3szt - Revision history

OCA at 09:58, 1 March 2024

OCA — Fri, 01 Mar 2024 09:58:14 GMT

←Older revision		Revision as of 09:58, 1 March 2024
Line 3:		Line 3:
	<StructureSection load='3szt' size='340' side='right'caption='[[3szt]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='3szt' size='340' side='right'caption='[[3szt]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3szt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SZT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3szt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SZT FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~, ~~<scene name='pdbligand=OHN:N-3-OXO-DODECANOYL-L-HOMOSERINE+LACTONE'>OHN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.55Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~PA1898, qscR ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OHN:N-3-OXO-DODECANOYL-L-HOMOSERINE+LACTONE'>OHN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3szt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3szt OCA], [https://pdbe.org/3szt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3szt RCSB], [https://www.ebi.ac.uk/pdbsum/3szt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3szt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3szt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3szt OCA], [https://pdbe.org/3szt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3szt RCSB], [https://www.ebi.ac.uk/pdbsum/3szt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3szt ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/Q9RMS5_PSEAI Q9RMS5_PSEAI]
-	Acyl-homoserine lactone (AHL) quorum sensing controls gene expression in hundreds of Proteobacteria including a number of plant and animal pathogens. Generally, the AHL receptors are members of a family of related transcription factors, and although they have been targets for development of antivirulence therapeutics there is very little structural information about this class of bacterial receptors. We have determined the structure of the transcription factor, QscR, bound to N-3-oxo-dodecanoyl-homoserine lactone from the opportunistic human pathogen Pseudomonas aeruginosa at a resolution of 2.55 A. The ligand-bound QscR is a dimer with a unique symmetric "cross-subunit" arrangement containing multiple dimerization interfaces involving both domains of each subunit. The QscR dimer appears poised to bind DNA. Predictions about signal binding and dimerization contacts were supported by studies of mutant QscR proteins in vivo. The acyl chain of the AHL is in close proximity to the dimerization interfaces. Our data are consistent with an allosteric mechanism of signal transmission in the regulation of DNA binding and thus virulence gene expression.	+
-		+
-	~~Crystal structure of QscR, a Pseudomonas aeruginosa quorum sensing signal receptor.,Lintz MJ, Oinuma K, Wysoczynski CL, Greenberg EP, Churchill ME Proc Natl Acad Sci U S A. 2011 Sep 20;108(38)~~:~~15763-8. Epub 2011 Sep 12. PMID:21911405<ref>PMID:21911405<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®~~/~~PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 3szt" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references~~/>	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Churchill, M E.A~~]]	+	[[Category: Pseudomonas aeruginosa]]
-	[[Category: ~~Lintz, M J~~]]	+	[[Category: Churchill MEA]]
-	[[Category: ~~3-oxo-c12 hsl]]~~	+	[[Category: Lintz MJ]]
-	~~[[Category: Helix-turn-helix]]~~	+
-	~~[[Category: Quorum sensing acyl-homoserine lactone]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription factor~~]]	+

OCA at 08:17, 29 June 2022

OCA — Wed, 29 Jun 2022 08:17:36 GMT

←Older revision		Revision as of 08:17, 29 June 2022
Line 1:		Line 1:

	==Quorum Sensing Control Repressor, QscR, Bound to N-3-oxo-dodecanoyl-L-Homoserine Lactone==		==Quorum Sensing Control Repressor, QscR, Bound to N-3-oxo-dodecanoyl-L-Homoserine Lactone==
-	<StructureSection load='3szt' size='340' side='right' caption='[[3szt]], [[Resolution\|resolution]] 2.55Å' scene=''>	+	<StructureSection load='3szt' size='340' side='right'caption='[[3szt]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3szt]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SZT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3SZT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3szt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SZT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OHN:N-3-OXO-DODECANOYL-L-HOMOSERINE+LACTONE'>OHN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OHN:N-3-OXO-DODECANOYL-L-HOMOSERINE+LACTONE'>OHN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PA1898, qscR ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PA1898, qscR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3szt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3szt OCA], [~~http~~://pdbe.org/3szt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3szt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3szt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3szt ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3szt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3szt OCA], [https://pdbe.org/3szt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3szt RCSB], [https://www.ebi.ac.uk/pdbsum/3szt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3szt ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Churchill, M E.A]]		[[Category: Churchill, M E.A]]
	[[Category: Lintz, M J]]		[[Category: Lintz, M J]]

