3rep - Revision history

OCA at 12:21, 14 March 2024

OCA — Thu, 14 Mar 2024 12:21:03 GMT

←Older revision		Revision as of 12:21, 14 March 2024
Line 3:		Line 3:
	<StructureSection load='3rep' size='340' side='right'caption='[[3rep]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3rep' size='340' side='right'caption='[[3rep]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3rep]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3REP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3rep]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3REP FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ATP:ADENOSINE~~-~~5-TRIPHOSPHATE'>ATP</scene>~~, ~~<scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[3kmu\|3kmu]], [[3kmw\|3kmw]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td><td class="sblockDat">ILK, ILK1, ILK2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), PARVA, MXRA2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rep OCA], [https://pdbe.org/3rep PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rep RCSB], [https://www.ebi.ac.uk/pdbsum/3rep PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rep ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rep OCA], [https://pdbe.org/3rep PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rep RCSB], [https://www.ebi.ac.uk/pdbsum/3rep PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rep ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ILK_HUMAN ILK_HUMAN]] Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. [[https://www.uniprot.org/uniprot/PARVA_HUMAN PARVA_HUMAN]] Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishement of cell polarity, cell adhesion, cell spreading, and directed cell migration.<ref>PMID:11331308</ref> <ref>PMID:11134073</ref> <ref>PMID:15284246</ref> <ref>PMID:20393563</ref>	+	[https://www.uniprot.org/uniprot/ILK_HUMAN ILK_HUMAN] Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.

	==See Also==		==See Also==
	*[[Parvin 3D structures\|Parvin 3D structures]]		*[[Parvin 3D structures\|Parvin 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Fukuda, K]]	+	[[Category: Fukuda K]]
-	[[Category: Qin, J]]	+	[[Category: Qin J]]
-	~~[[Category: Actin-binding]]~~	+
-	~~[[Category: Ank repeat]]~~	+
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Cell junction]]~~	+
-	~~[[Category: Cell membrane]]~~	+
-	~~[[Category: Cytoskeleton]]~~	+
-	~~[[Category: Integrin-binding protein]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Pseudokinase~~]]	+

OCA at 06:00, 15 June 2022

OCA — Wed, 15 Jun 2022 06:00:17 GMT

←Older revision		Revision as of 06:00, 15 June 2022
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	<StructureSection load='3rep' size='340' side='right'caption='[[3rep]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3rep' size='340' side='right'caption='[[3rep]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3rep]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3REP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3rep]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3REP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3kmu\|3kmu]], [[3kmw\|3kmw]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3kmu\|3kmu]], [[3kmw\|3kmw]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ILK, ILK1, ILK2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), PARVA, MXRA2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ILK, ILK1, ILK2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), PARVA, MXRA2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3rep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rep OCA], [~~http~~://pdbe.org/3rep PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3rep RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3rep PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3rep ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rep OCA], [https://pdbe.org/3rep PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rep RCSB], [https://www.ebi.ac.uk/pdbsum/3rep PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rep ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ILK_HUMAN ILK_HUMAN]] Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. [[~~http~~://www.uniprot.org/uniprot/PARVA_HUMAN PARVA_HUMAN]] Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishement of cell polarity, cell adhesion, cell spreading, and directed cell migration.<ref>PMID:11331308</ref> <ref>PMID:11134073</ref> <ref>PMID:15284246</ref> <ref>PMID:20393563</ref>	+	[[https://www.uniprot.org/uniprot/ILK_HUMAN ILK_HUMAN]] Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. [[https://www.uniprot.org/uniprot/PARVA_HUMAN PARVA_HUMAN]] Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishement of cell polarity, cell adhesion, cell spreading, and directed cell migration.<ref>PMID:11331308</ref> <ref>PMID:11134073</ref> <ref>PMID:15284246</ref> <ref>PMID:20393563</ref>

	==See Also==		==See Also==

OCA at 11:36, 17 July 2019

OCA — Wed, 17 Jul 2019 11:36:45 GMT

←Older revision		Revision as of 11:36, 17 July 2019
Line 1:		Line 1:

	==Crystal structure of the ILK/alpha-parvin core complex (MnATP)==		==Crystal structure of the ILK/alpha-parvin core complex (MnATP)==
-	<StructureSection load='3rep' size='340' side='right' caption='[[3rep]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='3rep' size='340' side='right'caption='[[3rep]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3rep]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3REP FirstGlance]. <br>		<table><tr><td colspan='2'>[[3rep]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3REP FirstGlance]. <br>
Line 13:		Line 13:

	==See Also==		==See Also==
-	*[[~~Alpha-parvin~~\|~~Alpha-parvin~~]]	+	*[[Parvin 3D structures\|Parvin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 19:		Line 19:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Fukuda, K]]		[[Category: Fukuda, K]]
	[[Category: Qin, J]]		[[Category: Qin, J]]

OCA at 18:54, 4 August 2016

OCA — Thu, 04 Aug 2016 18:54:17 GMT

←Older revision		Revision as of 18:54, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the ILK/alpha-parvin core complex (MnATP)==		==Crystal structure of the ILK/alpha-parvin core complex (MnATP)==
	<StructureSection load='3rep' size='340' side='right' caption='[[3rep]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3rep' size='340' side='right' caption='[[3rep]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3rep]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3REP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3rep]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3REP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3kmu\|3kmu]], [[3kmw\|3kmw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3kmu\|3kmu]], [[3kmw\|3kmw]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ILK, ILK1, ILK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~]), PARVA, MXRA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ILK, ILK1, ILK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), PARVA, MXRA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rep OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rep RCSB], [http://www.ebi.ac.uk/pdbsum/3rep PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rep OCA], [http://pdbe.org/3rep PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3rep RCSB], [http://www.ebi.ac.uk/pdbsum/3rep PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3rep ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Fukuda, K]]		[[Category: Fukuda, K]]
	[[Category: Qin, J]]		[[Category: Qin, J]]

