3rtk - Revision history

OCA at 12:36, 14 March 2024

OCA — Thu, 14 Mar 2024 12:36:47 GMT

←Older revision		Revision as of 12:36, 14 March 2024
Line 3:		Line 3:
	<StructureSection load='3rtk' size='340' side='right'caption='[[3rtk]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='3rtk' size='340' side='right'caption='[[3rtk]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3rtk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus~~ tuberculosis~~" (zopf 1883) klein 1884~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RTK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RTK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3rtk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RTK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RTK FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>groL2, groEL-2, groEL2, hsp65, Rv0440, MT0456, MTV037.04 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1773~~ "~~Bacillus tuberculosis~~" ~~(Zopf 1883) Klein 1884])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rtk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rtk OCA], [https://pdbe.org/3rtk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rtk RCSB], [https://www.ebi.ac.uk/pdbsum/3rtk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rtk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rtk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rtk OCA], [https://pdbe.org/3rtk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rtk RCSB], [https://www.ebi.ac.uk/pdbsum/3rtk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rtk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CH602_MYCTU CH602_MYCTU]] Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity).[HAMAP-Rule:MF_00600]	+	[https://www.uniprot.org/uniprot/CH602_MYCTU CH602_MYCTU] Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity).[HAMAP-Rule:MF_00600]
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Mycobacterium tuberculosis expresses two proteins (Cpn60.1 and Cpn60.2) that belong to the chaperonin (Cpn) family of heat shock proteins. Studies have shown that the two proteins have different functional roles in the bacterial life cycle and that Cpn60.2 is essential for cell viability and may be involved in M. tuberculosis pathogenicity. Cpn60.2 does not form a tetradecameric double ring, which is typical of other Cpns. We have determined the crystal structure of recombinant Cpn60.2 to 2.8 A resolution by molecular replacement; the asymmetric unit (AU) contains a dimer, which is consistent with size-exclusion high-performance liquid chromatography and dynamic light-scattering measurements of the soluble recombinant protein. However, we suggest that the actual Cpn60.2 dimer may be different from that identified within the AU on the basis of surface contact stability, solvation free-energy gain, and functional aspects. Unlike the dimer found in the AU, which is formed through apical domain interactions, the dimeric form we propose here provides a free apical domain that is required for normal chaperone activity and may be involved in M. tuberculosis association with macrophages and arthrosclerosis plaque formation. Here we describe in detail the structural aspects that lead to Cpn60.2 dimer formation and prevent the formation of heptameric rings and tetradecameric double rings.	+
-		+
-	The dimeric structure of the Cpn60.2 chaperonin of Mycobacterium tuberculosis at 2.8 A reveals possible modes of function.,Shahar A, Melamed-Frank M, Kashi Y, Shimon L, Adir N J Mol Biol. 2011 Sep 16;412(2):192-203. Epub 2011 Jul 23. PMID:21802426<ref>PMID:21802426</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3rtk" style="background-color:#fffaf0;"></div>~~	+

	==See Also==		==See Also==
	*[[Chaperonin 3D structures\|Chaperonin 3D structures]]		*[[Chaperonin 3D structures\|Chaperonin 3D structures]]
-	~~== References ==~~	+	*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Adir, N]]	+	[[Category: Mycobacterium tuberculosis]]
-	[[Category: Kashi, Y]]	+	[[Category: Adir N]]
-	[[Category: Melamed-Frank, M]]	+	[[Category: Kashi Y]]
-	[[Category: Shahar, A]]	+	[[Category: Melamed-Frank M]]
-	~~[[Category: Chaperone]]~~	+	[[Category: Shahar A]]
-	~~[[Category: Chaperonin]]~~	+
-	~~[[Category: Heat shock protein~~]]	+

OCA at 10:24, 22 June 2022

OCA — Wed, 22 Jun 2022 10:24:39 GMT

←Older revision		Revision as of 10:24, 22 June 2022
Line 1:		Line 1:

	==Crystal structure of Cpn60.2 from Mycobacterium tuberculosis at 2.8A==		==Crystal structure of Cpn60.2 from Mycobacterium tuberculosis at 2.8A==
-	<StructureSection load='3rtk' size='340' side='right' caption='[[3rtk]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='3rtk' size='340' side='right'caption='[[3rtk]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3rtk]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RTK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3RTK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3rtk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RTK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RTK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">groL2, groEL-2, groEL2, hsp65, Rv0440, MT0456, MTV037.04 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">groL2, groEL-2, groEL2, hsp65, Rv0440, MT0456, MTV037.04 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3rtk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rtk OCA], [~~http~~://pdbe.org/3rtk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3rtk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3rtk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3rtk ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rtk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rtk OCA], [https://pdbe.org/3rtk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rtk RCSB], [https://www.ebi.ac.uk/pdbsum/3rtk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rtk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CH602_MYCTU CH602_MYCTU]] Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity).[HAMAP-Rule:MF_00600]	+	[[https://www.uniprot.org/uniprot/CH602_MYCTU CH602_MYCTU]] Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity).[HAMAP-Rule:MF_00600]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Chaperonin\|Chaperonin]]	+	*[[Chaperonin 3D structures\|Chaperonin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Adir, N]]		[[Category: Adir, N]]
	[[Category: Kashi, Y]]		[[Category: Kashi, Y]]

