3ro9 - Revision history

OCA at 09:44, 1 March 2024

OCA — Fri, 01 Mar 2024 09:44:17 GMT

←Older revision		Revision as of 09:44, 1 March 2024
Line 3:		Line 3:
	<StructureSection load='3ro9' size='340' side='right'caption='[[3ro9]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3ro9' size='340' side='right'caption='[[3ro9]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ro9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_2001 Atcc 2001~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RO9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RO9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ro9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_glabrata Candida glabrata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RO9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RO9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=06U:6-ETHYL-5-{(3R)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1-YL}PYRIMIDINE-2,4-DIAMINE'>06U</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.596Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3roa\|3roa]], [[3qlx\|3qlx]], [[3qly\|3qly]], [[3qlz\|3qlz]], [[3eej\|3eej]], [[3eek\|3eek]], [[3eel\|3eel]], [[3eem\|3eem]], [[3cse\|3cse]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=06U:6-ETHYL-5-{(3R)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1-YL}PYRIMIDINE-2,4-DIAMINE'>06U</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CAGL0J03894g, DHFR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5478 ATCC 2001])</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ro9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ro9 OCA], [https://pdbe.org/3ro9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ro9 RCSB], [https://www.ebi.ac.uk/pdbsum/3ro9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ro9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ro9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ro9 OCA], [https://pdbe.org/3ro9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ro9 RCSB], [https://www.ebi.ac.uk/pdbsum/3ro9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ro9 ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/Q6FPH0_CANGA Q6FPH0_CANGA]
-	A novel strategy for targeting the pathogenic organisms Candida albicans and Candida glabrata focuses on the development of potent and selective antifolates effective against dihydrofolate reductase. Crystal structure analysis suggested that an essential loop at the active site (Thr 58-Phe 66) differs from the analogous residues in the human enzyme, potentially providing a mechanism for achieving selectivity. In order to probe the role of this loop, we employed chemical synthesis, crystal structure determination and molecular dynamics simulations. The results of these analyses show that the loop residues undergo ligand-induced conformational changes that are similar among the fungal and human species.	+
-		+
-	Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among species.,Paulsen JL, Viswanathan K, Wright DL, Anderson AC Bioorg Med Chem Lett. 2013 Mar 1;23(5):~~1279-84. doi: 10.1016~~/~~j.bmcl.2013.01.008. , Epub 2013 Jan 11. PMID:23375226<ref>PMID:23375226<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 3ro9" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references~~/>	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 2001]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Anderson~~, A C~~]]	+	[[Category: Anderson AC]]
-	[[Category: Paulsen~~, J L]]~~	+	[[Category: Paulsen JL]]
-	~~[[Category: Antifungal agent]]~~	+
-	~~[[Category: Candida glabrata]]~~	+
-	~~[[Category: Drug design]]~~	+
-	~~[[Category: Enzyme inhibitor]]~~	+
-	~~[[Category: Fungal protein]]~~	+
-	~~[[Category: Model]]~~	+
-	~~[[Category: Molecular structure]]~~	+
-	~~[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]~~	+
-	~~[[Category: Structure-activity relationship]]~~	+
-	~~[[Category: Tetrahydrofolate dehydrogenase~~]]	+

OCA at 10:19, 22 June 2022

OCA — Wed, 22 Jun 2022 10:19:19 GMT

←Older revision		Revision as of 10:19, 22 June 2022
Line 1:		Line 1:

	==Candida glabrata dihydrofolate reductase complexed with NADPH and 6-ethyl-5-[(3R)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP1006)==		==Candida glabrata dihydrofolate reductase complexed with NADPH and 6-ethyl-5-[(3R)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP1006)==
-	<StructureSection load='3ro9' size='340' side='right' caption='[[3ro9]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='3ro9' size='340' side='right'caption='[[3ro9]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ro9]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_2001 Atcc 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RO9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3RO9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ro9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_2001 Atcc 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RO9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RO9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=06U:6-ETHYL-5-{(3R)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1-YL}PYRIMIDINE-2,4-DIAMINE'>06U</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=06U:6-ETHYL-5-{(3R)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1-YL}PYRIMIDINE-2,4-DIAMINE'>06U</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3roa\|3roa]], [[3qlx\|3qlx]], [[3qly\|3qly]], [[3qlz\|3qlz]], [[3eej\|3eej]], [[3eek\|3eek]], [[3eel\|3eel]], [[3eem\|3eem]], [[3cse\|3cse]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3roa\|3roa]], [[3qlx\|3qlx]], [[3qly\|3qly]], [[3qlz\|3qlz]], [[3eej\|3eej]], [[3eek\|3eek]], [[3eel\|3eel]], [[3eem\|3eem]], [[3cse\|3cse]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CAGL0J03894g, DHFR ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5478 ATCC 2001])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CAGL0J03894g, DHFR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5478 ATCC 2001])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ro9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ro9 OCA], [~~http~~://pdbe.org/3ro9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ro9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ro9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ro9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ro9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ro9 OCA], [https://pdbe.org/3ro9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ro9 RCSB], [https://www.ebi.ac.uk/pdbsum/3ro9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ro9 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 2001]]		[[Category: Atcc 2001]]
		+	[[Category: Large Structures]]
	[[Category: Anderson, A C]]		[[Category: Anderson, A C]]
	[[Category: Paulsen, J L]]		[[Category: Paulsen, J L]]

