3rd8 - Revision history

OCA at 12:19, 14 March 2024

OCA — Thu, 14 Mar 2024 12:19:15 GMT

←Older revision		Revision as of 12:19, 14 March 2024
Line 3:		Line 3:
	<StructureSection load='3rd8' size='340' side='right'caption='[[3rd8]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3rd8' size='340' side='right'caption='[[3rd8]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3rd8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Mycs2 Mycs2~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RD8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RD8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3rd8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RD8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RD8 FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>MSMEG_5240 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=246196 MYCS2])</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	~~<tr id='activity'><td class~~="~~sblockLbl~~">~~<b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>~~[~~https://en.wikipedia.org/wiki/Fumarate_hydratase Fumarate hydratase~~]~~, with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.~~2.1.2 ~~4.2.1.2] </span>~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rd8 OCA], [https://pdbe.org/3rd8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rd8 RCSB], [https://www.ebi.ac.uk/pdbsum/3rd8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rd8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rd8 OCA], [https://pdbe.org/3rd8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rd8 RCSB], [https://www.ebi.ac.uk/pdbsum/3rd8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rd8 ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/A0R2U8_MYCS2 A0R2U8_MYCS2]
-	High-resolution three-dimensional structures of essential Mycobacterium tuberculosis (Mtb) proteins provide templates for TB drug design, but are available for only a small fraction of the Mtb proteome. Here we evaluate an intra-genus "homolog-rescue" strategy to increase the structural information available for TB drug discovery by using mycobacterial homologs with conserved active sites. Of 179 potential TB drug targets selected for x-ray structure determination, only 16 yielded a crystal structure. By adding 1675 homologs from nine other mycobacterial species to the pipeline, structures representing an additional 52 otherwise intractable targets were solved. To determine whether these homolog structures would be useful surrogates in TB drug design, we compared the active sites of 106 pairs of Mtb and non-TB mycobacterial (NTM) enzyme homologs with experimentally determined structures, using three metrics of active site similarity, including superposition of continuous pharmacophoric property distributions. Pair-wise structural comparisons revealed that 19/22 pairs with >55% overall sequence identity had active site Calpha RMSD <1 A, >85% side chain identity, and >/=80% PSAPF (similarity based on pharmacophoric properties) indicating highly conserved active site shape and chemistry. Applying these results to the 52 NTM structures described above, 41 shared >55% sequence identity with the Mtb target, thus increasing the effective structural coverage of the 179 Mtb targets over three-fold (from 9% to 32%). The utility of these structures in TB drug design can be tested by designing inhibitors using the homolog structure and assaying the cognate Mtb enzyme; a promising test case, Mtb cytidylate kinase, is described. The homolog-rescue strategy evaluated here for TB is also generalizable to drug targets for other diseases.	+
-		+
-	Increasing the structural coverage of tuberculosis drug targets.,Baugh L, Phan I, Begley DW, Clifton MC, Armour B, Dranow DM, Taylor BM, Muruthi MM, Abendroth J, Fairman JW, Fox D 3rd, Dieterich SH, Staker BL, Gardberg AS, Choi R, Hewitt SN, Napuli AJ, Myers J, Barrett LK, Zhang Y, Ferrell M, Mundt E, Thompkins K, Tran N, Lyons-Abbott S, Abramov A, Sekar A, Serbzhinskiy D, Lorimer D, Buchko GW, Stacy R, Stewart LJ, Edwards TE, Van Voorhis WC, Myler PJ Tuberculosis (Edinb). 2014 Dec 19. pii: ~~S1472-9792(14)20565-8. doi:, 10.1016~~/~~j.tube.2014.12.003. PMID:25613812<ref>PMID:25613812<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 3rd8" style="background-color:#fffaf0;"><~~/~~div>~~	+

