3rt4 - Revision history

OCA at 17:19, 1 November 2023

OCA — Wed, 01 Nov 2023 17:19:16 GMT

←Older revision		Revision as of 17:19, 1 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3rt4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Camelus_dromedarius Camelus dromedarius]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3mu9 3mu9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RT4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RT4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3rt4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Camelus_dromedarius Camelus dromedarius]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3mu9 3mu9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RT4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RT4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LP5:(R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL)+3-HYDROXYTETRADECANOATE'>LP5</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LP5:(R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL)+3-HYDROXYTETRADECANOATE'>LP5</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rt4 OCA], [https://pdbe.org/3rt4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rt4 RCSB], [https://www.ebi.ac.uk/pdbsum/3rt4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rt4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rt4 OCA], [https://pdbe.org/3rt4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rt4 RCSB], [https://www.ebi.ac.uk/pdbsum/3rt4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rt4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PGRP1_CAMDR PGRP1_CAMDR]] Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria. Involved in innate immunity. Is microbicidal for Gram-positive and Gram-negative bacteria and yeast. May function in intracellular killing of bacteria (By similarity).	+	[https://www.uniprot.org/uniprot/PGRP1_CAMDR PGRP1_CAMDR] Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria. Involved in innate immunity. Is microbicidal for Gram-positive and Gram-negative bacteria and yeast. May function in intracellular killing of bacteria (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 25:
	[[Category: Camelus dromedarius]]		[[Category: Camelus dromedarius]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dey, S]]	+	[[Category: Dey S]]
-	[[Category: Dube, D]]	+	[[Category: Dube D]]
-	[[Category: Kaur, P]]	+	[[Category: Kaur P]]
-	[[Category: Mishra, B]]	+	[[Category: Mishra B]]
-	[[Category: Mitra~~, D K~~]]	+	[[Category: Mitra DK]]
-	[[Category: Sharma, P]]	+	[[Category: Sharma P]]
-	[[Category: Sharma, S]]	+	[[Category: Sharma S]]
-	[[Category: Singh, A]]	+	[[Category: Singh A]]
-	[[Category: Singh, N]]	+	[[Category: Singh N]]
-	[[Category: Singh~~, T P~~]]	+	[[Category: Singh TP]]
-	[[Category: Sinha, M]]	+	[[Category: Sinha M]]
-	~~[[Category: Antimicrobial]]~~	+
-	~~[[Category: Immune response]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Peptidoglycan binding]]~~	+
-	~~[[Category: Pgrp]]~~	+
-	~~[[Category: Secreted~~]]	+

OCA at 10:24, 22 June 2022

OCA — Wed, 22 Jun 2022 10:24:22 GMT

←Older revision		Revision as of 10:24, 22 June 2022
Line 3:		Line 3:
	<StructureSection load='3rt4' size='340' side='right'caption='[[3rt4]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='3rt4' size='340' side='right'caption='[[3rt4]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3rt4]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Camelus_dromedarius Camelus dromedarius]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3mu9 3mu9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RT4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3RT4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3rt4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Camelus_dromedarius Camelus dromedarius]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3mu9 3mu9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RT4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RT4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LP5:(R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL)+3-HYDROXYTETRADECANOATE'>LP5</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LP5:(R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL)+3-HYDROXYTETRADECANOATE'>LP5</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3rt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rt4 OCA], [~~http~~://pdbe.org/3rt4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3rt4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3rt4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3rt4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rt4 OCA], [https://pdbe.org/3rt4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rt4 RCSB], [https://www.ebi.ac.uk/pdbsum/3rt4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rt4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PGRP1_CAMDR PGRP1_CAMDR]] Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria. Involved in innate immunity. Is microbicidal for Gram-positive and Gram-negative bacteria and yeast. May function in intracellular killing of bacteria (By similarity).	+	[[https://www.uniprot.org/uniprot/PGRP1_CAMDR PGRP1_CAMDR]] Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria. Involved in innate immunity. Is microbicidal for Gram-positive and Gram-negative bacteria and yeast. May function in intracellular killing of bacteria (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 15:33, 11 December 2019

OCA — Wed, 11 Dec 2019 15:33:48 GMT

←Older revision		Revision as of 15:33, 11 December 2019
Line 1:		Line 1:

