3rej - Revision history

OCA at 12:20, 14 March 2024

OCA — Thu, 14 Mar 2024 12:20:46 GMT

←Older revision		Revision as of 12:20, 14 March 2024
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	<StructureSection load='3rej' size='340' side='right'caption='[[3rej]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='3rej' size='340' side='right'caption='[[3rej]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3rej]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/~~African_clawed_frog African clawed frog~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3REJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3rej]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3REJ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.55Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1kx3\|1kx3]]~~, ~~[[1kx4\|1kx4]], [[1kx5\|1kx5]], [[2nzd\|2nzd]], [[3reh\|3reh]], [[3rei\|3rei]], [[3rek\|3rek]], [[3rel\|3rel]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rej OCA], [https://pdbe.org/3rej PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rej RCSB], [https://www.ebi.ac.uk/pdbsum/3rej PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rej ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rej OCA], [https://pdbe.org/3rej PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rej RCSB], [https://www.ebi.ac.uk/pdbsum/3rej PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rej ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/H2B11_XENLA H2B11_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[https://www.uniprot.org/uniprot/H32_XENLA H32_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[https://www.uniprot.org/uniprot/H2A1_XENLA H2A1_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[https://www.uniprot.org/uniprot/H4_XENLA H4_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	+	[https://www.uniprot.org/uniprot/H32_XENLA H32_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Heavy metal compounds have toxic and medicinal potential through capacity to form strong specific bonds with macromolecules, and the interaction of platinum drugs at the major groove nitrogen atom of guanine bases primarily underlies their therapeutic activity. By crystallographic analysis of transition metal-and in particular platinum compound-DNA site selectivity in the nucleosome core, we establish that steric accessibility, which is controlled by specific structural parameters of the double helix, modulates initial guanine-metal bond formation. Moreover, DNA conformational features can be linked to both similarities and distinctions in platinum drug adduct formation between the naked and nucleosomal DNA states. Notably, structures that facilitate initial platinum-guanine bond formation can oppose cross-link generation, rationalizing the occurrence of long-lived therapeutically ineffective monofunctional adducts. These findings illuminate DNA structure-dependent reactivity and provide a novel framework for understanding metal-double helix interactions, which should facilitate the development of improved chromatin-targeting medicinal agents.	+
-		+
-	Specific DNA structural attributes modulate platinum anticancer drug site selection and cross-link generation.,Wu B, Davey GE, Nazarov AA, Dyson PJ, Davey CA Nucleic Acids Res. 2011 Oct;39(18):8200-12. Epub 2011 Jun 30. PMID:21724603<ref>PMID:21724603</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3rej" style="background-color:#fffaf0;"></div>~~	+

	==See Also==		==See Also==
	*[[Histone 3D structures\|Histone 3D structures]]		*[[Histone 3D structures\|Histone 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~African clawed frog~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Davey, C A~~]]	+	[[Category: Xenopus laevis]]
-	[[Category: ~~Wu, B~~]]	+	[[Category: Davey CA]]
-	[[Category: ~~Nucleosome]]~~	+	[[Category: Wu B]]
-	~~[[Category: Structural protein-dna complex~~]]	+

OCA at 06:00, 15 June 2022

OCA — Wed, 15 Jun 2022 06:00:07 GMT

←Older revision		Revision as of 06:00, 15 June 2022
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	==2.55 Angstrom Crystal Structure of the Nucleosome Core Particle Assembled with a 146 bp Alpha-Satellite DNA (NCP146b)==		==2.55 Angstrom Crystal Structure of the Nucleosome Core Particle Assembled with a 146 bp Alpha-Satellite DNA (NCP146b)==
-	<StructureSection load='3rej' size='340' side='right' caption='[[3rej]], [[Resolution\|resolution]] 2.55Å' scene=''>	+	<StructureSection load='3rej' size='340' side='right'caption='[[3rej]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3rej]] is a 10 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3REJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3rej]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3REJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kx3\|1kx3]], [[1kx4\|1kx4]], [[1kx5\|1kx5]], [[2nzd\|2nzd]], [[3reh\|3reh]], [[3rei\|3rei]], [[3rek\|3rek]], [[3rel\|3rel]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1kx3\|1kx3]], [[1kx4\|1kx4]], [[1kx5\|1kx5]], [[2nzd\|2nzd]], [[3reh\|3reh]], [[3rei\|3rei]], [[3rek\|3rek]], [[3rel\|3rel]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3rej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rej OCA], [~~http~~://pdbe.org/3rej PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3rej RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3rej PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3rej ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rej OCA], [https://pdbe.org/3rej PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rej RCSB], [https://www.ebi.ac.uk/pdbsum/3rej PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rej ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/H2B11_XENLA H2B11_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[~~http~~://www.uniprot.org/uniprot/H32_XENLA H32_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[~~http~~://www.uniprot.org/uniprot/H2A1_XENLA H2A1_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[~~http~~://www.uniprot.org/uniprot/H4_XENLA H4_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	+	[[https://www.uniprot.org/uniprot/H2B11_XENLA H2B11_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[https://www.uniprot.org/uniprot/H32_XENLA H32_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[https://www.uniprot.org/uniprot/H2A1_XENLA H2A1_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[https://www.uniprot.org/uniprot/H4_XENLA H4_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Histone\|Histone]]	+	*[[Histone 3D structures\|Histone 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: African clawed frog]]		[[Category: African clawed frog]]
		+	[[Category: Large Structures]]
	[[Category: Davey, C A]]		[[Category: Davey, C A]]
	[[Category: Wu, B]]		[[Category: Wu, B]]
	[[Category: Nucleosome]]		[[Category: Nucleosome]]
	[[Category: Structural protein-dna complex]]		[[Category: Structural protein-dna complex]]

