3sh5 - Revision history

OCA at 07:55, 29 June 2022

OCA — Wed, 29 Jun 2022 07:55:58 GMT

OCA at 17:44, 14 August 2019

OCA — Wed, 14 Aug 2019 17:44:00 GMT

←Older revision		Revision as of 17:44, 14 August 2019
Line 1:		Line 1:

	==Calcium-bound Laminin G like domain 3 from human perlecan==		==Calcium-bound Laminin G like domain 3 from human perlecan==
-	<StructureSection load='3sh5' size='340' side='right' caption='[[3sh5]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='3sh5' size='340' side='right'caption='[[3sh5]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3sh5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SH5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SH5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3sh5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SH5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SH5 FirstGlance]. <br>
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
	[[Category: Kim, K K]]		[[Category: Kim, K K]]
	[[Category: Le, B Van]]		[[Category: Le, B Van]]

OCA at 15:57, 11 August 2016

OCA — Thu, 11 Aug 2016 15:57:24 GMT

←Older revision		Revision as of 15:57, 11 August 2016
Line 1:		Line 1:
		+
	==Calcium-bound Laminin G like domain 3 from human perlecan==		==Calcium-bound Laminin G like domain 3 from human perlecan==
	<StructureSection load='3sh5' size='340' side='right' caption='[[3sh5]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='3sh5' size='340' side='right' caption='[[3sh5]], [[Resolution\|resolution]] 2.80Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sh4\|3sh4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sh4\|3sh4]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sh5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sh5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sh5 RCSB], [http://www.ebi.ac.uk/pdbsum/3sh5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sh5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sh5 OCA], [http://pdbe.org/3sh5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3sh5 RCSB], [http://www.ebi.ac.uk/pdbsum/3sh5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3sh5 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/PGBM_HUMAN PGBM_HUMAN]] Dyssegmental dysplasia, Silverman-Handmaker type;Schwartz-Jampel syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PGBM_HUMAN PGBM_HUMAN]] Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development. Endorepellin in an anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6. The LG3 peptide has anti-angiogenic properties that require binding of calcium ions for full activity.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3sh5" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:12, 4 January 2015

OCA — Sun, 04 Jan 2015 09:12:46 GMT

←Older revision		Revision as of 09:12, 4 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3sh5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SH5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SH5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3sh5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SH5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SH5 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sh4\|3sh4]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sh4\|3sh4]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sh5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sh5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sh5 RCSB], [http://www.ebi.ac.uk/pdbsum/3sh5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sh5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sh5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sh5 RCSB], [http://www.ebi.ac.uk/pdbsum/3sh5 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	Crystal Structure of the LG3 Domain of Endorepellin, an Angiogenesis Inhibitor.,V Le B, Kim H, Choi J, Kim JH, Hahn MJ, Lee C, Kim KK, Hwang HY J Mol Biol. 2011 Nov 25;414(2):231-42. Epub 2011 Oct 4. PMID:21996443<ref>PMID:21996443</ref>		Crystal Structure of the LG3 Domain of Endorepellin, an Angiogenesis Inhibitor.,V Le B, Kim H, Choi J, Kim JH, Hahn MJ, Lee C, Kim KK, Hwang HY J Mol Biol. 2011 Nov 25;414(2):231-42. Epub 2011 Oct 4. PMID:21996443<ref>PMID:21996443</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Kim, K K.]]	+	[[Category: Kim, K K]]
-	[[Category: Le, B Van.]]	+	[[Category: Le, B Van]]
	[[Category: Actin disassambly activity]]		[[Category: Actin disassambly activity]]
	[[Category: Integrin alpha 2 beta 1]]		[[Category: Integrin alpha 2 beta 1]]
	[[Category: Metal binding protein]]		[[Category: Metal binding protein]]

OCA at 05:20, 5 June 2014

OCA — Thu, 05 Jun 2014 05:20:31 GMT

←Older revision		Revision as of 05:20, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3sh5.~~jpg~~\|~~left~~\|~~200px~~]]	+	==Calcium-bound Laminin G like domain 3 from human perlecan==
		+	<StructureSection load='3sh5' size='340' side='right' caption='[[3sh5]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3sh5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SH5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SH5 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sh4\|3sh4]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sh5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sh5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sh5 RCSB], [http://www.ebi.ac.uk/pdbsum/3sh5 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Endorepellin, the C-terminal region of perlecan, inhibits angiogenesis by disrupting actin cytoskeleton and focal adhesions. The C-terminal laminin-like globular domain (LG3) of endorepellin directs most of this antiangiogenic activity. To investigate the angiostatic mechanism and to identify structural determinants, we have solved crystal structures of the LG3 domain in both apo- and calcium-bound forms at resolutions of 1.5 A and 2.8 A, respectively. The conserved core has the jellyroll fold characteristic of LG domains. The calcium-induced structural changes seem very restricted, and the calcium binding site appears to be preformed, suggesting that the bound calcium ion, rather than structural rearrangements, contributes to antiangiogenesis. We have identified H4268 on the EF loop as a key residue for the biochemical function of LG3, since its mutation abolishes antiangiogenic activity, and mutant LG3 can no longer form a direct interaction with integrin. Taken together, we propose that these two distinct structural elements contribute to the angiostatic effect of endorepellin.