OCA at 12:54, 11 August 2016

OCA — Thu, 11 Aug 2016 12:54:31 GMT

←Older revision		Revision as of 12:54, 11 August 2016
Line 1:		Line 1:
		+
	==Quorum Sensing Control Repressor, QscR, Bound to N-3-oxo-dodecanoyl-L-Homoserine Lactone==		==Quorum Sensing Control Repressor, QscR, Bound to N-3-oxo-dodecanoyl-L-Homoserine Lactone==
	<StructureSection load='3szt' size='340' side='right' caption='[[3szt]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='3szt' size='340' side='right' caption='[[3szt]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3szt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pseudomonas_aeruginosa Pseudomonas aeruginosa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SZT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SZT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3szt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SZT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SZT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OHN:N-3-OXO-DODECANOYL-L-HOMOSERINE+LACTONE'>OHN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OHN:N-3-OXO-DODECANOYL-L-HOMOSERINE+LACTONE'>OHN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PA1898, qscR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 ~~Pseudomonas aeruginosa~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PA1898, qscR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3szt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3szt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3szt RCSB], [http://www.ebi.ac.uk/pdbsum/3szt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3szt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3szt OCA], [http://pdbe.org/3szt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3szt RCSB], [http://www.ebi.ac.uk/pdbsum/3szt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3szt ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3szt" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Pseudomonas aeruginosa]]
	[[Category: Churchill, M E.A]]		[[Category: Churchill, M E.A]]
	[[Category: Lintz, M J]]		[[Category: Lintz, M J]]

OCA at 09:46, 4 January 2015

OCA — Sun, 04 Jan 2015 09:46:58 GMT

←Older revision		Revision as of 09:46, 4 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3szt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SZT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SZT FirstGlance]. <br>		<table><tr><td colspan='2'>[[3szt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SZT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SZT FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OHN:N-3-OXO-DODECANOYL-L-HOMOSERINE+LACTONE'>OHN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OHN:N-3-OXO-DODECANOYL-L-HOMOSERINE+LACTONE'>OHN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PA1898, qscR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 Pseudomonas aeruginosa])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PA1898, qscR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 Pseudomonas aeruginosa])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3szt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3szt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3szt RCSB], [http://www.ebi.ac.uk/pdbsum/3szt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3szt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3szt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3szt RCSB], [http://www.ebi.ac.uk/pdbsum/3szt PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 13:		Line 13:
	Crystal structure of QscR, a Pseudomonas aeruginosa quorum sensing signal receptor.,Lintz MJ, Oinuma K, Wysoczynski CL, Greenberg EP, Churchill ME Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15763-8. Epub 2011 Sep 12. PMID:21911405<ref>PMID:21911405</ref>		Crystal structure of QscR, a Pseudomonas aeruginosa quorum sensing signal receptor.,Lintz MJ, Oinuma K, Wysoczynski CL, Greenberg EP, Churchill ME Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15763-8. Epub 2011 Sep 12. PMID:21911405<ref>PMID:21911405</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Pseudomonas aeruginosa]]		[[Category: Pseudomonas aeruginosa]]
-	[[Category: Churchill, M E.A.]]	+	[[Category: Churchill, M E.A]]
-	[[Category: Lintz, M J.]]	+	[[Category: Lintz, M J]]
	[[Category: 3-oxo-c12 hsl]]		[[Category: 3-oxo-c12 hsl]]
	[[Category: Helix-turn-helix]]		[[Category: Helix-turn-helix]]

OCA at 05:20, 5 June 2014

OCA — Thu, 05 Jun 2014 05:20:03 GMT

←Older revision		Revision as of 05:20, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3szt.~~png~~\|~~left~~\|~~200px~~]]	+	==Quorum Sensing Control Repressor, QscR, Bound to N-3-oxo-dodecanoyl-L-Homoserine Lactone==
		+	<StructureSection load='3szt' size='340' side='right' caption='[[3szt]], [[Resolution\|resolution]] 2.55Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3szt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SZT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SZT FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OHN:N-3-OXO-DODECANOYL-L-HOMOSERINE+LACTONE'>OHN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PA1898, qscR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 Pseudomonas aeruginosa])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3szt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3szt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3szt RCSB], [http://www.ebi.ac.uk/pdbsum/3szt PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Acyl-homoserine lactone (AHL) quorum sensing controls gene expression in hundreds of Proteobacteria including a number of plant and animal pathogens. Generally, the AHL receptors are members of a family of related transcription factors, and although they have been targets for development of antivirulence therapeutics there is very little structural information about this class of bacterial receptors. We have determined the structure of the transcription factor, QscR, bound to N-3-oxo-dodecanoyl-homoserine lactone from the opportunistic human pathogen Pseudomonas aeruginosa at a resolution of 2.55 A. The ligand-bound QscR is a dimer with a unique symmetric "cross-subunit" arrangement containing multiple dimerization interfaces involving both domains of each subunit. The QscR dimer appears poised to bind DNA. Predictions about signal binding and dimerization contacts were supported by studies of mutant QscR proteins in vivo. The acyl chain of the AHL is in close proximity to the dimerization interfaces. Our data are consistent with an allosteric mechanism of signal transmission in the regulation of DNA binding and thus virulence gene expression.

