3syr - Revision history

OCA at 08:16, 29 June 2022

OCA — Wed, 29 Jun 2022 08:16:17 GMT

OCA at 18:04, 14 August 2019

OCA — Wed, 14 Aug 2019 18:04:50 GMT

←Older revision		Revision as of 18:04, 14 August 2019
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	==Glycogen phosphorylase b in complex with beta-D-glucopyranonucleoside 5-fluorouracil==		==Glycogen phosphorylase b in complex with beta-D-glucopyranonucleoside 5-fluorouracil==
-	<StructureSection load='3syr' size='340' side='right' caption='[[3syr]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='3syr' size='340' side='right'caption='[[3syr]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3syr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SYR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SYR FirstGlance]. <br>		<table><tr><td colspan='2'>[[3syr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SYR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SYR FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 3syr" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3syr" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Glycogen phosphorylase 3D structures\|Glycogen phosphorylase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
	[[Category: Phosphorylase]]		[[Category: Phosphorylase]]

OCA at 09:45, 8 November 2017

OCA — Wed, 08 Nov 2017 09:45:29 GMT

←Older revision		Revision as of 09:45, 8 November 2017
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	</div>		</div>
	<div class="pdbe-citations 3syr" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3syr" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Glycogen Phosphorylase\|Glycogen Phosphorylase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:01, 5 August 2016

OCA — Fri, 05 Aug 2016 06:01:26 GMT

←Older revision		Revision as of 06:01, 5 August 2016
Line 1:		Line 1:
		+
	==Glycogen phosphorylase b in complex with beta-D-glucopyranonucleoside 5-fluorouracil==		==Glycogen phosphorylase b in complex with beta-D-glucopyranonucleoside 5-fluorouracil==
	<StructureSection load='3syr' size='340' side='right' caption='[[3syr]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3syr' size='340' side='right' caption='[[3syr]], [[Resolution\|resolution]] 2.40Å' scene=''>
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	<table><tr><td colspan='2'>[[3syr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SYR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SYR FirstGlance]. <br>		<table><tr><td colspan='2'>[[3syr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SYR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SYR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GPK:5-FLUORO-1-(BETA-D-GLUCOPYRANOSYL)PYRIMIDINE-2,4(1H,3H)-DIONE'>GPK</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GPK:5-FLUORO-1-(BETA-D-GLUCOPYRANOSYL)PYRIMIDINE-2,4(1H,3H)-DIONE'>GPK</scene></td></tr>
-	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:2-~~LYSINE(~~3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-~~YLMETHANE)~~'>LLP</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sym\|3sym]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sym\|3sym]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3syr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3syr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3syr RCSB], [http://www.ebi.ac.uk/pdbsum/3syr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3syr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3syr OCA], [http://pdbe.org/3syr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3syr RCSB], [http://www.ebi.ac.uk/pdbsum/3syr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3syr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3syr" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 23:39, 24 December 2014