OCA at 10:34, 4 August 2016

OCA — Thu, 04 Aug 2016 10:34:11 GMT

←Older revision		Revision as of 10:34, 4 August 2016
Line 1:		Line 1:
		+
	==2.55 Angstrom Crystal Structure of the Nucleosome Core Particle Assembled with a 146 bp Alpha-Satellite DNA (NCP146b)==		==2.55 Angstrom Crystal Structure of the Nucleosome Core Particle Assembled with a 146 bp Alpha-Satellite DNA (NCP146b)==
	<StructureSection load='3rej' size='340' side='right' caption='[[3rej]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='3rej' size='340' side='right' caption='[[3rej]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3rej]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Xenopus_laevis Xenopus laevis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3REJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3rej]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3REJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kx3\|1kx3]], [[1kx4\|1kx4]], [[1kx5\|1kx5]], [[2nzd\|2nzd]], [[3reh\|3reh]], [[3rei\|3rei]], [[3rek\|3rek]], [[3rel\|3rel]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kx3\|1kx3]], [[1kx4\|1kx4]], [[1kx5\|1kx5]], [[2nzd\|2nzd]], [[3reh\|3reh]], [[3rei\|3rei]], [[3rek\|3rek]], [[3rel\|3rel]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rej OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rej RCSB], [http://www.ebi.ac.uk/pdbsum/3rej PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rej OCA], [http://pdbe.org/3rej PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3rej RCSB], [http://www.ebi.ac.uk/pdbsum/3rej PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3rej ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3rej" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Xenopus laevis~~]]	+	[[Category: African clawed frog]]
	[[Category: Davey, C A]]		[[Category: Davey, C A]]
	[[Category: Wu, B]]		[[Category: Wu, B]]
	[[Category: Nucleosome]]		[[Category: Nucleosome]]
	[[Category: Structural protein-dna complex]]		[[Category: Structural protein-dna complex]]

OCA at 09:00, 24 December 2014

OCA — Wed, 24 Dec 2014 09:00:01 GMT

←Older revision		Revision as of 09:00, 24 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rej OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rej RCSB], [http://www.ebi.ac.uk/pdbsum/3rej PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rej OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rej RCSB], [http://www.ebi.ac.uk/pdbsum/3rej PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/H2B11_XENLA H2B11_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[http://www.uniprot.org/uniprot/H32_XENLA H32_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[http://www.uniprot.org/uniprot/H2A1_XENLA H2A1_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[http://www.uniprot.org/uniprot/H4_XENLA H4_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 11:55, 9 December 2014

OCA — Tue, 09 Dec 2014 11:55:15 GMT

←Older revision		Revision as of 11:55, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3rej.~~png~~\|~~left~~\|~~200px~~]]	+	==2.55 Angstrom Crystal Structure of the Nucleosome Core Particle Assembled with a 146 bp Alpha-Satellite DNA (NCP146b)==
		+	<StructureSection load='3rej' size='340' side='right' caption='[[3rej]], [[Resolution\|resolution]] 2.55Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3rej]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3REJ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kx3\|1kx3]], [[1kx4\|1kx4]], [[1kx5\|1kx5]], [[2nzd\|2nzd]], [[3reh\|3reh]], [[3rei\|3rei]], [[3rek\|3rek]], [[3rel\|3rel]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rej OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rej RCSB], [http://www.ebi.ac.uk/pdbsum/3rej PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Heavy metal compounds have toxic and medicinal potential through capacity to form strong specific bonds with macromolecules, and the interaction of platinum drugs at the major groove nitrogen atom of guanine bases primarily underlies their therapeutic activity. By crystallographic analysis of transition metal-and in particular platinum compound-DNA site selectivity in the nucleosome core, we establish that steric accessibility, which is controlled by specific structural parameters of the double helix, modulates initial guanine-metal bond formation. Moreover, DNA conformational features can be linked to both similarities and distinctions in platinum drug adduct formation between the naked and nucleosomal DNA states. Notably, structures that facilitate initial platinum-guanine bond formation can oppose cross-link generation, rationalizing the occurrence of long-lived therapeutically ineffective monofunctional adducts. These findings illuminate DNA structure-dependent reactivity and provide a novel framework for understanding metal-double helix interactions, which should facilitate the development of improved chromatin-targeting medicinal agents.

