3sg8 - Revision history

OCA at 09:50, 1 March 2024

OCA — Fri, 01 Mar 2024 09:50:22 GMT

←Older revision		Revision as of 09:50, 1 March 2024
Line 3:		Line 3:
	<StructureSection load='3sg8' size='340' side='right'caption='[[3sg8]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3sg8' size='340' side='right'caption='[[3sg8]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3sg8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"streptococcus_casseliflavus"_vaughan_et_al._1979 "streptococcus~~ casseliflavus~~" vaughan et al. 1979~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SG8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SG8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3sg8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_casseliflavus Enterococcus casseliflavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SG8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SG8 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~, ~~<scene name='pdbligand=TOY:TOBRAMYCIN'>TOY</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~aph(2~~''~~)-Id ([https:/~~/~~www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=37734 "Streptococcus casseliflavus" Vaughan et al. 1979])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TOY:TOBRAMYCIN'>TOY</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sg8 OCA], [https://pdbe.org/3sg8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sg8 RCSB], [https://www.ebi.ac.uk/pdbsum/3sg8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sg8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sg8 OCA], [https://pdbe.org/3sg8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sg8 RCSB], [https://www.ebi.ac.uk/pdbsum/3sg8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sg8 ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/O68183_ENTCA O68183_ENTCA]
-	~~Aminoglycoside 2''-phosphotransferase IVa~~ [APH(2'')-IVa] is a member of a family of bacterial enzymes responsible for medically relevant resistance to antibiotics. APH(2'')-IVa confers high-level resistance against several clinically used aminoglycoside antibiotics in various pathogenic Enterococcus species by phosphorylating the drug, thereby preventing it from binding to its ribosomal target and producing a bactericidal effect. We describe here three crystal structures of APH(2'')-IVa, one in its apo form and two in complex with a bound antibiotic, tobramycin and kanamycin A. The apo structure was refined to a resolution of 2.05 A, and the APH(2'')-IVa structures with tobramycin and kanamycin A bound were refined to resolutions of 1.80 and 2.15 A, respectively. Comparison among the structures provides insight concerning the substrate selectivity of this enzyme. In particular, conformational changes upon substrate binding, involving rotational shifts of two distinct segments of the enzyme, are observed. These substrate-induced shifts may also rationalize the altered substrate preference of APH(2'')-IVa in comparison to those of other members of the APH(2'') subfamily, which are structurally closely related. Finally, analysis of the interactions between the enzyme and aminoglycoside reveals a distinct binding mode as compared to the intended ribosomal target. The differences in the pattern of interactions can be utilized as a structural basis for the development of improved aminoglycosides that are not susceptible to these resistance factors.	+
-		+
-	Crystal Structures of Antibiotic-Bound Complexes of Aminoglycoside 2''-Phosphotransferase IVa Highlight the Diversity in Substrate Binding Modes among Aminoglycoside Kinases.,Shi K, Houston DR, Berghuis AM Biochemistry. 2011 Jun 27. PMID:21678960<ref>PMID:~~21678960<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®~~/~~PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 3sg8" style="background-color:#fffaf0;"><~~/~~div>~~	+

	==See Also==		==See Also==
	*[[Phosphotransferase 3D structures\|Phosphotransferase 3D structures]]		*[[Phosphotransferase 3D structures\|Phosphotransferase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Streptococcus~~ casseliflavus ~~vaughan et al. 1979~~]]	+	[[Category: Enterococcus casseliflavus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Berghuis~~, A M~~]]	+	[[Category: Berghuis AM]]
-	[[Category: Houston~~, D R~~]]	+	[[Category: Houston DR]]
-	[[Category: Shi, K]]	+	[[Category: Shi K]]
-	~~[[Category: Aminoglycoside]]~~	+
-	~~[[Category: Antibiotic resistance enzyme]]~~	+
-	~~[[Category: Phosphorylation]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Transferase-antibiotic complex~~]]	+

