3sht - Revision history

OCA at 17:26, 1 November 2023

OCA — Wed, 01 Nov 2023 17:26:01 GMT

←Older revision		Revision as of 17:26, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3sht' size='340' side='right'caption='[[3sht]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='3sht' size='340' side='right'caption='[[3sht]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3sht]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SHT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SHT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3sht]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SHT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SHT FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3shv\|3shv]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.95Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">MCPH1 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sht OCA], [https://pdbe.org/3sht PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sht RCSB], [https://www.ebi.ac.uk/pdbsum/3sht PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sht ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sht OCA], [https://pdbe.org/3sht PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sht RCSB], [https://www.ebi.ac.uk/pdbsum/3sht PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sht ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/MCPH1_HUMAN MCPH1_HUMAN]] Premature chromosome condensation with microcephaly and intellectual deficit;Autosomal recessive primary microcephaly. Defects in MCPH1 are the cause of microcephaly primary type 1 (MCPH1) [MIM:[https://omim.org/entry/251200 251200]]; also known as true microcephaly or microcephaly vera. Microcephaly is defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits. This entity is inherited as autosomal recessive trait.<ref>PMID:12046007</ref> <ref>PMID:15199523</ref> <ref>PMID:16211557</ref>	+	[https://www.uniprot.org/uniprot/MCPH1_HUMAN MCPH1_HUMAN] Premature chromosome condensation with microcephaly and intellectual deficit;Autosomal recessive primary microcephaly. Defects in MCPH1 are the cause of microcephaly primary type 1 (MCPH1) [MIM:[https://omim.org/entry/251200 251200]; also known as true microcephaly or microcephaly vera. Microcephaly is defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits. This entity is inherited as autosomal recessive trait.<ref>PMID:12046007</ref> <ref>PMID:15199523</ref> <ref>PMID:16211557</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MCPH1_HUMAN MCPH1_HUMAN]] Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.<ref>PMID:12046007</ref> <ref>PMID:15199523</ref> <ref>PMID:15220350</ref>	+	[https://www.uniprot.org/uniprot/MCPH1_HUMAN MCPH1_HUMAN] Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.<ref>PMID:12046007</ref> <ref>PMID:15199523</ref> <ref>PMID:15220350</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Li~~, F D~~]]	+	[[Category: Li FD]]
-	[[Category: Shao~~, Z H~~]]	+	[[Category: Shao ZH]]
-	[[Category: Yan, W]]	+	[[Category: Yan W]]
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Tandem brct domain~~]]	+

OCA at 07:56, 29 June 2022

OCA — Wed, 29 Jun 2022 07:56:43 GMT

←Older revision		Revision as of 07:56, 29 June 2022
Line 1:		Line 1:

	==Crystal structure of human MCPH1 tandem BRCT domains==		==Crystal structure of human MCPH1 tandem BRCT domains==
-	<StructureSection load='3sht' size='340' side='right' caption='[[3sht]], [[Resolution\|resolution]] 1.95Å' scene=''>	+	<StructureSection load='3sht' size='340' side='right'caption='[[3sht]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3sht]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SHT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3SHT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3sht]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SHT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SHT FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3shv\|3shv]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3shv\|3shv]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MCPH1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MCPH1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3sht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sht OCA], [~~http~~://pdbe.org/3sht PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3sht RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3sht PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3sht ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sht OCA], [https://pdbe.org/3sht PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sht RCSB], [https://www.ebi.ac.uk/pdbsum/3sht PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sht ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/MCPH1_HUMAN MCPH1_HUMAN]] Premature chromosome condensation with microcephaly and intellectual deficit;Autosomal recessive primary microcephaly. Defects in MCPH1 are the cause of microcephaly primary type 1 (MCPH1) [MIM:[~~http~~://omim.org/entry/251200 251200]]; also known as true microcephaly or microcephaly vera. Microcephaly is defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits. This entity is inherited as autosomal recessive trait.<ref>PMID:12046007</ref> <ref>PMID:15199523</ref> <ref>PMID:16211557</ref>	+	[[https://www.uniprot.org/uniprot/MCPH1_HUMAN MCPH1_HUMAN]] Premature chromosome condensation with microcephaly and intellectual deficit;Autosomal recessive primary microcephaly. Defects in MCPH1 are the cause of microcephaly primary type 1 (MCPH1) [MIM:[https://omim.org/entry/251200 251200]]; also known as true microcephaly or microcephaly vera. Microcephaly is defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits. This entity is inherited as autosomal recessive trait.<ref>PMID:12046007</ref> <ref>PMID:15199523</ref> <ref>PMID:16211557</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MCPH1_HUMAN MCPH1_HUMAN]] Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.<ref>PMID:12046007</ref> <ref>PMID:15199523</ref> <ref>PMID:15220350</ref>	+	[[https://www.uniprot.org/uniprot/MCPH1_HUMAN MCPH1_HUMAN]] Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.<ref>PMID:12046007</ref> <ref>PMID:15199523</ref> <ref>PMID:15220350</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Li, F D]]		[[Category: Li, F D]]
	[[Category: Shao, Z H]]		[[Category: Shao, Z H]]