OCA at 15:01, 5 August 2016

OCA — Fri, 05 Aug 2016 15:01:42 GMT

←Older revision		Revision as of 15:01, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of Cpn60.2 from Mycobacterium tuberculosis at 2.8A==		==Crystal structure of Cpn60.2 from Mycobacterium tuberculosis at 2.8A==
	<StructureSection load='3rtk' size='340' side='right' caption='[[3rtk]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='3rtk' size='340' side='right' caption='[[3rtk]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3rtk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis Mycobacterium~~ tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RTK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RTK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3rtk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RTK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RTK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">groL2, groEL-2, groEL2, hsp65, Rv0440, MT0456, MTV037.04 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 ~~Mycobacterium~~ tuberculosis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">groL2, groEL-2, groEL2, hsp65, Rv0440, MT0456, MTV037.04 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rtk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rtk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rtk RCSB], [http://www.ebi.ac.uk/pdbsum/3rtk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rtk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rtk OCA], [http://pdbe.org/3rtk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3rtk RCSB], [http://www.ebi.ac.uk/pdbsum/3rtk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3rtk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3rtk" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Mycobacterium tuberculosis]]
	[[Category: Adir, N]]		[[Category: Adir, N]]
	[[Category: Kashi, Y]]		[[Category: Kashi, Y]]

OCA at 03:27, 25 December 2014

OCA — Thu, 25 Dec 2014 03:27:59 GMT

←Older revision		Revision as of 03:27, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rtk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rtk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rtk RCSB], [http://www.ebi.ac.uk/pdbsum/3rtk PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rtk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rtk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rtk RCSB], [http://www.ebi.ac.uk/pdbsum/3rtk PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CH602_MYCTU CH602_MYCTU]] Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity).[HAMAP-Rule:MF_00600]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 10:43, 19 December 2014

OCA — Fri, 19 Dec 2014 10:43:54 GMT

←Older revision		Revision as of 10:43, 19 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3rtk\| PDB=3rtk \| SCENE= }}~~	+	==Crystal structure of Cpn60.2 from Mycobacterium tuberculosis at 2.8A==
-	===Crystal structure of Cpn60.2 from Mycobacterium tuberculosis at 2.8A===	+	<StructureSection load='3rtk' size='340' side='right' caption='[[3rtk]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21802426}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3rtk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RTK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RTK FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">groL2, groEL-2, groEL2, hsp65, Rv0440, MT0456, MTV037.04 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rtk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rtk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rtk RCSB], [http://www.ebi.ac.uk/pdbsum/3rtk PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mycobacterium tuberculosis expresses two proteins (Cpn60.1 and Cpn60.2) that belong to the chaperonin (Cpn) family of heat shock proteins. Studies have shown that the two proteins have different functional roles in the bacterial life cycle and that Cpn60.2 is essential for cell viability and may be involved in M. tuberculosis pathogenicity. Cpn60.2 does not form a tetradecameric double ring, which is typical of other Cpns. We have determined the crystal structure of recombinant Cpn60.2 to 2.8 A resolution by molecular replacement; the asymmetric unit (AU) contains a dimer, which is consistent with size-exclusion high-performance liquid chromatography and dynamic light-scattering measurements of the soluble recombinant protein. However, we suggest that the actual Cpn60.2 dimer may be different from that identified within the AU on the basis of surface contact stability, solvation free-energy gain, and functional aspects. Unlike the dimer found in the AU, which is formed through apical domain interactions, the dimeric form we propose here provides a free apical domain that is required for normal chaperone activity and may be involved in M. tuberculosis association with macrophages and arthrosclerosis plaque formation. Here we describe in detail the structural aspects that lead to Cpn60.2 dimer formation and prevent the formation of heptameric rings and tetradecameric double rings.

-	~~==Function==~~	+	The dimeric structure of the Cpn60.2 chaperonin of Mycobacterium tuberculosis at 2.8 A reveals possible modes of function.,Shahar A, Melamed-Frank M, Kashi Y, Shimon L, Adir N J Mol Biol. 2011 Sep 16;412(2):192-203. Epub 2011 Jul 23. PMID:21802426<ref>PMID:21802426</ref>
-	~~[[http://www~~.~~uniprot~~.~~org/uniprot/CH602_MYCTU CH602_MYCTU]] Prevents misfolding and promotes the refolding and proper assembly~~ of ~~unfolded polypeptides generated under stress conditions~~ (~~By similarity~~)~~.[HAMAP~~-~~Rule~~:~~MF_00600]~~	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3rtk]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3RTK OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:021802426</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Chaperonin\|Chaperonin]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
-	[[Category: Adir, N.]]	+	[[Category: Adir, N]]
-	[[Category: Kashi, Y.]]	+	[[Category: Kashi, Y]]
-	[[Category: Melamed-Frank, M.]]	+	[[Category: Melamed-Frank, M]]
-	[[Category: Shahar, A.]]	+	[[Category: Shahar, A]]
	[[Category: Chaperone]]		[[Category: Chaperone]]
	[[Category: Chaperonin]]		[[Category: Chaperonin]]
	[[Category: Heat shock protein]]		[[Category: Heat shock protein]]

