3rwj - Revision history

OCA at 17:20, 1 November 2023

OCA — Wed, 01 Nov 2023 17:20:03 GMT

←Older revision		Revision as of 17:20, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3rwj' size='340' side='right'caption='[[3rwj]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='3rwj' size='340' side='right'caption='[[3rwj]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3rwj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~] and [https://en.wikipedia.org/wiki/~~Macmu Macmu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RWJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RWJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3rwj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta] and [https://en.wikipedia.org/wiki/Simian_immunodeficiency_virus Simian immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RWJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RWJ FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3rwc\|3rwc]], [[3rwd\|3rwd]], [[3rwe\|3rwe]], [[3rwf\|3rwf]], [[3rwg\|3rwg]], [[3rwh\|3rwh]], [[3rwi\|3rwi]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">MHCI-B ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9544 MACMU]), B2M ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rwj OCA], [https://pdbe.org/3rwj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rwj RCSB], [https://www.ebi.ac.uk/pdbsum/3rwj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rwj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rwj OCA], [https://pdbe.org/3rwj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rwj RCSB], [https://www.ebi.ac.uk/pdbsum/3rwj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rwj ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[https://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>	+	[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[https://omim.org/entry/241600 241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
	== Function ==		== Function ==
-	~~[[https://www.uniprot.org/uniprot/Q9GJ77_MACMU Q9GJ77_MACMU]] Involved in the presentation of foreign antigens to the immune system (By similarity).[SAAS:SAAS003006_004_004364] [~~[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	+	[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 24:
	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]		*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
	*[[MHC 3D structures\|MHC 3D structures]]		*[[MHC 3D structures\|MHC 3D structures]]
		+	*[[MHC I 3D structures\|MHC I 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Macmu~~]]	+	[[Category: Macaca mulatta]]
-	[[Category: ~~Gao, F~~]]	+	[[Category: Simian immunodeficiency virus]]
-	[[Category: Gao~~, G~~ F]]	+	[[Category: Gao F]]
-	[[Category: ~~Liu, J~~]]	+	[[Category: Gao GF]]
-	[[Category: ~~Price, D A]]~~	+	[[Category: Liu J]]
-	~~[[Category: Qi,~~ J X]]	+	[[Category: Price DA]]
-	[[Category: ~~Wu, Y~~]]	+	[[Category: Qi JX]]
-	[[Category: ~~Antigenic peptide~~]]	+	[[Category: Wu Y]]
-	[[Category: ~~Immune response]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: T lymphocyte~~]]	+

OCA at 10:28, 22 June 2022

OCA — Wed, 22 Jun 2022 10:28:08 GMT

←Older revision		Revision as of 10:28, 22 June 2022
Line 1:		Line 1:

	==Rhesus macaque MHC class I molecule Mamu-B*17-HW8==		==Rhesus macaque MHC class I molecule Mamu-B*17-HW8==
-	<StructureSection load='3rwj' size='340' side='right' caption='[[3rwj]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='3rwj' size='340' side='right'caption='[[3rwj]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3rwj]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human] and [~~http~~://en.wikipedia.org/wiki/Macmu Macmu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RWJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3RWJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3rwj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human] and [https://en.wikipedia.org/wiki/Macmu Macmu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RWJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RWJ FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3rwc\|3rwc]], [[3rwd\|3rwd]], [[3rwe\|3rwe]], [[3rwf\|3rwf]], [[3rwg\|3rwg]], [[3rwh\|3rwh]], [[3rwi\|3rwi]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3rwc\|3rwc]], [[3rwd\|3rwd]], [[3rwe\|3rwe]], [[3rwf\|3rwf]], [[3rwg\|3rwg]], [[3rwh\|3rwh]], [[3rwi\|3rwi]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MHCI-B ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9544 MACMU]), B2M ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MHCI-B ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9544 MACMU]), B2M ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3rwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rwj OCA], [~~http~~://pdbe.org/3rwj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3rwj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3rwj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3rwj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rwj OCA], [https://pdbe.org/3rwj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rwj RCSB], [https://www.ebi.ac.uk/pdbsum/3rwj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rwj ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[~~http~~://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>	+	[[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[https://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/Q9GJ77_MACMU Q9GJ77_MACMU]] Involved in the presentation of foreign antigens to the immune system (By similarity).[SAAS:SAAS003006_004_004364] [[~~http~~://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	+	[[https://www.uniprot.org/uniprot/Q9GJ77_MACMU Q9GJ77_MACMU]] Involved in the presentation of foreign antigens to the immune system (By similarity).[SAAS:SAAS003006_004_004364] [[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:

