3rnz - Revision history

OCA at 17:18, 1 November 2023

OCA — Wed, 01 Nov 2023 17:18:49 GMT

←Older revision		Revision as of 17:18, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3rnz' size='340' side='right'caption='[[3rnz]], [[Resolution\|resolution]] 2.01Å' scene=''>		<StructureSection load='3rnz' size='340' side='right'caption='[[3rnz]], [[Resolution\|resolution]] 2.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3rnz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_amyloliquifaciens"_(sic)_fukumoto_1943 "bacillus amyloliquifaciens" (sic) fukumoto 1943~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RNZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RNZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3rnz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_amyloliquefaciens Bacillus amyloliquefaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RNZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RNZ FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3ro0\|3ro0]], [[3ro1\|3ro1]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.01Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">pcp ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=1390 "Bacillus amyloliquifaciens" (sic) Fukumoto 1943])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Pyroglutamyl-peptidase_I Pyroglutamyl-peptidase I], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.3 3.4.19.3] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rnz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rnz OCA], [https://pdbe.org/3rnz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rnz RCSB], [https://www.ebi.ac.uk/pdbsum/3rnz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rnz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rnz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rnz OCA], [https://pdbe.org/3rnz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rnz RCSB], [https://www.ebi.ac.uk/pdbsum/3rnz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rnz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PCP_BACAM PCP_BACAM]] Removes 5-oxoproline from various penultimate amino acid residues except L-proline.[HAMAP-Rule:MF_00417]	+	[https://www.uniprot.org/uniprot/PCP_BACAM PCP_BACAM] Removes 5-oxoproline from various penultimate amino acid residues except L-proline.[HAMAP-Rule:MF_00417]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus amyloliquefaciens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Pyroglutamyl-peptidase I]]~~	+	[[Category: Lo Y-C]]
-	[[Category: Lo, Y C]]	+	[[Category: Wang AH-J]]
-	[[Category: Wang~~, A H.~~J]]	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 10:19, 22 June 2022

OCA — Wed, 22 Jun 2022 10:19:04 GMT

←Older revision		Revision as of 10:19, 22 June 2022
Line 3:		Line 3:
	<StructureSection load='3rnz' size='340' side='right'caption='[[3rnz]], [[Resolution\|resolution]] 2.01Å' scene=''>		<StructureSection load='3rnz' size='340' side='right'caption='[[3rnz]], [[Resolution\|resolution]] 2.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3rnz]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_amyloliquifaciens"_(sic)_fukumoto_1943 "bacillus amyloliquifaciens" (sic) fukumoto 1943]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RNZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3RNZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3rnz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_amyloliquifaciens"_(sic)_fukumoto_1943 "bacillus amyloliquifaciens" (sic) fukumoto 1943]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RNZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RNZ FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ro0\|3ro0]], [[3ro1\|3ro1]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ro0\|3ro0]], [[3ro1\|3ro1]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pcp ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1390 "Bacillus amyloliquifaciens" (sic) Fukumoto 1943])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pcp ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1390 "Bacillus amyloliquifaciens" (sic) Fukumoto 1943])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Pyroglutamyl-peptidase_I Pyroglutamyl-peptidase I], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.3 3.4.19.3] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Pyroglutamyl-peptidase_I Pyroglutamyl-peptidase I], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.3 3.4.19.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3rnz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rnz OCA], [~~http~~://pdbe.org/3rnz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3rnz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3rnz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3rnz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rnz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rnz OCA], [https://pdbe.org/3rnz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rnz RCSB], [https://www.ebi.ac.uk/pdbsum/3rnz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rnz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PCP_BACAM PCP_BACAM]] Removes 5-oxoproline from various penultimate amino acid residues except L-proline.[HAMAP-Rule:MF_00417]	+	[[https://www.uniprot.org/uniprot/PCP_BACAM PCP_BACAM]] Removes 5-oxoproline from various penultimate amino acid residues except L-proline.[HAMAP-Rule:MF_00417]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 06:15, 16 October 2019

OCA — Wed, 16 Oct 2019 06:15:36 GMT

←Older revision		Revision as of 06:15, 16 October 2019
Line 1:		Line 1:

	==Crystal structure of Bacillus Amyloliquefaciens Pyroglutamyl Peptidase I==		==Crystal structure of Bacillus Amyloliquefaciens Pyroglutamyl Peptidase I==
-	<StructureSection load='3rnz' size='340' side='right' caption='[[3rnz]], [[Resolution\|resolution]] 2.01Å' scene=''>	+	<StructureSection load='3rnz' size='340' side='right'caption='[[3rnz]], [[Resolution\|resolution]] 2.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3rnz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_amyloliquifaciens"_(sic)_fukumoto_1943 "bacillus amyloliquifaciens" (sic) fukumoto 1943]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RNZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RNZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[3rnz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_amyloliquifaciens"_(sic)_fukumoto_1943 "bacillus amyloliquifaciens" (sic) fukumoto 1943]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RNZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RNZ FirstGlance]. <br>
Line 24:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Pyroglutamyl-peptidase I]]		[[Category: Pyroglutamyl-peptidase I]]
	[[Category: Lo, Y C]]		[[Category: Lo, Y C]]
	[[Category: Wang, A H.J]]		[[Category: Wang, A H.J]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 12:21, 5 August 2016

