3s3y - Revision history

OCA at 12:46, 14 March 2024

OCA — Thu, 14 Mar 2024 12:46:03 GMT

←Older revision		Revision as of 12:46, 14 March 2024
Line 3:		Line 3:
	<StructureSection load='3s3y' size='340' side='right'caption='[[3s3y]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3s3y' size='340' side='right'caption='[[3s3y]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3s3y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Anabaena_variabilis_var._ellipsospora Anabaena variabilis var. ellipsospora~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S3Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3s3y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Nostoc_ellipsosporum Nostoc ellipsosporum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S3Y FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[3s3z\|3s3z]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s3y OCA], [https://pdbe.org/3s3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s3y RCSB], [https://www.ebi.ac.uk/pdbsum/3s3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s3y ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s3y OCA], [https://pdbe.org/3s3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s3y RCSB], [https://www.ebi.ac.uk/pdbsum/3s3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s3y ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CVN_NOSEL CVN_NOSEL]] Mannose-binding lectin.<ref>PMID:9210678</ref> <ref>PMID:12678493</ref>	+	[https://www.uniprot.org/uniprot/CVN_NOSEL CVN_NOSEL] Mannose-binding lectin.<ref>PMID:9210678</ref> <ref>PMID:12678493</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Cyanovirin-N (CV-N) is a small, cyanobacterial lectin that neutralizes many enveloped viruses, including human immunodeficiency virus type I (HIV-1). This antiviral activity is attributed to two homologous carbohydrate binding sites that specifically bind high mannose glycosylation present on envelope glycoproteins such as HIV-1 gp120. We created obligate CV-N oligomers to determine whether increasing the number of binding sites has an effect on viral neutralization. A tandem repeat of two CV-N molecules (CVN(2)) increased HIV-1 neutralization activity by up to 18-fold compared to wild-type CV-N. In addition, the CVN(2) variants showed extensive cross-clade reactivity and were often more potent than broadly neutralizing anti-HIV antibodies. The improvement in activity and broad cross-strain HIV neutralization exhibited by these molecules holds promise for the future therapeutic utility of these and other engineered CV-N variants.	+
-		+
-	Designed oligomers of cyanovirin-N show enhanced HIV neutralization.,Keeffe JR, Gnanapragasam PN, Gillespie SK, Yong J, Bjorkman PJ, Mayo SL Proc Natl Acad Sci U S A. 2011 Jul 28. PMID:21799112<ref>PMID:21799112</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3s3y" style="background-color:#fffaf0;"></div~~>	+
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Anabaena variabilis var. ellipsospora]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Bjorkman, P J~~]]	+	[[Category: Nostoc ellipsosporum]]
-	[[Category: ~~Keeffe, J R~~]]	+	[[Category: Bjorkman PJ]]
-	[[Category: ~~Mayo, S L~~]]	+	[[Category: Keeffe JR]]
-	[[Category: ~~Antiviral protein]]~~	+	[[Category: Mayo SL]]
-	~~[[Category: Cyanovirin-n]]~~	+
-	~~[[Category: Engineered dimer]]~~	+
-	~~[[Category: Gp120]]~~	+
-	~~[[Category: Sugar-binding~~]]	+

OCA at 10:37, 22 June 2022

OCA — Wed, 22 Jun 2022 10:37:16 GMT

←Older revision		Revision as of 10:37, 22 June 2022
Line 3:		Line 3:
	<StructureSection load='3s3y' size='340' side='right'caption='[[3s3y]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3s3y' size='340' side='right'caption='[[3s3y]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3s3y]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Anabaena_variabilis_var._ellipsospora Anabaena variabilis var. ellipsospora]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S3Y OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3S3Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3s3y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Anabaena_variabilis_var._ellipsospora Anabaena variabilis var. ellipsospora]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S3Y FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3s3z\|3s3z]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3s3z\|3s3z]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3s3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s3y OCA], [~~http~~://pdbe.org/3s3y PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3s3y RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3s3y PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3s3y ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s3y OCA], [https://pdbe.org/3s3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s3y RCSB], [https://www.ebi.ac.uk/pdbsum/3s3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s3y ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CVN_NOSEL CVN_NOSEL]] Mannose-binding lectin.<ref>PMID:9210678</ref> <ref>PMID:12678493</ref>	+	[[https://www.uniprot.org/uniprot/CVN_NOSEL CVN_NOSEL]] Mannose-binding lectin.<ref>PMID:9210678</ref> <ref>PMID:12678493</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 16:28, 28 August 2019

OCA — Wed, 28 Aug 2019 16:28:50 GMT

←Older revision		Revision as of 16:28, 28 August 2019
Line 1:		Line 1:

	==Crystal Structure an Tandem Cyanovirin-N Dimer, CVN2L0==		==Crystal Structure an Tandem Cyanovirin-N Dimer, CVN2L0==
-	<StructureSection load='3s3y' size='340' side='right' caption='[[3s3y]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='3s3y' size='340' side='right'caption='[[3s3y]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3s3y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Anabaena_variabilis_var._ellipsospora Anabaena variabilis var. ellipsospora]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S3Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S3Y FirstGlance]. <br>		<table><tr><td colspan='2'>[[3s3y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Anabaena_variabilis_var._ellipsospora Anabaena variabilis var. ellipsospora]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S3Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S3Y FirstGlance]. <br>
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Anabaena variabilis var. ellipsospora]]		[[Category: Anabaena variabilis var. ellipsospora]]
		+	[[Category: Large Structures]]
	[[Category: Bjorkman, P J]]		[[Category: Bjorkman, P J]]
	[[Category: Keeffe, J R]]		[[Category: Keeffe, J R]]

OCA at 13:43, 4 August 2016

OCA — Thu, 04 Aug 2016 13:43:44 GMT

←Older revision		Revision as of 13:43, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure an Tandem Cyanovirin-N Dimer, CVN2L0==		==Crystal Structure an Tandem Cyanovirin-N Dimer, CVN2L0==
	<StructureSection load='3s3y' size='340' side='right' caption='[[3s3y]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3s3y' size='340' side='right' caption='[[3s3y]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3s3y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Nostoc_ellipsosporum Nostoc ellipsosporum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S3Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S3Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3s3y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Anabaena_variabilis_var._ellipsospora Anabaena variabilis var. ellipsospora]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S3Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S3Y FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3s3z\|3s3z]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3s3z\|3s3z]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s3y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3s3y RCSB], [http://www.ebi.ac.uk/pdbsum/3s3y PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s3y OCA], [http://pdbe.org/3s3y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3s3y RCSB], [http://www.ebi.ac.uk/pdbsum/3s3y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3s3y ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3s3y" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Nostoc ellipsosporum~~]]	+	[[Category: Anabaena variabilis var. ellipsospora]]
	[[Category: Bjorkman, P J]]		[[Category: Bjorkman, P J]]
	[[Category: Keeffe, J R]]		[[Category: Keeffe, J R]]

OCA at 09:50, 25 December 2014

OCA — Thu, 25 Dec 2014 09:50:13 GMT

←Older revision		Revision as of 09:50, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3s3y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Nostoc_ellipsosporum Nostoc ellipsosporum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S3Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S3Y FirstGlance]. <br>		<table><tr><td colspan='2'>[[3s3y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Nostoc_ellipsosporum Nostoc ellipsosporum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S3Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S3Y FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3s3z\|3s3z]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3s3z\|3s3z]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s3y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3s3y RCSB], [http://www.ebi.ac.uk/pdbsum/3s3y PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s3y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3s3y RCSB], [http://www.ebi.ac.uk/pdbsum/3s3y PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CVN_NOSEL CVN_NOSEL]] Mannose-binding lectin.<ref>PMID:9210678</ref> <ref>PMID:12678493</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 13:		Line 15:
	Designed oligomers of cyanovirin-N show enhanced HIV neutralization.,Keeffe JR, Gnanapragasam PN, Gillespie SK, Yong J, Bjorkman PJ, Mayo SL Proc Natl Acad Sci U S A. 2011 Jul 28. PMID:21799112<ref>PMID:21799112</ref>		Designed oligomers of cyanovirin-N show enhanced HIV neutralization.,Keeffe JR, Gnanapragasam PN, Gillespie SK, Yong J, Bjorkman PJ, Mayo SL Proc Natl Acad Sci U S A. 2011 Jul 28. PMID:21799112<ref>PMID:21799112</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 20:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Nostoc ellipsosporum]]		[[Category: Nostoc ellipsosporum]]
-	[[Category: Bjorkman, P J.]]	+	[[Category: Bjorkman, P J]]
-	[[Category: Keeffe, J R.]]	+	[[Category: Keeffe, J R]]
-	[[Category: Mayo, S L.]]	+	[[Category: Mayo, S L]]
	[[Category: Antiviral protein]]		[[Category: Antiviral protein]]
	[[Category: Cyanovirin-n]]		[[Category: Cyanovirin-n]]

OCA at 05:26, 5 June 2014

OCA — Thu, 05 Jun 2014 05:26:20 GMT

←Older revision		Revision as of 05:26, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3s3y.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal Structure an Tandem Cyanovirin-N Dimer, CVN2L0==
		+	<StructureSection load='3s3y' size='340' side='right' caption='[[3s3y]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3s3y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Nostoc_ellipsosporum Nostoc ellipsosporum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S3Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S3Y FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3s3z\|3s3z]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s3y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3s3y RCSB], [http://www.ebi.ac.uk/pdbsum/3s3y PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cyanovirin-N (CV-N) is a small, cyanobacterial lectin that neutralizes many enveloped viruses, including human immunodeficiency virus type I (HIV-1). This antiviral activity is attributed to two homologous carbohydrate binding sites that specifically bind high mannose glycosylation present on envelope glycoproteins such as HIV-1 gp120. We created obligate CV-N oligomers to determine whether increasing the number of binding sites has an effect on viral neutralization. A tandem repeat of two CV-N molecules (CVN(2)) increased HIV-1 neutralization activity by up to 18-fold compared to wild-type CV-N. In addition, the CVN(2) variants showed extensive cross-clade reactivity and were often more potent than broadly neutralizing anti-HIV antibodies. The improvement in activity and broad cross-strain HIV neutralization exhibited by these molecules holds promise for the future therapeutic utility of these and other engineered CV-N variants.

