3sen - Revision history

OCA at 12:55, 14 March 2024

OCA — Thu, 14 Mar 2024 12:55:10 GMT

←Older revision		Revision as of 12:55, 14 March 2024
Line 3:		Line 3:
	<StructureSection load='3sen' size='340' side='right'caption='[[3sen]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='3sen' size='340' side='right'caption='[[3sen]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3sen]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SEN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SEN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3sen]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SEN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SEN FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=K:POTASSIUM+ION'>K</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.1Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[3sei\|3sei]]~~<~~/div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">CASKIN1, KIAA1306 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sen OCA], [https://pdbe.org/3sen PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sen RCSB], [https://www.ebi.ac.uk/pdbsum/3sen PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sen ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sen OCA], [https://pdbe.org/3sen PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sen RCSB], [https://www.ebi.ac.uk/pdbsum/3sen PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sen ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CSKI1_HUMAN CSKI1_HUMAN]] May link the scaffolding protein CASK to downstream intracellular effectors (By similarity).	+	[https://www.uniprot.org/uniprot/CSKI1_HUMAN CSKI1_HUMAN] May link the scaffolding protein CASK to downstream intracellular effectors (By similarity).
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	The synaptic scaffolding proteins CASK and Caskin1 are part of the fibrous mesh of proteins that organize the active zones of neural synapses. CASK binds to a region of Caskin1 called the CASK interaction domain (CID). Adjacent to the CID, Caskin1 contains two tandem sterile alpha motif (SAM) domains. Many SAM domains form polymers so they are good candidates for forming the fibrous structures seen in the active zone. We show here that the SAM domains of Caskin1 form a new type of SAM helical polymer. The Caskin1 polymer interface exhibits a remarkable segregation of charged residues, resulting in a high sensitivity to ionic strength in vitro. The Caskin1 polymers can be decorated with CASK proteins, illustrating how these proteins may work together to organize the cytomatrix in active zones.	+
-		+
-	Tandem SAM domain structure of human Caskin1: a presynaptic, self-assembling scaffold for CASK.,Stafford RL, Hinde E, Knight MJ, Pennella MA, Ear J, Digman MA, Gratton E, Bowie JU Structure. 2011 Dec 7;19(12):1826-36. PMID:22153505<ref>PMID:22153505</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3sen" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bowie~~, J U~~]]	+	[[Category: Bowie JU]]
-	[[Category: Stafford~~, R L]]~~	+	[[Category: Stafford RL]]
-	~~[[Category: Protein-protein interaction]]~~	+
-	~~[[Category: Sam domain]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 07:53, 29 June 2022

OCA — Wed, 29 Jun 2022 07:53:25 GMT

←Older revision		Revision as of 07:53, 29 June 2022
Line 1:		Line 1:

	==Structure of Caskin1 Tandem SAMs==		==Structure of Caskin1 Tandem SAMs==
-	<StructureSection load='3sen' size='340' side='right' caption='[[3sen]], [[Resolution\|resolution]] 3.10Å' scene=''>	+	<StructureSection load='3sen' size='340' side='right'caption='[[3sen]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3sen]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SEN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3SEN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3sen]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SEN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SEN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sei\|3sei]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3sei\|3sei]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASKIN1, KIAA1306 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASKIN1, KIAA1306 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3sen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sen OCA], [~~http~~://pdbe.org/3sen PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3sen RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3sen PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3sen ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sen OCA], [https://pdbe.org/3sen PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sen RCSB], [https://www.ebi.ac.uk/pdbsum/3sen PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sen ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CSKI1_HUMAN CSKI1_HUMAN]] May link the scaffolding protein CASK to downstream intracellular effectors (By similarity).	+	[[https://www.uniprot.org/uniprot/CSKI1_HUMAN CSKI1_HUMAN]] May link the scaffolding protein CASK to downstream intracellular effectors (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bowie, J U]]		[[Category: Bowie, J U]]
	[[Category: Stafford, R L]]		[[Category: Stafford, R L]]

OCA at 16:51, 5 August 2016

OCA — Fri, 05 Aug 2016 16:51:30 GMT

←Older revision		Revision as of 16:51, 5 August 2016
Line 1:		Line 1:
		+
	==Structure of Caskin1 Tandem SAMs==		==Structure of Caskin1 Tandem SAMs==
	<StructureSection load='3sen' size='340' side='right' caption='[[3sen]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='3sen' size='340' side='right' caption='[[3sen]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3sen]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SEN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SEN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3sen]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SEN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SEN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sei\|3sei]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sei\|3sei]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASKIN1, KIAA1306 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASKIN1, KIAA1306 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sen OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sen RCSB], [http://www.ebi.ac.uk/pdbsum/3sen PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sen OCA], [http://pdbe.org/3sen PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3sen RCSB], [http://www.ebi.ac.uk/pdbsum/3sen PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3sen ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3sen" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Bowie, J U]]		[[Category: Bowie, J U]]
	[[Category: Stafford, R L]]		[[Category: Stafford, R L]]

