3sku - Revision history

OCA at 13:00, 14 March 2024

OCA — Thu, 14 Mar 2024 13:00:11 GMT

←Older revision		Revision as of 13:00, 14 March 2024
Line 3:		Line 3:
	<StructureSection load='3sku' size='340' side='right'caption='[[3sku]], [[Resolution\|resolution]] 4.00Å' scene=''>		<StructureSection load='3sku' size='340' side='right'caption='[[3sku]], [[Resolution\|resolution]] 4.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3sku]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Hhv-1 Hhv-1~~] and [https://en.wikipedia.org/wiki/Human ~~Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SKU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3sku]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1 Human alphaherpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SKU FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BMA:BETA~~-~~D-MANNOSE'>BMA</scene>~~, ~~<scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 4Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~PVRL1, HVEC, PRR1 ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sku OCA], [https://pdbe.org/3sku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sku RCSB], [https://www.ebi.ac.uk/pdbsum/3sku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sku ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sku OCA], [https://pdbe.org/3sku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sku RCSB], [https://www.ebi.ac.uk/pdbsum/3sku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sku ProSAT]</span></td></tr>
	</table>		</table>
-	== Disease ==
-	[[https://www.uniprot.org/uniprot/PVRL1_HUMAN PVRL1_HUMAN]] Zlotogora-Ogur syndrome;Cleft lip with or without cleft palate. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~PVRL1_HUMAN PVRL1_HUMAN~~]] Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and PVRL4/nectin-4. Functions as an entry receptor for herpes simplex virus and pseudorabies virus.<ref>PMID:7721102</ref>	+	[https://www.uniprot.org/uniprot/Q991M3_HHV1 Q991M3_HHV1]
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Binding of herpes simplex virus (HSV) glycoprotein D (gD) to a cell surface receptor is required to trigger membrane fusion during entry into host cells. Nectin-1 is a cell adhesion molecule and the main HSV receptor in neurons and epithelial cells. We report the structure of gD bound to nectin-1 determined by x-ray crystallography to 4.0 A resolution. The structure reveals that the nectin-1 binding site on gD differs from the binding site of the HVEM receptor. A surface on the first Ig-domain of nectin-1, which mediates homophilic interactions of Ig-like cell adhesion molecules, buries an area composed by residues from both the gD N- and C-terminal extensions. Phenylalanine 129, at the tip of the loop connecting beta-strands F and G of nectin-1, protrudes into a groove on gD, which is otherwise occupied by C-terminal residues in the unliganded gD and by N-terminal residues in the gD/HVEM complex. Notably, mutation of Phe129 to alanine prevents nectin-1 binding to gD and HSV entry. Together these data are consistent with previous studies showing that gD disrupts the normal nectin-1 homophilic interactions. Furthermore, the structure of the complex supports a model in which gD-receptor binding triggers HSV entry through receptor-mediated displacement of the gD C-terminal region.	+
-		+
-	Structure of herpes simplex virus glycoprotein d bound to the human receptor nectin-1.,Di Giovine P, Settembre EC, Bhargava AK, Luftig MA, Lou H, Cohen GH, Eisenberg RJ, Krummenacher C, Carfi A PLoS Pathog. 2011 Sep;7(9):e1002277. Epub 2011 Sep 29. PMID:21980294<ref>PMID:21980294</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3sku" style="background-color:#fffaf0;"></div>~~	+

	==See Also==		==See Also==
	*[[Glycoproteins B and D\|Glycoproteins B and D]]		*[[Glycoproteins B and D\|Glycoproteins B and D]]
	*[[Poliovirus receptor-related protein\|Poliovirus receptor-related protein]]		*[[Poliovirus receptor-related protein\|Poliovirus receptor-related protein]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Hhv-1~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Human]]	+	[[Category: Human alphaherpesvirus 1]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bhargava~~, A K~~]]	+	[[Category: Bhargava AK]]
-	[[Category: Carfi, A]]	+	[[Category: Carfi A]]
-	[[Category: Cohen~~, G H~~]]	+	[[Category: Cohen GH]]
-	[[Category: ~~Eisenberg, R J~~]]	+	[[Category: Di Giovine P]]
-	[[Category: ~~Giovine, P Di~~]]	+	[[Category: Eisenberg RJ]]
-	[[Category: Krummenacher, C]]	+	[[Category: Krummenacher C]]
-	[[Category: Lou, H]]	+	[[Category: Lou H]]
-	[[Category: Luftig~~, M A~~]]	+	[[Category: Luftig MA]]
-	[[Category: Settembre~~, E C]]~~	+	[[Category: Settembre EC]]
-	~~[[Category: Immunoglobulin-like fold]]~~	+
-	~~[[Category: Viral protein-protein binding complex~~]]	+

