3s7j - Revision history

OCA at 09:48, 1 March 2024

OCA — Fri, 01 Mar 2024 09:48:11 GMT

←Older revision		Revision as of 09:48, 1 March 2024
Line 3:		Line 3:
	<StructureSection load='3s7j' size='340' side='right'caption='[[3s7j]], [[Resolution\|resolution]] 3.04Å' scene=''>		<StructureSection load='3s7j' size='340' side='right'caption='[[3s7j]], [[Resolution\|resolution]] 3.04Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3s7j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S7J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S7J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3s7j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S7J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S7J FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SAM:S~~-~~ADENOSYLMETHIONINE'>SAM</scene>~~, ~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.04Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[3s7b\|3s7b]], [[3s7d\|3s7d]], [[3s7f\|3s7f]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">SMYD2, KMT3C ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s7j OCA], [https://pdbe.org/3s7j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s7j RCSB], [https://www.ebi.ac.uk/pdbsum/3s7j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s7j ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s7j OCA], [https://pdbe.org/3s7j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s7j RCSB], [https://www.ebi.ac.uk/pdbsum/3s7j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s7j ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SMYD2_HUMAN SMYD2_HUMAN]] Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates 'Lys-860' of RB1/RB.<ref>PMID:17108971</ref> <ref>PMID:17805299</ref> <ref>PMID:18065756</ref> <ref>PMID:20870719</ref>	+	[https://www.uniprot.org/uniprot/SMYD2_HUMAN SMYD2_HUMAN] Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates 'Lys-860' of RB1/RB.<ref>PMID:17108971</ref> <ref>PMID:17805299</ref> <ref>PMID:18065756</ref> <ref>PMID:20870719</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Protein lysine methyltransferases are important regulators of epigenetic signaling. These enzymes catalyze the transfer of donor methyl groups from S-adenosylmethionine to specific acceptor lysines on histones, leading to changes in chromatin structure and transcriptional regulation. These enzymes also methylate nonhistone protein substrates, revealing an additional mechanism to regulate cellular physiology. The oncogenic protein SMYD2 represses the functional activities of the tumor suppressor proteins p53 and Rb, making it an attractive drug target. Here we report the discovery of AZ505, a potent and selective inhibitor of SMYD2 that was identified from a high throughput chemical screen. We also present the crystal structures of SMYD2 with p53 substrate and product peptides, and notably, in complex with AZ505. This substrate competitive inhibitor is bound in the peptide binding groove of SMYD2. These results have implications for the development of SMYD2 inhibitors, and indicate the potential for developing novel therapies targeting this target class.	+
-		+
-	Structural Basis of Substrate Methylation and Inhibition of SMYD2.,Ferguson AD, Larsen NA, Howard T, Pollard H, Green I, Grande C, Cheung T, Garcia-Arenas R, Cowen S, Wu J, Godin R, Chen H, Keen N Structure. 2011 Jul 20. PMID:21782458<ref>PMID:21782458</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3s7j" style="background-color:#fffaf0;"></div~~>	+

	==See Also==		==See Also==
Line 27:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ferguson~~, A D]]~~	+	[[Category: Ferguson AD]]
-	~~[[Category: Methyltransferase]]~~	+
-	~~[[Category: P53]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 10:41, 22 June 2022

OCA — Wed, 22 Jun 2022 10:41:21 GMT

←Older revision		Revision as of 10:41, 22 June 2022
Line 1:		Line 1:

	==Structural Basis of Substrate Methylation and Inhibition of SMYD2==		==Structural Basis of Substrate Methylation and Inhibition of SMYD2==
-	<StructureSection load='3s7j' size='340' side='right' caption='[[3s7j]], [[Resolution\|resolution]] 3.04Å' scene=''>	+	<StructureSection load='3s7j' size='340' side='right'caption='[[3s7j]], [[Resolution\|resolution]] 3.04Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3s7j]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S7J OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3S7J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3s7j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S7J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S7J FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3s7b\|3s7b]], [[3s7d\|3s7d]], [[3s7f\|3s7f]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3s7b\|3s7b]], [[3s7d\|3s7d]], [[3s7f\|3s7f]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SMYD2, KMT3C ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SMYD2, KMT3C ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3s7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s7j OCA], [~~http~~://pdbe.org/3s7j PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3s7j RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3s7j PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3s7j ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s7j OCA], [https://pdbe.org/3s7j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s7j RCSB], [https://www.ebi.ac.uk/pdbsum/3s7j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s7j ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SMYD2_HUMAN SMYD2_HUMAN]] Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates 'Lys-860' of RB1/RB.<ref>PMID:17108971</ref> <ref>PMID:17805299</ref> <ref>PMID:18065756</ref> <ref>PMID:20870719</ref>	+	[[https://www.uniprot.org/uniprot/SMYD2_HUMAN SMYD2_HUMAN]] Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates 'Lys-860' of RB1/RB.<ref>PMID:17108971</ref> <ref>PMID:17805299</ref> <ref>PMID:18065756</ref> <ref>PMID:20870719</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Histone methyltransferase\|Histone methyltransferase]]	+	*[[Histone methyltransferase 3D structures\|Histone methyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Ferguson, A D]]		[[Category: Ferguson, A D]]
	[[Category: Methyltransferase]]		[[Category: Methyltransferase]]
	[[Category: P53]]		[[Category: P53]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 11:16, 10 December 2016

OCA — Sat, 10 Dec 2016 11:16:41 GMT

←Older revision		Revision as of 11:16, 10 December 2016
Line 1:		Line 1:
		+
	==Structural Basis of Substrate Methylation and Inhibition of SMYD2==		==Structural Basis of Substrate Methylation and Inhibition of SMYD2==
	<StructureSection load='3s7j' size='340' side='right' caption='[[3s7j]], [[Resolution\|resolution]] 3.04Å' scene=''>		<StructureSection load='3s7j' size='340' side='right' caption='[[3s7j]], [[Resolution\|resolution]] 3.04Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3s7j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S7J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S7J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3s7j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S7J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S7J FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3s7b\|3s7b]], [[3s7d\|3s7d]], [[3s7f\|3s7f]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3s7b\|3s7b]], [[3s7d\|3s7d]], [[3s7f\|3s7f]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SMYD2, KMT3C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SMYD2, KMT3C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s7j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3s7j RCSB], [http://www.ebi.ac.uk/pdbsum/3s7j PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s7j OCA], [http://pdbe.org/3s7j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3s7j RCSB], [http://www.ebi.ac.uk/pdbsum/3s7j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3s7j ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SMYD2_HUMAN SMYD2_HUMAN]] Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates 'Lys-860' of RB1/RB.<ref>PMID:17108971</ref> <ref>PMID:17805299</ref> <ref>PMID:18065756</ref> <ref>PMID:20870719</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 16:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3s7j" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 23:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Ferguson, A D]]		[[Category: Ferguson, A D]]
	[[Category: Methyltransferase]]		[[Category: Methyltransferase]]
	[[Category: P53]]		[[Category: P53]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 13:13, 9 December 2014

OCA — Tue, 09 Dec 2014 13:13:45 GMT

←Older revision		Revision as of 13:13, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3s7j.~~png~~\|~~left~~\|~~200px~~]]	+	==Structural Basis of Substrate Methylation and Inhibition of SMYD2==
		+	<StructureSection load='3s7j' size='340' side='right' caption='[[3s7j]], [[Resolution\|resolution]] 3.04Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3s7j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S7J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S7J FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3s7b\|3s7b]], [[3s7d\|3s7d]], [[3s7f\|3s7f]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SMYD2, KMT3C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s7j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3s7j RCSB], [http://www.ebi.ac.uk/pdbsum/3s7j PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Protein lysine methyltransferases are important regulators of epigenetic signaling. These enzymes catalyze the transfer of donor methyl groups from S-adenosylmethionine to specific acceptor lysines on histones, leading to changes in chromatin structure and transcriptional regulation. These enzymes also methylate nonhistone protein substrates, revealing an additional mechanism to regulate cellular physiology. The oncogenic protein SMYD2 represses the functional activities of the tumor suppressor proteins p53 and Rb, making it an attractive drug target. Here we report the discovery of AZ505, a potent and selective inhibitor of SMYD2 that was identified from a high throughput chemical screen. We also present the crystal structures of SMYD2 with p53 substrate and product peptides, and notably, in complex with AZ505. This substrate competitive inhibitor is bound in the peptide binding groove of SMYD2. These results have implications for the development of SMYD2 inhibitors, and indicate the potential for developing novel therapies targeting this target class.