	==See Also==		==See Also==
	*[[Fumarase\|Fumarase]]		*[[Fumarase\|Fumarase]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Fumarate hydratase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Mycs2]]~~	+	[[Category: Mycolicibacterium smegmatis MC2 155]]
-	~~[[Category: Structural genomic]]~~	+
-	~~[[Category: Fumarate hydratase class ii]]~~	+
-	~~[[Category: Hydratase]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Ssgcid~~]]	+

OCA at 05:58, 15 June 2022

OCA — Wed, 15 Jun 2022 05:58:42 GMT

←Older revision		Revision as of 05:58, 15 June 2022
Line 1:		Line 1:

	==Crystal structure of fumarate hydratase class II Mycobacterium smegmatis==		==Crystal structure of fumarate hydratase class II Mycobacterium smegmatis==
-	<StructureSection load='3rd8' size='340' side='right' caption='[[3rd8]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='3rd8' size='340' side='right'caption='[[3rd8]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3rd8]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RD8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3RD8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3rd8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RD8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RD8 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MSMEG_5240 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 MYCS2])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MSMEG_5240 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 MYCS2])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Fumarate_hydratase Fumarate hydratase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.2 4.2.1.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Fumarate_hydratase Fumarate hydratase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.2 4.2.1.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3rd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rd8 OCA], [~~http~~://pdbe.org/3rd8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3rd8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3rd8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3rd8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rd8 OCA], [https://pdbe.org/3rd8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rd8 RCSB], [https://www.ebi.ac.uk/pdbsum/3rd8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rd8 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 3rd8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3rd8" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Fumarase\|Fumarase]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Fumarate hydratase]]		[[Category: Fumarate hydratase]]
		+	[[Category: Large Structures]]
	[[Category: Mycs2]]		[[Category: Mycs2]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

OCA at 18:50, 1 February 2017

OCA — Wed, 01 Feb 2017 18:50:19 GMT

←Older revision		Revision as of 18:50, 1 February 2017
Line 1:		Line 1:
		+
	==Crystal structure of fumarate hydratase class II Mycobacterium smegmatis==		==Crystal structure of fumarate hydratase class II Mycobacterium smegmatis==
	<StructureSection load='3rd8' size='340' side='right' caption='[[3rd8]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3rd8' size='340' side='right' caption='[[3rd8]], [[Resolution\|resolution]] 2.20Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MSMEG_5240 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 MYCS2])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MSMEG_5240 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 MYCS2])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fumarate_hydratase Fumarate hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.2 4.2.1.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fumarate_hydratase Fumarate hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.2 4.2.1.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rd8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rd8 RCSB], [http://www.ebi.ac.uk/pdbsum/3rd8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rd8 OCA], [http://pdbe.org/3rd8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3rd8 RCSB], [http://www.ebi.ac.uk/pdbsum/3rd8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3rd8 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
-		+	<div class="pdbe-citations 3rd8" style="background-color:#fffaf0;"></div>
-	==~~See Also==~~	+
-	*[[Fumarase\|Fumarase]]	+
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:16, 22 April 2015