	==See Also==		==See Also==
-	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]	+	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
-	*[[~~Major histocompatibility complex~~\|~~Major histocompatibility complex~~]]	+	*[[MHC 3D structures\|MHC 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Macmu]]		[[Category: Macmu]]
	[[Category: Gao, F]]		[[Category: Gao, F]]

OCA at 11:19, 10 December 2016

OCA — Sat, 10 Dec 2016 11:19:01 GMT

←Older revision		Revision as of 11:19, 10 December 2016
Line 1:		Line 1:
		+
	==Rhesus macaque MHC class I molecule Mamu-B*17-HW8==		==Rhesus macaque MHC class I molecule Mamu-B*17-HW8==
	<StructureSection load='3rwj' size='340' side='right' caption='[[3rwj]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='3rwj' size='340' side='right' caption='[[3rwj]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3rwj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~] and [http://en.wikipedia.org/wiki/~~Macaca_mulatta Macaca mulatta~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RWJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RWJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3rwj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Macmu Macmu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RWJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RWJ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3rwc\|3rwc]], [[3rwd\|3rwd]], [[3rwe\|3rwe]], [[3rwf\|3rwf]], [[3rwg\|3rwg]], [[3rwh\|3rwh]], [[3rwi\|3rwi]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3rwc\|3rwc]], [[3rwd\|3rwd]], [[3rwe\|3rwe]], [[3rwf\|3rwf]], [[3rwg\|3rwg]], [[3rwh\|3rwh]], [[3rwi\|3rwi]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MHCI-B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9544 ~~Macaca mulatta~~]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MHCI-B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9544 MACMU]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rwj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rwj RCSB], [http://www.ebi.ac.uk/pdbsum/3rwj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rwj OCA], [http://pdbe.org/3rwj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3rwj RCSB], [http://www.ebi.ac.uk/pdbsum/3rwj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3rwj ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3rwj" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 27:		Line 29:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
-	[[Category: ~~Macaca mulatta~~]]	+	[[Category: Macmu]]
	[[Category: Gao, F]]		[[Category: Gao, F]]
	[[Category: Gao, G F]]		[[Category: Gao, G F]]

OCA at 07:34, 15 February 2015

OCA — Sun, 15 Feb 2015 07:34:04 GMT

←Older revision		Revision as of 07:34, 15 February 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_3rwj~~\| ~~PDB~~=3rwj \| ~~SCENE~~= }}	+	==Rhesus macaque MHC class I molecule Mamu-B*17-HW8==
-	===~~Rhesus macaque~~ MHC class I molecule Mamu-B*17-HW8~~===~~	+	<StructureSection load='3rwj' size='340' side='right' caption='[[3rwj]], [[Resolution\|resolution]] 2.70Å' scene=''>
-	~~{{ABSTRACT_PUBMED_22084443}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3rwj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RWJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RWJ FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3rwc\|3rwc]], [[3rwd\|3rwd]], [[3rwe\|3rwe]], [[3rwf\|3rwf]], [[3rwg\|3rwg]], [[3rwh\|3rwh]], [[3rwi\|3rwi]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MHCI-B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9544 Macaca mulatta]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rwj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rwj RCSB], [http://www.ebi.ac.uk/pdbsum/3rwj PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q9GJ77_MACMU Q9GJ77_MACMU]] Involved in the presentation of foreign antigens to the immune system (By similarity).[SAAS:SAAS003006_004_004364] [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The MHC class I molecule Mamu-B17 has been associated with elite control of SIV infection in rhesus macaques, akin to the protective effects described for HLA-B57 in HIV-infected individuals. In this study, we determined the crystal structures of Mamu-B17 in complex with eight different peptides corresponding to immunodominant SIV(mac)239-derived CD8(+) T cell epitopes: HW8 (HLEVQGYW), GW10 (GSHLEVQGYW), MW9 (MHPAQTSQW), QW9 (QTSQWDDPW), FW9 (FQWMGYELW), MF8 (MRHVLEPF), IW9 (IRYPKTFGW), and IW11 (IRYPKTFGWLW). The structures reveal that not only P2, but also P1 and P3, can be used as N-terminal anchor residues by Mamu-B17-restricted peptides. Moreover, the N-terminal anchor residues exhibit a broad chemical specificity, encompassing basic (H and R), bulky polar aliphatic (Q), and small (T) residues. In contrast, Mamu-B17 exhibits a very narrow preference for aromatic residues (W and F) at the C terminus, similar to that displayed by HLA-B57. Flexibility within the whole peptide-binding groove contributes to the accommodation of these diverse peptides, which adopt distinct conformations. Furthermore, the unusually large pocket D enables compensation from other peptide residues if P3 is occupied by an amino acid with a small side chain. In addition, residues located at likely TCR contact regions present highly flexible conformations, which may impact TCR repertoire profiles. These findings provide novel insights into the structural basis of diverse peptide accommodation by Mamu-B*17 and highlight unique atomic features that might contribute to the protective effect of this MHC I molecule in SIV-infected rhesus macaques.

