3s5i - Revision history

OCA at 12:47, 14 March 2024

OCA — Thu, 14 Mar 2024 12:47:26 GMT

←Older revision		Revision as of 12:47, 14 March 2024
Line 3:		Line 3:
	<StructureSection load='3s5i' size='340' side='right'caption='[[3s5i]], [[Resolution\|resolution]] 1.74Å' scene=''>		<StructureSection load='3s5i' size='340' side='right'caption='[[3s5i]], [[Resolution\|resolution]] 1.74Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3s5i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Plafx Plafx~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S5I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S5I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3s5i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_HB3 Plasmodium falciparum HB3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S5I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S5I FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3s5h\|3s5h]], [[3s5k\|3s5k]], [[3s5m\|3s5m]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.743Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">flN, PF13_0322 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=137071 PLAFX])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s5i OCA], [https://pdbe.org/3s5i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s5i RCSB], [https://www.ebi.ac.uk/pdbsum/3s5i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s5i ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s5i OCA], [https://pdbe.org/3s5i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s5i RCSB], [https://www.ebi.ac.uk/pdbsum/3s5i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s5i ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/FCLN_PLAF7 FCLN_PLAF7] In the food vacuole, acts downstream of proteases plasmepsins PMI and PMII and falcipains during the catabolism of host hemoglobin by cleaving peptide fragments of alpha and beta hemoglobin subunits generated by PMI and PMII and falcipains (PubMed:17074076). In the apicoplast, degrades apicoplast transit peptides after their cleavage (PubMed:17074076). Prefers bulky hydrophobic amino acids in the P1' position at both acidic and neutral pH (By similarity). At P2', prefers hydrophobic residues at acidic pH; at neutral pH, these same residues are abundant but prefers Arg (By similarity). At P3', prefers hydrophobic residues, especially Met, at both pH conditions. At P4' and P5', prefers acidic residues at acidic pH, however, at neutral pH, the enzyme is less selective at these positions (By similarity). The optimal site cleavage at acidic pH is YNEHS-\|-FFMEE and, at neutral pH, MKRHS-\|-FRMRG (By similarity).[UniProtKB:A0A0L7KF24]<ref>PMID:17074076</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Plafx~~]]	+	[[Category: Plasmodium falciparum HB3]]
-	[[Category: Eneqvist, T]]	+	[[Category: Eneqvist T]]
-	[[Category: Goldberg, D]]	+	[[Category: Goldberg D]]
-	[[Category: Istvan, E]]	+	[[Category: Istvan E]]
-	[[Category: Morgunova, E]]	+	[[Category: Morgunova E]]
-	[[Category: Ponpuak, M]]	+	[[Category: Ponpuak M]]
-	[[Category: Popov, A]]	+	[[Category: Popov A]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: M16 metalloprotease]]~~	+
-	~~[[Category: Peptidase~~]]	+

OCA at 10:39, 22 June 2022

OCA — Wed, 22 Jun 2022 10:39:02 GMT

←Older revision		Revision as of 10:39, 22 June 2022
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	==Crystal structures of falcilysin, a M16 metalloprotease from the malaria parasite Plasmodium falciparum==		==Crystal structures of falcilysin, a M16 metalloprotease from the malaria parasite Plasmodium falciparum==
-	<StructureSection load='3s5i' size='340' side='right' caption='[[3s5i]], [[Resolution\|resolution]] 1.74Å' scene=''>	+	<StructureSection load='3s5i' size='340' side='right'caption='[[3s5i]], [[Resolution\|resolution]] 1.74Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3s5i]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Plafx Plafx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S5I OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3S5I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3s5i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plafx Plafx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S5I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S5I FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3s5h\|3s5h]], [[3s5k\|3s5k]], [[3s5m\|3s5m]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3s5h\|3s5h]], [[3s5k\|3s5k]], [[3s5m\|3s5m]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">flN, PF13_0322 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=137071 PLAFX])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">flN, PF13_0322 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=137071 PLAFX])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3s5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s5i OCA], [~~http~~://pdbe.org/3s5i PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3s5i RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3s5i PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3s5i ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s5i OCA], [https://pdbe.org/3s5i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s5i RCSB], [https://www.ebi.ac.uk/pdbsum/3s5i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s5i ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Plafx]]		[[Category: Plafx]]
	[[Category: Eneqvist, T]]		[[Category: Eneqvist, T]]