OCA at 09:50, 4 August 2016

OCA — Thu, 04 Aug 2016 09:50:13 GMT

←Older revision		Revision as of 09:50, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of human MCPH1 tandem BRCT domains==		==Crystal structure of human MCPH1 tandem BRCT domains==
	<StructureSection load='3sht' size='340' side='right' caption='[[3sht]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='3sht' size='340' side='right' caption='[[3sht]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3sht]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SHT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SHT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3sht]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SHT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SHT FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3shv\|3shv]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3shv\|3shv]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MCPH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MCPH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sht OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sht RCSB], [http://www.ebi.ac.uk/pdbsum/3sht PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sht OCA], [http://pdbe.org/3sht PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3sht RCSB], [http://www.ebi.ac.uk/pdbsum/3sht PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3sht ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3sht" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Li, F D]]		[[Category: Li, F D]]
	[[Category: Shao, Z H]]		[[Category: Shao, Z H]]

OCA at 06:39, 21 December 2014

OCA — Sun, 21 Dec 2014 06:39:13 GMT

←Older revision		Revision as of 06:39, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3sht\| PDB=3sht \| SCENE= }}~~	+	==Crystal structure of human MCPH1 tandem BRCT domains==
-	===Crystal structure of human MCPH1 tandem BRCT domains===	+	<StructureSection load='3sht' size='340' side='right' caption='[[3sht]], [[Resolution\|resolution]] 1.95Å' scene=''>
-	~~{{ABSTRACT_PUBMED_22154951}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3sht]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SHT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SHT FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3shv\|3shv]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MCPH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sht OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sht RCSB], [http://www.ebi.ac.uk/pdbsum/3sht PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/MCPH1_HUMAN MCPH1_HUMAN]] Premature chromosome condensation with microcephaly and intellectual deficit;Autosomal recessive primary microcephaly. Defects in MCPH1 are the cause of microcephaly primary type 1 (MCPH1) [MIM:[http://omim.org/entry/251200 251200]]; also known as true microcephaly or microcephaly vera. Microcephaly is defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits. This entity is inherited as autosomal recessive trait.<ref>PMID:12046007</ref> <ref>PMID:15199523</ref> <ref>PMID:16211557</ref>		[[http://www.uniprot.org/uniprot/MCPH1_HUMAN MCPH1_HUMAN]] Premature chromosome condensation with microcephaly and intellectual deficit;Autosomal recessive primary microcephaly. Defects in MCPH1 are the cause of microcephaly primary type 1 (MCPH1) [MIM:[http://omim.org/entry/251200 251200]]; also known as true microcephaly or microcephaly vera. Microcephaly is defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits. This entity is inherited as autosomal recessive trait.<ref>PMID:12046007</ref> <ref>PMID:15199523</ref> <ref>PMID:16211557</ref>
-		+	== Function ==
-	==Function==	+
	[[http://www.uniprot.org/uniprot/MCPH1_HUMAN MCPH1_HUMAN]] Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.<ref>PMID:12046007</ref> <ref>PMID:15199523</ref> <ref>PMID:15220350</ref>		[[http://www.uniprot.org/uniprot/MCPH1_HUMAN MCPH1_HUMAN]] Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.<ref>PMID:12046007</ref> <ref>PMID:15199523</ref> <ref>PMID:15220350</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	MCPH1 is especially important for linking chromatin remodeling to DNA damage response. It contains three BRCT (BRCA1-carboxyl terminal) domains. The N-terminal region directly binds with chromatin remodeling complex SWI-SNF, and the C-terminal BRCT2-BRCT3 domains (tandem BRCT domains) are involved in cellular DNA damage response. The MCPH1 gene associates with evolution of brain size, and its variation can cause primary microcephaly. In this study we solve the crystal structures of MCPH1 natural variant (A761) C-terminal tandem BRCT domains alone as well as in complex with gammaH2AX tail. Compared with other structures of tandem BRCT domains, the most significant differences lie in phosphopeptide binding pocket. Additionally, fluorescence polarization assays demonstrate that MCPH1 tandem BRCT domains show a binding selectivity on pSer +3 and prefer to bind phosphopeptide with free COOH-terminus. Taken together, our research provides new structural insights into BRCT-phosphopeptide recognition mechanism.