OCA — Wed, 22 Apr 2015 07:16:26 GMT

←Older revision		Revision as of 07:16, 22 April 2015
Line 2:		Line 2:
	<StructureSection load='3rd8' size='340' side='right' caption='[[3rd8]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3rd8' size='340' side='right' caption='[[3rd8]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3rd8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_smegmatis Mycobacterium smegmatis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RD8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RD8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3rd8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RD8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RD8 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MSMEG_5240 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~1772 Mycobacterium smegmatis~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MSMEG_5240 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 MYCS2])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fumarate_hydratase Fumarate hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.2 4.2.1.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fumarate_hydratase Fumarate hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.2 4.2.1.2] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rd8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rd8 RCSB], [http://www.ebi.ac.uk/pdbsum/3rd8 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rd8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rd8 RCSB], [http://www.ebi.ac.uk/pdbsum/3rd8 PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	High-resolution three-dimensional structures of essential Mycobacterium tuberculosis (Mtb) proteins provide templates for TB drug design, but are available for only a small fraction of the Mtb proteome. Here we evaluate an intra-genus "homolog-rescue" strategy to increase the structural information available for TB drug discovery by using mycobacterial homologs with conserved active sites. Of 179 potential TB drug targets selected for x-ray structure determination, only 16 yielded a crystal structure. By adding 1675 homologs from nine other mycobacterial species to the pipeline, structures representing an additional 52 otherwise intractable targets were solved. To determine whether these homolog structures would be useful surrogates in TB drug design, we compared the active sites of 106 pairs of Mtb and non-TB mycobacterial (NTM) enzyme homologs with experimentally determined structures, using three metrics of active site similarity, including superposition of continuous pharmacophoric property distributions. Pair-wise structural comparisons revealed that 19/22 pairs with >55% overall sequence identity had active site Calpha RMSD <1 A, >85% side chain identity, and >/=80% PSAPF (similarity based on pharmacophoric properties) indicating highly conserved active site shape and chemistry. Applying these results to the 52 NTM structures described above, 41 shared >55% sequence identity with the Mtb target, thus increasing the effective structural coverage of the 179 Mtb targets over three-fold (from 9% to 32%). The utility of these structures in TB drug design can be tested by designing inhibitors using the homolog structure and assaying the cognate Mtb enzyme; a promising test case, Mtb cytidylate kinase, is described. The homolog-rescue strategy evaluated here for TB is also generalizable to drug targets for other diseases.
		+
		+	Increasing the structural coverage of tuberculosis drug targets.,Baugh L, Phan I, Begley DW, Clifton MC, Armour B, Dranow DM, Taylor BM, Muruthi MM, Abendroth J, Fairman JW, Fox D 3rd, Dieterich SH, Staker BL, Gardberg AS, Choi R, Hewitt SN, Napuli AJ, Myers J, Barrett LK, Zhang Y, Ferrell M, Mundt E, Thompkins K, Tran N, Lyons-Abbott S, Abramov A, Sekar A, Serbzhinskiy D, Lorimer D, Buchko GW, Stacy R, Stewart LJ, Edwards TE, Van Voorhis WC, Myler PJ Tuberculosis (Edinb). 2014 Dec 19. pii: S1472-9792(14)20565-8. doi:, 10.1016/j.tube.2014.12.003. PMID:25613812<ref>PMID:25613812</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Fumarase\|Fumarase]]		*[[Fumarase\|Fumarase]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Fumarate hydratase]]		[[Category: Fumarate hydratase]]
-	[[Category: ~~Mycobacterium smegmatis~~]]	+	[[Category: Mycs2]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Fumarate hydratase class ii]]		[[Category: Fumarate hydratase class ii]]

OCA at 11:06, 19 December 2014

OCA — Fri, 19 Dec 2014 11:06:36 GMT

←Older revision		Revision as of 11:06, 19 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3rd8\| PDB~~=3rd8 \| ~~SCENE~~= }}	+	==Crystal structure of fumarate hydratase class II Mycobacterium smegmatis==
-	===~~Crystal~~ structure ~~of fumarate hydratase~~ class II Mycobacterium smegmatis===	+	<StructureSection load='3rd8' size='340' side='right' caption='[[3rd8]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3rd8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RD8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RD8 FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MSMEG_5240 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1772 Mycobacterium smegmatis])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fumarate_hydratase Fumarate hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.2 4.2.1.2] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rd8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rd8 RCSB], [http://www.ebi.ac.uk/pdbsum/3rd8 PDBsum]</span></td></tr>
		+	</table>