-	~~==Disease==~~	+	Structural basis of diverse peptide accommodation by the rhesus macaque MHC class I molecule Mamu-B*17: insights into immune protection from simian immunodeficiency virus.,Wu Y, Gao F, Liu J, Qi J, Gostick E, Price DA, Gao GF J Immunol. 2011 Dec 15;187(12):6382-92. Epub 2011 Nov 14. PMID:22084443<ref>PMID:22084443</ref>
-	~~[[http~~:~~//www~~.~~uniprot~~.~~org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia~~ (~~HYCATHYP~~) ~~[MIM~~:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-~~2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states~~. ~~The capacity to assemble into amyloid fibrils is concentration dependent~~. ~~Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>~~PMID:3532124</ref><ref>PMID:1336137</ref><ref>PMID:7554280</ref><ref>PMID:4586824</ref><ref>PMID:8084451</ref><ref>PMID:12119416</ref><ref>PMID:12796775</ref><ref>PMID:16901902</ref><ref>PMID:16491088</ref><ref>PMID:17646174</ref><ref>PMID:18835253</ref><ref>PMID:18395224</ref><ref>PMID:~~19284997~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www.uniprot.org/uniprot/Q9GJ77_MACMU Q9GJ77_MACMU]] Involved in the presentation~~ of ~~foreign antigens to~~ the ~~immune system (By similarity)~~.~~[SAAS:SAAS003006_004_004364] [[http://www~~.~~uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component~~ of ~~the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system~~.	+	</div>
-		+
-	~~==About this Structure==~~	+
-	~~[[3rwj]] is a 3 chain structure with sequence from [http:~~//en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RWJ OCA].	+

	==See Also==		==See Also==
	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]		*[[Beta-2 microglobulin\|Beta-2 microglobulin]]
	*[[Major histocompatibility complex\|Major histocompatibility complex]]		*[[Major histocompatibility complex\|Major histocompatibility complex]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:022084443</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Macaca mulatta]]		[[Category: Macaca mulatta]]
-	[[Category: Gao, F.]]	+	[[Category: Gao, F]]
-	[[Category: Gao, G F.]]	+	[[Category: Gao, G F]]
-	[[Category: Liu, J.]]	+	[[Category: Liu, J]]
-	[[Category: Price, D A.]]	+	[[Category: Price, D A]]
-	[[Category: Qi, J X.]]	+	[[Category: Qi, J X]]
-	[[Category: Wu, Y.]]	+	[[Category: Wu, Y]]
	[[Category: Antigenic peptide]]		[[Category: Antigenic peptide]]
	[[Category: Immune response]]		[[Category: Immune response]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: T lymphocyte]]		[[Category: T lymphocyte]]

OCA at 04:18, 25 March 2013

OCA — Mon, 25 Mar 2013 04:18:13 GMT

←Older revision		Revision as of 04:18, 25 March 2013
Line 1:		Line 1:
-	[[Image:3rwj.png\|left\|200px]]
-
	{{STRUCTURE_3rwj\| PDB=3rwj \| SCENE= }}		{{STRUCTURE_3rwj\| PDB=3rwj \| SCENE= }}
-
	===Rhesus macaque MHC class I molecule Mamu-B*17-HW8===		===Rhesus macaque MHC class I molecule Mamu-B*17-HW8===
		+	{{ABSTRACT_PUBMED_22084443}}

