3sdr - Revision history

OCA at 09:49, 1 March 2024

OCA — Fri, 01 Mar 2024 09:49:41 GMT

←Older revision		Revision as of 09:49, 1 March 2024
Line 3:		Line 3:
	<StructureSection load='3sdr' size='340' side='right'caption='[[3sdr]], [[Resolution\|resolution]] 1.86Å' scene=''>		<StructureSection load='3sdr' size='340' side='right'caption='[[3sdr]], [[Resolution\|resolution]] 1.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3sdr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Abigr Abigr~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SDR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SDR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3sdr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Abies_grandis Abies grandis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SDR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SDR FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=210:PAMIDRONATE'>210</scene>~~, ~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.86Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[3sae\|3sae]], [[3sdq\|3sdq]], [[3sdt\|3sdt]], [[3sdv\|3sdv]], [[3sdu\|3sdu]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=210:PAMIDRONATE'>210</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~ag1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=46611 ABIGR])</td~~></tr>	+
-	<~~tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Alpha-bisabolene_synthase Alpha-bisabolene synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.38 4.2.3.38]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sdr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sdr OCA], [https://pdbe.org/3sdr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sdr RCSB], [https://www.ebi.ac.uk/pdbsum/3sdr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sdr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sdr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sdr OCA], [https://pdbe.org/3sdr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sdr RCSB], [https://www.ebi.ac.uk/pdbsum/3sdr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sdr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TPSD1_ABIGR TPSD1_ABIGR]] Involved in defensive oleoresin formation in conifers in response to insect attack or other injury. Involved in sesquiterpene (C15) olefins biosynthesis.<ref>PMID:9539701</ref>	+	[https://www.uniprot.org/uniprot/TPSD1_ABIGR TPSD1_ABIGR] Involved in defensive oleoresin formation in conifers in response to insect attack or other injury. Involved in sesquiterpene (C15) olefins biosynthesis.<ref>PMID:9539701</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	The sesquiterpene bisabolene was recently identified as a biosynthetic precursor to bisabolane, an advanced biofuel with physicochemical properties similar to those of D2 diesel. High-titer microbial bisabolene production was achieved using Abies grandis alpha-bisabolene synthase (AgBIS). Here, we report the structure of AgBIS, a three-domain plant sesquiterpene synthase, crystallized in its apo form and bound to five different inhibitors. Structural and biochemical characterization of the AgBIS terpene synthase Class I active site leads us to propose a catalytic mechanism for the cyclization of farnesyl diphosphate into bisabolene via a bisabolyl cation intermediate. Further, we describe the nonfunctional AgBIS Class II active site whose high similarity to bifunctional diterpene synthases makes it an important link in understanding terpene synthase evolution. Practically, the AgBIS crystal structure is important in future protein engineering efforts to increase the microbial production of bisabolene.	+
-		+
-	Structure of a three-domain sesquiterpene synthase: a prospective target for advanced biofuels production.,McAndrew RP, Peralta-Yahya PP, DeGiovanni A, Pereira JH, Hadi MZ, Keasling JD, Adams PD Structure. 2011 Dec 7;19(12):1876-84. PMID:22153510<ref>PMID:22153510</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3sdr" style="background-color:#fffaf0;"></div~~>	+
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Abigr]]~~	+	[[Category: Abies grandis]]
-	~~[[Category: Alpha-bisabolene synthase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Adams~~, P D~~]]	+	[[Category: Adams PD]]
-	[[Category: DeGiovanni, A]]	+	[[Category: DeGiovanni A]]
-	[[Category: Hadi~~, M Z~~]]	+	[[Category: Hadi MZ]]
-	[[Category: Keasling~~, J D~~]]	+	[[Category: Keasling JD]]
-	[[Category: McAndrew~~, R P~~]]	+	[[Category: McAndrew RP]]
-	[[Category: Peralta-Yahya~~, P P~~]]	+	[[Category: Peralta-Yahya PP]]
-	[[Category: Pereira~~, J H]]~~	+	[[Category: Pereira JH]]
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Terpene synthase~~]]	+

OCA at 07:52, 29 June 2022

OCA — Wed, 29 Jun 2022 07:52:30 GMT

←Older revision		Revision as of 07:52, 29 June 2022
Line 1:		Line 1:

	==Structure of a three-domain sesquiterpene synthase: a prospective target for advanced biofuels production==		==Structure of a three-domain sesquiterpene synthase: a prospective target for advanced biofuels production==
-	<StructureSection load='3sdr' size='340' side='right' caption='[[3sdr]], [[Resolution\|resolution]] 1.86Å' scene=''>	+	<StructureSection load='3sdr' size='340' side='right'caption='[[3sdr]], [[Resolution\|resolution]] 1.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3sdr]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Abigr Abigr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SDR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3SDR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3sdr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Abigr Abigr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SDR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SDR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=210:PAMIDRONATE'>210</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=210:PAMIDRONATE'>210</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sae\|3sae]], [[3sdq\|3sdq]], [[3sdt\|3sdt]], [[3sdv\|3sdv]], [[3sdu\|3sdu]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3sae\|3sae]], [[3sdq\|3sdq]], [[3sdt\|3sdt]], [[3sdv\|3sdv]], [[3sdu\|3sdu]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ag1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=46611 ABIGR])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ag1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=46611 ABIGR])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Alpha-bisabolene_synthase Alpha-bisabolene synthase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.38 4.2.3.38] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Alpha-bisabolene_synthase Alpha-bisabolene synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.38 4.2.3.38] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3sdr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sdr OCA], [~~http~~://pdbe.org/3sdr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3sdr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3sdr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3sdr ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sdr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sdr OCA], [https://pdbe.org/3sdr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sdr RCSB], [https://www.ebi.ac.uk/pdbsum/3sdr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sdr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TPSD1_ABIGR TPSD1_ABIGR]] Involved in defensive oleoresin formation in conifers in response to insect attack or other injury. Involved in sesquiterpene (C15) olefins biosynthesis.<ref>PMID:9539701</ref>	+	[[https://www.uniprot.org/uniprot/TPSD1_ABIGR TPSD1_ABIGR]] Involved in defensive oleoresin formation in conifers in response to insect attack or other injury. Involved in sesquiterpene (C15) olefins biosynthesis.<ref>PMID:9539701</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 27:
	[[Category: Abigr]]		[[Category: Abigr]]
	[[Category: Alpha-bisabolene synthase]]		[[Category: Alpha-bisabolene synthase]]
		+	[[Category: Large Structures]]
	[[Category: Adams, P D]]		[[Category: Adams, P D]]
	[[Category: DeGiovanni, A]]		[[Category: DeGiovanni, A]]

OCA at 02:43, 5 August 2016

OCA — Fri, 05 Aug 2016 02:43:47 GMT

←Older revision		Revision as of 02:43, 5 August 2016
Line 1:		Line 1:
		+
	==Structure of a three-domain sesquiterpene synthase: a prospective target for advanced biofuels production==		==Structure of a three-domain sesquiterpene synthase: a prospective target for advanced biofuels production==
	<StructureSection load='3sdr' size='340' side='right' caption='[[3sdr]], [[Resolution\|resolution]] 1.86Å' scene=''>		<StructureSection load='3sdr' size='340' side='right' caption='[[3sdr]], [[Resolution\|resolution]] 1.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3sdr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Abies_grandis Abies grandis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SDR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SDR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3sdr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Abigr Abigr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SDR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SDR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=210:PAMIDRONATE'>210</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=210:PAMIDRONATE'>210</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sae\|3sae]], [[3sdq\|3sdq]], [[3sdt\|3sdt]], [[3sdv\|3sdv]], [[3sdu\|3sdu]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sae\|3sae]], [[3sdq\|3sdq]], [[3sdt\|3sdt]], [[3sdv\|3sdv]], [[3sdu\|3sdu]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ag1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=46611 ~~Abies grandis~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ag1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=46611 ABIGR])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-bisabolene_synthase Alpha-bisabolene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.38 4.2.3.38] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-bisabolene_synthase Alpha-bisabolene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.38 4.2.3.38] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sdr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sdr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sdr RCSB], [http://www.ebi.ac.uk/pdbsum/3sdr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sdr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sdr OCA], [http://pdbe.org/3sdr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3sdr RCSB], [http://www.ebi.ac.uk/pdbsum/3sdr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3sdr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3sdr" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Abies grandis~~]]	+	[[Category: Abigr]]
	[[Category: Alpha-bisabolene synthase]]		[[Category: Alpha-bisabolene synthase]]
	[[Category: Adams, P D]]		[[Category: Adams, P D]]

