3rkj - Revision history

OCA at 12:27, 14 March 2024

OCA — Thu, 14 Mar 2024 12:27:48 GMT

←Older revision		Revision as of 12:27, 14 March 2024
Line 3:		Line 3:
	<StructureSection load='3rkj' size='340' side='right'caption='[[3rkj]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3rkj' size='340' side='right'caption='[[3rkj]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3rkj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus~~ pneumoniae~~" (schroeter 1886) flugge 1886~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RKJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RKJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3rkj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RKJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RKJ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>blaNDM-1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~573~~ "~~Bacillus pneumoniae~~" ~~(Schroeter 1886) Flugge 1886])</td~~><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rkj OCA], [https://pdbe.org/3rkj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rkj RCSB], [https://www.ebi.ac.uk/pdbsum/3rkj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rkj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rkj OCA], [https://pdbe.org/3rkj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rkj RCSB], [https://www.ebi.ac.uk/pdbsum/3rkj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rkj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN]] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.	+	[https://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	The New Delhi Metallo-beta-lactamase (NDM-1) gene makes multiple pathogenic microorganisms resistant to all known beta-lactam antibiotics. The rapid emergence of NDM-1 has been linked to mobile plasmids that move between different strains resulting in world-wide dissemination. Biochemical studies revealed that NDM-1 is capable of efficiently hydrolyzing a wide range of beta-lactams, including many carbapenems considered as "last resort" antibiotics. The crystal structures of metal-free apo- and monozinc forms of NDM-1 presented here revealed an enlarged and flexible active site of class B1 metallo-beta-lactamase. This site is capable of accommodating many beta-lactam substrates by having many of the catalytic residues on flexible loops, which explains the observed extended spectrum activity of this zinc dependent beta-lactamase. Indeed, five loops contribute "keg" residues in the active site including side chains involved in metal binding. Loop 1 in particular, shows conformational flexibility, apparently related to the acceptance and positioning of substrates for cleavage by a zinc-activated water molecule.	+
-		+
-	Structure of apo- and monometalated forms of NDM-1--a highly potent carbapenem-hydrolyzing metallo-beta-lactamase.,Kim Y, Tesar C, Mire J, Jedrzejczak R, Binkowski A, Babnigg G, Sacchettini J, Joachimiak A PLoS One. 2011;6(9):e24621. Epub 2011 Sep 8. PMID:21931780<ref>PMID:21931780</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3rkj" style="background-color:#fffaf0;"></div>~~	+

	==See Also==		==See Also==
	*[[Beta-lactamase 3D structures\|Beta-lactamase 3D structures]]		*[[Beta-lactamase 3D structures\|Beta-lactamase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Beta-lactamase~~]]	+	[[Category: Klebsiella pneumoniae]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Babnigg, G]]	+	[[Category: Babnigg G]]
-	[[Category: Binkowski~~, T A~~]]	+	[[Category: Binkowski TA]]
-	[[Category: Jedrzejczak, R]]	+	[[Category: Jedrzejczak R]]
-	[[Category: Joachimiak, A]]	+	[[Category: Joachimiak A]]
-	[[Category: Kim, Y]]	+	[[Category: Kim Y]]
-	~~[[Category: Structural genomic]]~~	+	[[Category: Sacchettini J]]
-	~~[[Category: MTBI, Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors~~]]	+	[[Category: Tesar C]]
-	[[Category: Sacchettini, J]]	+
-	[[Category: Tesar, C]]	+
-	~~[[Category: Alpha-beta structure]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Mcsg]]~~	+
-	~~[[Category: Mtbi]]~~	+
-	~~[[Category: Psi-biology]]~~	+
-	~~[[Category: Structures of mtb proteins conferring susceptibility to known mtb inhibitor~~]]	+

OCA at 10:14, 22 June 2022

OCA — Wed, 22 Jun 2022 10:14:42 GMT

←Older revision		Revision as of 10:14, 22 June 2022
Line 1:		Line 1:

