3rwv - Revision history

OCA at 09:46, 1 March 2024

OCA — Fri, 01 Mar 2024 09:46:01 GMT

←Older revision		Revision as of 09:46, 1 March 2024
Line 3:		Line 3:
	<StructureSection load='3rwv' size='340' side='right'caption='[[3rwv]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='3rwv' size='340' side='right'caption='[[3rwv]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3rwv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RWV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RWV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3rwv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RWV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RWV FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[2evt\|2evt]], [[1swx\|1swx]], [[3rzn\|3rzn]], [[3s0i\|3s0i]], [[3s0k\|3s0k]], [[3ric\|3ric]]~~<~~/div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">GLTP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rwv OCA], [https://pdbe.org/3rwv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rwv RCSB], [https://www.ebi.ac.uk/pdbsum/3rwv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rwv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rwv OCA], [https://pdbe.org/3rwv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rwv RCSB], [https://www.ebi.ac.uk/pdbsum/3rwv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rwv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GLTP_HUMAN GLTP_HUMAN]] Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides.<ref>PMID:18261224</ref> <ref>PMID:15504043</ref> <ref>PMID:17980653</ref> <ref>PMID:15329726</ref>	+	[https://www.uniprot.org/uniprot/GLTP_HUMAN GLTP_HUMAN] Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides.<ref>PMID:18261224</ref> <ref>PMID:15504043</ref> <ref>PMID:17980653</ref> <ref>PMID:15329726</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Human glycolipid transfer protein (GLTP) fold represents a novel structural motif for lipid binding/transfer and reversible membrane translocation. GLTPs transfer glycosphingolipids (GSLs) that are key regulators of cell growth, division, surface adhesion, and neurodevelopment. Herein, we report structure-guided engineering of the lipid binding features of GLTP. New crystal structures of wild-type GLTP and two mutants (D48V and A47D \|\|D48V), each containing bound N-nervonoyl-sulfatide, reveal the molecular basis for selective anchoring of sulfatide (3-O-sulfo-galactosylceramide) by D48V-GLTP. Directed point mutations of "portal entrance" residues, A47 and D48, reversibly regulate sphingosine access to the hydrophobic pocket via a mechanism that could involve homodimerization. "Door-opening" conformational changes by phenylalanines within the hydrophobic pocket are revealed during lipid encapsulation by new crystal structures of bona fide apo-GLTP and GLTP complexed with N-oleoyl-glucosylceramide. The development of "engineered GLTPs" with enhanced specificity for select GSLs provides a potential new therapeutic approach for targeting GSL-mediated pathologies.	+
-		+
-	Enhanced selectivity for sulfatide by engineered human glycolipid transfer protein.,Samygina VR, Popov AN, Cabo-Bilbao A, Ochoa-Lizarralde B, Goni-de-Cerio F, Zhai X, Molotkovsky JG, Patel DJ, Brown RE, Malinina L Structure. 2011 Nov 9;19(11):1644-54. PMID:22078563<ref>PMID:22078563</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3rwv" style="background-color:#fffaf0;"></div~~>	+
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Brown~~, R E~~]]	+	[[Category: Brown RE]]
-	[[Category: Cabo-Bilbao, A]]	+	[[Category: Cabo-Bilbao A]]
-	[[Category: Goni-de-Cerio, F]]	+	[[Category: Goni-de-Cerio F]]
-	[[Category: Malinina, L]]	+	[[Category: Malinina L]]
-	[[Category: Ochoa-Lizarralde, B]]	+	[[Category: Ochoa-Lizarralde B]]
-	[[Category: Patel~~, D J~~]]	+	[[Category: Patel DJ]]
-	[[Category: Popov~~, A N~~]]	+	[[Category: Popov AN]]
-	[[Category: Samygina, V]]	+	[[Category: Samygina V]]
-	~~[[Category: Gltp-fold]]~~	+
-	~~[[Category: Lipid transport~~]]	+

OCA at 10:28, 22 June 2022

OCA — Wed, 22 Jun 2022 10:28:30 GMT

←Older revision		Revision as of 10:28, 22 June 2022
Line 1:		Line 1:

	==Crystal Structure of apo-form of Human Glycolipid Transfer Protein at 1.5 A resolution==		==Crystal Structure of apo-form of Human Glycolipid Transfer Protein at 1.5 A resolution==
-	<StructureSection load='3rwv' size='340' side='right' caption='[[3rwv]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='3rwv' size='340' side='right'caption='[[3rwv]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3rwv]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RWV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3RWV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3rwv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RWV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RWV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2evt\|2evt]], [[1swx\|1swx]], [[3rzn\|3rzn]], [[3s0i\|3s0i]], [[3s0k\|3s0k]], [[3ric\|3ric]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2evt\|2evt]], [[1swx\|1swx]], [[3rzn\|3rzn]], [[3s0i\|3s0i]], [[3s0k\|3s0k]], [[3ric\|3ric]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GLTP ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GLTP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3rwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rwv OCA], [~~http~~://pdbe.org/3rwv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3rwv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3rwv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3rwv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rwv OCA], [https://pdbe.org/3rwv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rwv RCSB], [https://www.ebi.ac.uk/pdbsum/3rwv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rwv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GLTP_HUMAN GLTP_HUMAN]] Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides.<ref>PMID:18261224</ref> <ref>PMID:15504043</ref> <ref>PMID:17980653</ref> <ref>PMID:15329726</ref>	+	[[https://www.uniprot.org/uniprot/GLTP_HUMAN GLTP_HUMAN]] Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides.<ref>PMID:18261224</ref> <ref>PMID:15504043</ref> <ref>PMID:17980653</ref> <ref>PMID:15329726</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Brown, R E]]		[[Category: Brown, R E]]
	[[Category: Cabo-Bilbao, A]]		[[Category: Cabo-Bilbao, A]]

OCA at 13:01, 4 August 2016

OCA — Thu, 04 Aug 2016 13:01:13 GMT

←Older revision		Revision as of 13:01, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of apo-form of Human Glycolipid Transfer Protein at 1.5 A resolution==		==Crystal Structure of apo-form of Human Glycolipid Transfer Protein at 1.5 A resolution==
	<StructureSection load='3rwv' size='340' side='right' caption='[[3rwv]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='3rwv' size='340' side='right' caption='[[3rwv]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3rwv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RWV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RWV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3rwv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RWV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RWV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2evt\|2evt]], [[1swx\|1swx]], [[3rzn\|3rzn]], [[3s0i\|3s0i]], [[3s0k\|3s0k]], [[3ric\|3ric]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2evt\|2evt]], [[1swx\|1swx]], [[3rzn\|3rzn]], [[3s0i\|3s0i]], [[3s0k\|3s0k]], [[3ric\|3ric]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GLTP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GLTP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rwv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rwv RCSB], [http://www.ebi.ac.uk/pdbsum/3rwv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rwv OCA], [http://pdbe.org/3rwv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3rwv RCSB], [http://www.ebi.ac.uk/pdbsum/3rwv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3rwv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3rwv" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Brown, R E]]		[[Category: Brown, R E]]
	[[Category: Cabo-Bilbao, A]]		[[Category: Cabo-Bilbao, A]]

