3sxn - Revision history

OCA at 08:37, 20 March 2024

OCA — Wed, 20 Mar 2024 08:37:11 GMT

←Older revision		Revision as of 08:37, 20 March 2024
Line 3:		Line 3:
	<StructureSection load='3sxn' size='340' side='right'caption='[[3sxn]], [[Resolution\|resolution]] 2.03Å' scene=''>		<StructureSection load='3sxn' size='340' side='right'caption='[[3sxn]], [[Resolution\|resolution]] 2.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3sxn]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Mycs2 Mycs2~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SXN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SXN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3sxn]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SXN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SXN FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=COA:COENZYME+A'>COA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.03Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[3ryo\|3ryo]], [[3uy5\|3uy5]]~~<~~/div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">Eis, MSMEG_3513 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 MYCS2])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sxn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sxn OCA], [https://pdbe.org/3sxn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sxn RCSB], [https://www.ebi.ac.uk/pdbsum/3sxn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sxn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sxn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sxn OCA], [https://pdbe.org/3sxn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sxn RCSB], [https://www.ebi.ac.uk/pdbsum/3sxn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sxn ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/A0QY29_MYCS2 A0QY29_MYCS2]
-	The intracellular pathogen Mycobacterium tuberculosis (Mtb) causes tuberculosis. Enhanced intracellular survival (Eis) protein, secreted by Mtb, enhances survival of Mycobacterium smegmatis (Msm) in macrophages. Mtb Eis was shown to suppress host immune defenses by negatively modulating autophagy, inflammation, and cell death through JNK-dependent inhibition of reactive oxygen species (ROS) generation. Mtb Eis was recently demonstrated to contribute to drug resistance by acetylating multiple amines of aminoglycosides. However, the mechanism of enhanced intracellular survival by Mtb Eis remains unanswered. Therefore, we have characterized both Mtb and Msm Eis proteins biochemically and structurally. We have discovered that Mtb Eis is an efficient N(epsilon)-acetyltransferase, rapidly acetylating Lys55 of dual-specificity protein phosphatase 16 (DUSP16)/mitogen-activated protein kinase phosphatase-7 (MKP-7), a JNK-specific phosphatase. In contrast, Msm Eis is more efficient as an N(alpha)-acetyltransferase. We also show that Msm Eis acetylates aminoglycosides as readily as Mtb Eis. Furthermore, Mtb Eis, but not Msm Eis, inhibits LPS-induced JNK phosphorylation. This functional difference against DUSP16/MKP-7 can be understood by comparing the structures of two Eis proteins. The active site of Mtb Eis with a narrow channel seems more suitable for sequence-specific recognition of the protein substrate than the pocket-shaped active site of Msm Eis. We propose that Mtb Eis initiates the inhibition of JNK-dependent autophagy, phagosome maturation, and ROS generation by acetylating DUSP16/MKP-7. Our work thus provides insight into the mechanism of suppressing host immune responses and enhancing mycobacterial survival within macrophages by Mtb Eis.	+
-		+
-	Mycobacterium tuberculosis Eis protein initiates suppression of host immune responses by acetylation of DUSP16/MKP-7.,Kim KH, An DR, Song J, Yoon JY, Kim HS, Yoon HJ, Im HN, Kim J, Kim do J, Lee SJ, Kim KH, Lee HM, Kim HJ, Jo EK, Lee JY, Suh SW Proc Natl Acad Sci U S A. 2012 May 15;109(20):~~7729-34. Epub 2012 Apr 30. PMID:22547814<ref>PMID:22547814<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®~~/~~PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 3sxn" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references~~/>	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Mycs2~~]]	+	[[Category: Mycolicibacterium smegmatis MC2 155]]
-	[[Category: An~~, D R~~]]	+	[[Category: An DR]]
-	[[Category: Im~~, H N~~]]	+	[[Category: Im HN]]
-	[[Category: Kim~~, D J~~]]	+	[[Category: Kim DJ]]
-	[[Category: Kim~~, H J~~]]	+	[[Category: Kim HJ]]
-	[[Category: Kim~~, H S~~]]	+	[[Category: Kim HS]]
-	[[Category: Kim, J]]	+	[[Category: Kim J]]
-	[[Category: Kim~~, K H~~]]	+	[[Category: Kim KH]]
-	[[Category: Lee~~, J Y~~]]	+	[[Category: Lee JY]]
-	[[Category: Lee~~, S J~~]]	+	[[Category: Lee SJ]]
-	[[Category: Song~~, J S~~]]	+	[[Category: Song JS]]
-	[[Category: Suh~~, S W~~]]	+	[[Category: Suh SW]]
-	[[Category: Yoon~~, H J~~]]	+	[[Category: Yoon HJ]]
-	[[Category: Yoon~~, J Y]]~~	+	[[Category: Yoon JY]]
-	~~[[Category: Acetyl coa binding]]~~	+
-	~~[[Category: Acetyltransferase]]~~	+
-	~~[[Category: Gnat fold]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 08:14, 29 June 2022

