3s8u - Revision history

OCA at 12:50, 14 March 2024

OCA — Thu, 14 Mar 2024 12:50:04 GMT

←Older revision		Revision as of 12:50, 14 March 2024
Line 3:		Line 3:
	<StructureSection load='3s8u' size='340' side='right'caption='[[3s8u]], [[Resolution\|resolution]] 1.20Å' scene=''>		<StructureSection load='3s8u' size='340' side='right'caption='[[3s8u]], [[Resolution\|resolution]] 1.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3s8u]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S8U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3s8u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S8U FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=AT7:2~~-~~DEOXY-2-TRIAZA-1~~,~~2-DIEN-2-IUM-~~1~~-YL-ADENINE-5-MONOPHOSPHATE'>AT7</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[3dvz\|3dvz]], [[3s7c\|3s7c]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AT7:2-DEOXY-2-TRIAZA-1,2-DIEN-2-IUM-1-YL-ADENINE-5-MONOPHOSPHATE'>AT7</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s8u OCA], [https://pdbe.org/3s8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s8u RCSB], [https://www.ebi.ac.uk/pdbsum/3s8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s8u ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s8u OCA], [https://pdbe.org/3s8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s8u RCSB], [https://www.ebi.ac.uk/pdbsum/3s8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s8u ProSAT]</span></td></tr>
	</table>		</table>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Chemical modification can significantly enrich the structural and functional repertoire of ribonucleic acids and endow them with new outstanding properties. Here, we report the syntheses of novel 2'-azido cytidine and 2'-azido guanosine building blocks and demonstrate their efficient site-specific incorporation into RNA by mastering the synthetic challenge of using phosphoramidite chemistry in the presence of azido groups. Our study includes the detailed characterization of 2'-azido nucleoside containing RNA using UV-melting profile analysis and CD and NMR spectroscopy. Importantly, the X-ray crystallographic analysis of 2'-azido uridine and 2'-azido adenosine modified RNAs reveals crucial structural details of this modification within an A-form double helical environment. The 2'-azido group supports the C3'-endo ribose conformation and shows distinct water-bridged hydrogen bonding patterns in the minor groove. Additionally, siRNA induced silencing of the brain acid soluble protein (BASP1) encoding gene in chicken fibroblasts demonstrated that 2'-azido modifications are well tolerated in the guide strand, even directly at the cleavage site. Furthermore, the 2'-azido modifications are compatible with 2'-fluoro and/or 2'-O-methyl modifications to achieve siRNAs of rich modification patterns and tunable properties, such as increased nuclease resistance or additional chemical reactivity. The latter was demonstrated by the utilization of the 2'-azido groups for bioorthogonal Click reactions that allows efficient fluorescent labeling of the RNA. In summary, the present comprehensive investigation on site-specifically modified 2'-azido RNA including all four nucleosides provides a basic rationale behind the physico- and biochemical properties of this flexible and thus far neglected type of RNA modification.
-
-	2'-Azido RNA, a Versatile Tool for Chemical Biology: Synthesis, X-ray Structure, siRNA Applications, Click Labeling.,Fauster K, Hartl M, Santner T, Aigner M, Kreutz C, Bister K, Ennifar E, Micura R ACS Chem Biol. 2012 Mar 16;7(3):581-9. Epub 2012 Jan 24. PMID:22273279<ref>PMID:22273279</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3s8u" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ennifar, E]]	+	[[Category: Ennifar E]]
-	[[Category: Micura, R]]	+	[[Category: Micura R]]
-	~~[[Category: 2'-azido-adenine]]~~	+
-	~~[[Category: Hairpin rna]]~~	+
-	~~[[Category: Rna]]~~	+
-	~~[[Category: Rna labelling~~]]	+

OCA at 10:42, 22 June 2022

OCA — Wed, 22 Jun 2022 10:42:57 GMT

←Older revision		Revision as of 10:42, 22 June 2022
Line 1:		Line 1:

	==Crystal structure of a 2-azido-adenine-modified RNA==		==Crystal structure of a 2-azido-adenine-modified RNA==
-	<StructureSection load='3s8u' size='340' side='right' caption='[[3s8u]], [[Resolution\|resolution]] 1.20Å' scene=''>	+	<StructureSection load='3s8u' size='340' side='right'caption='[[3s8u]], [[Resolution\|resolution]] 1.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3s8u]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S8U OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3S8U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3s8u]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S8U FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AT7:2-DEOXY-2-TRIAZA-1,2-DIEN-2-IUM-1-YL-ADENINE-5-MONOPHOSPHATE'>AT7</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AT7:2-DEOXY-2-TRIAZA-1,2-DIEN-2-IUM-1-YL-ADENINE-5-MONOPHOSPHATE'>AT7</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3dvz\|3dvz]], [[3s7c\|3s7c]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3dvz\|3dvz]], [[3s7c\|3s7c]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3s8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s8u OCA], [~~http~~://pdbe.org/3s8u PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3s8u RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3s8u PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3s8u ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s8u OCA], [https://pdbe.org/3s8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s8u RCSB], [https://www.ebi.ac.uk/pdbsum/3s8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s8u ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Ennifar, E]]		[[Category: Ennifar, E]]
	[[Category: Micura, R]]		[[Category: Micura, R]]