OCA at 09:32, 25 December 2014

OCA — Thu, 25 Dec 2014 09:32:24 GMT

←Older revision		Revision as of 09:32, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3rwv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RWV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RWV FirstGlance]. <br>		<table><tr><td colspan='2'>[[3rwv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RWV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RWV FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2evt\|2evt]], [[1swx\|1swx]], [[3rzn\|3rzn]], [[3s0i\|3s0i]], [[3s0k\|3s0k]], [[3ric\|3ric]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2evt\|2evt]], [[1swx\|1swx]], [[3rzn\|3rzn]], [[3s0i\|3s0i]], [[3s0k\|3s0k]], [[3ric\|3ric]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GLTP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GLTP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rwv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rwv RCSB], [http://www.ebi.ac.uk/pdbsum/3rwv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rwv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rwv RCSB], [http://www.ebi.ac.uk/pdbsum/3rwv PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GLTP_HUMAN GLTP_HUMAN]] Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides.<ref>PMID:18261224</ref> <ref>PMID:15504043</ref> <ref>PMID:17980653</ref> <ref>PMID:15329726</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 16:
	Enhanced selectivity for sulfatide by engineered human glycolipid transfer protein.,Samygina VR, Popov AN, Cabo-Bilbao A, Ochoa-Lizarralde B, Goni-de-Cerio F, Zhai X, Molotkovsky JG, Patel DJ, Brown RE, Malinina L Structure. 2011 Nov 9;19(11):1644-54. PMID:22078563<ref>PMID:22078563</ref>		Enhanced selectivity for sulfatide by engineered human glycolipid transfer protein.,Samygina VR, Popov AN, Cabo-Bilbao A, Ochoa-Lizarralde B, Goni-de-Cerio F, Zhai X, Molotkovsky JG, Patel DJ, Brown RE, Malinina L Structure. 2011 Nov 9;19(11):1644-54. PMID:22078563<ref>PMID:22078563</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 21:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Brown, R E.]]	+	[[Category: Brown, R E]]
-	[[Category: Cabo-Bilbao, A.]]	+	[[Category: Cabo-Bilbao, A]]
-	[[Category: Goni-de-Cerio, F.]]	+	[[Category: Goni-de-Cerio, F]]
-	[[Category: Malinina, L.]]	+	[[Category: Malinina, L]]
-	[[Category: Ochoa-Lizarralde, B.]]	+	[[Category: Ochoa-Lizarralde, B]]
-	[[Category: Patel, D J.]]	+	[[Category: Patel, D J]]
-	[[Category: Popov, A N.]]	+	[[Category: Popov, A N]]
-	[[Category: Samygina, V.]]	+	[[Category: Samygina, V]]
	[[Category: Gltp-fold]]		[[Category: Gltp-fold]]
	[[Category: Lipid transport]]		[[Category: Lipid transport]]

OCA at 04:49, 5 June 2014

OCA — Thu, 05 Jun 2014 04:49:27 GMT

←Older revision		Revision as of 04:49, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3rwv.~~jpg~~\|~~left~~\|~~200px~~]]	+	==Crystal Structure of apo-form of Human Glycolipid Transfer Protein at 1.5 A resolution==
		+	<StructureSection load='3rwv' size='340' side='right' caption='[[3rwv]], [[Resolution\|resolution]] 1.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3rwv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RWV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RWV FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2evt\|2evt]], [[1swx\|1swx]], [[3rzn\|3rzn]], [[3s0i\|3s0i]], [[3s0k\|3s0k]], [[3ric\|3ric]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GLTP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rwv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rwv RCSB], [http://www.ebi.ac.uk/pdbsum/3rwv PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human glycolipid transfer protein (GLTP) fold represents a novel structural motif for lipid binding/transfer and reversible membrane translocation. GLTPs transfer glycosphingolipids (GSLs) that are key regulators of cell growth, division, surface adhesion, and neurodevelopment. Herein, we report structure-guided engineering of the lipid binding features of GLTP. New crystal structures of wild-type GLTP and two mutants (D48V and A47D \|\|D48V), each containing bound N-nervonoyl-sulfatide, reveal the molecular basis for selective anchoring of sulfatide (3-O-sulfo-galactosylceramide) by D48V-GLTP. Directed point mutations of "portal entrance" residues, A47 and D48, reversibly regulate sphingosine access to the hydrophobic pocket via a mechanism that could involve homodimerization. "Door-opening" conformational changes by phenylalanines within the hydrophobic pocket are revealed during lipid encapsulation by new crystal structures of bona fide apo-GLTP and GLTP complexed with N-oleoyl-glucosylceramide. The development of "engineered GLTPs" with enhanced specificity for select GSLs provides a potential new therapeutic approach for targeting GSL-mediated pathologies.