OCA — Wed, 29 Jun 2022 08:14:53 GMT

←Older revision		Revision as of 08:14, 29 June 2022
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	==Mycobacterium tuberculosis Eis protein initiates modulation of host immune responses by acetylation of DUSP16/MKP-7==		==Mycobacterium tuberculosis Eis protein initiates modulation of host immune responses by acetylation of DUSP16/MKP-7==
-	<StructureSection load='3sxn' size='340' side='right' caption='[[3sxn]], [[Resolution\|resolution]] 2.03Å' scene=''>	+	<StructureSection load='3sxn' size='340' side='right'caption='[[3sxn]], [[Resolution\|resolution]] 2.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3sxn]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SXN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3SXN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3sxn]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SXN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SXN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ryo\|3ryo]], [[3uy5\|3uy5]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ryo\|3ryo]], [[3uy5\|3uy5]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Eis, MSMEG_3513 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 MYCS2])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Eis, MSMEG_3513 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 MYCS2])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3sxn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sxn OCA], [~~http~~://pdbe.org/3sxn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3sxn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3sxn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3sxn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sxn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sxn OCA], [https://pdbe.org/3sxn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sxn RCSB], [https://www.ebi.ac.uk/pdbsum/3sxn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sxn ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mycs2]]		[[Category: Mycs2]]
	[[Category: An, D R]]		[[Category: An, D R]]

OCA at 10:24, 11 August 2016

OCA — Thu, 11 Aug 2016 10:24:32 GMT

←Older revision		Revision as of 10:24, 11 August 2016
Line 1:		Line 1:
		+
	==Mycobacterium tuberculosis Eis protein initiates modulation of host immune responses by acetylation of DUSP16/MKP-7==		==Mycobacterium tuberculosis Eis protein initiates modulation of host immune responses by acetylation of DUSP16/MKP-7==
	<StructureSection load='3sxn' size='340' side='right' caption='[[3sxn]], [[Resolution\|resolution]] 2.03Å' scene=''>		<StructureSection load='3sxn' size='340' side='right' caption='[[3sxn]], [[Resolution\|resolution]] 2.03Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ryo\|3ryo]], [[3uy5\|3uy5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ryo\|3ryo]], [[3uy5\|3uy5]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Eis, MSMEG_3513 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 MYCS2])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Eis, MSMEG_3513 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 MYCS2])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sxn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sxn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sxn RCSB], [http://www.ebi.ac.uk/pdbsum/3sxn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sxn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sxn OCA], [http://pdbe.org/3sxn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3sxn RCSB], [http://www.ebi.ac.uk/pdbsum/3sxn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3sxn ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3sxn" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:50, 4 January 2015

OCA — Sun, 04 Jan 2015 10:50:53 GMT

←Older revision		Revision as of 10:50, 4 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_3sxn\| PDB=3sxn \| SCENE= }}~~	+	==Mycobacterium tuberculosis Eis protein initiates modulation of host immune responses by acetylation of DUSP16/MKP-7==
-	===Mycobacterium tuberculosis Eis protein initiates modulation of host immune responses by acetylation of DUSP16/MKP-7===	+	<StructureSection load='3sxn' size='340' side='right' caption='[[3sxn]], [[Resolution\|resolution]] 2.03Å' scene=''>
-	~~{{ABSTRACT_PUBMED_22547814}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3sxn]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SXN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SXN FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ryo\|3ryo]], [[3uy5\|3uy5]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Eis, MSMEG_3513 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 MYCS2])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sxn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sxn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sxn RCSB], [http://www.ebi.ac.uk/pdbsum/3sxn PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The intracellular pathogen Mycobacterium tuberculosis (Mtb) causes tuberculosis. Enhanced intracellular survival (Eis) protein, secreted by Mtb, enhances survival of Mycobacterium smegmatis (Msm) in macrophages. Mtb Eis was shown to suppress host immune defenses by negatively modulating autophagy, inflammation, and cell death through JNK-dependent inhibition of reactive oxygen species (ROS) generation. Mtb Eis was recently demonstrated to contribute to drug resistance by acetylating multiple amines of aminoglycosides. However, the mechanism of enhanced intracellular survival by Mtb Eis remains unanswered. Therefore, we have characterized both Mtb and Msm Eis proteins biochemically and structurally. We have discovered that Mtb Eis is an efficient N(epsilon)-acetyltransferase, rapidly acetylating Lys55 of dual-specificity protein phosphatase 16 (DUSP16)/mitogen-activated protein kinase phosphatase-7 (MKP-7), a JNK-specific phosphatase. In contrast, Msm Eis is more efficient as an N(alpha)-acetyltransferase. We also show that Msm Eis acetylates aminoglycosides as readily as Mtb Eis. Furthermore, Mtb Eis, but not Msm Eis, inhibits LPS-induced JNK phosphorylation. This functional difference against DUSP16/MKP-7 can be understood by comparing the structures of two Eis proteins. The active site of Mtb Eis with a narrow channel seems more suitable for sequence-specific recognition of the protein substrate than the pocket-shaped active site of Msm Eis. We propose that Mtb Eis initiates the inhibition of JNK-dependent autophagy, phagosome maturation, and ROS generation by acetylating DUSP16/MKP-7. Our work thus provides insight into the mechanism of suppressing host immune responses and enhancing mycobacterial survival within macrophages by Mtb Eis.