-	~~{{STRUCTURE_3s7j\| PDB=3s7j \| SCENE= }}~~	+	Structural Basis of Substrate Methylation and Inhibition of SMYD2.,Ferguson AD, Larsen NA, Howard T, Pollard H, Green I, Grande C, Cheung T, Garcia-Arenas R, Cowen S, Wu J, Godin R, Chen H, Keen N Structure. 2011 Jul 20. PMID:21782458<ref>PMID:21782458</ref>

-	~~===Structural Basis~~ of ~~Substrate Methylation and Inhibition of SMYD2===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21782458}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3s7j]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3S7J OCA].~~	+

	==See Also==		==See Also==
	*[[Histone methyltransferase\|Histone methyltransferase]]		*[[Histone methyltransferase\|Histone methyltransferase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021782458<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Ferguson, A D.]]	+	[[Category: Ferguson, A D]]
	[[Category: Methyltransferase]]		[[Category: Methyltransferase]]
	[[Category: P53]]		[[Category: P53]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 07:18, 20 October 2012

OCA — Sat, 20 Oct 2012 07:18:41 GMT

←Older revision		Revision as of 07:18, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3s7j]] is a 1 chain structure ~~of [[Histone methyltransferase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S7J OCA].	+	[[3s7j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S7J OCA].

	==See Also==		==See Also==

OCA at 15:55, 25 July 2012

OCA — Wed, 25 Jul 2012 15:55:02 GMT

←Older revision		Revision as of 15:55, 25 July 2012
Line 1:		Line 1:
	[[Image:3s7j.png\|left\|200px]]		[[Image:3s7j.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3s7j", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3s7j\| PDB=3s7j \| SCENE= }}		{{STRUCTURE_3s7j\| PDB=3s7j \| SCENE= }}

	===Structural Basis of Substrate Methylation and Inhibition of SMYD2===		===Structural Basis of Substrate Methylation and Inhibition of SMYD2===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21782458}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21782458 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21782458}}		{{ABSTRACT_PUBMED_21782458}}

	==About this Structure==		==About this Structure==
-	[[3s7j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S7J OCA].	+	[[3s7j]] is a 1 chain structure of [[Histone methyltransferase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S7J OCA].
		+
		+	==See Also==
		+	*[[Histone methyltransferase\|Histone methyltransferase]]

	==Reference==		==Reference==

OCA at 04:59, 21 September 2011

OCA — Wed, 21 Sep 2011 04:59:39 GMT

←Older revision		Revision as of 04:59, 21 September 2011
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-	[[Image:3s7j.~~jpg~~\|left\|200px]]	+	[[Image:3s7j.png\|left\|200px]]

	<!--		<!--

OCA at 05:57, 10 August 2011

OCA — Wed, 10 Aug 2011 05:57:38 GMT

←Older revision		Revision as of 05:57, 10 August 2011
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-	~~'''Unreleased structure'''~~	+	[[Image:3s7j.jpg\|left\|200px]]

-	The ~~entry 3s7j~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3s7j", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3s7j\| PDB=3s7j \| SCENE= }}

-	~~Authors: Ferguson, A.D.~~	+	===Structural Basis of Substrate Methylation and Inhibition of SMYD2===

-	~~Description~~: ~~Structural Basis of Substrate Methylation and Inhibition of SMYD2~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21782458}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21782458 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21782458}}
		+
		+	==About this Structure==
		+	[[3s7j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S7J OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021782458</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Ferguson, A D.]]
		+	[[Category: Methyltransferase]]
		+	[[Category: P53]]
		+	[[Category: Transferase]]

OCA at 16:18, 22 June 2011

OCA — Wed, 22 Jun 2011 16:18:56 GMT

←Older revision		Revision as of 16:18, 22 June 2011
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3s7j is ON HOLD	+	The entry 3s7j is ON HOLD until Paper Publication

	Authors: Ferguson, A.D.		Authors: Ferguson, A.D.

	Description: Structural Basis of Substrate Methylation and Inhibition of SMYD2		Description: Structural Basis of Substrate Methylation and Inhibition of SMYD2

OCA at 05:55, 15 June 2011

OCA — Wed, 15 Jun 2011 05:55:31 GMT

←Older revision		Revision as of 05:55, 15 June 2011
Line 5:		Line 5:
	Authors: Ferguson, A.D.		Authors: Ferguson, A.D.

-	Description: ~~Not available~~	+	Description: Structural Basis of Substrate Methylation and Inhibition of SMYD2