OCA — Wed, 24 Dec 2014 23:39:17 GMT

←Older revision		Revision as of 23:39, 24 December 2014
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-	[[~~Image:~~3syr.~~png~~\|~~left~~\|~~200px~~]]	+	==Glycogen phosphorylase b in complex with beta-D-glucopyranonucleoside 5-fluorouracil==
		+	<StructureSection load='3syr' size='340' side='right' caption='[[3syr]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3syr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SYR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SYR FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GPK:5-FLUORO-1-(BETA-D-GLUCOPYRANOSYL)PYRIMIDINE-2,4(1H,3H)-DIONE'>GPK</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE)'>LLP</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sym\|3sym]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3syr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3syr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3syr RCSB], [http://www.ebi.ac.uk/pdbsum/3syr PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PYGM_RABIT PYGM_RABIT]] Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Glycogen phosphorylase is a molecular target for the design of potential hypoglycaemic agents. Structure based design pinpointed that the 3'-position of glucopyranose equipped with a suitable group has the potential to form interactions with enzyme's cofactor, PLP, thus enhancing the inhibitory potency. Hence, we have investigated the binding of two ligands, 1-(beta-D-glucopyranosyl)5-fluorouracil (GlcFU) and its 3'-CH(2) OH glucopyranose derivative. Both ligands were found to be low muM inhibitors with K(i) values of 7.9 and 27.1 muM, respectively. X-ray crystallography revealed that the 3'-CH(2) OH glucopyranose substituent is indeed involved in additional molecular interactions with the PLP gamma-phosphate compared to GlcFU. However it is 3.4 times less potent. To elucidate this discovery, docking followed by post-docking Quantum Mechanics/Molecular Mechanics - Poisson Boltzmann Surface Area (QM/MM-PBSA) binding affinity calculations were performed. While the docking predictions failed to reflect the kinetic results, the QM/MM-PBSA revealed that the desolvation energy cost for binding of the 3'-CH(2) OH-substituted glucopyranose derivative out-weigh the enthalpy gains from the extra contacts formed. The benefits of performing post-docking calculations employing a more accurate solvation model and the QM/MM-PBSA methodology in lead optimization is therefore highlighted, specifically when the role of a highly polar/charged binding interface is significant. (c) 2012 John Wiley & Sons A/S.

-	~~{{STRUCTURE_3syr\| PDB=3syr \| SCENE= }}~~	+	3'-axial CH(2) OH substitution on glucopyranose does not increase glycogen phosphorylase inhibitory potency. QM/MM-PBSA calculations suggest why.,Manta S, Xipnitou A, Kiritsis C, Kantsadi AL, Hayes JM, Skamnaki VT, Lamprakis C, Kontou M, Zoumpoulakis P, Zographos SE, Leonidas DD, Komiotis D Chem Biol Drug Des. 2012 Feb 2. doi: 10.1111/j.1747-0285.2012.01349.x. PMID:22296957<ref>PMID:22296957</ref>

-	~~===Glycogen phosphorylase b in complex with beta-D-glucopyranonucleoside 5-fluorouracil===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22296957}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3syr]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3SYR OCA].~~	+

	==See Also==		==See Also==
	*[[Glycogen Phosphorylase\|Glycogen Phosphorylase]]		*[[Glycogen Phosphorylase\|Glycogen Phosphorylase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:022296957<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
	[[Category: Phosphorylase]]		[[Category: Phosphorylase]]
-	[[Category: Kantsadi, A L.]]	+	[[Category: Kantsadi, A L]]
-	[[Category: Kontou, M.]]	+	[[Category: Kontou, M]]
-	[[Category: Leonidas, D D.]]	+	[[Category: Leonidas, D D]]
-	[[Category: Skamnaki, V T.]]	+	[[Category: Skamnaki, V T]]
	[[Category: Muscle]]		[[Category: Muscle]]
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Transferase-transferase inhibitor complex]]		[[Category: Transferase-transferase inhibitor complex]]

OCA at 10:17, 20 October 2012

OCA — Sat, 20 Oct 2012 10:17:34 GMT

←Older revision		Revision as of 10:17, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[3syr]] is a 1 chain structure ~~of [[Glycogen Phosphorylase]]~~ with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SYR OCA].	+	[[3syr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SYR OCA].

	==See Also==		==See Also==

OCA at 01:37, 26 July 2012

OCA — Thu, 26 Jul 2012 01:37:27 GMT

←Older revision		Revision as of 01:37, 26 July 2012
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	[[Image:3syr.png\|left\|200px]]		[[Image:3syr.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3syr", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3syr\| PDB=3syr \| SCENE= }}		{{STRUCTURE_3syr\| PDB=3syr \| SCENE= }}

	===Glycogen phosphorylase b in complex with beta-D-glucopyranonucleoside 5-fluorouracil===		===Glycogen phosphorylase b in complex with beta-D-glucopyranonucleoside 5-fluorouracil===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_22296957}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 22296957 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_22296957}}		{{ABSTRACT_PUBMED_22296957}}