OCA at 08:22, 11 August 2016

OCA — Thu, 11 Aug 2016 08:22:56 GMT

←Older revision		Revision as of 08:22, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structures of falcilysin, a M16 metalloprotease from the malaria parasite Plasmodium falciparum==		==Crystal structures of falcilysin, a M16 metalloprotease from the malaria parasite Plasmodium falciparum==
	<StructureSection load='3s5i' size='340' side='right' caption='[[3s5i]], [[Resolution\|resolution]] 1.74Å' scene=''>		<StructureSection load='3s5i' size='340' side='right' caption='[[3s5i]], [[Resolution\|resolution]] 1.74Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3s5i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Plasmodium_falciparum Plasmodium falciparum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S5I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3s5i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafx Plafx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S5I FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3s5h\|3s5h]], [[3s5k\|3s5k]], [[3s5m\|3s5m]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3s5h\|3s5h]], [[3s5k\|3s5k]], [[3s5m\|3s5m]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">flN, PF13_0322 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~5833 Plasmodium falciparum~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">flN, PF13_0322 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=137071 PLAFX])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s5i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3s5i RCSB], [http://www.ebi.ac.uk/pdbsum/3s5i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s5i OCA], [http://pdbe.org/3s5i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3s5i RCSB], [http://www.ebi.ac.uk/pdbsum/3s5i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3s5i ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Plasmodium falciparum~~]]	+	[[Category: Plafx]]
	[[Category: Eneqvist, T]]		[[Category: Eneqvist, T]]
	[[Category: Goldberg, D]]		[[Category: Goldberg, D]]

OCA at 10:31, 4 January 2015

OCA — Sun, 04 Jan 2015 10:31:39 GMT

←Older revision		Revision as of 10:31, 4 January 2015
Line 1:		Line 1:
-	~~[[Image:3s5i.jpg\|left\|200px]]~~	+	==Crystal structures of falcilysin, a M16 metalloprotease from the malaria parasite Plasmodium falciparum==
-		+	<StructureSection load='3s5i' size='340' side='right' caption='[[3s5i]], [[Resolution\|resolution]] 1.74Å' scene=''>
-	~~<!--~~	+	== Structural highlights ==
-	~~The line below this paragraph, containing "STRUCTURE_3s5i", creates the "Structure Box" on the page.~~	+	<table><tr><td colspan='2'>[[3s5i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S5I FirstGlance]. <br>
-	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3s5h\|3s5h]], [[3s5k\|3s5k]], [[3s5m\|3s5m]]</td></tr>
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">flN, PF13_0322 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 Plasmodium falciparum])</td></tr>
-	~~or leave the SCENE parameter empty for the default display.~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s5i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3s5i RCSB], [http://www.ebi.ac.uk/pdbsum/3s5i PDBsum]</span></td></tr>
-	~~-->~~	+	</table>
-	~~{{STRUCTURE_3s5i\| PDB=3s5i \| SCENE= }}~~	+	__TOC__
-		+	</StructureSection>
-	===Crystal structures of falcilysin, a M16 metalloprotease from the malaria parasite Plasmodium falciparum===	+
-		+
-		+
-	==~~About this Structure~~==	+
-	[[3s5i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S5I OCA].	+
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
-	[[Category: Eneqvist, T.]]	+	[[Category: Eneqvist, T]]
-	[[Category: Goldberg, D.]]	+	[[Category: Goldberg, D]]
-	[[Category: Istvan, E.]]	+	[[Category: Istvan, E]]
-	[[Category: Morgunova, E.]]	+	[[Category: Morgunova, E]]
-	[[Category: Ponpuak, M.]]	+	[[Category: Ponpuak, M]]
-	[[Category: Popov, A.]]	+	[[Category: Popov, A]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: M16 metalloprotease]]		[[Category: M16 metalloprotease]]
	[[Category: Peptidase]]		[[Category: Peptidase]]