	==Crystal Structure of New Delhi Metallo-Beta-Lactamase-1 from Klebsiella pnueumoniae==		==Crystal Structure of New Delhi Metallo-Beta-Lactamase-1 from Klebsiella pnueumoniae==
-	<StructureSection load='3rkj' size='340' side='right' caption='[[3rkj]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='3rkj' size='340' side='right'caption='[[3rkj]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3rkj]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RKJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3RKJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3rkj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RKJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RKJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">blaNDM-1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">blaNDM-1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3rkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rkj OCA], [~~http~~://pdbe.org/3rkj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3rkj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3rkj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3rkj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rkj OCA], [https://pdbe.org/3rkj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rkj RCSB], [https://www.ebi.ac.uk/pdbsum/3rkj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rkj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN]] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.	+	[[https://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN]] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Beta-lactamase\|Beta-lactamase]]	+	*[[Beta-lactamase 3D structures\|Beta-lactamase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
		+	[[Category: Large Structures]]
	[[Category: Babnigg, G]]		[[Category: Babnigg, G]]
	[[Category: Binkowski, T A]]		[[Category: Binkowski, T A]]

OCA at 08:01, 4 August 2016

OCA — Thu, 04 Aug 2016 08:01:23 GMT

←Older revision		Revision as of 08:01, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of New Delhi Metallo-Beta-Lactamase-1 from Klebsiella pnueumoniae==		==Crystal Structure of New Delhi Metallo-Beta-Lactamase-1 from Klebsiella pnueumoniae==
	<StructureSection load='3rkj' size='340' side='right' caption='[[3rkj]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3rkj' size='340' side='right' caption='[[3rkj]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3rkj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Klebsiella_pneumoniae Klebsiella~~ pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RKJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RKJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3rkj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RKJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RKJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">blaNDM-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 ~~Klebsiella~~ pneumoniae])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">blaNDM-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rkj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rkj RCSB], [http://www.ebi.ac.uk/pdbsum/3rkj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rkj OCA], [http://pdbe.org/3rkj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3rkj RCSB], [http://www.ebi.ac.uk/pdbsum/3rkj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3rkj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3rkj" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
-	[[Category: Klebsiella pneumoniae]]
	[[Category: Babnigg, G]]		[[Category: Babnigg, G]]
	[[Category: Binkowski, T A]]		[[Category: Binkowski, T A]]

OCA at 07:20, 24 December 2014

OCA — Wed, 24 Dec 2014 07:20:24 GMT

←Older revision		Revision as of 07:20, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rkj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rkj RCSB], [http://www.ebi.ac.uk/pdbsum/3rkj PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rkj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rkj RCSB], [http://www.ebi.ac.uk/pdbsum/3rkj PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN]] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 11:47, 9 December 2014

OCA — Tue, 09 Dec 2014 11:47:16 GMT

←Older revision		Revision as of 11:47, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3rkj.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal Structure of New Delhi Metallo-Beta-Lactamase-1 from Klebsiella pnueumoniae==
		+	<StructureSection load='3rkj' size='340' side='right' caption='[[3rkj]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3rkj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RKJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RKJ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">blaNDM-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 Klebsiella pneumoniae])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rkj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rkj RCSB], [http://www.ebi.ac.uk/pdbsum/3rkj PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The New Delhi Metallo-beta-lactamase (NDM-1) gene makes multiple pathogenic microorganisms resistant to all known beta-lactam antibiotics. The rapid emergence of NDM-1 has been linked to mobile plasmids that move between different strains resulting in world-wide dissemination. Biochemical studies revealed that NDM-1 is capable of efficiently hydrolyzing a wide range of beta-lactams, including many carbapenems considered as "last resort" antibiotics. The crystal structures of metal-free apo- and monozinc forms of NDM-1 presented here revealed an enlarged and flexible active site of class B1 metallo-beta-lactamase. This site is capable of accommodating many beta-lactam substrates by having many of the catalytic residues on flexible loops, which explains the observed extended spectrum activity of this zinc dependent beta-lactamase. Indeed, five loops contribute "keg" residues in the active site including side chains involved in metal binding. Loop 1 in particular, shows conformational flexibility, apparently related to the acceptance and positioning of substrates for cleavage by a zinc-activated water molecule.