OCA at 07:55, 29 June 2022

OCA — Wed, 29 Jun 2022 07:55:01 GMT

←Older revision		Revision as of 07:55, 29 June 2022
Line 1:		Line 1:

	==Crystal Structure of Aminoglycoside-2''-Phosphotransferase Type IVa Tobramycin Complex==		==Crystal Structure of Aminoglycoside-2''-Phosphotransferase Type IVa Tobramycin Complex==
-	<StructureSection load='3sg8' size='340' side='right' caption='[[3sg8]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='3sg8' size='340' side='right'caption='[[3sg8]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3sg8]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"streptococcus_casseliflavus"_vaughan_et_al._1979 "streptococcus casseliflavus" vaughan et al. 1979]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SG8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3SG8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3sg8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"streptococcus_casseliflavus"_vaughan_et_al._1979 "streptococcus casseliflavus" vaughan et al. 1979]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SG8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SG8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TOY:TOBRAMYCIN'>TOY</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TOY:TOBRAMYCIN'>TOY</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aph(2'')-Id ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=37734 "Streptococcus casseliflavus" Vaughan et al. 1979])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aph(2'')-Id ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=37734 "Streptococcus casseliflavus" Vaughan et al. 1979])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3sg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sg8 OCA], [~~http~~://pdbe.org/3sg8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3sg8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3sg8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3sg8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sg8 OCA], [https://pdbe.org/3sg8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sg8 RCSB], [https://www.ebi.ac.uk/pdbsum/3sg8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sg8 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 19:		Line 19:

	==See Also==		==See Also==
-	*[[Phosphotransferase\|Phosphotransferase]]	+	*[[Phosphotransferase 3D structures\|Phosphotransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Streptococcus casseliflavus vaughan et al. 1979]]		[[Category: Streptococcus casseliflavus vaughan et al. 1979]]
		+	[[Category: Large Structures]]
	[[Category: Berghuis, A M]]		[[Category: Berghuis, A M]]
	[[Category: Houston, D R]]		[[Category: Houston, D R]]

OCA at 11:17, 10 December 2016

OCA — Sat, 10 Dec 2016 11:17:42 GMT

←Older revision		Revision as of 11:17, 10 December 2016
Line 1:		Line 1:
		+
	==Crystal Structure of Aminoglycoside-2''-Phosphotransferase Type IVa Tobramycin Complex==		==Crystal Structure of Aminoglycoside-2''-Phosphotransferase Type IVa Tobramycin Complex==
	<StructureSection load='3sg8' size='340' side='right' caption='[[3sg8]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3sg8' size='340' side='right' caption='[[3sg8]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3sg8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Enterococcus_casseliflavus Enterococcus~~ casseliflavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SG8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SG8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3sg8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"streptococcus_casseliflavus"_vaughan_et_al._1979 "streptococcus casseliflavus" vaughan et al. 1979]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SG8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SG8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TOY:TOBRAMYCIN'>TOY</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TOY:TOBRAMYCIN'>TOY</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aph(2'')-Id ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=37734 ~~Enterococcus~~ casseliflavus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aph(2'')-Id ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=37734 "Streptococcus casseliflavus" Vaughan et al. 1979])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sg8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sg8 RCSB], [http://www.ebi.ac.uk/pdbsum/3sg8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sg8 OCA], [http://pdbe.org/3sg8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3sg8 RCSB], [http://www.ebi.ac.uk/pdbsum/3sg8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3sg8 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3sg8" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 22:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Enterococcus~~ casseliflavus]]	+	[[Category: Streptococcus casseliflavus vaughan et al. 1979]]
	[[Category: Berghuis, A M]]		[[Category: Berghuis, A M]]
	[[Category: Houston, D R]]		[[Category: Houston, D R]]