OCA at 18:28, 11 August 2016

OCA — Thu, 11 Aug 2016 18:28:02 GMT

←Older revision		Revision as of 18:28, 11 August 2016
Line 1:		Line 1:
		+
	==Candida glabrata dihydrofolate reductase complexed with NADPH and 6-ethyl-5-[(3R)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP1006)==		==Candida glabrata dihydrofolate reductase complexed with NADPH and 6-ethyl-5-[(3R)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP1006)==
	<StructureSection load='3ro9' size='340' side='right' caption='[[3ro9]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3ro9' size='340' side='right' caption='[[3ro9]], [[Resolution\|resolution]] 2.60Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3roa\|3roa]], [[3qlx\|3qlx]], [[3qly\|3qly]], [[3qlz\|3qlz]], [[3eej\|3eej]], [[3eek\|3eek]], [[3eel\|3eel]], [[3eem\|3eem]], [[3cse\|3cse]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3roa\|3roa]], [[3qlx\|3qlx]], [[3qly\|3qly]], [[3qlz\|3qlz]], [[3eej\|3eej]], [[3eek\|3eek]], [[3eel\|3eel]], [[3eem\|3eem]], [[3cse\|3cse]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CAGL0J03894g, DHFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5478 ATCC 2001])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CAGL0J03894g, DHFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5478 ATCC 2001])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ro9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ro9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ro9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ro9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ro9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ro9 OCA], [http://pdbe.org/3ro9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ro9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ro9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ro9 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ro9" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:39, 20 January 2015

OCA — Tue, 20 Jan 2015 08:39:06 GMT

←Older revision		Revision as of 08:39, 20 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_3ro9\| PDB=3ro9 \| SCENE= }}~~	+	==Candida glabrata dihydrofolate reductase complexed with NADPH and 6-ethyl-5-[(3R)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP1006)==
-	===Candida glabrata dihydrofolate reductase complexed with NADPH and 6-ethyl-5-[(3R)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP1006)===	+	<StructureSection load='3ro9' size='340' side='right' caption='[[3ro9]], [[Resolution\|resolution]] 2.60Å' scene=''>
-	{~~{ABSTRACT_PUBMED_23375226}~~}	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ro9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_2001 Atcc 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RO9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RO9 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=06U:6-ETHYL-5-{(3R)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1-YL}PYRIMIDINE-2,4-DIAMINE'>06U</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3roa\|3roa]], [[3qlx\|3qlx]], [[3qly\|3qly]], [[3qlz\|3qlz]], [[3eej\|3eej]], [[3eek\|3eek]], [[3eel\|3eel]], [[3eem\|3eem]], [[3cse\|3cse]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CAGL0J03894g, DHFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5478 ATCC 2001])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ro9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ro9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ro9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ro9 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A novel strategy for targeting the pathogenic organisms Candida albicans and Candida glabrata focuses on the development of potent and selective antifolates effective against dihydrofolate reductase. Crystal structure analysis suggested that an essential loop at the active site (Thr 58-Phe 66) differs from the analogous residues in the human enzyme, potentially providing a mechanism for achieving selectivity. In order to probe the role of this loop, we employed chemical synthesis, crystal structure determination and molecular dynamics simulations. The results of these analyses show that the loop residues undergo ligand-induced conformational changes that are similar among the fungal and human species.

-	~~==About this Structure==~~	+	Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among species.,Paulsen JL, Viswanathan K, Wright DL, Anderson AC Bioorg Med Chem Lett. 2013 Mar 1;23(5):1279-84. doi: 10.1016/j.bmcl.2013.01.008. , Epub 2013 Jan 11. PMID:23375226<ref>PMID:23375226</ref>
-	~~[[3ro9]] is a 2 chain structure with sequence~~ from ~~[http://en~~.~~wikipedia~~.~~org/wiki/Atcc_2001 Atcc 2001]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=3RO9 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:023375226</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Atcc 2001]]		[[Category: Atcc 2001]]
-	[[Category: Anderson, A C.]]	+	[[Category: Anderson, A C]]
-	[[Category: Paulsen, J L.]]	+	[[Category: Paulsen, J L]]
	[[Category: Antifungal agent]]		[[Category: Antifungal agent]]
	[[Category: Candida glabrata]]		[[Category: Candida glabrata]]