	==Structural Basis of Recognition of Pathogen-associated Molecular Patterns and Inhibition of Proinflammatory Cytokines by Camel Peptidoglycan Recognition Protein==		==Structural Basis of Recognition of Pathogen-associated Molecular Patterns and Inhibition of Proinflammatory Cytokines by Camel Peptidoglycan Recognition Protein==
-	<StructureSection load='3rt4' size='340' side='right' caption='[[3rt4]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='3rt4' size='340' side='right'caption='[[3rt4]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3rt4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_dromedarius Camelus dromedarius]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3mu9 3mu9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RT4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RT4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3rt4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_dromedarius Camelus dromedarius]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3mu9 3mu9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RT4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RT4 FirstGlance]. <br>
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Camelus dromedarius]]		[[Category: Camelus dromedarius]]
		+	[[Category: Large Structures]]
	[[Category: Dey, S]]		[[Category: Dey, S]]
	[[Category: Dube, D]]		[[Category: Dube, D]]

OCA at 07:32, 4 August 2016

OCA — Thu, 04 Aug 2016 07:32:55 GMT

←Older revision		Revision as of 07:32, 4 August 2016
Line 1:		Line 1:
		+
	==Structural Basis of Recognition of Pathogen-associated Molecular Patterns and Inhibition of Proinflammatory Cytokines by Camel Peptidoglycan Recognition Protein==		==Structural Basis of Recognition of Pathogen-associated Molecular Patterns and Inhibition of Proinflammatory Cytokines by Camel Peptidoglycan Recognition Protein==
	<StructureSection load='3rt4' size='340' side='right' caption='[[3rt4]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='3rt4' size='340' side='right' caption='[[3rt4]], [[Resolution\|resolution]] 1.70Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[3rt4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_dromedarius Camelus dromedarius]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3mu9 3mu9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RT4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RT4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3rt4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_dromedarius Camelus dromedarius]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3mu9 3mu9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RT4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RT4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LP5:(R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL)+3-HYDROXYTETRADECANOATE'>LP5</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LP5:(R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL)+3-HYDROXYTETRADECANOATE'>LP5</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rt4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rt4 RCSB], [http://www.ebi.ac.uk/pdbsum/3rt4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rt4 OCA], [http://pdbe.org/3rt4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3rt4 RCSB], [http://www.ebi.ac.uk/pdbsum/3rt4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3rt4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3rt4" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:57, 24 December 2014

OCA — Wed, 24 Dec 2014 06:57:48 GMT

←Older revision		Revision as of 06:57, 24 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rt4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rt4 RCSB], [http://www.ebi.ac.uk/pdbsum/3rt4 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rt4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rt4 RCSB], [http://www.ebi.ac.uk/pdbsum/3rt4 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PGRP1_CAMDR PGRP1_CAMDR]] Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria. Involved in innate immunity. Is microbicidal for Gram-positive and Gram-negative bacteria and yeast. May function in intracellular killing of bacteria (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 10:24, 19 December 2014