-	==~~About this Structure~~==	+	==See Also==
-	[[~~3rd8~~]] ~~is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RD8 OCA].~~	+	*[[Fumarase\|Fumarase]]
		+	__TOC__
		+	</StructureSection>
	[[Category: Fumarate hydratase]]		[[Category: Fumarate hydratase]]
	[[Category: Mycobacterium smegmatis]]		[[Category: Mycobacterium smegmatis]]
-	[[Category: ~~SSGCID, Seattle~~ Structural ~~Genomics Center for Infectious Disease.~~]]	+	[[Category: Structural genomic]]
	[[Category: Fumarate hydratase class ii]]		[[Category: Fumarate hydratase class ii]]
	[[Category: Hydratase]]		[[Category: Hydratase]]
	[[Category: Lyase]]		[[Category: Lyase]]
-	[[Category: Seattle structural genomics center for infectious disease]]
	[[Category: Ssgcid]]		[[Category: Ssgcid]]
-	[[Category: Structural genomic]]

OCA at 08:07, 16 May 2013

OCA — Thu, 16 May 2013 08:07:06 GMT

←Older revision		Revision as of 08:07, 16 May 2013
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-	[[Image:3rd8.jpg\|left\|200px]]
-
-	<!--
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-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3rd8\| PDB=3rd8 \| SCENE= }}		{{STRUCTURE_3rd8\| PDB=3rd8 \| SCENE= }}
-
	===Crystal structure of fumarate hydratase class II Mycobacterium smegmatis===		===Crystal structure of fumarate hydratase class II Mycobacterium smegmatis===
-

	==About this Structure==		==About this Structure==
Line 17:		Line 7:
	[[Category: Mycobacterium smegmatis]]		[[Category: Mycobacterium smegmatis]]
	[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]		[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]
		+	[[Category: Fumarate hydratase class ii]]
		+	[[Category: Hydratase]]
		+	[[Category: Lyase]]
		+	[[Category: Seattle structural genomics center for infectious disease]]
		+	[[Category: Ssgcid]]
		+	[[Category: Structural genomic]]

OCA at 05:23, 8 June 2011

OCA — Wed, 08 Jun 2011 05:23:58 GMT

←Older revision		Revision as of 05:23, 8 June 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3rd8.jpg\|left\|200px]]

-	The ~~entry 3rd8~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3rd8", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3rd8\| PDB=3rd8 \| SCENE= }}

-	~~Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)~~	+	===Crystal structure of fumarate hydratase class II Mycobacterium smegmatis===

-	~~Description: Crystal~~ structure ~~of fumarate~~ hydratase ~~class II~~ Mycobacterium smegmatis	+
		+	==About this Structure==
		+	[[3rd8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RD8 OCA].
		+	[[Category: Fumarate hydratase]]
		+	[[Category: Mycobacterium smegmatis]]
		+	[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]

OCA at 06:30, 4 May 2011

OCA — Wed, 04 May 2011 06:30:31 GMT

←Older revision		Revision as of 06:30, 4 May 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3rd8 is ON HOLD ~~until sometime in the future~~	+	The entry 3rd8 is ON HOLD

	Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)		Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)

-	Description: ~~CRYSTAL STRUCTURE OF FUMARATE HYDRATASE CLASS~~ II ~~MYCOBACTERIUM SMEGMATIS~~	+	Description: Crystal structure of fumarate hydratase class II Mycobacterium smegmatis

OCA at 10:20, 21 April 2011

OCA — Thu, 21 Apr 2011 10:20:31 GMT

←Older revision		Revision as of 10:20, 21 April 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3rd8 is ON HOLD	+	The entry 3rd8 is ON HOLD until sometime in the future

	Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)		Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)

	Description: CRYSTAL STRUCTURE OF FUMARATE HYDRATASE CLASS II MYCOBACTERIUM SMEGMATIS		Description: CRYSTAL STRUCTURE OF FUMARATE HYDRATASE CLASS II MYCOBACTERIUM SMEGMATIS

OCA: Protected "3rd8" [edit=sysop:move=sysop]

OCA — Wed, 06 Apr 2011 08:44:24 GMT

Protected "3rd8" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:44, 6 April 2011