OCA — Fri, 05 Aug 2016 12:21:34 GMT

←Older revision		Revision as of 12:21, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of Bacillus Amyloliquefaciens Pyroglutamyl Peptidase I==		==Crystal structure of Bacillus Amyloliquefaciens Pyroglutamyl Peptidase I==
	<StructureSection load='3rnz' size='340' side='right' caption='[[3rnz]], [[Resolution\|resolution]] 2.01Å' scene=''>		<StructureSection load='3rnz' size='340' side='right' caption='[[3rnz]], [[Resolution\|resolution]] 2.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3rnz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_amyloliquefaciens Bacillus amyloliquefaciens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RNZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RNZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3rnz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_amyloliquifaciens"_(sic)_fukumoto_1943 "bacillus amyloliquifaciens" (sic) fukumoto 1943]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RNZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RNZ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ro0\|3ro0]], [[3ro1\|3ro1]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ro0\|3ro0]], [[3ro1\|3ro1]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pcp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1390 Bacillus ~~amyloliquefaciens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pcp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1390 "Bacillus amyloliquifaciens" (sic) Fukumoto 1943])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pyroglutamyl-peptidase_I Pyroglutamyl-peptidase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.3 3.4.19.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pyroglutamyl-peptidase_I Pyroglutamyl-peptidase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.3 3.4.19.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rnz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rnz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rnz RCSB], [http://www.ebi.ac.uk/pdbsum/3rnz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rnz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rnz OCA], [http://pdbe.org/3rnz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3rnz RCSB], [http://www.ebi.ac.uk/pdbsum/3rnz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3rnz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3rnz" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus amyloliquefaciens]]
	[[Category: Pyroglutamyl-peptidase I]]		[[Category: Pyroglutamyl-peptidase I]]
	[[Category: Lo, Y C]]		[[Category: Lo, Y C]]
	[[Category: Wang, A H.J]]		[[Category: Wang, A H.J]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 02:24, 25 December 2014

OCA — Thu, 25 Dec 2014 02:24:28 GMT

←Older revision		Revision as of 02:24, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3rnz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_amyloliquefaciens Bacillus amyloliquefaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RNZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RNZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[3rnz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_amyloliquefaciens Bacillus amyloliquefaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RNZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RNZ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ro0\|3ro0]], [[3ro1\|3ro1]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ro0\|3ro0]], [[3ro1\|3ro1]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pcp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1390 Bacillus amyloliquefaciens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pcp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1390 Bacillus amyloliquefaciens])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pyroglutamyl-peptidase_I Pyroglutamyl-peptidase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.3 3.4.19.3] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pyroglutamyl-peptidase_I Pyroglutamyl-peptidase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.3 3.4.19.3] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rnz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rnz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rnz RCSB], [http://www.ebi.ac.uk/pdbsum/3rnz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rnz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rnz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rnz RCSB], [http://www.ebi.ac.uk/pdbsum/3rnz PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PCP_BACAM PCP_BACAM]] Removes 5-oxoproline from various penultimate amino acid residues except L-proline.[HAMAP-Rule:MF_00417]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 16:
	Terpyridine Platinum(II) Complexes Inhibit Cysteine Proteases by Binding to Active-site Cysteine.,Lo YC, Su WC, Ko TP, Wang NC, Wang AH J Biomol Struct Dyn. 2011 Oct;29(2):267-82. PMID:21875148<ref>PMID:21875148</ref>		Terpyridine Platinum(II) Complexes Inhibit Cysteine Proteases by Binding to Active-site Cysteine.,Lo YC, Su WC, Ko TP, Wang NC, Wang AH J Biomol Struct Dyn. 2011 Oct;29(2):267-82. PMID:21875148<ref>PMID:21875148</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 22:		Line 24:
	[[Category: Bacillus amyloliquefaciens]]		[[Category: Bacillus amyloliquefaciens]]
	[[Category: Pyroglutamyl-peptidase I]]		[[Category: Pyroglutamyl-peptidase I]]
-	[[Category: Lo, Y C.]]	+	[[Category: Lo, Y C]]
-	[[Category: Wang, A H.J.]]	+	[[Category: Wang, A H.J]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 04:38, 5 June 2014