OCA — Fri, 19 Dec 2014 10:24:10 GMT

←Older revision		Revision as of 10:24, 19 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3rt4\| PDB=3rt4 \| SCENE= }}~~	+	==Structural Basis of Recognition of Pathogen-associated Molecular Patterns and Inhibition of Proinflammatory Cytokines by Camel Peptidoglycan Recognition Protein==
-	===Structural Basis of Recognition of Pathogen-associated Molecular Patterns and Inhibition of Proinflammatory Cytokines by Camel Peptidoglycan Recognition Protein===	+	<StructureSection load='3rt4' size='340' side='right' caption='[[3rt4]], [[Resolution\|resolution]] 1.70Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21454594}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3rt4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_dromedarius Camelus dromedarius]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3mu9 3mu9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RT4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RT4 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LP5:(R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL)+3-HYDROXYTETRADECANOATE'>LP5</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rt4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rt4 RCSB], [http://www.ebi.ac.uk/pdbsum/3rt4 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Peptidoglycan recognition proteins (PGRPs) are involved in the recognition of pathogen-associated molecular patterns. The well known pathogen-associated molecular patterns include LPS from Gram-negative bacteria and lipoteichoic acid (LTA) from Gram-positive bacteria. In this work, the crystal structures of two complexes of the short form of camel PGRP (CPGRP-S) with LPS and LTA determined at 1.7- and 2.1-A resolutions, respectively, are reported. Both compounds were held firmly inside the complex formed with four CPGRP-S molecules designated A, B, C, and D. The binding cleft is located at the interface of molecules C and D, which is extendable to the interface of molecules A and C. The interface of molecules A and B is tightly packed, whereas that of molecules B and D forms a wide channel. The hydrophilic moieties of these compounds occupy a common region, whereas hydrophobic chains interact with distinct regions in the binding site. The binding studies showed that CPGRP-S binds to LPS and LTA with affinities of 1.6 x 10(-9) and 2.4 x 10(-8) m, respectively. The flow cytometric studies showed that both LPS- and LTA-induced expression of the proinflammatory cytokines TNF-alpha and IL-6 was inhibited by CPGRP-S. The results of animal studies using mouse models indicated that both LPS- and LTA-induced mortality rates decreased drastically when CPGRP-S was administered. The recognition of both LPS and LTA, their high binding affinities for CPGRP-S, the significant decrease in the production of LPS- and LTA-induced TNF-alpha and IL-6, and the drastic reduction in the mortality rates in mice by CPGRP-S indicate its useful properties as an antibiotic agent.

-	~~==Function==~~	+	Structural Basis of Recognition of Pathogen-associated Molecular Patterns and Inhibition of Proinflammatory Cytokines by Camel Peptidoglycan Recognition Protein.,Sharma P, Dube D, Singh A, Mishra B, Singh N, Sinha M, Dey S, Kaur P, Mitra DK, Sharma S, Singh TP J Biol Chem. 2011 May 6;286(18):16208-17. Epub 2011 Mar 21. PMID:21454594<ref>PMID:21454594</ref>
-	~~[[http://www.uniprot.org/uniprot/PGRP1_CAMDR PGRP1_CAMDR]] Pattern receptor that binds to murein peptidoglycans (PGN)~~ of ~~Gram~~-~~positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria~~ by ~~interfering with peptidoglycan biosynthesis~~. ~~Binds also to Gram-negative bacteria. Involved in innate immunity. Is microbicidal for Gram-positive and Gram-negative bacteria and yeast~~. May ~~function in intracellular killing of bacteria~~ (~~By similarity~~).	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3rt4]] is~~ a ~~4 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_dromedarius Camelus dromedarius]. This structure supersedes~~ the ~~now removed PDB entry [http://oca~~.~~weizmann~~.ac.il/~~oca-bin/send-pdb?obs=1&id=3mu9 3mu9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RT4 OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:021454594</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Camelus dromedarius]]		[[Category: Camelus dromedarius]]
-	[[Category: Dey, S.]]	+	[[Category: Dey, S]]
-	[[Category: Dube, D.]]	+	[[Category: Dube, D]]
-	[[Category: Kaur, P.]]	+	[[Category: Kaur, P]]
-	[[Category: Mishra, B.]]	+	[[Category: Mishra, B]]
-	[[Category: Mitra, D K.]]	+	[[Category: Mitra, D K]]
-	[[Category: Sharma, P.]]	+	[[Category: Sharma, P]]
-	[[Category: Sharma, S.]]	+	[[Category: Sharma, S]]
-	[[Category: Singh, A.]]	+	[[Category: Singh, A]]
-	[[Category: Singh, N.]]	+	[[Category: Singh, N]]
-	[[Category: Singh, T P.]]	+	[[Category: Singh, T P]]
-	[[Category: Sinha, M.]]	+	[[Category: Sinha, M]]
	[[Category: Antimicrobial]]		[[Category: Antimicrobial]]
	[[Category: Immune response]]		[[Category: Immune response]]

