3rrc - Revision history

OCA at 10:22, 22 June 2022

OCA — Wed, 22 Jun 2022 10:22:41 GMT

←Older revision		Revision as of 10:22, 22 June 2022
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	==Crystal Structure of Region II from Plasmodium vivax Duffy Binding Protein==		==Crystal Structure of Region II from Plasmodium vivax Duffy Binding Protein==
-	<StructureSection load='3rrc' size='340' side='right' caption='[[3rrc]], [[Resolution\|resolution]] 1.95Å' scene=''>	+	<StructureSection load='3rrc' size='340' side='right'caption='[[3rrc]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3rrc]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Plavs Plavs]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RRC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3RRC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3rrc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plavs Plavs]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RRC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RRC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PVDR ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=126793 PLAVS])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PVDR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=126793 PLAVS])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3rrc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rrc OCA], [~~http~~://pdbe.org/3rrc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3rrc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3rrc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3rrc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rrc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rrc OCA], [https://pdbe.org/3rrc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rrc RCSB], [https://www.ebi.ac.uk/pdbsum/3rrc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rrc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PVDR_PLAVS PVDR_PLAVS]] Binds to the human erythrocytes Duffy blood group determinant.	+	[[https://www.uniprot.org/uniprot/PVDR_PLAVS PVDR_PLAVS]] Binds to the human erythrocytes Duffy blood group determinant.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 3rrc" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3rrc" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Erythrocyte binding antigen\|Erythrocyte binding antigen]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Plavs]]		[[Category: Plavs]]
	[[Category: Tolia, N H]]		[[Category: Tolia, N H]]

OCA at 13:12, 4 August 2016

OCA — Thu, 04 Aug 2016 13:12:37 GMT

←Older revision		Revision as of 13:12, 4 August 2016
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		+
	==Crystal Structure of Region II from Plasmodium vivax Duffy Binding Protein==		==Crystal Structure of Region II from Plasmodium vivax Duffy Binding Protein==
	<StructureSection load='3rrc' size='340' side='right' caption='[[3rrc]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='3rrc' size='340' side='right' caption='[[3rrc]], [[Resolution\|resolution]] 1.95Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PVDR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=126793 PLAVS])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PVDR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=126793 PLAVS])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rrc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rrc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rrc RCSB], [http://www.ebi.ac.uk/pdbsum/3rrc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rrc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rrc OCA], [http://pdbe.org/3rrc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3rrc RCSB], [http://www.ebi.ac.uk/pdbsum/3rrc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3rrc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3rrc" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:36, 25 December 2014

OCA — Thu, 25 Dec 2014 09:36:34 GMT

←Older revision		Revision as of 09:36, 25 December 2014
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-	~~{{STRUCTURE_3rrc\| PDB=3rrc \| SCENE= }}~~	+	==Crystal Structure of Region II from Plasmodium vivax Duffy Binding Protein==
-	===Crystal Structure of Region II from Plasmodium vivax Duffy Binding Protein===	+	<StructureSection load='3rrc' size='340' side='right' caption='[[3rrc]], [[Resolution\|resolution]] 1.95Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21743458}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3rrc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plavs Plavs]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RRC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RRC FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PVDR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=126793 PLAVS])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rrc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rrc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rrc RCSB], [http://www.ebi.ac.uk/pdbsum/3rrc PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/PVDR_PLAVS PVDR_PLAVS]] Binds to the human erythrocytes Duffy blood group determinant.		[[http://www.uniprot.org/uniprot/PVDR_PLAVS PVDR_PLAVS]] Binds to the human erythrocytes Duffy blood group determinant.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Plasmodium vivax and Plasmodium knowlesi invasion depends on the parasite Duffy-binding protein DBL domain (RII-PvDBP or RII-PkDBP) engaging the Duffy antigen receptor for chemokines (DARC) on red blood cells. Inhibition of this key interaction provides an excellent opportunity for parasite control. There are competing models for whether Plasmodium ligands engage receptors as monomers or dimers, a question whose resolution has profound implications for parasite biology and control. We report crystallographic, solution and functional studies of RII-PvDBP showing that dimerization is required for and driven by receptor engagement. This work provides a unifying framework for prior studies and accounts for the action of naturally acquired blocking antibodies and the mechanism of immune evasion. We show that dimerization is conserved in DBL-domain receptor engagement and propose that receptor-mediated ligand dimerization drives receptor affinity and specificity. Because dimerization is prevalent in signaling, our studies raise the possibility that induced dimerization may activate pathways for invasion.