OCA at 18:40, 11 August 2016

OCA — Thu, 11 Aug 2016 18:40:34 GMT

←Older revision		Revision as of 18:40, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of a 2-azido-adenine-modified RNA==		==Crystal structure of a 2-azido-adenine-modified RNA==
	<StructureSection load='3s8u' size='340' side='right' caption='[[3s8u]], [[Resolution\|resolution]] 1.20Å' scene=''>		<StructureSection load='3s8u' size='340' side='right' caption='[[3s8u]], [[Resolution\|resolution]] 1.20Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AT7:2-DEOXY-2-TRIAZA-1,2-DIEN-2-IUM-1-YL-ADENINE-5-MONOPHOSPHATE'>AT7</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AT7:2-DEOXY-2-TRIAZA-1,2-DIEN-2-IUM-1-YL-ADENINE-5-MONOPHOSPHATE'>AT7</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3dvz\|3dvz]], [[3s7c\|3s7c]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3dvz\|3dvz]], [[3s7c\|3s7c]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s8u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3s8u RCSB], [http://www.ebi.ac.uk/pdbsum/3s8u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s8u OCA], [http://pdbe.org/3s8u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3s8u RCSB], [http://www.ebi.ac.uk/pdbsum/3s8u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3s8u ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3s8u" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:17, 4 January 2015

OCA — Sun, 04 Jan 2015 10:17:07 GMT

←Older revision		Revision as of 10:17, 4 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3s8u]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S8U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S8U FirstGlance]. <br>		<table><tr><td colspan='2'>[[3s8u]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S8U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S8U FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AT7:2-DEOXY-2-TRIAZA-1,2-DIEN-2-IUM-1-YL-ADENINE-5-MONOPHOSPHATE'>AT7</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AT7:2-DEOXY-2-TRIAZA-1,2-DIEN-2-IUM-1-YL-ADENINE-5-MONOPHOSPHATE'>AT7</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3dvz\|3dvz]], [[3s7c\|3s7c]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3dvz\|3dvz]], [[3s7c\|3s7c]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s8u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3s8u RCSB], [http://www.ebi.ac.uk/pdbsum/3s8u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s8u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3s8u RCSB], [http://www.ebi.ac.uk/pdbsum/3s8u PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 13:		Line 13:
	2'-Azido RNA, a Versatile Tool for Chemical Biology: Synthesis, X-ray Structure, siRNA Applications, Click Labeling.,Fauster K, Hartl M, Santner T, Aigner M, Kreutz C, Bister K, Ennifar E, Micura R ACS Chem Biol. 2012 Mar 16;7(3):581-9. Epub 2012 Jan 24. PMID:22273279<ref>PMID:22273279</ref>		2'-Azido RNA, a Versatile Tool for Chemical Biology: Synthesis, X-ray Structure, siRNA Applications, Click Labeling.,Fauster K, Hartl M, Santner T, Aigner M, Kreutz C, Bister K, Ennifar E, Micura R ACS Chem Biol. 2012 Mar 16;7(3):581-9. Epub 2012 Jan 24. PMID:22273279<ref>PMID:22273279</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Ennifar, E.]]	+	[[Category: Ennifar, E]]
-	[[Category: Micura, R.]]	+	[[Category: Micura, R]]
	[[Category: 2'-azido-adenine]]		[[Category: 2'-azido-adenine]]
	[[Category: Hairpin rna]]		[[Category: Hairpin rna]]
	[[Category: Rna]]		[[Category: Rna]]
	[[Category: Rna labelling]]		[[Category: Rna labelling]]

