3smz - Revision history

OCA at 13:01, 14 March 2024

OCA — Thu, 14 Mar 2024 13:01:51 GMT

←Older revision		Revision as of 13:01, 14 March 2024
Line 3:		Line 3:
	<StructureSection load='3smz' size='340' side='right'caption='[[3smz]], [[Resolution\|resolution]] 1.99Å' scene=''>		<StructureSection load='3smz' size='340' side='right'caption='[[3smz]], [[Resolution\|resolution]] 1.99Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3smz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SMZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SMZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3smz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SMZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SMZ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.99Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[3h2u\|3h2u]], [[3h2v\|3h2v]]~~<~~/div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">KIAA1978, RAVER1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3smz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3smz OCA], [https://pdbe.org/3smz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3smz RCSB], [https://www.ebi.ac.uk/pdbsum/3smz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3smz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3smz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3smz OCA], [https://pdbe.org/3smz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3smz RCSB], [https://www.ebi.ac.uk/pdbsum/3smz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3smz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RAVR1_HUMAN RAVR1_HUMAN]] Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity).	+	[https://www.uniprot.org/uniprot/RAVR1_HUMAN RAVR1_HUMAN] Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity).
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Raver1 is a multifunctional protein that modulates both alternative splicing and focal adhesion assembly by binding to the nucleoplasmic splicing repressor polypyrimidine tract protein (PTB) or to the cytoskeletal proteins vinculin and alpha-actinin. The amino-terminal region of raver1 has three RNA recognition motif (RRM1, RRM2, and RRM3) domains, and RRM1 interacts with the vinculin tail (Vt) domain and vinculin mRNA. We previously determined the crystal structure of the raver1 RRM1-3 domains in complex with Vt at 2.75 A resolution. Here, we report crystal structure of the unbound raver1 RRM1-3 domains at 2 A resolution. The apo structure reveals that a bound sulfate ion disrupts an electrostatic interaction between the RRM1 and RRM2 domains, triggering a large relative domain movement of over 30 degrees . Superposition with other RNA-bound RRM structures places the sulfate ion near the superposed RNA phosphate group suggesting that this is the raver1 RNA binding site. While several single and some tandem RRM domain structures have been described, to the best of our knowledge, this is the second report of a three-tandem RRM domain structure.	+
-		+
-	~~Apo raver1 structure reveals distinct RRM domain orientations.,Rangarajan ES, Lee JH, Izard T Protein Sci. 2011 Jun 1. doi: 10.1002/pro.664. PMID:21633983<ref>PMID:21633983</ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3smz" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Izard, T]]	+	[[Category: Izard T]]
-	[[Category: Lee~~, J H~~]]	+	[[Category: Lee JH]]
-	[[Category: Rangarajan~~, E S]]~~	+	[[Category: Rangarajan ES]]
-	~~[[Category: Alpha-actinin]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Ribonucleoprotein]]~~	+
-	~~[[Category: Rna binding]]~~	+
-	~~[[Category: Rna binding protein]]~~	+
-	~~[[Category: Rna recognition motif]]~~	+
-	~~[[Category: Vinculin~~]]	+

OCA at 08:02, 29 June 2022

OCA — Wed, 29 Jun 2022 08:02:30 GMT

←Older revision		Revision as of 08:02, 29 June 2022
Line 1:		Line 1:

	==Human raver1 RRM1-3 domains (residues 39-320)==		==Human raver1 RRM1-3 domains (residues 39-320)==
-	<StructureSection load='3smz' size='340' side='right' caption='[[3smz]], [[Resolution\|resolution]] 1.99Å' scene=''>	+	<StructureSection load='3smz' size='340' side='right'caption='[[3smz]], [[Resolution\|resolution]] 1.99Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3smz]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SMZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3SMZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3smz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SMZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SMZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3h2u\|3h2u]], [[3h2v\|3h2v]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3h2u\|3h2u]], [[3h2v\|3h2v]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KIAA1978, RAVER1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KIAA1978, RAVER1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3smz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3smz OCA], [~~http~~://pdbe.org/3smz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3smz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3smz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3smz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3smz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3smz OCA], [https://pdbe.org/3smz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3smz RCSB], [https://www.ebi.ac.uk/pdbsum/3smz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3smz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RAVR1_HUMAN RAVR1_HUMAN]] Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity).	+	[[https://www.uniprot.org/uniprot/RAVR1_HUMAN RAVR1_HUMAN]] Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Izard, T]]		[[Category: Izard, T]]
	[[Category: Lee, J H]]		[[Category: Lee, J H]]