OCA at 08:00, 29 June 2022

OCA — Wed, 29 Jun 2022 08:00:25 GMT

←Older revision		Revision as of 08:00, 29 June 2022
Line 1:		Line 1:

	==Herpes simplex virus glycoprotein D bound to the human receptor nectin-1==		==Herpes simplex virus glycoprotein D bound to the human receptor nectin-1==
-	<StructureSection load='3sku' size='340' side='right' caption='[[3sku]], [[Resolution\|resolution]] 4.00Å' scene=''>	+	<StructureSection load='3sku' size='340' side='right'caption='[[3sku]], [[Resolution\|resolution]] 4.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3sku]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Hhv-1 Hhv-1] and [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SKU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3SKU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3sku]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Hhv-1 Hhv-1] and [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SKU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PVRL1, HVEC, PRR1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PVRL1, HVEC, PRR1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3sku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sku OCA], [~~http~~://pdbe.org/3sku PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3sku RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3sku PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3sku ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sku OCA], [https://pdbe.org/3sku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sku RCSB], [https://www.ebi.ac.uk/pdbsum/3sku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sku ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/PVRL1_HUMAN PVRL1_HUMAN]] Zlotogora-Ogur syndrome;Cleft lip with or without cleft palate. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.	+	[[https://www.uniprot.org/uniprot/PVRL1_HUMAN PVRL1_HUMAN]] Zlotogora-Ogur syndrome;Cleft lip with or without cleft palate. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PVRL1_HUMAN PVRL1_HUMAN]] Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and PVRL4/nectin-4. Functions as an entry receptor for herpes simplex virus and pseudorabies virus.<ref>PMID:7721102</ref>	+	[[https://www.uniprot.org/uniprot/PVRL1_HUMAN PVRL1_HUMAN]] Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and PVRL4/nectin-4. Functions as an entry receptor for herpes simplex virus and pseudorabies virus.<ref>PMID:7721102</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	==See Also==		==See Also==
	*[[Glycoproteins B and D\|Glycoproteins B and D]]		*[[Glycoproteins B and D\|Glycoproteins B and D]]
		+	*[[Poliovirus receptor-related protein\|Poliovirus receptor-related protein]]
	== References ==		== References ==
	<references/>		<references/>
Line 30:		Line 31:
	[[Category: Hhv-1]]		[[Category: Hhv-1]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bhargava, A K]]		[[Category: Bhargava, A K]]
	[[Category: Carfi, A]]		[[Category: Carfi, A]]

OCA at 11:29, 10 December 2016

OCA — Sat, 10 Dec 2016 11:29:31 GMT

←Older revision		Revision as of 11:29, 10 December 2016
Line 1:		Line 1:
		+
	==Herpes simplex virus glycoprotein D bound to the human receptor nectin-1==		==Herpes simplex virus glycoprotein D bound to the human receptor nectin-1==
	<StructureSection load='3sku' size='340' side='right' caption='[[3sku]], [[Resolution\|resolution]] 4.00Å' scene=''>		<StructureSection load='3sku' size='340' side='right' caption='[[3sku]], [[Resolution\|resolution]] 4.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3sku]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~] and [http://en.wikipedia.org/wiki/~~Human_herpesvirus_1~~ Human ~~herpesvirus 1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SKU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SKU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3sku]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Hhv-1 Hhv-1] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SKU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SKU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PVRL1, HVEC, PRR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PVRL1, HVEC, PRR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sku OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sku RCSB], [http://www.ebi.ac.uk/pdbsum/3sku PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sku OCA], [http://pdbe.org/3sku PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3sku RCSB], [http://www.ebi.ac.uk/pdbsum/3sku PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3sku ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3sku" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Hhv-1]]
-	[[Category: Human ~~herpesvirus 1~~]]	+	[[Category: Human]]
	[[Category: Bhargava, A K]]		[[Category: Bhargava, A K]]
	[[Category: Carfi, A]]		[[Category: Carfi, A]]