-	~~{{STRUCTURE_3rej\| PDB=3rej \| SCENE= }}~~	+	Specific DNA structural attributes modulate platinum anticancer drug site selection and cross-link generation.,Wu B, Davey GE, Nazarov AA, Dyson PJ, Davey CA Nucleic Acids Res. 2011 Oct;39(18):8200-12. Epub 2011 Jun 30. PMID:21724603<ref>PMID:21724603</ref>

-	~~===2.55 Angstrom Crystal Structure~~ of the ~~Nucleosome Core Particle Assembled with a 146 bp Alpha-Satellite DNA (NCP146b)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21724603}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3rej]] is a 10 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Xenopus_laevis Xenopus laevis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3REJ OCA].~~	+

	==See Also==		==See Also==
	*[[Histone\|Histone]]		*[[Histone\|Histone]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021724603<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Xenopus laevis]]		[[Category: Xenopus laevis]]
-	[[Category: Davey, C A.]]	+	[[Category: Davey, C A]]
-	[[Category: Wu, B.]]	+	[[Category: Wu, B]]
	[[Category: Nucleosome]]		[[Category: Nucleosome]]
	[[Category: Structural protein-dna complex]]		[[Category: Structural protein-dna complex]]

OCA at 05:59, 20 October 2012

OCA — Sat, 20 Oct 2012 05:59:43 GMT

←Older revision		Revision as of 05:59, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3rej]] is a 10 chain structure ~~of [[Histone]]~~ with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REJ OCA].	+	[[3rej]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REJ OCA].

	==See Also==		==See Also==

OCA at 11:46, 25 July 2012

OCA — Wed, 25 Jul 2012 11:46:31 GMT

←Older revision		Revision as of 11:46, 25 July 2012
Line 1:		Line 1:
-	[[Image:3rej.~~jpg~~\|left\|200px]]	+	[[Image:3rej.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3rej", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3rej\| PDB=3rej \| SCENE= }}		{{STRUCTURE_3rej\| PDB=3rej \| SCENE= }}

	===2.55 Angstrom Crystal Structure of the Nucleosome Core Particle Assembled with a 146 bp Alpha-Satellite DNA (NCP146b)===		===2.55 Angstrom Crystal Structure of the Nucleosome Core Particle Assembled with a 146 bp Alpha-Satellite DNA (NCP146b)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21724603}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21724603 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21724603}}		{{ABSTRACT_PUBMED_21724603}}

	==About this Structure==		==About this Structure==
-	[[3rej]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REJ OCA].	+	[[3rej]] is a 10 chain structure of [[Histone]] with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REJ OCA].
		+
		+	==See Also==
		+	*[[Histone\|Histone]]

	==Reference==		==Reference==

OCA at 06:39, 14 March 2012

OCA — Wed, 14 Mar 2012 06:39:07 GMT

←Older revision		Revision as of 06:39, 14 March 2012
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-	~~'''Unreleased structure'''~~	+	[[Image:3rej.jpg\|left\|200px]]

-	The ~~entry 3rej~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3rej", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3rej\| PDB=3rej \| SCENE= }}

-	~~Authors: Wu, B., Davey, C.A~~.	+	===2.55 Angstrom Crystal Structure of the Nucleosome Core Particle Assembled with a 146 bp Alpha-Satellite DNA (NCP146b)===

-	~~Description~~: ~~NCP146b~~-~~native~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21724603}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21724603 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21724603}}
		+
		+	==About this Structure==
		+	[[3rej]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REJ OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021724603</ref><references group="xtra"/>
		+	[[Category: Xenopus laevis]]
		+	[[Category: Davey, C A.]]
		+	[[Category: Wu, B.]]
		+	[[Category: Nucleosome]]
		+	[[Category: Structural protein-dna complex]]

OCA at 16:14, 22 June 2011

OCA — Wed, 22 Jun 2011 16:14:51 GMT

←Older revision		Revision as of 16:14, 22 June 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3rej is ON HOLD	+	The entry 3rej is ON HOLD until Paper Publication

	Authors: Wu, B., Davey, C.A.		Authors: Wu, B., Davey, C.A.

	Description: NCP146b-native		Description: NCP146b-native

OCA at 05:20, 1 June 2011

OCA — Wed, 01 Jun 2011 05:20:41 GMT

←Older revision		Revision as of 05:20, 1 June 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3rej is ON HOLD ~~until Paper Publication~~	+	The entry 3rej is ON HOLD

	Authors: Wu, B., Davey, C.A.		Authors: Wu, B., Davey, C.A.

	Description: NCP146b-native		Description: NCP146b-native