OCA at 13:16, 9 December 2014

OCA — Tue, 09 Dec 2014 13:16:39 GMT

←Older revision		Revision as of 13:16, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3sg8.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal Structure of Aminoglycoside-2''-Phosphotransferase Type IVa Tobramycin Complex==
		+	<StructureSection load='3sg8' size='340' side='right' caption='[[3sg8]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3sg8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_casseliflavus Enterococcus casseliflavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SG8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SG8 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TOY:TOBRAMYCIN'>TOY</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aph(2'')-Id ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=37734 Enterococcus casseliflavus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sg8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sg8 RCSB], [http://www.ebi.ac.uk/pdbsum/3sg8 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Aminoglycoside 2''-phosphotransferase IVa [APH(2'')-IVa] is a member of a family of bacterial enzymes responsible for medically relevant resistance to antibiotics. APH(2'')-IVa confers high-level resistance against several clinically used aminoglycoside antibiotics in various pathogenic Enterococcus species by phosphorylating the drug, thereby preventing it from binding to its ribosomal target and producing a bactericidal effect. We describe here three crystal structures of APH(2'')-IVa, one in its apo form and two in complex with a bound antibiotic, tobramycin and kanamycin A. The apo structure was refined to a resolution of 2.05 A, and the APH(2'')-IVa structures with tobramycin and kanamycin A bound were refined to resolutions of 1.80 and 2.15 A, respectively. Comparison among the structures provides insight concerning the substrate selectivity of this enzyme. In particular, conformational changes upon substrate binding, involving rotational shifts of two distinct segments of the enzyme, are observed. These substrate-induced shifts may also rationalize the altered substrate preference of APH(2'')-IVa in comparison to those of other members of the APH(2'') subfamily, which are structurally closely related. Finally, analysis of the interactions between the enzyme and aminoglycoside reveals a distinct binding mode as compared to the intended ribosomal target. The differences in the pattern of interactions can be utilized as a structural basis for the development of improved aminoglycosides that are not susceptible to these resistance factors.

-	~~{{STRUCTURE_3sg8\| PDB=3sg8 \| SCENE= }}~~	+	Crystal Structures of Antibiotic-Bound Complexes of Aminoglycoside 2''-Phosphotransferase IVa Highlight the Diversity in Substrate Binding Modes among Aminoglycoside Kinases.,Shi K, Houston DR, Berghuis AM Biochemistry. 2011 Jun 27. PMID:21678960<ref>PMID:21678960</ref>

-	~~===Crystal Structure~~ of ~~Aminoglycoside-2''-Phosphotransferase Type IVa Tobramycin Complex===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21678960}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3sg8]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Enterococcus_casseliflavus Enterococcus casseliflavus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3SG8 OCA].~~	+

	==See Also==		==See Also==
	*[[Phosphotransferase\|Phosphotransferase]]		*[[Phosphotransferase\|Phosphotransferase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021678960<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Enterococcus casseliflavus]]		[[Category: Enterococcus casseliflavus]]
-	[[Category: Berghuis, A M.]]	+	[[Category: Berghuis, A M]]
-	[[Category: Houston, D R.]]	+	[[Category: Houston, D R]]
-	[[Category: Shi, K.]]	+	[[Category: Shi, K]]
	[[Category: Aminoglycoside]]		[[Category: Aminoglycoside]]
	[[Category: Antibiotic resistance enzyme]]		[[Category: Antibiotic resistance enzyme]]

OCA at 06:12, 20 October 2012

OCA — Sat, 20 Oct 2012 06:12:59 GMT

←Older revision		Revision as of 06:12, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3sg8]] is a 2 chain structure ~~of [[Phosphotransferase]]~~ with sequence from [http://en.wikipedia.org/wiki/Enterococcus_casseliflavus Enterococcus casseliflavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SG8 OCA].	+	[[3sg8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_casseliflavus Enterococcus casseliflavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SG8 OCA].