OCA at 12:10, 9 December 2014

OCA — Tue, 09 Dec 2014 12:10:43 GMT

←Older revision		Revision as of 12:10, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3sku.~~png~~\|~~left~~\|~~200px~~]]	+	==Herpes simplex virus glycoprotein D bound to the human receptor nectin-1==
		+	<StructureSection load='3sku' size='340' side='right' caption='[[3sku]], [[Resolution\|resolution]] 4.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3sku]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_herpesvirus_1 Human herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SKU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SKU FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PVRL1, HVEC, PRR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sku OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sku RCSB], [http://www.ebi.ac.uk/pdbsum/3sku PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/PVRL1_HUMAN PVRL1_HUMAN]] Zlotogora-Ogur syndrome;Cleft lip with or without cleft palate. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PVRL1_HUMAN PVRL1_HUMAN]] Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and PVRL4/nectin-4. Functions as an entry receptor for herpes simplex virus and pseudorabies virus.<ref>PMID:7721102</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Binding of herpes simplex virus (HSV) glycoprotein D (gD) to a cell surface receptor is required to trigger membrane fusion during entry into host cells. Nectin-1 is a cell adhesion molecule and the main HSV receptor in neurons and epithelial cells. We report the structure of gD bound to nectin-1 determined by x-ray crystallography to 4.0 A resolution. The structure reveals that the nectin-1 binding site on gD differs from the binding site of the HVEM receptor. A surface on the first Ig-domain of nectin-1, which mediates homophilic interactions of Ig-like cell adhesion molecules, buries an area composed by residues from both the gD N- and C-terminal extensions. Phenylalanine 129, at the tip of the loop connecting beta-strands F and G of nectin-1, protrudes into a groove on gD, which is otherwise occupied by C-terminal residues in the unliganded gD and by N-terminal residues in the gD/HVEM complex. Notably, mutation of Phe129 to alanine prevents nectin-1 binding to gD and HSV entry. Together these data are consistent with previous studies showing that gD disrupts the normal nectin-1 homophilic interactions. Furthermore, the structure of the complex supports a model in which gD-receptor binding triggers HSV entry through receptor-mediated displacement of the gD C-terminal region.

-	~~{{STRUCTURE_3sku\| PDB=3sku \| SCENE= }}~~	+	Structure of herpes simplex virus glycoprotein d bound to the human receptor nectin-1.,Di Giovine P, Settembre EC, Bhargava AK, Luftig MA, Lou H, Cohen GH, Eisenberg RJ, Krummenacher C, Carfi A PLoS Pathog. 2011 Sep;7(9):e1002277. Epub 2011 Sep 29. PMID:21980294<ref>PMID:21980294</ref>

-	~~===Herpes simplex virus glycoprotein D bound to~~ the ~~human receptor nectin-1===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21980294}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3sku]] is a 6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens] and [http://en~~.~~wikipedia.org~~/~~wiki/Human_herpesvirus_1 Human herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SKU OCA].~~	+

	==See Also==		==See Also==
	*[[Glycoproteins B and D\|Glycoproteins B and D]]		*[[Glycoproteins B and D\|Glycoproteins B and D]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021980294<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Human herpesvirus 1]]		[[Category: Human herpesvirus 1]]
-	[[Category: Bhargava, A K.]]	+	[[Category: Bhargava, A K]]
-	[[Category: Carfi, A.]]	+	[[Category: Carfi, A]]
-	[[Category: Cohen, G H.]]	+	[[Category: Cohen, G H]]
-	[[Category: Eisenberg, R J.]]	+	[[Category: Eisenberg, R J]]
-	[[Category: Giovine, P Di.]]	+	[[Category: Giovine, P Di]]
-	[[Category: Krummenacher, C.]]	+	[[Category: Krummenacher, C]]
-	[[Category: Lou, H.]]	+	[[Category: Lou, H]]
-	[[Category: Luftig, M A.]]	+	[[Category: Luftig, M A]]
-	[[Category: Settembre, E C.]]	+	[[Category: Settembre, E C]]
	[[Category: Immunoglobulin-like fold]]		[[Category: Immunoglobulin-like fold]]
	[[Category: Viral protein-protein binding complex]]		[[Category: Viral protein-protein binding complex]]

OCA at 19:28, 20 October 2012

OCA — Sat, 20 Oct 2012 19:28:51 GMT

←Older revision		Revision as of 19:28, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3sku]] is a 6 chain structure ~~of [[Glycoproteins B and D]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_herpesvirus_1 Human herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SKU OCA].	+	[[3sku]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_herpesvirus_1 Human herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SKU OCA].

