteric Inhibition of BACE1 by an Exosite-Binding Antibody

OCA: Protected "3r1g" [edit=sysop:move=sysop]

OCA — Wed, 16 Mar 2011 08:08:06 GMT

Protected "3r1g" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:08, 16 March 2011

OCA: New page: '''Unreleased structure''' The entry 3r1g is ON HOLD Authors: Weiru Wang, Lionel Rouge, Ping Wu, Cecilia Chiu, Yongmei Chen, Yan Wu, Ryan J. Watts Description: Structure Basis of Allos...

OCA — Wed, 16 Mar 2011 08:08:05 GMT

New page: '''Unreleased structure''' The entry 3r1g is ON HOLD Authors: Weiru Wang, Lionel Rouge, Ping Wu, Cecilia Chiu, Yongmei Chen, Yan Wu, Ryan J. Watts Description: Structure Basis of Allos...

New page

'''Unreleased structure'''

The entry 3r1g is ON HOLD

Authors: Weiru Wang, Lionel Rouge, Ping Wu, Cecilia Chiu, Yongmei Chen, Yan Wu, Ryan J. Watts

Description: Structure Basis of Allosteric Inhibition of BACE1 by an Exosite-Binding Antibody