3rqr - Revision history

OCA at 09:44, 1 March 2024

OCA — Fri, 01 Mar 2024 09:44:30 GMT

←Older revision		Revision as of 09:44, 1 March 2024
Line 3:		Line 3:
	<StructureSection load='3rqr' size='340' side='right'caption='[[3rqr]], [[Resolution\|resolution]] 2.16Å' scene=''>		<StructureSection load='3rqr' size='340' side='right'caption='[[3rqr]], [[Resolution\|resolution]] 2.16Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3rqr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~European_rabbit European rabbit~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RQR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RQR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3rqr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RQR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RQR FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.16Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">RYR1 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9986 European rabbit])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rqr OCA], [https://pdbe.org/3rqr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rqr RCSB], [https://www.ebi.ac.uk/pdbsum/3rqr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rqr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rqr OCA], [https://pdbe.org/3rqr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rqr RCSB], [https://www.ebi.ac.uk/pdbsum/3rqr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rqr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RYR1_RABIT RYR1_RABIT]] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).<ref>PMID:10388749</ref> <ref>PMID:22036948</ref>	+	[https://www.uniprot.org/uniprot/RYR1_RABIT RYR1_RABIT] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).<ref>PMID:10388749</ref> <ref>PMID:22036948</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	The ryanodine receptor (RyR) is a large, homotetrameric sarcoplasmic reticulum (SR) membrane protein essential for Ca(2+) cycling in both skeletal and cardiac muscle. Genetic mutations in RyR1 are associated with severe conditions including malignant hyperthermia (MH) and central core disease (CCD). One phosphorylation site (Ser 2843) has been identified in a segment of RyR1 flanked by two RyR motifs, which are found exclusively in all RyR isoforms organized as closely-associated tandem (or paired) motifs, and named after the protein itself. These motifs also contain six known MH mutations. In this study we designed, expressed, and purified the tandem RyR motifs and show that this domain contains a putative binding site for the Ca(2+) /calmodulin-dependent protein kinase beta isoform. We present a 2.2A resolution crystal structure of the RyR domain revealing a two-fold, symmetric, extended four-helix bundle stabilized by a beta-sheet. Using mathematical modelling we fit our crystal structure within a tetrameric EM structure of native RyR1 and propose that this domain is localized in the RyR's clamp region, which is absent in its cousin protein inositol 1,4,5-trisphosphate receptor. (c) 2012 The Authors Journal compilation (c) 2012 FEBS.	+
-		+
-	Structural Determination of the Phosphorylation Domain of the Ryanodine Receptor.,Sharma P, Ishiyama N, Nair U, Li W, Dong A, Miyake T, Wilson A, Ryan T, Maclennan DH, Kislinger T, Ikura M, Dhe-Paganon S, Gramolini AO FEBS J. 2012 Aug 22. doi: 10.1111/j.1742-4658.2012.08755.x. PMID:22913516<ref>PMID:22913516</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3rqr" style="background-color:#fffaf0;"></div~~>	+

	==See Also==		==See Also==
Line 26:		Line 16:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: European rabbit]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Oryctolagus cuniculus]]
-	[[Category: Bountra, C]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Dhe-Paganon, S]]	+	[[Category: Bountra C]]
-	[[Category: Dong, A]]	+	[[Category: Dhe-Paganon S]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Dong A]]
-	[[Category: Gramolini, A]]	+	[[Category: Edwards AM]]
-	[[Category: Li, W]]	+	[[Category: Gramolini A]]
-	[[Category: Nair~~, U B]]~~	+	[[Category: Li W]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Nair UB]]
-	[[Category: Walker~~, J R~~]]	+	[[Category: Walker JR]]
-	[[Category: Weigelt, J]]	+	[[Category: Weigelt J]]
-	~~[[Category: Metal transport]]~~	+
-	~~[[Category: Ryanodine receptor]]~~	+
-	~~[[Category: Ryr domain~~]]	+

OCA at 10:22, 22 June 2022

OCA — Wed, 22 Jun 2022 10:22:04 GMT

←Older revision		Revision as of 10:22, 22 June 2022
Line 1:		Line 1:

	==Crystal structure of the RYR domain of the rabbit ryanodine receptor==		==Crystal structure of the RYR domain of the rabbit ryanodine receptor==
-	<StructureSection load='3rqr' size='340' side='right' caption='[[3rqr]], [[Resolution\|resolution]] 2.16Å' scene=''>	+	<StructureSection load='3rqr' size='340' side='right'caption='[[3rqr]], [[Resolution\|resolution]] 2.16Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3rqr]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/European_rabbit European rabbit]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RQR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3RQR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3rqr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/European_rabbit European rabbit]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RQR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RQR FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RYR1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RYR1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3rqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rqr OCA], [~~http~~://pdbe.org/3rqr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3rqr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3rqr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3rqr ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rqr OCA], [https://pdbe.org/3rqr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rqr RCSB], [https://www.ebi.ac.uk/pdbsum/3rqr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rqr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RYR1_RABIT RYR1_RABIT]] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).<ref>PMID:10388749</ref> <ref>PMID:22036948</ref>	+	[[https://www.uniprot.org/uniprot/RYR1_RABIT RYR1_RABIT]] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).<ref>PMID:10388749</ref> <ref>PMID:22036948</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Ryanodine receptor\|Ryanodine receptor]]	+	*[[Ryanodine receptor 3D structures\|Ryanodine receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: European rabbit]]		[[Category: European rabbit]]
		+	[[Category: Large Structures]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]