OCA at 22:08, 24 December 2014

OCA — Wed, 24 Dec 2014 22:08:30 GMT

←Older revision		Revision as of 22:08, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3sdr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Abies_grandis Abies grandis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SDR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SDR FirstGlance]. <br>		<table><tr><td colspan='2'>[[3sdr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Abies_grandis Abies grandis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SDR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SDR FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=210:PAMIDRONATE'>210</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=210:PAMIDRONATE'>210</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sae\|3sae]], [[3sdq\|3sdq]], [[3sdt\|3sdt]], [[3sdv\|3sdv]], [[3sdu\|3sdu]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sae\|3sae]], [[3sdq\|3sdq]], [[3sdt\|3sdt]], [[3sdv\|3sdv]], [[3sdu\|3sdu]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ag1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=46611 Abies grandis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ag1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=46611 Abies grandis])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-bisabolene_synthase Alpha-bisabolene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.38 4.2.3.38] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-bisabolene_synthase Alpha-bisabolene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.38 4.2.3.38] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sdr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sdr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sdr RCSB], [http://www.ebi.ac.uk/pdbsum/3sdr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sdr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sdr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sdr RCSB], [http://www.ebi.ac.uk/pdbsum/3sdr PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TPSD1_ABIGR TPSD1_ABIGR]] Involved in defensive oleoresin formation in conifers in response to insect attack or other injury. Involved in sesquiterpene (C15) olefins biosynthesis.<ref>PMID:9539701</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 25:
	[[Category: Abies grandis]]		[[Category: Abies grandis]]
	[[Category: Alpha-bisabolene synthase]]		[[Category: Alpha-bisabolene synthase]]
-	[[Category: Adams, P D.]]	+	[[Category: Adams, P D]]
-	[[Category: DeGiovanni, A.]]	+	[[Category: DeGiovanni, A]]
-	[[Category: Hadi, M Z.]]	+	[[Category: Hadi, M Z]]
-	[[Category: Keasling, J D.]]	+	[[Category: Keasling, J D]]
-	[[Category: McAndrew, R P.]]	+	[[Category: McAndrew, R P]]
-	[[Category: Peralta-Yahya, P P.]]	+	[[Category: Peralta-Yahya, P P]]
-	[[Category: Pereira, J H.]]	+	[[Category: Pereira, J H]]
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Terpene synthase]]		[[Category: Terpene synthase]]

OCA at 06:49, 9 June 2014

OCA — Mon, 09 Jun 2014 06:49:45 GMT

←Older revision		Revision as of 06:49, 9 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3sdr.~~png~~\|~~left~~\|~~200px~~]]	+	==Structure of a three-domain sesquiterpene synthase: a prospective target for advanced biofuels production==
		+	<StructureSection load='3sdr' size='340' side='right' caption='[[3sdr]], [[Resolution\|resolution]] 1.86Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3sdr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Abies_grandis Abies grandis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SDR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SDR FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=210:PAMIDRONATE'>210</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sae\|3sae]], [[3sdq\|3sdq]], [[3sdt\|3sdt]], [[3sdv\|3sdv]], [[3sdu\|3sdu]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ag1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=46611 Abies grandis])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-bisabolene_synthase Alpha-bisabolene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.38 4.2.3.38] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sdr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sdr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sdr RCSB], [http://www.ebi.ac.uk/pdbsum/3sdr PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The sesquiterpene bisabolene was recently identified as a biosynthetic precursor to bisabolane, an advanced biofuel with physicochemical properties similar to those of D2 diesel. High-titer microbial bisabolene production was achieved using Abies grandis alpha-bisabolene synthase (AgBIS). Here, we report the structure of AgBIS, a three-domain plant sesquiterpene synthase, crystallized in its apo form and bound to five different inhibitors. Structural and biochemical characterization of the AgBIS terpene synthase Class I active site leads us to propose a catalytic mechanism for the cyclization of farnesyl diphosphate into bisabolene via a bisabolyl cation intermediate. Further, we describe the nonfunctional AgBIS Class II active site whose high similarity to bifunctional diterpene synthases makes it an important link in understanding terpene synthase evolution. Practically, the AgBIS crystal structure is important in future protein engineering efforts to increase the microbial production of bisabolene.