-	~~{{STRUCTURE_3rkj\| PDB=3rkj \| SCENE= }}~~	+	Structure of apo- and monometalated forms of NDM-1--a highly potent carbapenem-hydrolyzing metallo-beta-lactamase.,Kim Y, Tesar C, Mire J, Jedrzejczak R, Binkowski A, Babnigg G, Sacchettini J, Joachimiak A PLoS One. 2011;6(9):e24621. Epub 2011 Sep 8. PMID:21931780<ref>PMID:21931780</ref>

-	~~===Crystal Structure~~ of ~~New Delhi Metallo-Beta-Lactamase-1 from Klebsiella pnueumoniae===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21931780}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3rkj]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3RKJ OCA].~~	+

	==See Also==		==See Also==
	*[[Beta-lactamase\|Beta-lactamase]]		*[[Beta-lactamase\|Beta-lactamase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021931780<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
	[[Category: Klebsiella pneumoniae]]		[[Category: Klebsiella pneumoniae]]
-	[[Category: Babnigg, G.]]	+	[[Category: Babnigg, G]]
-	[[Category: Binkowski, T A.]]	+	[[Category: Binkowski, T A]]
-	[[Category: Jedrzejczak, R.]]	+	[[Category: Jedrzejczak, R]]
-	[[Category: Joachimiak, A.]]	+	[[Category: Joachimiak, A]]
-	[[Category: Kim, Y.]]	+	[[Category: Kim, Y]]
-	[[Category: ~~MCSG, Midwest Center for~~ Structural ~~Genomics.~~]]	+	[[Category: Structural genomic]]
-	[[Category: MTBI, Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors.]]	+	[[Category: MTBI, Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors]]
-	[[Category: Sacchettini, J.]]	+	[[Category: Sacchettini, J]]
-	[[Category: Tesar, C.]]	+	[[Category: Tesar, C]]
	[[Category: Alpha-beta structure]]		[[Category: Alpha-beta structure]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Mcsg]]		[[Category: Mcsg]]
-	[[Category: Midwest center for structural genomic]]
	[[Category: Mtbi]]		[[Category: Mtbi]]
	[[Category: Psi-biology]]		[[Category: Psi-biology]]
-	[[Category: Structural genomic]]
	[[Category: Structures of mtb proteins conferring susceptibility to known mtb inhibitor]]		[[Category: Structures of mtb proteins conferring susceptibility to known mtb inhibitor]]

OCA at 05:25, 20 October 2012

OCA — Sat, 20 Oct 2012 05:25:05 GMT

←Older revision		Revision as of 05:25, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3rkj]] is a 2 chain structure ~~of [[Beta-lactamase]]~~ with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RKJ OCA].	+	[[3rkj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RKJ OCA].

	==See Also==		==See Also==

OCA at 09:58, 25 July 2012

OCA — Wed, 25 Jul 2012 09:58:03 GMT

←Older revision		Revision as of 09:58, 25 July 2012
Line 1:		Line 1:
	[[Image:3rkj.png\|left\|200px]]		[[Image:3rkj.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3rkj", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3rkj\| PDB=3rkj \| SCENE= }}		{{STRUCTURE_3rkj\| PDB=3rkj \| SCENE= }}

	===Crystal Structure of New Delhi Metallo-Beta-Lactamase-1 from Klebsiella pnueumoniae===		===Crystal Structure of New Delhi Metallo-Beta-Lactamase-1 from Klebsiella pnueumoniae===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21931780}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21931780 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21931780}}		{{ABSTRACT_PUBMED_21931780}}