-	~~==About this Structure==~~	+	Specific recognition of phosphorylated tail of H2AX by the tandem BRCT domains of MCPH1 revealed by complex structure.,Shao Z, Li F, Sy SM, Yan W, Zhang Z, Gong D, Wen B, Huen MS, Gong Q, Wu J, Shi Y J Struct Biol. 2011 Dec 1. PMID:22154951<ref>PMID:22154951</ref>
-	~~[[3sht]] is a 3 chain~~ structure ~~with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3SHT OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:022154951</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Li, F D.]]	+	[[Category: Li, F D]]
-	[[Category: Shao, Z H.]]	+	[[Category: Shao, Z H]]
-	[[Category: Yan, W.]]	+	[[Category: Yan, W]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]
	[[Category: Tandem brct domain]]		[[Category: Tandem brct domain]]

OCA at 07:39, 20 June 2013

OCA — Thu, 20 Jun 2013 07:39:41 GMT

←Older revision		Revision as of 07:39, 20 June 2013
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-	[[Image:3sht.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3sht", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_3sht\| PDB=3sht \| SCENE= }}		{{STRUCTURE_3sht\| PDB=3sht \| SCENE= }}
-
	===Crystal structure of human MCPH1 tandem BRCT domains===		===Crystal structure of human MCPH1 tandem BRCT domains===
		+	{{ABSTRACT_PUBMED_22154951}}

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/MCPH1_HUMAN MCPH1_HUMAN]] Premature chromosome condensation with microcephaly and intellectual deficit;Autosomal recessive primary microcephaly. Defects in MCPH1 are the cause of microcephaly primary type 1 (MCPH1) [MIM:[http://omim.org/entry/251200 251200]]; also known as true microcephaly or microcephaly vera. Microcephaly is defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits. This entity is inherited as autosomal recessive trait.<ref>PMID:12046007</ref> <ref>PMID:15199523</ref> <ref>PMID:16211557</ref>

-	~~<!--~~	+	==Function==
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_22154951}}, adds the Publication Abstract to the page~~	+	[[http://www.uniprot.org/uniprot/MCPH1_HUMAN MCPH1_HUMAN]] Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.<ref>PMID:12046007</ref> <ref>PMID:15199523</ref> <ref>PMID:15220350</ref>
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov), where 22154951 is~~ the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_22154951}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:022154951</ref><references group="xtra"/>	+	<ref group="xtra">PMID:022154951</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Li, F D.]]		[[Category: Li, F D.]]

OCA at 07:24, 28 December 2011

OCA — Wed, 28 Dec 2011 07:24:48 GMT

←Older revision		Revision as of 07:24, 28 December 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3sht.jpg\|left\|200px]]

-	The ~~entry 3sht~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3sht", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3sht\| PDB=3sht \| SCENE= }}

-	~~Authors: Shao, Z.H., Li, F.D., Yan, W.~~	+	===Crystal structure of human MCPH1 tandem BRCT domains===

-	~~Description~~: ~~Crystal~~ structure ~~of human Microcephalin~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22154951}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22154951 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22154951}}
		+
		+	==About this Structure==
		+	[[3sht]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SHT OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022154951</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Li, F D.]]
		+	[[Category: Shao, Z H.]]
		+	[[Category: Yan, W.]]
		+	[[Category: Cell cycle]]
		+	[[Category: Tandem brct domain]]

OCA at 05:45, 29 June 2011

OCA — Wed, 29 Jun 2011 05:45:22 GMT

←Older revision		Revision as of 05:45, 29 June 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3sht is ON HOLD	+	The entry 3sht is ON HOLD until Paper Publication

	Authors: Shao, Z.H., Li, F.D., Yan, W.		Authors: Shao, Z.H., Li, F.D., Yan, W.

	Description: Crystal structure of human Microcephalin		Description: Crystal structure of human Microcephalin

OCA: Protected "3sht" [edit=sysop:move=sysop]

OCA — Wed, 22 Jun 2011 16:25:14 GMT

Protected "3sht" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:25, 22 June 2011

OCA: New page: '''Unreleased structure''' The entry 3sht is ON HOLD Authors: Shao, Z.H., Li, F.D., Yan, W. Description: Crystal structure of human Microcephalin

OCA — Wed, 22 Jun 2011 16:25:13 GMT

New page: '''Unreleased structure''' The entry 3sht is ON HOLD Authors: Shao, Z.H., Li, F.D., Yan, W. Description: Crystal structure of human Microcephalin

New page

'''Unreleased structure'''

The entry 3sht is ON HOLD

Authors: Shao, Z.H., Li, F.D., Yan, W.

Description: Crystal structure of human Microcephalin