OCA at 07:58, 16 May 2013

OCA — Thu, 16 May 2013 07:58:07 GMT

←Older revision		Revision as of 07:58, 16 May 2013
Line 1:		Line 1:
-	[[Image:3rt4.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3rt4", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3rt4\| PDB=3rt4 \| SCENE= }}		{{STRUCTURE_3rt4\| PDB=3rt4 \| SCENE= }}
-
	===Structural Basis of Recognition of Pathogen-associated Molecular Patterns and Inhibition of Proinflammatory Cytokines by Camel Peptidoglycan Recognition Protein===		===Structural Basis of Recognition of Pathogen-associated Molecular Patterns and Inhibition of Proinflammatory Cytokines by Camel Peptidoglycan Recognition Protein===
		+	{{ABSTRACT_PUBMED_21454594}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/PGRP1_CAMDR PGRP1_CAMDR]] Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria. Involved in innate immunity. Is microbicidal for Gram-positive and Gram-negative bacteria and yeast. May function in intracellular killing of bacteria (By similarity).
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21454594}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~)~~, where 21454594 is the PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_21454594}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:021454594</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021454594</ref><references group="xtra"/><references/>
	[[Category: Camelus dromedarius]]		[[Category: Camelus dromedarius]]
	[[Category: Dey, S.]]		[[Category: Dey, S.]]

OCA at 06:10, 15 June 2011

OCA — Wed, 15 Jun 2011 06:10:01 GMT

←Older revision		Revision as of 06:10, 15 June 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3rt4.jpg\|left\|200px]]

-	The ~~entry 3rt4~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3rt4", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3rt4\| PDB=3rt4 \| SCENE= }}

-	~~Authors: Sharma, P., Dube, D., Singh, A., Mishra, B., Singh, N., Sinha, M., Dey, S., Kaur, P., Mitra, D.K., Sharma, S., Singh, T.P.~~	+	===Structural Basis of Recognition of Pathogen-associated Molecular Patterns and Inhibition of Proinflammatory Cytokines by Camel Peptidoglycan Recognition Protein===

-	~~Description~~: ~~Structural Basis of Recognition of Pathogen~~-~~associated Molecular Patterns and Inhibition of Proinflammatory Cytokines by Camel~~ Peptidoglycan ~~Recognition Protein~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21454594}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21454594 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21454594}}
		+
		+	==About this Structure==
		+	[[3rt4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_dromedarius Camelus dromedarius]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3mu9 3mu9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RT4 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021454594</ref><references group="xtra"/>
		+	[[Category: Camelus dromedarius]]
		+	[[Category: Dey, S.]]
		+	[[Category: Dube, D.]]
		+	[[Category: Kaur, P.]]
		+	[[Category: Mishra, B.]]
		+	[[Category: Mitra, D K.]]
		+	[[Category: Sharma, P.]]
		+	[[Category: Sharma, S.]]
		+	[[Category: Singh, A.]]
		+	[[Category: Singh, N.]]
		+	[[Category: Singh, T P.]]
		+	[[Category: Sinha, M.]]
		+	[[Category: Antimicrobial]]
		+	[[Category: Immune response]]
		+	[[Category: Immune system]]
		+	[[Category: Peptidoglycan binding]]
		+	[[Category: Pgrp]]
		+	[[Category: Secreted]]

OCA at 05:09, 25 May 2011

OCA — Wed, 25 May 2011 05:09:37 GMT

←Older revision		Revision as of 05:09, 25 May 2011
Line 3:		Line 3:
	The entry 3rt4 is ON HOLD		The entry 3rt4 is ON HOLD

-	Authors: Sharma, P. , Dube, D. , Singh, A., Mishra, B., Singh, N., Sinha, M., Dey, S., Kaur, P., Mitra, D. K., Sharma, S., Singh, T.P.	+	Authors: Sharma, P., Dube, D., Singh, A., Mishra, B., Singh, N., Sinha, M., Dey, S., Kaur, P., Mitra, D.K., Sharma, S., Singh, T.P.

	Description: Structural Basis of Recognition of Pathogen-associated Molecular Patterns and Inhibition of Proinflammatory Cytokines by Camel Peptidoglycan Recognition Protein		Description: Structural Basis of Recognition of Pathogen-associated Molecular Patterns and Inhibition of Proinflammatory Cytokines by Camel Peptidoglycan Recognition Protein

OCA: Protected "3rt4" [edit=sysop:move=sysop]

OCA — Thu, 12 May 2011 04:23:52 GMT

Protected "3rt4" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:23, 12 May 2011