OCA at 17:58, 4 August 2016

OCA — Thu, 04 Aug 2016 17:58:45 GMT

←Older revision		Revision as of 17:58, 4 August 2016
Line 1:		Line 1:
		+
	==Human raver1 RRM1-3 domains (residues 39-320)==		==Human raver1 RRM1-3 domains (residues 39-320)==
	<StructureSection load='3smz' size='340' side='right' caption='[[3smz]], [[Resolution\|resolution]] 1.99Å' scene=''>		<StructureSection load='3smz' size='340' side='right' caption='[[3smz]], [[Resolution\|resolution]] 1.99Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3smz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SMZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SMZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3smz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SMZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SMZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3h2u\|3h2u]], [[3h2v\|3h2v]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3h2u\|3h2u]], [[3h2v\|3h2v]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KIAA1978, RAVER1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KIAA1978, RAVER1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3smz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3smz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3smz RCSB], [http://www.ebi.ac.uk/pdbsum/3smz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3smz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3smz OCA], [http://pdbe.org/3smz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3smz RCSB], [http://www.ebi.ac.uk/pdbsum/3smz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3smz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3smz" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Izard, T]]		[[Category: Izard, T]]
	[[Category: Lee, J H]]		[[Category: Lee, J H]]

OCA at 11:40, 25 December 2014

OCA — Thu, 25 Dec 2014 11:40:14 GMT

←Older revision		Revision as of 11:40, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3smz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SMZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SMZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[3smz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SMZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SMZ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3h2u\|3h2u]], [[3h2v\|3h2v]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3h2u\|3h2u]], [[3h2v\|3h2v]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KIAA1978, RAVER1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KIAA1978, RAVER1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3smz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3smz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3smz RCSB], [http://www.ebi.ac.uk/pdbsum/3smz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3smz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3smz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3smz RCSB], [http://www.ebi.ac.uk/pdbsum/3smz PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RAVR1_HUMAN RAVR1_HUMAN]] Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 16:
	Apo raver1 structure reveals distinct RRM domain orientations.,Rangarajan ES, Lee JH, Izard T Protein Sci. 2011 Jun 1. doi: 10.1002/pro.664. PMID:21633983<ref>PMID:21633983</ref>		Apo raver1 structure reveals distinct RRM domain orientations.,Rangarajan ES, Lee JH, Izard T Protein Sci. 2011 Jun 1. doi: 10.1002/pro.664. PMID:21633983<ref>PMID:21633983</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 21:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Izard, T.]]	+	[[Category: Izard, T]]
-	[[Category: Lee, J H.]]	+	[[Category: Lee, J H]]
-	[[Category: Rangarajan, E S.]]	+	[[Category: Rangarajan, E S]]
	[[Category: Alpha-actinin]]		[[Category: Alpha-actinin]]
	[[Category: Nucleus]]		[[Category: Nucleus]]

OCA at 05:18, 5 June 2014

OCA — Thu, 05 Jun 2014 05:18:28 GMT

←Older revision		Revision as of 05:18, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3smz.~~jpg~~\|~~left~~\|~~200px~~]]	+	==Human raver1 RRM1-3 domains (residues 39-320)==
		+	<StructureSection load='3smz' size='340' side='right' caption='[[3smz]], [[Resolution\|resolution]] 1.99Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3smz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SMZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SMZ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3h2u\|3h2u]], [[3h2v\|3h2v]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KIAA1978, RAVER1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3smz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3smz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3smz RCSB], [http://www.ebi.ac.uk/pdbsum/3smz PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Raver1 is a multifunctional protein that modulates both alternative splicing and focal adhesion assembly by binding to the nucleoplasmic splicing repressor polypyrimidine tract protein (PTB) or to the cytoskeletal proteins vinculin and alpha-actinin. The amino-terminal region of raver1 has three RNA recognition motif (RRM1, RRM2, and RRM3) domains, and RRM1 interacts with the vinculin tail (Vt) domain and vinculin mRNA. We previously determined the crystal structure of the raver1 RRM1-3 domains in complex with Vt at 2.75 A resolution. Here, we report crystal structure of the unbound raver1 RRM1-3 domains at 2 A resolution. The apo structure reveals that a bound sulfate ion disrupts an electrostatic interaction between the RRM1 and RRM2 domains, triggering a large relative domain movement of over 30 degrees . Superposition with other RNA-bound RRM structures places the sulfate ion near the superposed RNA phosphate group suggesting that this is the raver1 RNA binding site. While several single and some tandem RRM domain structures have been described, to the best of our knowledge, this is the second report of a three-tandem RRM domain structure.