	==See Also==		==See Also==

OCA at 12:29, 25 July 2012

OCA — Wed, 25 Jul 2012 12:29:02 GMT

←Older revision		Revision as of 12:29, 25 July 2012
Line 1:		Line 1:
	[[Image:3sg8.png\|left\|200px]]		[[Image:3sg8.png\|left\|200px]]

-	<!--
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-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_3sg8\| PDB=3sg8 \| SCENE= }}		{{STRUCTURE_3sg8\| PDB=3sg8 \| SCENE= }}

	===Crystal Structure of Aminoglycoside-2''-Phosphotransferase Type IVa Tobramycin Complex===		===Crystal Structure of Aminoglycoside-2''-Phosphotransferase Type IVa Tobramycin Complex===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21678960}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21678960 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_21678960}}		{{ABSTRACT_PUBMED_21678960}}

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	==See Also==		==See Also==
-	*[[Phosphotransferase]]	+	*[[Phosphotransferase\|Phosphotransferase]]

	==Reference==		==Reference==

OCA at 04:46, 27 July 2011

OCA — Wed, 27 Jul 2011 04:46:15 GMT

←Older revision		Revision as of 04:46, 27 July 2011
Line 1:		Line 1:
-	[[Image:3sg8.~~jpg~~\|left\|200px]]	+	[[Image:3sg8.png\|left\|200px]]

	<!--		<!--
Line 19:		Line 19:

	==About this Structure==		==About this Structure==
-	[[3sg8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_casseliflavus Enterococcus casseliflavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SG8 OCA].	+	[[3sg8]] is a 2 chain structure of [[Phosphotransferase]] with sequence from [http://en.wikipedia.org/wiki/Enterococcus_casseliflavus Enterococcus casseliflavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SG8 OCA].
		+
		+	==See Also==
		+	*[[Phosphotransferase]]

	==Reference==		==Reference==

OCA at 06:03, 29 June 2011

OCA — Wed, 29 Jun 2011 06:03:48 GMT

←Older revision		Revision as of 06:03, 29 June 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3sg8.jpg\|left\|200px]]

-	The ~~entry 3sg8~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3sg8", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3sg8\| PDB=3sg8 \| SCENE= }}

-	~~Authors: Shi, K., Houston, D.R., Berghuis, A.M.~~	+	===Crystal Structure of Aminoglycoside-2''-Phosphotransferase Type IVa Tobramycin Complex===

-	~~Description~~: ~~Crystal Structure of Aminoglycoside~~-2''-~~Phosphotransferase Type IVa Tobramycin Complex~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21678960}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21678960 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21678960}}
		+
		+	==About this Structure==
		+	[[3sg8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_casseliflavus Enterococcus casseliflavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SG8 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021678960</ref><references group="xtra"/>
		+	[[Category: Enterococcus casseliflavus]]
		+	[[Category: Berghuis, A M.]]
		+	[[Category: Houston, D R.]]
		+	[[Category: Shi, K.]]
		+	[[Category: Aminoglycoside]]
		+	[[Category: Antibiotic resistance enzyme]]
		+	[[Category: Phosphorylation]]
		+	[[Category: Transferase]]
		+	[[Category: Transferase-antibiotic complex]]

OCA: Protected "3sg8" [edit=sysop:move=sysop]

OCA — Wed, 22 Jun 2011 16:23:40 GMT

Protected "3sg8" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:23, 22 June 2011

OCA: New page: '''Unreleased structure''' The entry 3sg8 is ON HOLD Authors: Shi, K., Houston, D.R., Berghuis, A.M. Description: Crystal Structure of Aminoglycoside-2''-Phosphotransferase Type IVa To...

OCA — Wed, 22 Jun 2011 16:23:39 GMT

New page: '''Unreleased structure''' The entry 3sg8 is ON HOLD Authors: Shi, K., Houston, D.R., Berghuis, A.M. Description: Crystal Structure of Aminoglycoside-2''-Phosphotransferase Type IVa To...

New page

'''Unreleased structure'''

The entry 3sg8 is ON HOLD

Authors: Shi, K., Houston, D.R., Berghuis, A.M.

Description: Crystal Structure of Aminoglycoside-2''-Phosphotransferase Type IVa Tobramycin Complex