-	<!--	+	Enhanced selectivity for sulfatide by engineered human glycolipid transfer protein.,Samygina VR, Popov AN, Cabo-Bilbao A, Ochoa-Lizarralde B, Goni-de-Cerio F, Zhai X, Molotkovsky JG, Patel DJ, Brown RE, Malinina L Structure. 2011 Nov 9;19(11):1644-54. PMID:22078563<ref>PMID:22078563</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3rwv"~~, ~~creates the "~~Structure ~~Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_3rwv\| PDB=3rwv \| SCENE= }}~~	+

-	~~===Crystal Structure~~ of ~~apo-form of Human Glycolipid Transfer Protein at 1.5 A resolution===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_22078563}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22078563 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_22078563}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3rwv]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RWV OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022078563<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Brown, R E.]]		[[Category: Brown, R E.]]

OCA at 06:26, 8 February 2012

OCA — Wed, 08 Feb 2012 06:26:34 GMT

←Older revision		Revision as of 06:26, 8 February 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3rwv.jpg\|left\|200px]]

-	The ~~entry 3rwv~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3rwv", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3rwv\| PDB=3rwv \| SCENE= }}

-	~~Authors: Samygina, V., Cabo~~-~~Bilbao, A~~.~~, Popov,~~ A~~.N., Ochoa-Lizarralde, B., Goni-de-Cerio, F., Patel, D.J., Brown, R.E., Malinina, L.~~	+	===Crystal Structure of apo-form of Human Glycolipid Transfer Protein at 1.5 A resolution===

-	~~Description~~: ~~Crystal~~ Structure ~~of apo~~-~~form of Human Glycolipid Transfer Protein at 1~~.5 A ~~resolution~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22078563}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22078563 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22078563}}
		+
		+	==About this Structure==
		+	[[3rwv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RWV OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022078563</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Brown, R E.]]
		+	[[Category: Cabo-Bilbao, A.]]
		+	[[Category: Goni-de-Cerio, F.]]
		+	[[Category: Malinina, L.]]
		+	[[Category: Ochoa-Lizarralde, B.]]
		+	[[Category: Patel, D J.]]
		+	[[Category: Popov, A N.]]
		+	[[Category: Samygina, V.]]
		+	[[Category: Gltp-fold]]
		+	[[Category: Lipid transport]]

OCA at 05:24, 1 June 2011

OCA — Wed, 01 Jun 2011 05:24:29 GMT

←Older revision		Revision as of 05:24, 1 June 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3rwv is ON HOLD	+	The entry 3rwv is ON HOLD until Paper Publication

	Authors: Samygina, V., Cabo-Bilbao, A., Popov, A.N., Ochoa-Lizarralde, B., Goni-de-Cerio, F., Patel, D.J., Brown, R.E., Malinina, L.		Authors: Samygina, V., Cabo-Bilbao, A., Popov, A.N., Ochoa-Lizarralde, B., Goni-de-Cerio, F., Patel, D.J., Brown, R.E., Malinina, L.

	Description: Crystal Structure of apo-form of Human Glycolipid Transfer Protein at 1.5 A resolution		Description: Crystal Structure of apo-form of Human Glycolipid Transfer Protein at 1.5 A resolution

OCA: Protected "3rwv" [edit=sysop:move=sysop]

OCA — Wed, 18 May 2011 05:17:43 GMT

Protected "3rwv" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:17, 18 May 2011

OCA: New page: '''Unreleased structure''' The entry 3rwv is ON HOLD Authors: Samygina, V., Cabo-Bilbao, A., Popov, A.N., Ochoa-Lizarralde, B., Goni-de-Cerio, F., Patel, D.J., Brown, R.E., Malinina, L....

OCA — Wed, 18 May 2011 05:17:42 GMT

New page: '''Unreleased structure''' The entry 3rwv is ON HOLD Authors: Samygina, V., Cabo-Bilbao, A., Popov, A.N., Ochoa-Lizarralde, B., Goni-de-Cerio, F., Patel, D.J., Brown, R.E., Malinina, L....

New page

'''Unreleased structure'''

The entry 3rwv is ON HOLD

Authors: Samygina, V., Cabo-Bilbao, A., Popov, A.N., Ochoa-Lizarralde, B., Goni-de-Cerio, F., Patel, D.J., Brown, R.E., Malinina, L.

Description: Crystal Structure of apo-form of Human Glycolipid Transfer Protein at 1.5 A resolution