-	~~<!--~~	+	Apo raver1 structure reveals distinct RRM domain orientations.,Rangarajan ES, Lee JH, Izard T Protein Sci. 2011 Jun 1. doi: 10.1002/pro.664. PMID:21633983<ref>PMID:21633983</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3smz"~~, ~~creates the "Structure Box" on the page.~~	+
-	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded)~~,	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_3smz\| PDB=3smz \| SCENE= }}~~	+

-	~~===Human raver1 RRM1-3 domains (residues 39-320)===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_21633983}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21633983 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_21633983}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3smz]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SMZ OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021633983<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Izard, T.]]		[[Category: Izard, T.]]

OCA at 05:57, 10 August 2011

OCA — Wed, 10 Aug 2011 05:57:39 GMT

←Older revision		Revision as of 05:57, 10 August 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3smz.jpg\|left\|200px]]

-	The ~~entry 3smz~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3smz", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3smz\| PDB=3smz \| SCENE= }}

-	~~Authors: Rangarajan, E.S., Lee, J.H., Izard, T.~~	+	===Human raver1 RRM1-3 domains (residues 39-320)===

-	~~Description: Human raver1 RRM1~~-~~3 domains (residues 39~~-~~320~~)	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21633983}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21633983 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21633983}}
		+
		+	==About this Structure==
		+	[[3smz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SMZ OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021633983</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Izard, T.]]
		+	[[Category: Lee, J H.]]
		+	[[Category: Rangarajan, E S.]]
		+	[[Category: Alpha-actinin]]
		+	[[Category: Nucleus]]
		+	[[Category: Ribonucleoprotein]]
		+	[[Category: Rna binding]]
		+	[[Category: Rna binding protein]]
		+	[[Category: Rna recognition motif]]
		+	[[Category: Vinculin]]

OCA at 08:20, 3 August 2011

OCA — Wed, 03 Aug 2011 08:20:05 GMT

←Older revision		Revision as of 08:20, 3 August 2011
Line 5:		Line 5:
	Authors: Rangarajan, E.S., Lee, J.H., Izard, T.		Authors: Rangarajan, E.S., Lee, J.H., Izard, T.

-	Description: Human raver1 RRM1-3 domains (residues 39-~~321~~)	+	Description: Human raver1 RRM1-3 domains (residues 39-320)

OCA at 06:13, 20 July 2011

OCA — Wed, 20 Jul 2011 06:13:05 GMT

←Older revision		Revision as of 06:13, 20 July 2011
Line 5:		Line 5:
	Authors: Rangarajan, E.S., Lee, J.H., Izard, T.		Authors: Rangarajan, E.S., Lee, J.H., Izard, T.

-	Description: ~~human~~ raver1 RRM1-3 domains (residues 39-321)	+	Description: Human raver1 RRM1-3 domains (residues 39-321)

OCA: Protected "3smz" [edit=sysop:move=sysop]

OCA — Wed, 06 Jul 2011 18:29:19 GMT

Protected "3smz" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:29, 6 July 2011

OCA: New page: '''Unreleased structure''' The entry 3smz is ON HOLD Authors: Rangarajan, E.S., Lee, J.H., Izard, T. Description: human raver1 RRM1-3 domains (residues 39-321)

OCA — Wed, 06 Jul 2011 18:29:18 GMT

New page: '''Unreleased structure''' The entry 3smz is ON HOLD Authors: Rangarajan, E.S., Lee, J.H., Izard, T. Description: human raver1 RRM1-3 domains (residues 39-321)

New page

'''Unreleased structure'''

The entry 3smz is ON HOLD

Authors: Rangarajan, E.S., Lee, J.H., Izard, T.

Description: human raver1 RRM1-3 domains (residues 39-321)