-	~~==About this Structure==~~	+	Mycobacterium tuberculosis Eis protein initiates suppression of host immune responses by acetylation of DUSP16/MKP-7.,Kim KH, An DR, Song J, Yoon JY, Kim HS, Yoon HJ, Im HN, Kim J, Kim do J, Lee SJ, Kim KH, Lee HM, Kim HJ, Jo EK, Lee JY, Suh SW Proc Natl Acad Sci U S A. 2012 May 15;109(20):7729-34. Epub 2012 Apr 30. PMID:22547814<ref>PMID:22547814</ref>
-	~~[[3sxn]] is a 6 chain structure with sequence from [http:~~/~~/en~~.~~wikipedia~~.~~org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=3SXN OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:022547814</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Mycs2]]		[[Category: Mycs2]]
-	[[Category: An, D R.]]	+	[[Category: An, D R]]
-	[[Category: Im, H N.]]	+	[[Category: Im, H N]]
-	[[Category: Kim, D J.]]	+	[[Category: Kim, D J]]
-	[[Category: Kim, H J.]]	+	[[Category: Kim, H J]]
-	[[Category: Kim, H S.]]	+	[[Category: Kim, H S]]
-	[[Category: Kim, J.]]	+	[[Category: Kim, J]]
-	[[Category: Kim, K H.]]	+	[[Category: Kim, K H]]
-	[[Category: Lee, J Y.]]	+	[[Category: Lee, J Y]]
-	[[Category: Lee, S J.]]	+	[[Category: Lee, S J]]
-	[[Category: Song, J S.]]	+	[[Category: Song, J S]]
-	[[Category: Suh, S W.]]	+	[[Category: Suh, S W]]
-	[[Category: Yoon, H J.]]	+	[[Category: Yoon, H J]]
-	[[Category: Yoon, J Y.]]	+	[[Category: Yoon, J Y]]
	[[Category: Acetyl coa binding]]		[[Category: Acetyl coa binding]]
	[[Category: Acetyltransferase]]		[[Category: Acetyltransferase]]
	[[Category: Gnat fold]]		[[Category: Gnat fold]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 14:17, 12 March 2014

OCA — Wed, 12 Mar 2014 14:17:08 GMT

←Older revision		Revision as of 14:17, 12 March 2014
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-	[[Image:3sxn.jpg\|left\|200px]]
-
-	<!--
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	{{STRUCTURE_3sxn\| PDB=3sxn \| SCENE= }}		{{STRUCTURE_3sxn\| PDB=3sxn \| SCENE= }}
-
	===Mycobacterium tuberculosis Eis protein initiates modulation of host immune responses by acetylation of DUSP16/MKP-7===		===Mycobacterium tuberculosis Eis protein initiates modulation of host immune responses by acetylation of DUSP16/MKP-7===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_22547814}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 22547814 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_22547814}}		{{ABSTRACT_PUBMED_22547814}}

	==About this Structure==		==About this Structure==
-	[[3sxn]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_smegmatis Mycobacterium smegmatis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SXN OCA].	+	[[3sxn]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SXN OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:022547814</ref><references group="xtra"/>	+	<ref group="xtra">PMID:022547814</ref><references group="xtra"/><references/>
-	[[Category: ~~Mycobacterium smegmatis~~]]	+	[[Category: Mycs2]]
	[[Category: An, D R.]]		[[Category: An, D R.]]
	[[Category: Im, H N.]]		[[Category: Im, H N.]]