-	~~{{STRUCTURE_3sdr\| PDB=3sdr \| SCENE= }}~~	+	Structure of a three-domain sesquiterpene synthase: a prospective target for advanced biofuels production.,McAndrew RP, Peralta-Yahya PP, DeGiovanni A, Pereira JH, Hadi MZ, Keasling JD, Adams PD Structure. 2011 Dec 7;19(12):1876-84. PMID:22153510<ref>PMID:22153510</ref>

-	~~===Structure~~ of ~~a three-domain sesquiterpene synthase: a prospective target for advanced biofuels production===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22153510}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3sdr]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Abies_grandis Abies grandis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3SDR OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022153510<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Abies grandis]]		[[Category: Abies grandis]]
	[[Category: Alpha-bisabolene synthase]]		[[Category: Alpha-bisabolene synthase]]

OCA at 05:03, 22 August 2012

OCA — Wed, 22 Aug 2012 05:03:52 GMT

←Older revision		Revision as of 05:03, 22 August 2012
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	[[Image:3sdr.png\|left\|200px]]		[[Image:3sdr.png\|left\|200px]]

-	<!--
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-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3sdr\| PDB=3sdr \| SCENE= }}		{{STRUCTURE_3sdr\| PDB=3sdr \| SCENE= }}

	===Structure of a three-domain sesquiterpene synthase: a prospective target for advanced biofuels production===		===Structure of a three-domain sesquiterpene synthase: a prospective target for advanced biofuels production===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_22153510}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 22153510 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_22153510}}		{{ABSTRACT_PUBMED_22153510}}

OCA at 06:34, 28 March 2012

OCA — Wed, 28 Mar 2012 06:34:17 GMT

←Older revision		Revision as of 06:34, 28 March 2012
Line 1:		Line 1:
-	[[Image:3sdr.~~jpg~~\|left\|200px]]	+	[[Image:3sdr.png\|left\|200px]]

	<!--		<!--
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	===Structure of a three-domain sesquiterpene synthase: a prospective target for advanced biofuels production===		===Structure of a three-domain sesquiterpene synthase: a prospective target for advanced biofuels production===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22153510}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22153510 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22153510}}

	==About this Structure==		==About this Structure==
	[[3sdr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Abies_grandis Abies grandis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SDR OCA].		[[3sdr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Abies_grandis Abies grandis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SDR OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022153510</ref><references group="xtra"/>
	[[Category: Abies grandis]]		[[Category: Abies grandis]]
	[[Category: Alpha-bisabolene synthase]]		[[Category: Alpha-bisabolene synthase]]

OCA at 11:49, 14 December 2011

OCA — Wed, 14 Dec 2011 11:49:43 GMT

←Older revision		Revision as of 11:49, 14 December 2011
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-	~~'''Unreleased structure'''~~	+	[[Image:3sdr.jpg\|left\|200px]]

-	The ~~entry 3sdr~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3sdr", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3sdr\| PDB=3sdr \| SCENE= }}

-	~~Authors: McAndrew, R.P., Peralta~~-~~Yahya, P.P., DeGiovanni, A., Pereira, J.H., Hadi, M.Z., Keasling, J.D., Adams, P.D.~~	+	===Structure of a three-domain sesquiterpene synthase: a prospective target for advanced biofuels production===

-	~~Description:~~ Structure of a ~~three~~-~~domain sesquiterpene~~ synthase: ~~a prospective target for advanced biofuels production~~	+
		+	==About this Structure==
		+	[[3sdr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Abies_grandis Abies grandis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SDR OCA].
		+	[[Category: Abies grandis]]
		+	[[Category: Alpha-bisabolene synthase]]
		+	[[Category: Adams, P D.]]
		+	[[Category: DeGiovanni, A.]]
		+	[[Category: Hadi, M Z.]]
		+	[[Category: Keasling, J D.]]
		+	[[Category: McAndrew, R P.]]
		+	[[Category: Peralta-Yahya, P P.]]
		+	[[Category: Pereira, J H.]]
		+	[[Category: Lyase]]
		+	[[Category: Terpene synthase]]

OCA at 05:43, 29 June 2011

OCA — Wed, 29 Jun 2011 05:43:27 GMT

←Older revision		Revision as of 05:43, 29 June 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3sdr is ON HOLD	+	The entry 3sdr is ON HOLD until Paper Publication

	Authors: McAndrew, R.P., Peralta-Yahya, P.P., DeGiovanni, A., Pereira, J.H., Hadi, M.Z., Keasling, J.D., Adams, P.D.		Authors: McAndrew, R.P., Peralta-Yahya, P.P., DeGiovanni, A., Pereira, J.H., Hadi, M.Z., Keasling, J.D., Adams, P.D.

	Description: Structure of a three-domain sesquiterpene synthase: a prospective target for advanced biofuels production		Description: Structure of a three-domain sesquiterpene synthase: a prospective target for advanced biofuels production

OCA: Protected "3sdr" [edit=sysop:move=sysop]

OCA — Wed, 15 Jun 2011 05:59:51 GMT

Protected "3sdr" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:59, 15 June 2011