-	~~<!--~~	+	Crystal structure of QscR, a Pseudomonas aeruginosa quorum sensing signal receptor.,Lintz MJ, Oinuma K, Wysoczynski CL, Greenberg EP, Churchill ME Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15763-8. Epub 2011 Sep 12. PMID:21911405<ref>PMID:21911405</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3szt"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_3szt\| PDB=3szt \| SCENE= }}~~	+

-	~~===Quorum Sensing Control Repressor~~, ~~QscR, Bound to N-3-oxo-dodecanoyl-L-Homoserine Lactone===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21911405}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21911405 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_21911405}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3szt]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SZT OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021911405<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Pseudomonas aeruginosa]]		[[Category: Pseudomonas aeruginosa]]
	[[Category: Churchill, M E.A.]]		[[Category: Churchill, M E.A.]]

OCA at 05:40, 5 October 2011

OCA — Wed, 05 Oct 2011 05:40:51 GMT

←Older revision		Revision as of 05:40, 5 October 2011
Line 1:		Line 1:
-	[[Image:3szt.~~jpg~~\|left\|200px]]	+	[[Image:3szt.png\|left\|200px]]

	<!--		<!--

OCA at 05:35, 28 September 2011

OCA — Wed, 28 Sep 2011 05:35:34 GMT

←Older revision		Revision as of 05:35, 28 September 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3szt.jpg\|left\|200px]]

-	The ~~entry 3szt~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3szt", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3szt\| PDB=3szt \| SCENE= }}

-	~~Authors: Churchill~~, ~~M.E.A.~~, ~~Lintz, M.J.~~	+	===Quorum Sensing Control Repressor, QscR, Bound to N-3-oxo-dodecanoyl-L-Homoserine Lactone===

-	~~Description: Quorum Sensing Control Repressor~~, ~~QscR~~, ~~Bound~~ to N-3-oxo-~~dodecanoyl~~-L-~~Homoserine Lactone~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21911405}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21911405 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21911405}}
		+
		+	==About this Structure==
		+	[[3szt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SZT OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021911405</ref><references group="xtra"/>
		+	[[Category: Pseudomonas aeruginosa]]
		+	[[Category: Churchill, M E.A.]]
		+	[[Category: Lintz, M J.]]
		+	[[Category: 3-oxo-c12 hsl]]
		+	[[Category: Helix-turn-helix]]
		+	[[Category: Quorum sensing acyl-homoserine lactone]]
		+	[[Category: Transcription]]
		+	[[Category: Transcription factor]]

OCA at 07:07, 24 August 2011

OCA — Wed, 24 Aug 2011 07:07:42 GMT

←Older revision		Revision as of 07:07, 24 August 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3szt is ON HOLD	+	The entry 3szt is ON HOLD until Paper Publication

	Authors: Churchill, M.E.A., Lintz, M.J.		Authors: Churchill, M.E.A., Lintz, M.J.

	Description: Quorum Sensing Control Repressor, QscR, Bound to N-3-oxo-dodecanoyl-L-Homoserine Lactone		Description: Quorum Sensing Control Repressor, QscR, Bound to N-3-oxo-dodecanoyl-L-Homoserine Lactone

OCA at 08:23, 3 August 2011

OCA — Wed, 03 Aug 2011 08:23:01 GMT

←Older revision		Revision as of 08:23, 3 August 2011
Line 3:		Line 3:
	The entry 3szt is ON HOLD		The entry 3szt is ON HOLD

-	Authors: Churchill, M.E.A., Lintz,M.J.	+	Authors: Churchill, M.E.A., Lintz, M.J.

	Description: Quorum Sensing Control Repressor, QscR, Bound to N-3-oxo-dodecanoyl-L-Homoserine Lactone		Description: Quorum Sensing Control Repressor, QscR, Bound to N-3-oxo-dodecanoyl-L-Homoserine Lactone

OCA: Protected "3szt" [edit=sysop:move=sysop]

OCA — Wed, 27 Jul 2011 05:46:20 GMT

Protected "3szt" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:46, 27 July 2011