OCA — Thu, 05 Jun 2014 04:38:34 GMT

←Older revision		Revision as of 04:38, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3rnz.~~jpg~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of Bacillus Amyloliquefaciens Pyroglutamyl Peptidase I==
		+	<StructureSection load='3rnz' size='340' side='right' caption='[[3rnz]], [[Resolution\|resolution]] 2.01Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3rnz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_amyloliquefaciens Bacillus amyloliquefaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RNZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RNZ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ro0\|3ro0]], [[3ro1\|3ro1]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pcp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1390 Bacillus amyloliquefaciens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pyroglutamyl-peptidase_I Pyroglutamyl-peptidase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.3 3.4.19.3] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rnz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rnz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rnz RCSB], [http://www.ebi.ac.uk/pdbsum/3rnz PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Platinum(II) complexes have been demonstrated to form covalent bonds with sulfur-donating ligands (in glutathione, metallothionein and other sulfur-containing biomolecules) or coordination bonds with nitrogen-donating ligands (such as histidine and guanine). To investigate how these compounds interact with cysteine proteases, we chose terpyridine platinum(II) (TP-Pt(II)) complexes as a model system. By using X-ray crystallography, we demonstrated that TP-Pt(II) formed a covalent bond with the catalytic cysteine residue in pyroglutamyl peptidase I. Moreover, by using MALDI (matrix-assisted laser desorption/ionization) and TOF-TOF (time of flight) mass spectrometry, we elucidated that the TP-Pt(II) complex formed a covalent bond with the active-site cysteine residue in two other types of cysteine protease. Taken together, the results unequivocally showed that TP-Pt(II) complexes can selectively bind to the active site of most cysteine proteases. Our findings here can be useful in the design of new anti-cancer, anti-parasite or anti-virus platinum(II) compounds.

-	<!--	+	Terpyridine Platinum(II) Complexes Inhibit Cysteine Proteases by Binding to Active-site Cysteine.,Lo YC, Su WC, Ko TP, Wang NC, Wang AH J Biomol Struct Dyn. 2011 Oct;29(2):267-82. PMID:21875148<ref>PMID:21875148</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3rnz"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_3rnz\| PDB=3rnz \| SCENE= }}~~	+

-	~~===Crystal structure~~ of ~~Bacillus Amyloliquefaciens Pyroglutamyl Peptidase I===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21875148}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21875148 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_21875148}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3rnz]] is a 4 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Bacillus_amyloliquefaciens Bacillus amyloliquefaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RNZ OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021875148<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Bacillus amyloliquefaciens]]		[[Category: Bacillus amyloliquefaciens]]
	[[Category: Pyroglutamyl-peptidase I]]		[[Category: Pyroglutamyl-peptidase I]]

OCA at 06:32, 5 October 2011

OCA — Wed, 05 Oct 2011 06:32:08 GMT

←Older revision		Revision as of 06:32, 5 October 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3rnz.jpg\|left\|200px]]

-	The ~~entry 3rnz~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3rnz", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3rnz\| PDB=3rnz \| SCENE= }}

-	~~Authors: Lo, Y.-C., Wang, A.H.-J.~~	+	===Crystal structure of Bacillus Amyloliquefaciens Pyroglutamyl Peptidase I===

-	~~Description~~: ~~Crystal~~ structure of Bacillus ~~Amyloliquefaciens~~ Pyroglutamyl ~~Peptidase~~ I	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21875148}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21875148 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21875148}}
		+
		+	==About this Structure==
		+	[[3rnz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_amyloliquefaciens Bacillus amyloliquefaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RNZ OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021875148</ref><references group="xtra"/>
		+	[[Category: Bacillus amyloliquefaciens]]
		+	[[Category: Pyroglutamyl-peptidase I]]
		+	[[Category: Lo, Y C.]]
		+	[[Category: Wang, A H.J.]]
		+	[[Category: Hydrolase]]

OCA at 05:22, 1 June 2011

OCA — Wed, 01 Jun 2011 05:22:13 GMT

←Older revision		Revision as of 05:22, 1 June 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3rnz is ON HOLD	+	The entry 3rnz is ON HOLD until Paper Publication

	Authors: Lo, Y.-C., Wang, A.H.-J.		Authors: Lo, Y.-C., Wang, A.H.-J.

	Description: Crystal structure of Bacillus Amyloliquefaciens Pyroglutamyl Peptidase I		Description: Crystal structure of Bacillus Amyloliquefaciens Pyroglutamyl Peptidase I

OCA at 05:14, 18 May 2011

OCA — Wed, 18 May 2011 05:14:07 GMT

←Older revision		Revision as of 05:14, 18 May 2011
Line 3:		Line 3:
	The entry 3rnz is ON HOLD		The entry 3rnz is ON HOLD

-	Authors: Lo, Y.-C., Wang, A. H.-J.	+	Authors: Lo, Y.-C., Wang, A.H.-J.

-	Description: ~~CRYSTAL STRUCTURE OF BACILLUS AMYLOLIQUEFACIENS PYROGLUTAMYL PEPTIDASE~~ I	+	Description: Crystal structure of Bacillus Amyloliquefaciens Pyroglutamyl Peptidase I

OCA: Protected "3rnz" [edit=sysop:move=sysop]

OCA — Wed, 04 May 2011 06:34:00 GMT

Protected "3rnz" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:34, 4 May 2011