-	~~<!--~~	+	Crystal Structure of the LG3 Domain of Endorepellin, an Angiogenesis Inhibitor.,V Le B, Kim H, Choi J, Kim JH, Hahn MJ, Lee C, Kim KK, Hwang HY J Mol Biol. 2011 Nov 25;414(2):231-42. Epub 2011 Oct 4. PMID:21996443<ref>PMID:21996443</ref>
-	~~The line below this paragraph, containing "STRUCTURE_3sh5", creates the "~~Structure ~~Box" on~~ the ~~page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_3sh5\| PDB=3sh5 \| SCENE= }}~~	+

-	~~===Calcium-bound Laminin G like domain 3 from human perlecan===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_21996443}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21996443 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_21996443}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3sh5]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SH5 OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021996443<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Kim, K K.]]		[[Category: Kim, K K.]]

OCA at 11:37, 14 December 2011

OCA — Wed, 14 Dec 2011 11:37:36 GMT

←Older revision		Revision as of 11:37, 14 December 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3sh5.jpg\|left\|200px]]

-	The ~~entry 3sh5~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3sh5", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3sh5\| PDB=3sh5 \| SCENE= }}

-	~~Authors: Le, B.V., Kim, K.K.~~	+	===Calcium-bound Laminin G like domain 3 from human perlecan===

-	~~Description~~: ~~Calcium~~-~~bound Laminin G like domain 3~~ from ~~human perlecan~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21996443}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21996443 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21996443}}
		+
		+	==About this Structure==
		+	[[3sh5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SH5 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021996443</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Kim, K K.]]
		+	[[Category: Le, B Van.]]
		+	[[Category: Actin disassambly activity]]
		+	[[Category: Integrin alpha 2 beta 1]]
		+	[[Category: Metal binding protein]]

OCA at 05:41, 7 September 2011

OCA — Wed, 07 Sep 2011 05:41:58 GMT

←Older revision		Revision as of 05:41, 7 September 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3sh5 is ON HOLD	+	The entry 3sh5 is ON HOLD until Paper Publication

	Authors: Le, B.V., Kim, K.K.		Authors: Le, B.V., Kim, K.K.

	Description: Calcium-bound Laminin G like domain 3 from human perlecan		Description: Calcium-bound Laminin G like domain 3 from human perlecan

OCA at 18:26, 6 July 2011

OCA — Wed, 06 Jul 2011 18:26:00 GMT

←Older revision		Revision as of 18:26, 6 July 2011
Line 3:		Line 3:
	The entry 3sh5 is ON HOLD		The entry 3sh5 is ON HOLD

-	Authors: Le, ~~Binh~~ V., Kim, ~~Kyeong Kyu~~	+	Authors: Le, B.V., Kim, K.K.

	Description: Calcium-bound Laminin G like domain 3 from human perlecan		Description: Calcium-bound Laminin G like domain 3 from human perlecan

OCA: Protected "3sh5" [edit=sysop:move=sysop]

OCA — Wed, 22 Jun 2011 16:24:34 GMT

Protected "3sh5" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:24, 22 June 2011

OCA: New page: '''Unreleased structure''' The entry 3sh5 is ON HOLD Authors: Le, Binh V., Kim, Kyeong Kyu Description: Calcium-bound Laminin G like domain 3 from human perlecan

OCA — Wed, 22 Jun 2011 16:24:32 GMT

New page: '''Unreleased structure''' The entry 3sh5 is ON HOLD Authors: Le, Binh V., Kim, Kyeong Kyu Description: Calcium-bound Laminin G like domain 3 from human perlecan

New page

'''Unreleased structure'''

The entry 3sh5 is ON HOLD

Authors: Le, Binh V., Kim, Kyeong Kyu

Description: Calcium-bound Laminin G like domain 3 from human perlecan

←Older revision		Revision as of 07:55, 29 June 2022
Line 3:		Line 3:
	<StructureSection load='3sh5' size='340' side='right'caption='[[3sh5]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='3sh5' size='340' side='right'caption='[[3sh5]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3sh5]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SH5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3SH5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3sh5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SH5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SH5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sh4\|3sh4]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3sh4\|3sh4]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3sh5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sh5 OCA], [~~http~~://pdbe.org/3sh5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3sh5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3sh5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3sh5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sh5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sh5 OCA], [https://pdbe.org/3sh5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sh5 RCSB], [https://www.ebi.ac.uk/pdbsum/3sh5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sh5 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/PGBM_HUMAN PGBM_HUMAN]] Dyssegmental dysplasia, Silverman-Handmaker type;Schwartz-Jampel syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.	+	[[https://www.uniprot.org/uniprot/PGBM_HUMAN PGBM_HUMAN]] Dyssegmental dysplasia, Silverman-Handmaker type;Schwartz-Jampel syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PGBM_HUMAN PGBM_HUMAN]] Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development. Endorepellin in an anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6. The LG3 peptide has anti-angiogenic properties that require binding of calcium ions for full activity.	+	[[https://www.uniprot.org/uniprot/PGBM_HUMAN PGBM_HUMAN]] Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development. Endorepellin in an anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6. The LG3 peptide has anti-angiogenic properties that require binding of calcium ions for full activity.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==