	==See Also==		==See Also==

OCA at 07:29, 27 July 2012

OCA — Fri, 27 Jul 2012 07:29:18 GMT

←Older revision		Revision as of 07:29, 27 July 2012
Line 1:		Line 1:
	[[Image:3sku.png\|left\|200px]]		[[Image:3sku.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3sku", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3sku\| PDB=3sku \| SCENE= }}		{{STRUCTURE_3sku\| PDB=3sku \| SCENE= }}

	===Herpes simplex virus glycoprotein D bound to the human receptor nectin-1===		===Herpes simplex virus glycoprotein D bound to the human receptor nectin-1===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21980294}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21980294 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21980294}}		{{ABSTRACT_PUBMED_21980294}}

	==About this Structure==		==About this Structure==
-	[[3sku]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_herpesvirus_1 Human herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SKU OCA].	+	[[3sku]] is a 6 chain structure of [[Glycoproteins B and D]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_herpesvirus_1 Human herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SKU OCA].
		+
		+	==See Also==
		+	*[[Glycoproteins B and D\|Glycoproteins B and D]]

	==Reference==		==Reference==

OCA at 08:11, 30 October 2011

OCA — Sun, 30 Oct 2011 08:11:49 GMT

←Older revision		Revision as of 08:11, 30 October 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3sku.png\|left\|200px]]

-	The ~~entry 3sku~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3sku", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3sku\| PDB=3sku \| SCENE= }}

-	~~Authors: Di Giovine, P., Settembre, E.C., Bhargava, A.K., Luftig, M.A., Lou, H., Cohen, G.H., Eisenberg, R.J., Krummenacher, C., Carfi, A.~~	+	===Herpes simplex virus glycoprotein D bound to the human receptor nectin-1===

-	~~Description: Herpes simplex virus glycoprotein D bound~~ to the ~~human receptor nectin~~-1	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21980294}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21980294 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21980294}}
		+
		+	==About this Structure==
		+	[[3sku]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_herpesvirus_1 Human herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SKU OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021980294</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Human herpesvirus 1]]
		+	[[Category: Bhargava, A K.]]
		+	[[Category: Carfi, A.]]
		+	[[Category: Cohen, G H.]]
		+	[[Category: Eisenberg, R J.]]
		+	[[Category: Giovine, P Di.]]
		+	[[Category: Krummenacher, C.]]
		+	[[Category: Lou, H.]]
		+	[[Category: Luftig, M A.]]
		+	[[Category: Settembre, E C.]]
		+	[[Category: Immunoglobulin-like fold]]
		+	[[Category: Viral protein-protein binding complex]]

OCA at 05:39, 27 July 2011

OCA — Wed, 27 Jul 2011 05:39:48 GMT

←Older revision		Revision as of 05:39, 27 July 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3sku is ON HOLD ~~until sometime in the future~~	+	The entry 3sku is ON HOLD

	Authors: Di Giovine, P., Settembre, E.C., Bhargava, A.K., Luftig, M.A., Lou, H., Cohen, G.H., Eisenberg, R.J., Krummenacher, C., Carfi, A.		Authors: Di Giovine, P., Settembre, E.C., Bhargava, A.K., Luftig, M.A., Lou, H., Cohen, G.H., Eisenberg, R.J., Krummenacher, C., Carfi, A.

	Description: Herpes simplex virus glycoprotein D bound to the human receptor nectin-1		Description: Herpes simplex virus glycoprotein D bound to the human receptor nectin-1

OCA at 06:12, 20 July 2011

OCA — Wed, 20 Jul 2011 06:12:31 GMT

←Older revision		Revision as of 06:12, 20 July 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3sku is ON HOLD	+	The entry 3sku is ON HOLD until sometime in the future

	Authors: Di Giovine, P., Settembre, E.C., Bhargava, A.K., Luftig, M.A., Lou, H., Cohen, G.H., Eisenberg, R.J., Krummenacher, C., Carfi, A.		Authors: Di Giovine, P., Settembre, E.C., Bhargava, A.K., Luftig, M.A., Lou, H., Cohen, G.H., Eisenberg, R.J., Krummenacher, C., Carfi, A.

	Description: Herpes simplex virus glycoprotein D bound to the human receptor nectin-1		Description: Herpes simplex virus glycoprotein D bound to the human receptor nectin-1

OCA: Protected "3sku" [edit=sysop:move=sysop]

OCA — Wed, 29 Jun 2011 05:48:33 GMT

Protected "3sku" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:48, 29 June 2011