Line 22:		Line 11:

	==See Also==		==See Also==
-	*[[Beta-lactamase]]	+	*[[Beta-lactamase\|Beta-lactamase]]

	==Reference==		==Reference==

OCA at 06:33, 28 March 2012

OCA — Wed, 28 Mar 2012 06:33:38 GMT

←Older revision		Revision as of 06:33, 28 March 2012
Line 11:		Line 11:
	===Crystal Structure of New Delhi Metallo-Beta-Lactamase-1 from Klebsiella pnueumoniae===		===Crystal Structure of New Delhi Metallo-Beta-Lactamase-1 from Klebsiella pnueumoniae===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21931780}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21931780 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21931780}}

	==About this Structure==		==About this Structure==
-	[[3rkj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RKJ OCA].	+	[[3rkj]] is a 2 chain structure of [[Beta-lactamase]] with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RKJ OCA].
		+
		+	==See Also==
		+	*[[Beta-lactamase]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021931780</ref><references group="xtra"/>
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
	[[Category: Klebsiella pneumoniae]]		[[Category: Klebsiella pneumoniae]]

OCA at 05:08, 21 September 2011

OCA — Wed, 21 Sep 2011 05:08:37 GMT

←Older revision		Revision as of 05:08, 21 September 2011
Line 1:		Line 1:
-	[[Image:3rkj.~~jpg~~\|left\|200px]]	+	[[Image:3rkj.png\|left\|200px]]

	<!--		<!--
Line 22:		Line 22:
	[[Category: Kim, Y.]]		[[Category: Kim, Y.]]
	[[Category: MCSG, Midwest Center for Structural Genomics.]]		[[Category: MCSG, Midwest Center for Structural Genomics.]]
		+	[[Category: MTBI, Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors.]]
	[[Category: Sacchettini, J.]]		[[Category: Sacchettini, J.]]
	[[Category: Tesar, C.]]		[[Category: Tesar, C.]]
		+	[[Category: Alpha-beta structure]]
		+	[[Category: Hydrolase]]
		+	[[Category: Mcsg]]
		+	[[Category: Midwest center for structural genomic]]
		+	[[Category: Mtbi]]
		+	[[Category: Psi-biology]]
		+	[[Category: Structural genomic]]
		+	[[Category: Structures of mtb proteins conferring susceptibility to known mtb inhibitor]]

OCA at 05:56, 18 May 2011

OCA — Wed, 18 May 2011 05:56:06 GMT

←Older revision		Revision as of 05:56, 18 May 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3rkj.jpg\|left\|200px]]

-	The ~~entry 3rkj~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3rkj", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3rkj\| PDB=3rkj \| SCENE= }}

-	~~Authors: Kim, Y., Tesar, C., Jedrzejczak, R., Binkowski, T.A., Babnigg, G., Sacchettini, J., Joachimiak, A., Midwest Center for Structural Genomics (MCSG)~~	+	===Crystal Structure of New Delhi Metallo-Beta-Lactamase-1 from Klebsiella pnueumoniae===

-	~~Description: Crystal~~ Structure ~~of New Delhi Metallo~~-Beta-~~Lactamase-1 from Enterococcus faecium~~	+
		+	==About this Structure==
		+	[[3rkj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RKJ OCA].
		+	[[Category: Beta-lactamase]]
		+	[[Category: Klebsiella pneumoniae]]
		+	[[Category: Babnigg, G.]]
		+	[[Category: Binkowski, T A.]]
		+	[[Category: Jedrzejczak, R.]]
		+	[[Category: Joachimiak, A.]]
		+	[[Category: Kim, Y.]]
		+	[[Category: MCSG, Midwest Center for Structural Genomics.]]
		+	[[Category: Sacchettini, J.]]
		+	[[Category: Tesar, C.]]