OCA at 12:15, 20 November 2013

OCA — Wed, 20 Nov 2013 12:15:40 GMT

←Older revision		Revision as of 12:15, 20 November 2013
Line 4:		Line 4:

	==About this Structure==		==About this Structure==
-	[[3ro9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Candida_glabrata Candida glabrata~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RO9 OCA].	+	[[3ro9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_2001 Atcc 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RO9 OCA].
-	[[Category: ~~Candida glabrata~~]]	+
		+	==Reference==
		+	<ref group="xtra">PMID:023375226</ref><references group="xtra"/><references/>
		+	[[Category: Atcc 2001]]
	[[Category: Anderson, A C.]]		[[Category: Anderson, A C.]]
	[[Category: Paulsen, J L.]]		[[Category: Paulsen, J L.]]

OCA at 07:40, 27 March 2013

OCA — Wed, 27 Mar 2013 07:40:39 GMT

←Older revision		Revision as of 07:40, 27 March 2013
Line 1:		Line 1:
-	[[Image:3ro9.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3ro9", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3ro9\| PDB=3ro9 \| SCENE= }}		{{STRUCTURE_3ro9\| PDB=3ro9 \| SCENE= }}
-
	===Candida glabrata dihydrofolate reductase complexed with NADPH and 6-ethyl-5-[(3R)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP1006)===		===Candida glabrata dihydrofolate reductase complexed with NADPH and 6-ethyl-5-[(3R)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP1006)===
-		+	{{ABSTRACT_PUBMED_23375226}}

	==About this Structure==		==About this Structure==

OCA at 09:19, 9 May 2012

OCA — Wed, 09 May 2012 09:19:21 GMT

←Older revision		Revision as of 09:19, 9 May 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3ro9.jpg\|left\|200px]]

-	The ~~entry 3ro9~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3ro9", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3ro9\| PDB=3ro9 \| SCENE= }}

-	~~Authors: Paulsen~~, ~~J.L., Anderson, A.C.~~	+	===Candida glabrata dihydrofolate reductase complexed with NADPH and 6-ethyl-5-[(3R)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP1006)===

-	~~Description~~: Candida glabrata ~~dihydrofolate reductase complexed with NADPH and 6-ethyl-5-~~[~~(3R)-3~~-[~~3-methoxy-5-(pyridin-4-yl)phenyl~~]~~but-1-yn-1-yl~~]~~pyrimidine-2~~,4-~~diamine (UCP1006)~~	+
		+	==About this Structure==
		+	[[3ro9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_glabrata Candida glabrata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RO9 OCA].
		+	[[Category: Candida glabrata]]
		+	[[Category: Anderson, A C.]]
		+	[[Category: Paulsen, J L.]]
		+	[[Category: Antifungal agent]]
		+	[[Category: Candida glabrata]]
		+	[[Category: Drug design]]
		+	[[Category: Enzyme inhibitor]]
		+	[[Category: Fungal protein]]
		+	[[Category: Model]]
		+	[[Category: Molecular structure]]
		+	[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
		+	[[Category: Structure-activity relationship]]
		+	[[Category: Tetrahydrofolate dehydrogenase]]

OCA at 05:22, 1 June 2011

OCA — Wed, 01 Jun 2011 05:22:19 GMT

←Older revision		Revision as of 05:22, 1 June 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3ro9 is ON HOLD	+	The entry 3ro9 is ON HOLD until Paper Publication

	Authors: Paulsen, J.L., Anderson, A.C.		Authors: Paulsen, J.L., Anderson, A.C.

	Description: Candida glabrata dihydrofolate reductase complexed with NADPH and 6-ethyl-5-[(3R)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP1006)		Description: Candida glabrata dihydrofolate reductase complexed with NADPH and 6-ethyl-5-[(3R)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP1006)

OCA: Protected "3ro9" [edit=sysop:move=sysop]

OCA — Wed, 04 May 2011 06:34:17 GMT

Protected "3ro9" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:34, 4 May 2011

OCA: New page: '''Unreleased structure''' The entry 3ro9 is ON HOLD Authors: Paulsen, J.L., Anderson, A.C. Description: Candida glabrata dihydrofolate reductase complexed with NADPH and 6-ethyl-5-[(3...

OCA — Wed, 04 May 2011 06:34:16 GMT

New page: '''Unreleased structure''' The entry 3ro9 is ON HOLD Authors: Paulsen, J.L., Anderson, A.C. Description: Candida glabrata dihydrofolate reductase complexed with NADPH and 6-ethyl-5-[(3...

New page

'''Unreleased structure'''

The entry 3ro9 is ON HOLD

Authors: Paulsen, J.L., Anderson, A.C.

Description: Candida glabrata dihydrofolate reductase complexed with NADPH and 6-ethyl-5-[(3R)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP1006)