OCA at 06:05, 23 May 2012

OCA — Wed, 23 May 2012 06:05:02 GMT

←Older revision		Revision as of 06:05, 23 May 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3sxn.jpg\|left\|200px]]

-	The ~~entry 3sxn~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3sxn", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3sxn\| PDB=3sxn \| SCENE= }}

-	~~Authors: Kim, K.H., An, D.R., Yoon, J.Y., Kim, H.S., Yoon, H.J., Song, J.S., Im, H.N., Kim, J., Kim, D.J., Lee, S.J., Kim, H.J., Lee, J.Y., Suh, S.W.~~	+	===Mycobacterium tuberculosis Eis protein initiates modulation of host immune responses by acetylation of DUSP16/MKP-7===

-	~~Description~~: Mycobacterium ~~tuberculosis Eis protein initiates modulation of host immune responses by acetylation of DUSP16~~/~~MKP~~-7	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22547814}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22547814 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22547814}}
		+
		+	==About this Structure==
		+	[[3sxn]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SXN OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022547814</ref><references group="xtra"/>
		+	[[Category: Mycobacterium smegmatis]]
		+	[[Category: An, D R.]]
		+	[[Category: Im, H N.]]
		+	[[Category: Kim, D J.]]
		+	[[Category: Kim, H J.]]
		+	[[Category: Kim, H S.]]
		+	[[Category: Kim, J.]]
		+	[[Category: Kim, K H.]]
		+	[[Category: Lee, J Y.]]
		+	[[Category: Lee, S J.]]
		+	[[Category: Song, J S.]]
		+	[[Category: Suh, S W.]]
		+	[[Category: Yoon, H J.]]
		+	[[Category: Yoon, J Y.]]
		+	[[Category: Acetyl coa binding]]
		+	[[Category: Acetyltransferase]]
		+	[[Category: Gnat fold]]
		+	[[Category: Transferase]]

OCA at 11:04, 14 December 2011

OCA — Wed, 14 Dec 2011 11:04:54 GMT

←Older revision		Revision as of 11:04, 14 December 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3sxn is ON HOLD	+	The entry 3sxn is ON HOLD until Paper Publication

	Authors: Kim, K.H., An, D.R., Yoon, J.Y., Kim, H.S., Yoon, H.J., Song, J.S., Im, H.N., Kim, J., Kim, D.J., Lee, S.J., Kim, H.J., Lee, J.Y., Suh, S.W.		Authors: Kim, K.H., An, D.R., Yoon, J.Y., Kim, H.S., Yoon, H.J., Song, J.S., Im, H.N., Kim, J., Kim, D.J., Lee, S.J., Kim, H.J., Lee, J.Y., Suh, S.W.

	Description: Mycobacterium tuberculosis Eis protein initiates modulation of host immune responses by acetylation of DUSP16/MKP-7		Description: Mycobacterium tuberculosis Eis protein initiates modulation of host immune responses by acetylation of DUSP16/MKP-7

OCA: Protected "3sxn" [edit=sysop:move=sysop]

OCA — Wed, 20 Jul 2011 06:20:36 GMT

Protected "3sxn" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:20, 20 July 2011

OCA: New page: '''Unreleased structure''' The entry 3sxn is ON HOLD Authors: Kim, K.H., An, D.R., Yoon, J.Y., Kim, H.S., Yoon, H.J., Song, J.S., Im, H.N., Kim, J., Kim, D.J., Lee, S.J., Kim, H.J., Lee...

OCA — Wed, 20 Jul 2011 06:20:35 GMT

New page: '''Unreleased structure''' The entry 3sxn is ON HOLD Authors: Kim, K.H., An, D.R., Yoon, J.Y., Kim, H.S., Yoon, H.J., Song, J.S., Im, H.N., Kim, J., Kim, D.J., Lee, S.J., Kim, H.J., Lee...

New page

'''Unreleased structure'''

The entry 3sxn is ON HOLD

Authors: Kim, K.H., An, D.R., Yoon, J.Y., Kim, H.S., Yoon, H.J., Song, J.S., Im, H.N., Kim, J., Kim, D.J., Lee, S.J., Kim, H.J., Lee, J.Y., Suh, S.W.

Description: Mycobacterium tuberculosis Eis protein initiates modulation of host immune responses by acetylation of DUSP16/MKP-7