	==About this Structure==		==About this Structure==
-	[[3syr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SYR OCA].	+	[[3syr]] is a 1 chain structure of [[Glycogen Phosphorylase]] with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SYR OCA].
		+
		+	==See Also==
		+	*[[Glycogen Phosphorylase\|Glycogen Phosphorylase]]

	==Reference==		==Reference==

OCA at 06:58, 18 April 2012

OCA — Wed, 18 Apr 2012 06:58:48 GMT

←Older revision		Revision as of 06:58, 18 April 2012
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-	[[Image:3syr.~~jpg~~\|left\|200px]]	+	[[Image:3syr.png\|left\|200px]]

	<!--		<!--

OCA at 06:40, 15 February 2012

OCA — Wed, 15 Feb 2012 06:40:35 GMT

←Older revision		Revision as of 06:40, 15 February 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3syr.jpg\|left\|200px]]

-	The ~~entry 3syr~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3syr", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3syr\| PDB=3syr \| SCENE= }}

-	~~Authors: Skamnaki, V.T., Kantsadi, A.L., Kontou, M., Leonidas,~~ D~~.D.~~	+	===Glycogen phosphorylase b in complex with beta-D-glucopyranonucleoside 5-fluorouracil===

-	~~Description~~: ~~Glycogen phosphorylase b in complex~~ with ~~beta~~-D-~~glucopyranonucleoside 5-fluorouracil~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22296957}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22296957 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22296957}}
		+
		+	==About this Structure==
		+	[[3syr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SYR OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022296957</ref><references group="xtra"/>
		+	[[Category: Oryctolagus cuniculus]]
		+	[[Category: Phosphorylase]]
		+	[[Category: Kantsadi, A L.]]
		+	[[Category: Kontou, M.]]
		+	[[Category: Leonidas, D D.]]
		+	[[Category: Skamnaki, V T.]]
		+	[[Category: Muscle]]
		+	[[Category: Transferase]]
		+	[[Category: Transferase-transferase inhibitor complex]]

OCA at 06:19, 31 August 2011

OCA — Wed, 31 Aug 2011 06:19:55 GMT

←Older revision		Revision as of 06:19, 31 August 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3syr is ON HOLD	+	The entry 3syr is ON HOLD until Paper Publication

	Authors: Skamnaki, V.T., Kantsadi, A.L., Kontou, M., Leonidas, D.D.		Authors: Skamnaki, V.T., Kantsadi, A.L., Kontou, M., Leonidas, D.D.

	Description: Glycogen phosphorylase b in complex with beta-D-glucopyranonucleoside 5-fluorouracil		Description: Glycogen phosphorylase b in complex with beta-D-glucopyranonucleoside 5-fluorouracil

←Older revision		Revision as of 08:16, 29 June 2022
Line 3:		Line 3:
	<StructureSection load='3syr' size='340' side='right'caption='[[3syr]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3syr' size='340' side='right'caption='[[3syr]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3syr]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SYR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3SYR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3syr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SYR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SYR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GPK:5-FLUORO-1-(BETA-D-GLUCOPYRANOSYL)PYRIMIDINE-2,4(1H,3H)-DIONE'>GPK</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GPK:5-FLUORO-1-(BETA-D-GLUCOPYRANOSYL)PYRIMIDINE-2,4(1H,3H)-DIONE'>GPK</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sym\|3sym]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3sym\|3sym]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3syr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3syr OCA], [~~http~~://pdbe.org/3syr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3syr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3syr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3syr ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3syr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3syr OCA], [https://pdbe.org/3syr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3syr RCSB], [https://www.ebi.ac.uk/pdbsum/3syr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3syr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PYGM_RABIT PYGM_RABIT]] Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.	+	[[https://www.uniprot.org/uniprot/PYGM_RABIT PYGM_RABIT]] Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==