-	~~{{ABSTRACT_PUBMED_22084443}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref><ref>PMID:1336137</ref><ref>PMID:7554280</ref><ref>PMID:4586824</ref><ref>PMID:8084451</ref><ref>PMID:12119416</ref><ref>PMID:12796775</ref><ref>PMID:16901902</ref><ref>PMID:16491088</ref><ref>PMID:17646174</ref><ref>PMID:18835253</ref><ref>PMID:18395224</ref><ref>PMID:19284997</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/Q9GJ77_MACMU Q9GJ77_MACMU]] Involved in the presentation of foreign antigens to the immune system (By similarity).[SAAS:SAAS003006_004_004364] [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

	==About this Structure==		==About this Structure==
Line 15:		Line 17:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:022084443</ref><references group="xtra"/>	+	<ref group="xtra">PMID:022084443</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Macaca mulatta]]		[[Category: Macaca mulatta]]

OCA at 17:23, 20 October 2012

OCA — Sat, 20 Oct 2012 17:23:24 GMT

←Older revision		Revision as of 17:23, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3rwj]] is a 3 chain structure ~~of [[Beta-2 microglobulin]] and [[Major histocompatibility complex]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RWJ OCA].	+	[[3rwj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RWJ OCA].

	==See Also==		==See Also==

OCA at 00:44, 27 July 2012

OCA — Fri, 27 Jul 2012 00:44:31 GMT

←Older revision		Revision as of 00:44, 27 July 2012
Line 1:		Line 1:
-	[[Image:3rwj.~~jpg~~\|left\|200px]]	+	[[Image:3rwj.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3rwj", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3rwj\| PDB=3rwj \| SCENE= }}		{{STRUCTURE_3rwj\| PDB=3rwj \| SCENE= }}

	===Rhesus macaque MHC class I molecule Mamu-B*17-HW8===		===Rhesus macaque MHC class I molecule Mamu-B*17-HW8===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_22084443}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 22084443 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_22084443}}		{{ABSTRACT_PUBMED_22084443}}

	==About this Structure==		==About this Structure==
-	[[3rwj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RWJ OCA].	+	[[3rwj]] is a 3 chain structure of [[Beta-2 microglobulin]] and [[Major histocompatibility complex]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RWJ OCA].
		+
		+	==See Also==
		+	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]
		+	*[[Major histocompatibility complex\|Major histocompatibility complex]]

	==Reference==		==Reference==

OCA at 07:32, 21 March 2012

OCA — Wed, 21 Mar 2012 07:32:10 GMT

←Older revision		Revision as of 07:32, 21 March 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3rwj.jpg\|left\|200px]]

-	The ~~entry 3rwj~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3rwj", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3rwj\| PDB=3rwj \| SCENE= }}

-	~~Authors: Wu, Y., Gao, F., Liu, J., Qi, J.X., Price, D.A., Gao, G.F.~~	+	===Rhesus macaque MHC class I molecule Mamu-B*17-HW8===

-	~~Description~~: ~~Rhesus macaque MHC class I molecule Mamu~~-~~B*17~~-~~HW8~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22084443}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22084443 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22084443}}
		+
		+	==About this Structure==
		+	[[3rwj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RWJ OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022084443</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Macaca mulatta]]
		+	[[Category: Gao, F.]]
		+	[[Category: Gao, G F.]]
		+	[[Category: Liu, J.]]
		+	[[Category: Price, D A.]]
		+	[[Category: Qi, J X.]]
		+	[[Category: Wu, Y.]]
		+	[[Category: Antigenic peptide]]
		+	[[Category: Immune response]]
		+	[[Category: Immune system]]
		+	[[Category: T lymphocyte]]

OCA at 05:10, 25 May 2011

OCA — Wed, 25 May 2011 05:10:38 GMT

←Older revision		Revision as of 05:10, 25 May 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3rwj is ON HOLD	+	The entry 3rwj is ON HOLD until Paper Publication

-	Authors: WU, Y., ~~GAO~~, F., ~~LIU~~, J., QI, J.X., ~~PRICE~~, D.A., ~~GAO~~, G.F.	+	Authors: Wu, Y., Gao, F., Liu, J., Qi, J.X., Price, D.A., Gao, G.F.

-	Description: ~~rhesus~~ macaque MHC class I molecule Mamu-B*17-HW8	+	Description: Rhesus macaque MHC class I molecule Mamu-B*17-HW8

OCA: Protected "3rwj" [edit=sysop:move=sysop]

OCA — Wed, 18 May 2011 05:17:23 GMT

Protected "3rwj" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:17, 18 May 2011