OCA at 12:08, 25 December 2014

OCA — Thu, 25 Dec 2014 12:08:58 GMT

←Older revision		Revision as of 12:08, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rep OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rep RCSB], [http://www.ebi.ac.uk/pdbsum/3rep PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rep OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rep RCSB], [http://www.ebi.ac.uk/pdbsum/3rep PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ILK_HUMAN ILK_HUMAN]] Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. [[http://www.uniprot.org/uniprot/PARVA_HUMAN PARVA_HUMAN]] Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishement of cell polarity, cell adhesion, cell spreading, and directed cell migration.<ref>PMID:11331308</ref> <ref>PMID:11134073</ref> <ref>PMID:15284246</ref> <ref>PMID:20393563</ref>

	==See Also==		==See Also==
	*[[Alpha-parvin\|Alpha-parvin]]		*[[Alpha-parvin\|Alpha-parvin]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 13:43, 9 December 2014

OCA — Tue, 09 Dec 2014 13:43:28 GMT

←Older revision		Revision as of 13:43, 9 December 2014
Line 1:		Line 1:
-	~~[[Image:3rep.png\|left\|200px]]~~	+	==Crystal structure of the ILK/alpha-parvin core complex (MnATP)==
-		+	<StructureSection load='3rep' size='340' side='right' caption='[[3rep]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~{{STRUCTURE_3rep\| PDB=3rep \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3rep]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3REP FirstGlance]. <br>
-	===Crystal structure of the ILK/alpha-parvin core complex (MnATP)===	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3kmu\|3kmu]], [[3kmw\|3kmw]]</td></tr>
-		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ILK, ILK1, ILK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), PARVA, MXRA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	==~~About this Structure~~==	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rep OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rep RCSB], [http://www.ebi.ac.uk/pdbsum/3rep PDBsum]</span></td></tr>
-	[[3rep]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REP OCA].	+	</table>

	==See Also==		==See Also==
	*[[Alpha-parvin\|Alpha-parvin]]		*[[Alpha-parvin\|Alpha-parvin]]
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Fukuda, K.]]	+	[[Category: Fukuda, K]]
-	[[Category: Qin, J.]]	+	[[Category: Qin, J]]
	[[Category: Actin-binding]]		[[Category: Actin-binding]]
	[[Category: Ank repeat]]		[[Category: Ank repeat]]

OCA at 16:29, 20 October 2012

OCA — Sat, 20 Oct 2012 16:29:24 GMT

←Older revision		Revision as of 16:29, 20 October 2012
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[3rep]] is a 2 chain structure ~~of [[Alpha-parvin]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REP OCA].	+	[[3rep]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REP OCA].

	==See Also==		==See Also==

OCA at 21:51, 26 July 2012

OCA — Thu, 26 Jul 2012 21:51:24 GMT

←Older revision		Revision as of 21:51, 26 July 2012
Line 1:		Line 1:
-	[[Image:3rep.~~jpg~~\|left\|200px]]	+	[[Image:3rep.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3rep", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3rep\| PDB=3rep \| SCENE= }}		{{STRUCTURE_3rep\| PDB=3rep \| SCENE= }}

Line 13:		Line 7:

	==About this Structure==		==About this Structure==
-	[[3rep]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REP OCA].	+	[[3rep]] is a 2 chain structure of [[Alpha-parvin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REP OCA].
		+
		+	==See Also==
		+	*[[Alpha-parvin\|Alpha-parvin]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Fukuda, K.]]		[[Category: Fukuda, K.]]
	[[Category: Qin, J.]]		[[Category: Qin, J.]]
		+	[[Category: Actin-binding]]
		+	[[Category: Ank repeat]]
		+	[[Category: Atp-binding]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Cell junction]]
		+	[[Category: Cell membrane]]
		+	[[Category: Cytoskeleton]]
		+	[[Category: Integrin-binding protein]]
		+	[[Category: Membrane]]
		+	[[Category: Nucleotide-binding]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Pseudokinase]]

OCA at 07:30, 27 April 2011

OCA — Wed, 27 Apr 2011 07:30:32 GMT

←Older revision		Revision as of 07:30, 27 April 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3rep.jpg\|left\|200px]]

-	The ~~entry 3rep~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3rep", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3rep\| PDB=3rep \| SCENE= }}

-	~~Authors: Fukuda, K., Qin, J.~~	+	===Crystal structure of the ILK/alpha-parvin core complex (MnATP)===

-	~~Description: Crystal~~ structure ~~of the ILK~~/~~alpha~~-~~parvin core complex (MnATP)~~	+
		+	==About this Structure==
		+	[[3rep]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3REP OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Fukuda, K.]]
		+	[[Category: Qin, J.]]

OCA: Protected "3rep" [edit=sysop:move=sysop]

OCA — Wed, 13 Apr 2011 05:00:03 GMT

Protected "3rep" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:00, 13 April 2011