OCA at 04:10, 25 December 2014

OCA — Thu, 25 Dec 2014 04:10:36 GMT

←Older revision		Revision as of 04:10, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3sen]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SEN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SEN FirstGlance]. <br>		<table><tr><td colspan='2'>[[3sen]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SEN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SEN FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sei\|3sei]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sei\|3sei]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASKIN1, KIAA1306 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASKIN1, KIAA1306 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sen OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sen RCSB], [http://www.ebi.ac.uk/pdbsum/3sen PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sen OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sen RCSB], [http://www.ebi.ac.uk/pdbsum/3sen PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CSKI1_HUMAN CSKI1_HUMAN]] May link the scaffolding protein CASK to downstream intracellular effectors (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 16:
	Tandem SAM domain structure of human Caskin1: a presynaptic, self-assembling scaffold for CASK.,Stafford RL, Hinde E, Knight MJ, Pennella MA, Ear J, Digman MA, Gratton E, Bowie JU Structure. 2011 Dec 7;19(12):1826-36. PMID:22153505<ref>PMID:22153505</ref>		Tandem SAM domain structure of human Caskin1: a presynaptic, self-assembling scaffold for CASK.,Stafford RL, Hinde E, Knight MJ, Pennella MA, Ear J, Digman MA, Gratton E, Bowie JU Structure. 2011 Dec 7;19(12):1826-36. PMID:22153505<ref>PMID:22153505</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 21:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Bowie, J U.]]	+	[[Category: Bowie, J U]]
-	[[Category: Stafford, R L.]]	+	[[Category: Stafford, R L]]
	[[Category: Protein-protein interaction]]		[[Category: Protein-protein interaction]]
	[[Category: Sam domain]]		[[Category: Sam domain]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

OCA at 05:31, 5 June 2014

OCA — Thu, 05 Jun 2014 05:31:26 GMT

←Older revision		Revision as of 05:31, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3sen.~~png~~\|~~left~~\|~~200px~~]]	+	==Structure of Caskin1 Tandem SAMs==
		+	<StructureSection load='3sen' size='340' side='right' caption='[[3sen]], [[Resolution\|resolution]] 3.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3sen]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SEN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SEN FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sei\|3sei]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASKIN1, KIAA1306 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sen OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sen RCSB], [http://www.ebi.ac.uk/pdbsum/3sen PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The synaptic scaffolding proteins CASK and Caskin1 are part of the fibrous mesh of proteins that organize the active zones of neural synapses. CASK binds to a region of Caskin1 called the CASK interaction domain (CID). Adjacent to the CID, Caskin1 contains two tandem sterile alpha motif (SAM) domains. Many SAM domains form polymers so they are good candidates for forming the fibrous structures seen in the active zone. We show here that the SAM domains of Caskin1 form a new type of SAM helical polymer. The Caskin1 polymer interface exhibits a remarkable segregation of charged residues, resulting in a high sensitivity to ionic strength in vitro. The Caskin1 polymers can be decorated with CASK proteins, illustrating how these proteins may work together to organize the cytomatrix in active zones.

-	<!--	+	Tandem SAM domain structure of human Caskin1: a presynaptic, self-assembling scaffold for CASK.,Stafford RL, Hinde E, Knight MJ, Pennella MA, Ear J, Digman MA, Gratton E, Bowie JU Structure. 2011 Dec 7;19(12):1826-36. PMID:22153505<ref>PMID:22153505</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3sen"~~, ~~creates the "~~Structure ~~Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_3sen\| PDB=3sen \| SCENE= }}~~	+

-	~~===Structure~~ of ~~Caskin1 Tandem SAMs===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_22153505}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22153505 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_22153505}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3sen]] is a 4 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SEN OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022153505<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bowie, J U.]]		[[Category: Bowie, J U.]]

OCA at 07:05, 28 March 2012

OCA — Wed, 28 Mar 2012 07:05:09 GMT

←Older revision		Revision as of 07:05, 28 March 2012
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-	[[Image:3sen.~~jpg~~\|left\|200px]]	+	[[Image:3sen.png\|left\|200px]]

	<!--		<!--
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	===Structure of Caskin1 Tandem SAMs===		===Structure of Caskin1 Tandem SAMs===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22153505}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22153505 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22153505}}

	==About this Structure==		==About this Structure==
	[[3sen]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SEN OCA].		[[3sen]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SEN OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022153505</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bowie, J U.]]		[[Category: Bowie, J U.]]

OCA at 11:50, 14 December 2011

OCA — Wed, 14 Dec 2011 11:50:26 GMT

←Older revision		Revision as of 11:50, 14 December 2011
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-	~~'''Unreleased structure'''~~	+	[[Image:3sen.jpg\|left\|200px]]

-	The ~~entry 3sen~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3sen", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3sen\| PDB=3sen \| SCENE= }}

-	~~Authors: Stafford, R.L., Bowie, J.U.~~	+	===Structure of Caskin1 Tandem SAMs===

-	~~Description:~~ Structure ~~of Caskin1 Tandem SAMs~~	+
		+	==About this Structure==
		+	[[3sen]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SEN OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Bowie, J U.]]
		+	[[Category: Stafford, R L.]]
		+	[[Category: Protein-protein interaction]]
		+	[[Category: Sam domain]]
		+	[[Category: Signaling protein]]

OCA: Protected "3sen" [edit=sysop:move=sysop]

OCA — Wed, 22 Jun 2011 16:21:53 GMT

Protected "3sen" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:21, 22 June 2011

OCA: New page: '''Unreleased structure''' The entry 3sen is ON HOLD until Paper Publication Authors: Stafford, R.L., Bowie, J.U. Description: Structure of Caskin1 Tandem SAMs

OCA — Wed, 22 Jun 2011 16:21:53 GMT

New page: '''Unreleased structure''' The entry 3sen is ON HOLD until Paper Publication Authors: Stafford, R.L., Bowie, J.U. Description: Structure of Caskin1 Tandem SAMs

New page

'''Unreleased structure'''

The entry 3sen is ON HOLD until Paper Publication

Authors: Stafford, R.L., Bowie, J.U.

Description: Structure of Caskin1 Tandem SAMs