OCA at 05:20, 5 June 2014

OCA — Thu, 05 Jun 2014 05:20:00 GMT

←Older revision		Revision as of 05:20, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3s8u.~~jpg~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of a 2-azido-adenine-modified RNA==
		+	<StructureSection load='3s8u' size='340' side='right' caption='[[3s8u]], [[Resolution\|resolution]] 1.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3s8u]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S8U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S8U FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AT7:2-DEOXY-2-TRIAZA-1,2-DIEN-2-IUM-1-YL-ADENINE-5-MONOPHOSPHATE'>AT7</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3dvz\|3dvz]], [[3s7c\|3s7c]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s8u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3s8u RCSB], [http://www.ebi.ac.uk/pdbsum/3s8u PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Chemical modification can significantly enrich the structural and functional repertoire of ribonucleic acids and endow them with new outstanding properties. Here, we report the syntheses of novel 2'-azido cytidine and 2'-azido guanosine building blocks and demonstrate their efficient site-specific incorporation into RNA by mastering the synthetic challenge of using phosphoramidite chemistry in the presence of azido groups. Our study includes the detailed characterization of 2'-azido nucleoside containing RNA using UV-melting profile analysis and CD and NMR spectroscopy. Importantly, the X-ray crystallographic analysis of 2'-azido uridine and 2'-azido adenosine modified RNAs reveals crucial structural details of this modification within an A-form double helical environment. The 2'-azido group supports the C3'-endo ribose conformation and shows distinct water-bridged hydrogen bonding patterns in the minor groove. Additionally, siRNA induced silencing of the brain acid soluble protein (BASP1) encoding gene in chicken fibroblasts demonstrated that 2'-azido modifications are well tolerated in the guide strand, even directly at the cleavage site. Furthermore, the 2'-azido modifications are compatible with 2'-fluoro and/or 2'-O-methyl modifications to achieve siRNAs of rich modification patterns and tunable properties, such as increased nuclease resistance or additional chemical reactivity. The latter was demonstrated by the utilization of the 2'-azido groups for bioorthogonal Click reactions that allows efficient fluorescent labeling of the RNA. In summary, the present comprehensive investigation on site-specifically modified 2'-azido RNA including all four nucleosides provides a basic rationale behind the physico- and biochemical properties of this flexible and thus far neglected type of RNA modification.

-	<!--	+	2'-Azido RNA, a Versatile Tool for Chemical Biology: Synthesis, X-ray Structure, siRNA Applications, Click Labeling.,Fauster K, Hartl M, Santner T, Aigner M, Kreutz C, Bister K, Ennifar E, Micura R ACS Chem Biol. 2012 Mar 16;7(3):581-9. Epub 2012 Jan 24. PMID:22273279<ref>PMID:22273279</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3s8u"~~, ~~creates the "~~Structure ~~Box" on the page~~.	+
-	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded)~~,	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_3s8u\| PDB=3s8u \| SCENE= }}~~	+

-	~~===Crystal structure~~ of ~~a 2-azido-adenine-modified RNA===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_22273279}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22273279 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_22273279}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3s8u]] is a 1 chain structure. Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3S8U OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022273279<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Ennifar, E.]]		[[Category: Ennifar, E.]]
	[[Category: Micura, R.]]		[[Category: Micura, R.]]

OCA at 06:58, 11 April 2012

OCA — Wed, 11 Apr 2012 06:58:19 GMT

←Older revision		Revision as of 06:58, 11 April 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3s8u.jpg\|left\|200px]]

-	The ~~entry 3s8u~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3s8u", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3s8u\| PDB=3s8u \| SCENE= }}

-	~~Authors: Ennifar, E., Micura, R.~~	+	===Crystal structure of a 2-azido-adenine-modified RNA===

-	~~Description~~: ~~Crystal structure of~~ a 2-azido-adenine~~-modified RNA~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22273279}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22273279 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22273279}}
		+
		+	==About this Structure==
		+	[[3s8u]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S8U OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022273279</ref><references group="xtra"/>
		+	[[Category: Ennifar, E.]]
		+	[[Category: Micura, R.]]
		+	[[Category: 2'-azido-adenine]]
		+	[[Category: Hairpin rna]]
		+	[[Category: Rna]]
		+	[[Category: Rna labelling]]

OCA at 05:41, 7 September 2011

OCA — Wed, 07 Sep 2011 05:41:09 GMT

←Older revision		Revision as of 05:41, 7 September 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3s8u is ON HOLD	+	The entry 3s8u is ON HOLD until Paper Publication

	Authors: Ennifar, E., Micura, R.		Authors: Ennifar, E., Micura, R.

	Description: Crystal structure of a 2-azido-adenine-modified RNA		Description: Crystal structure of a 2-azido-adenine-modified RNA

OCA: Protected "3s8u" [edit=sysop:move=sysop]

OCA — Wed, 08 Jun 2011 04:55:04 GMT

Protected "3s8u" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:55, 8 June 2011

OCA: New page: '''Unreleased structure''' The entry 3s8u is ON HOLD Authors: Ennifar, E., Micura, R. Description: Crystal structure of a 2-azido-adenine-modified RNA

OCA — Wed, 08 Jun 2011 04:55:02 GMT

New page: '''Unreleased structure''' The entry 3s8u is ON HOLD Authors: Ennifar, E., Micura, R. Description: Crystal structure of a 2-azido-adenine-modified RNA

New page

'''Unreleased structure'''

The entry 3s8u is ON HOLD

Authors: Ennifar, E., Micura, R.

Description: Crystal structure of a 2-azido-adenine-modified RNA