OCA at 13:31, 4 August 2016

OCA — Thu, 04 Aug 2016 13:31:57 GMT

←Older revision		Revision as of 13:31, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the RYR domain of the rabbit ryanodine receptor==		==Crystal structure of the RYR domain of the rabbit ryanodine receptor==
	<StructureSection load='3rqr' size='340' side='right' caption='[[3rqr]], [[Resolution\|resolution]] 2.16Å' scene=''>		<StructureSection load='3rqr' size='340' side='right' caption='[[3rqr]], [[Resolution\|resolution]] 2.16Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3rqr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Oryctolagus_cuniculus Oryctolagus cuniculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RQR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RQR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3rqr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RQR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RQR FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RYR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 ~~Oryctolagus cuniculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RYR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rqr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rqr RCSB], [http://www.ebi.ac.uk/pdbsum/3rqr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rqr OCA], [http://pdbe.org/3rqr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3rqr RCSB], [http://www.ebi.ac.uk/pdbsum/3rqr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3rqr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3rqr" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ryanodine receptor\|Ryanodine receptor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Oryctolagus cuniculus~~]]	+	[[Category: European rabbit]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]

OCA at 15:04, 24 December 2014

OCA — Wed, 24 Dec 2014 15:04:53 GMT

←Older revision		Revision as of 15:04, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rqr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rqr RCSB], [http://www.ebi.ac.uk/pdbsum/3rqr PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rqr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rqr RCSB], [http://www.ebi.ac.uk/pdbsum/3rqr PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RYR1_RABIT RYR1_RABIT]] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).<ref>PMID:10388749</ref> <ref>PMID:22036948</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:34, 9 December 2014

OCA — Tue, 09 Dec 2014 12:34:09 GMT

←Older revision		Revision as of 12:34, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3rqr.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of the RYR domain of the rabbit ryanodine receptor==
		+	<StructureSection load='3rqr' size='340' side='right' caption='[[3rqr]], [[Resolution\|resolution]] 2.16Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3rqr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RQR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RQR FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RYR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 Oryctolagus cuniculus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rqr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rqr RCSB], [http://www.ebi.ac.uk/pdbsum/3rqr PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The ryanodine receptor (RyR) is a large, homotetrameric sarcoplasmic reticulum (SR) membrane protein essential for Ca(2+) cycling in both skeletal and cardiac muscle. Genetic mutations in RyR1 are associated with severe conditions including malignant hyperthermia (MH) and central core disease (CCD). One phosphorylation site (Ser 2843) has been identified in a segment of RyR1 flanked by two RyR motifs, which are found exclusively in all RyR isoforms organized as closely-associated tandem (or paired) motifs, and named after the protein itself. These motifs also contain six known MH mutations. In this study we designed, expressed, and purified the tandem RyR motifs and show that this domain contains a putative binding site for the Ca(2+) /calmodulin-dependent protein kinase beta isoform. We present a 2.2A resolution crystal structure of the RyR domain revealing a two-fold, symmetric, extended four-helix bundle stabilized by a beta-sheet. Using mathematical modelling we fit our crystal structure within a tetrameric EM structure of native RyR1 and propose that this domain is localized in the RyR's clamp region, which is absent in its cousin protein inositol 1,4,5-trisphosphate receptor. (c) 2012 The Authors Journal compilation (c) 2012 FEBS.

-	~~{{STRUCTURE_3rqr\| PDB=3rqr \| SCENE= }}~~	+	Structural Determination of the Phosphorylation Domain of the Ryanodine Receptor.,Sharma P, Ishiyama N, Nair U, Li W, Dong A, Miyake T, Wilson A, Ryan T, Maclennan DH, Kislinger T, Ikura M, Dhe-Paganon S, Gramolini AO FEBS J. 2012 Aug 22. doi: 10.1111/j.1742-4658.2012.08755.x. PMID:22913516<ref>PMID:22913516</ref>