OCA at 08:13, 19 June 2013

OCA — Wed, 19 Jun 2013 08:13:20 GMT

←Older revision		Revision as of 08:13, 19 June 2013
Line 1:		Line 1:
-	[[Image:3rtk.png\|left\|200px]]
-
	{{STRUCTURE_3rtk\| PDB=3rtk \| SCENE= }}		{{STRUCTURE_3rtk\| PDB=3rtk \| SCENE= }}
-
	===Crystal structure of Cpn60.2 from Mycobacterium tuberculosis at 2.8A===		===Crystal structure of Cpn60.2 from Mycobacterium tuberculosis at 2.8A===
		+	{{ABSTRACT_PUBMED_21802426}}

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/CH602_MYCTU CH602_MYCTU]] Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity).[HAMAP-Rule:MF_00600]

	==About this Structure==		==About this Structure==
	[[3rtk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RTK OCA].		[[3rtk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RTK OCA].

-	==~~See Also~~==	+	==Reference==
-	*[[Chaperonin\|Chaperonin]]	+	<ref group="xtra">PMID:021802426</ref><references group="xtra"/><references/>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Adir, N.]]		[[Category: Adir, N.]]

OCA at 12:09, 20 October 2012

OCA — Sat, 20 Oct 2012 12:09:11 GMT

←Older revision		Revision as of 12:09, 20 October 2012
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[3rtk]] is a 2 chain structure ~~of [[Chaperonin]]~~ with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RTK OCA].	+	[[3rtk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RTK OCA].

	==See Also==		==See Also==

OCA at 07:47, 26 July 2012

OCA — Thu, 26 Jul 2012 07:47:07 GMT

←Older revision		Revision as of 07:47, 26 July 2012
Line 1:		Line 1:
-	[[Image:3rtk.~~jpg~~\|left\|200px]]	+	[[Image:3rtk.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3rtk", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3rtk\| PDB=3rtk \| SCENE= }}		{{STRUCTURE_3rtk\| PDB=3rtk \| SCENE= }}

Line 13:		Line 7:

	==About this Structure==		==About this Structure==
-	[[3rtk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RTK OCA].	+	[[3rtk]] is a 2 chain structure of [[Chaperonin]] with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RTK OCA].
		+
		+	==See Also==
		+	*[[Chaperonin\|Chaperonin]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Adir, N.]]		[[Category: Adir, N.]]

OCA at 06:19, 10 August 2011

OCA — Wed, 10 Aug 2011 06:19:34 GMT

←Older revision		Revision as of 06:19, 10 August 2011
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-	~~'''Unreleased structure'''~~	+	[[Image:3rtk.jpg\|left\|200px]]

-	The ~~entry 3rtk~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3rtk", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3rtk\| PDB=3rtk \| SCENE= }}

-	~~Authors: Shahar, A~~.~~, Melamed-Frank, M., Kashi, Y., Adir, N~~.	+	===Crystal structure of Cpn60.2 from Mycobacterium tuberculosis at 2.8A===

-	~~Description: Crystal~~ structure ~~of Cpn60~~.2 from Mycobacterium tuberculosis ~~at 2~~.8A	+
		+	==About this Structure==
		+	[[3rtk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RTK OCA].
		+	[[Category: Mycobacterium tuberculosis]]
		+	[[Category: Adir, N.]]
		+	[[Category: Kashi, Y.]]
		+	[[Category: Melamed-Frank, M.]]
		+	[[Category: Shahar, A.]]
		+	[[Category: Chaperone]]
		+	[[Category: Chaperonin]]
		+	[[Category: Heat shock protein]]

OCA at 05:09, 25 May 2011

OCA — Wed, 25 May 2011 05:09:40 GMT

←Older revision		Revision as of 05:09, 25 May 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3rtk is ON HOLD	+	The entry 3rtk is ON HOLD until Paper Publication

	Authors: Shahar, A., Melamed-Frank, M., Kashi, Y., Adir, N.		Authors: Shahar, A., Melamed-Frank, M., Kashi, Y., Adir, N.

	Description: Crystal structure of Cpn60.2 from Mycobacterium tuberculosis at 2.8A		Description: Crystal structure of Cpn60.2 from Mycobacterium tuberculosis at 2.8A