-	<!--	+	Designed oligomers of cyanovirin-N show enhanced HIV neutralization.,Keeffe JR, Gnanapragasam PN, Gillespie SK, Yong J, Bjorkman PJ, Mayo SL Proc Natl Acad Sci U S A. 2011 Jul 28. PMID:21799112<ref>PMID:21799112</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3s3y"~~, ~~creates the "Structure Box" on the page.~~	+
-	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded)~~,	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_3s3y\| PDB=3s3y \| SCENE= }}~~	+

-	~~===Crystal Structure an Tandem Cyanovirin-N Dimer~~, ~~CVN2L0===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21799112}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21799112 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_21799112}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3s3y]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Nostoc_ellipsosporum Nostoc ellipsosporum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S3Y OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021799112<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Nostoc ellipsosporum]]		[[Category: Nostoc ellipsosporum]]
	[[Category: Bjorkman, P J.]]		[[Category: Bjorkman, P J.]]

OCA at 05:07, 10 August 2011

OCA — Wed, 10 Aug 2011 05:07:00 GMT

←Older revision		Revision as of 05:07, 10 August 2011
Line 1:		Line 1:
-	[[Image:3s3y.~~jpg~~\|left\|200px]]	+	[[Image:3s3y.png\|left\|200px]]

	<!--		<!--
Line 11:		Line 11:
	===Crystal Structure an Tandem Cyanovirin-N Dimer, CVN2L0===		===Crystal Structure an Tandem Cyanovirin-N Dimer, CVN2L0===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21799112}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21799112 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21799112}}

	==About this Structure==		==About this Structure==
	[[3s3y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Nostoc_ellipsosporum Nostoc ellipsosporum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S3Y OCA].		[[3s3y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Nostoc_ellipsosporum Nostoc ellipsosporum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S3Y OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021799112</ref><references group="xtra"/>
	[[Category: Nostoc ellipsosporum]]		[[Category: Nostoc ellipsosporum]]
	[[Category: Bjorkman, P J.]]		[[Category: Bjorkman, P J.]]

OCA at 09:01, 3 August 2011

OCA — Wed, 03 Aug 2011 09:01:17 GMT

←Older revision		Revision as of 09:01, 3 August 2011
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-	~~'''Unreleased structure'''~~	+	[[Image:3s3y.jpg\|left\|200px]]

-	The ~~entry 3s3y~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3s3y", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3s3y\| PDB=3s3y \| SCENE= }}

-	~~Authors: Keeffe~~, ~~J.R., Bjorkman, P.J., Mayo, S.L.~~	+	===Crystal Structure an Tandem Cyanovirin-N Dimer, CVN2L0===

-	~~Description: Crystal~~ Structure ~~an Tandem Cyanovirin~~-~~N Dimer~~, ~~CVN2L0~~	+
		+	==About this Structure==
		+	[[3s3y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Nostoc_ellipsosporum Nostoc ellipsosporum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S3Y OCA].
		+	[[Category: Nostoc ellipsosporum]]
		+	[[Category: Bjorkman, P J.]]
		+	[[Category: Keeffe, J R.]]
		+	[[Category: Mayo, S L.]]
		+	[[Category: Antiviral protein]]
		+	[[Category: Cyanovirin-n]]
		+	[[Category: Engineered dimer]]
		+	[[Category: Gp120]]
		+	[[Category: Sugar-binding]]

OCA: Protected "3s3y" [edit=sysop:move=sysop]

OCA — Wed, 25 May 2011 05:16:09 GMT

Protected "3s3y" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:16, 25 May 2011

OCA: New page: '''Unreleased structure''' The entry 3s3y is ON HOLD Authors: Keeffe, J.R., Bjorkman, P.J., Mayo, S.L. Description: Crystal Structure an Tandem Cyanovirin-N Dimer, CVN2L0

OCA — Wed, 25 May 2011 05:16:08 GMT

New page: '''Unreleased structure''' The entry 3s3y is ON HOLD Authors: Keeffe, J.R., Bjorkman, P.J., Mayo, S.L. Description: Crystal Structure an Tandem Cyanovirin-N Dimer, CVN2L0

New page

'''Unreleased structure'''

The entry 3s3y is ON HOLD

Authors: Keeffe, J.R., Bjorkman, P.J., Mayo, S.L.

Description: Crystal Structure an Tandem Cyanovirin-N Dimer, CVN2L0