-	~~===Crystal structure~~ of the ~~RYR domain~~ of ~~the rabbit ryanodine receptor===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22913516}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[3rqr]] is a 2 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RQR OCA].~~	+	</StructureSection>
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Bountra, C.]]	+	[[Category: Bountra, C]]
-	[[Category: Dhe-Paganon, S.]]	+	[[Category: Dhe-Paganon, S]]
-	[[Category: Dong, A.]]	+	[[Category: Dong, A]]
-	[[Category: Edwards, A M.]]	+	[[Category: Edwards, A M]]
-	[[Category: Gramolini, A.]]	+	[[Category: Gramolini, A]]
-	[[Category: Li, W.]]	+	[[Category: Li, W]]
-	[[Category: Nair, U B.]]	+	[[Category: Nair, U B]]
-	[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Walker, J R.]]	+	[[Category: Walker, J R]]
-	[[Category: Weigelt, J.]]	+	[[Category: Weigelt, J]]
	[[Category: Metal transport]]		[[Category: Metal transport]]
	[[Category: Ryanodine receptor]]		[[Category: Ryanodine receptor]]
	[[Category: Ryr domain]]		[[Category: Ryr domain]]

OCA at 05:23, 5 September 2012

OCA — Wed, 05 Sep 2012 05:23:22 GMT

←Older revision		Revision as of 05:23, 5 September 2012
Line 1:		Line 1:
-	[[Image:3rqr.~~jpg~~\|left\|200px]]	+	[[Image:3rqr.png\|left\|200px]]

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-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3rqr\| PDB=3rqr \| SCENE= }}		{{STRUCTURE_3rqr\| PDB=3rqr \| SCENE= }}

	===Crystal structure of the RYR domain of the rabbit ryanodine receptor===		===Crystal structure of the RYR domain of the rabbit ryanodine receptor===

		+	{{ABSTRACT_PUBMED_22913516}}

	==About this Structure==		==About this Structure==

OCA at 16:51, 22 June 2011

OCA — Wed, 22 Jun 2011 16:51:41 GMT

←Older revision		Revision as of 16:51, 22 June 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3rqr.jpg\|left\|200px]]

-	The ~~entry 3rqr~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3rqr", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3rqr\| PDB=3rqr \| SCENE= }}

-	~~Authors: Li, W., Nair, U.B., Dong, A., Walker, J.R., Gramolini, A., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Dhe-Paganon, S., Structural Genomics Consort(SGC)~~	+	===Crystal structure of the RYR domain of the rabbit ryanodine receptor===

-	~~Description: Crystal~~ structure ~~of mammalian ryr domain of the ryanodine~~ receptor	+
		+	==About this Structure==
		+	[[3rqr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RQR OCA].
		+	[[Category: Oryctolagus cuniculus]]
		+	[[Category: Arrowsmith, C H.]]
		+	[[Category: Bountra, C.]]
		+	[[Category: Dhe-Paganon, S.]]
		+	[[Category: Dong, A.]]
		+	[[Category: Edwards, A M.]]
		+	[[Category: Gramolini, A.]]
		+	[[Category: Li, W.]]
		+	[[Category: Nair, U B.]]
		+	[[Category: SGC, Structural Genomics Consortium.]]
		+	[[Category: Walker, J R.]]
		+	[[Category: Weigelt, J.]]
		+	[[Category: Metal transport]]
		+	[[Category: Ryanodine receptor]]
		+	[[Category: Ryr domain]]

OCA at 04:21, 12 May 2011

OCA — Thu, 12 May 2011 04:21:48 GMT

←Older revision		Revision as of 04:21, 12 May 2011
Line 3:		Line 3:
	The entry 3rqr is ON HOLD		The entry 3rqr is ON HOLD

-	Authors: Li, W., Nair, U.B., Dong, A., Walker, J.R., Gramolini, A., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Dhe-Paganon, S.~~, (Sgc)~~, Structural Genomics Consort	+	Authors: Li, W., Nair, U.B., Dong, A., Walker, J.R., Gramolini, A., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Dhe-Paganon, S., Structural Genomics Consort(SGC)

-	Description: ~~CRYSTAL STRUCTURE OF MAMMALIAN RYR DOMAIN OF THE RYANODINE RECEPTOR~~	+	Description: Crystal structure of mammalian ryr domain of the ryanodine receptor

OCA: Protected "3rqr" [edit=sysop:move=sysop]

OCA — Wed, 04 May 2011 06:36:53 GMT

Protected "3rqr" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:36, 4 May 2011

OCA: New page: '''Unreleased structure''' The entry 3rqr is ON HOLD Authors: Li, W., Nair, U.B., Dong, A., Walker, J.R., Gramolini, A., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Dhe-P...

OCA — Wed, 04 May 2011 06:36:52 GMT

New page: '''Unreleased structure''' The entry 3rqr is ON HOLD Authors: Li, W., Nair, U.B., Dong, A., Walker, J.R., Gramolini, A., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Dhe-P...

New page

'''Unreleased structure'''

The entry 3rqr is ON HOLD

Authors: Li, W., Nair, U.B., Dong, A., Walker, J.R., Gramolini, A., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Dhe-Paganon, S., (Sgc), Structural Genomics Consort

Description: CRYSTAL STRUCTURE OF MAMMALIAN RYR DOMAIN OF THE RYANODINE RECEPTOR