OCA at 06:11, 23 May 2012

OCA — Wed, 23 May 2012 06:11:20 GMT

←Older revision		Revision as of 06:11, 23 May 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3s5i.jpg\|left\|200px]]

-	The ~~entry 3s5i~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3s5i", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3s5i\| PDB=3s5i \| SCENE= }}

-	~~Authors: Morgunova~~, ~~E., Ponpuak, M., Istvan, E., Popov, A., Goldberg, D., Eneqvist, T.~~	+	===Crystal structures of falcilysin, a M16 metalloprotease from the malaria parasite Plasmodium falciparum===

-	~~Description: Crystal structures of falcilysin,~~ a ~~M16 metalloprotease~~ from ~~the malaria parasite~~ Plasmodium falciparum	+
		+	==About this Structure==
		+	[[3s5i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S5I OCA].
		+	[[Category: Plasmodium falciparum]]
		+	[[Category: Eneqvist, T.]]
		+	[[Category: Goldberg, D.]]
		+	[[Category: Istvan, E.]]
		+	[[Category: Morgunova, E.]]
		+	[[Category: Ponpuak, M.]]
		+	[[Category: Popov, A.]]
		+	[[Category: Hydrolase]]
		+	[[Category: M16 metalloprotease]]
		+	[[Category: Peptidase]]

OCA at 05:36, 27 July 2011

OCA — Wed, 27 Jul 2011 05:36:57 GMT

←Older revision		Revision as of 05:36, 27 July 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3s5i is ON HOLD until ~~sometime in the future~~	+	The entry 3s5i is ON HOLD until Paper Publication

	Authors: Morgunova, E., Ponpuak, M., Istvan, E., Popov, A., Goldberg, D., Eneqvist, T.		Authors: Morgunova, E., Ponpuak, M., Istvan, E., Popov, A., Goldberg, D., Eneqvist, T.

	Description: Crystal structures of falcilysin, a M16 metalloprotease from the malaria parasite Plasmodium falciparum		Description: Crystal structures of falcilysin, a M16 metalloprotease from the malaria parasite Plasmodium falciparum

OCA at 06:49, 13 July 2011

OCA — Wed, 13 Jul 2011 06:49:13 GMT

←Older revision		Revision as of 06:49, 13 July 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3s5i is ON HOLD	+	The entry 3s5i is ON HOLD until sometime in the future

	Authors: Morgunova, E., Ponpuak, M., Istvan, E., Popov, A., Goldberg, D., Eneqvist, T.		Authors: Morgunova, E., Ponpuak, M., Istvan, E., Popov, A., Goldberg, D., Eneqvist, T.

	Description: Crystal structures of falcilysin, a M16 metalloprotease from the malaria parasite Plasmodium falciparum		Description: Crystal structures of falcilysin, a M16 metalloprotease from the malaria parasite Plasmodium falciparum

OCA: Protected "3s5i" [edit=sysop:move=sysop]

OCA — Wed, 01 Jun 2011 05:27:03 GMT

Protected "3s5i" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:27, 1 June 2011

OCA: New page: '''Unreleased structure''' The entry 3s5i is ON HOLD Authors: Morgunova, E., Ponpuak, M., Istvan, E., Popov, A., Goldberg, D., Eneqvist, T. Description: Crystal structures of falcilysi...

OCA — Wed, 01 Jun 2011 05:27:01 GMT

New page: '''Unreleased structure''' The entry 3s5i is ON HOLD Authors: Morgunova, E., Ponpuak, M., Istvan, E., Popov, A., Goldberg, D., Eneqvist, T. Description: Crystal structures of falcilysi...

New page

'''Unreleased structure'''

The entry 3s5i is ON HOLD

Authors: Morgunova, E., Ponpuak, M., Istvan, E., Popov, A., Goldberg, D., Eneqvist, T.

Description: Crystal structures of falcilysin, a M16 metalloprotease from the malaria parasite Plasmodium falciparum