-	~~==About this Structure==~~	+	Dimerization of Plasmodium vivax DBP is induced upon receptor binding and drives recognition of DARC.,Batchelor JD, Zahm JA, Tolia NH Nat Struct Mol Biol. 2011 Jul 10;18(8):908-14. doi: 10.1038/nsmb.2088. PMID:21743458<ref>PMID:21743458</ref>
-	~~[[3rrc]]~~ is ~~a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Plavs Plavs]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=3RRC OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:021743458</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Plavs]]		[[Category: Plavs]]
-	[[Category: Tolia, N H.]]	+	[[Category: Tolia, N H]]
	[[Category: Cell invasion]]		[[Category: Cell invasion]]
	[[Category: Duffy antigen receptor for chemokine]]		[[Category: Duffy antigen receptor for chemokine]]
	[[Category: Duffy binding like]]		[[Category: Duffy binding like]]
	[[Category: Receptor recognition]]		[[Category: Receptor recognition]]

OCA at 08:24, 16 April 2014

OCA — Wed, 16 Apr 2014 08:24:02 GMT

←Older revision		Revision as of 08:24, 16 April 2014
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-	[[Image:3rrc.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3rrc", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3rrc\| PDB=3rrc \| SCENE= }}		{{STRUCTURE_3rrc\| PDB=3rrc \| SCENE= }}
-
	===Crystal Structure of Region II from Plasmodium vivax Duffy Binding Protein===		===Crystal Structure of Region II from Plasmodium vivax Duffy Binding Protein===
		+	{{ABSTRACT_PUBMED_21743458}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/PVDR_PLAVS PVDR_PLAVS]] Binds to the human erythrocytes Duffy blood group determinant.
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21743458}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov), where 21743458 is~~ the ~~PubMed ID number~~.	+
-	~~-->~~	+
-	~~{{ABSTRACT_PUBMED_21743458}}~~	+

	==About this Structure==		==About this Structure==
-	[[3rrc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Plasmodium_vivax Plasmodium vivax~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RRC OCA].	+	[[3rrc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plavs Plavs]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RRC OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:021743458</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021743458</ref><references group="xtra"/><references/>
-	[[Category: ~~Plasmodium vivax~~]]	+	[[Category: Plavs]]
	[[Category: Tolia, N H.]]		[[Category: Tolia, N H.]]
	[[Category: Cell invasion]]		[[Category: Cell invasion]]

OCA at 05:35, 30 November 2011

OCA — Wed, 30 Nov 2011 05:35:23 GMT

←Older revision		Revision as of 05:35, 30 November 2011
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-	[[Image:3rrc.~~jpg~~\|left\|200px]]	+	[[Image:3rrc.png\|left\|200px]]

	<!--		<!--
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	===Crystal Structure of Region II from Plasmodium vivax Duffy Binding Protein===		===Crystal Structure of Region II from Plasmodium vivax Duffy Binding Protein===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21743458}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21743458 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21743458}}

	==About this Structure==		==About this Structure==
	[[3rrc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RRC OCA].		[[3rrc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RRC OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021743458</ref><references group="xtra"/>
	[[Category: Plasmodium vivax]]		[[Category: Plasmodium vivax]]
	[[Category: Tolia, N H.]]		[[Category: Tolia, N H.]]

OCA at 07:50, 13 July 2011

OCA — Wed, 13 Jul 2011 07:50:13 GMT

←Older revision		Revision as of 07:50, 13 July 2011
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-	~~'''Unreleased structure'''~~	+	[[Image:3rrc.jpg\|left\|200px]]

-	The ~~entry 3rrc~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3rrc", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3rrc\| PDB=3rrc \| SCENE= }}

-	~~Authors: Tolia, N.H.~~	+	===Crystal Structure of Region II from Plasmodium vivax Duffy Binding Protein===

-	~~Description: Crystal~~ Structure ~~of Region II~~ from Plasmodium vivax Duffy ~~Binding Protein~~	+
		+	==About this Structure==
		+	[[3rrc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RRC OCA].
		+	[[Category: Plasmodium vivax]]
		+	[[Category: Tolia, N H.]]
		+	[[Category: Cell invasion]]
		+	[[Category: Duffy antigen receptor for chemokine]]
		+	[[Category: Duffy binding like]]
		+	[[Category: Receptor recognition]]

OCA: Protected "3rrc" [edit=sysop:move=sysop]

OCA — Thu, 12 May 2011 04:22:11 GMT

Protected "3rrc" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:22, 12 May 2011

OCA: New page: '''Unreleased structure''' The entry 3rrc is ON HOLD until Paper Publication Authors: Tolia, N.H. Description: Crystal Structure of Region II from Plasmodium vivax Duffy Binding Protei...

OCA — Thu, 12 May 2011 04:22:09 GMT

New page: '''Unreleased structure''' The entry 3rrc is ON HOLD until Paper Publication Authors: Tolia, N.H. Description: Crystal Structure of Region II from Plasmodium vivax Duffy Binding Protei...

New page

'''Unreleased structure'''

The entry 3rrc is ON HOLD until Paper Publication

Authors: Tolia, N.H.

Description: Crystal Structure of Region II from Plasmodium vivax Duffy Binding Protein