3t2g - Revision history

OCA at 13:15, 14 March 2024

OCA — Thu, 14 Mar 2024 13:15:46 GMT

←Older revision		Revision as of 13:15, 14 March 2024
Line 3:		Line 3:
	<StructureSection load='3t2g' size='340' side='right'caption='[[3t2g]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='3t2g' size='340' side='right'caption='[[3t2g]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3t2g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Pyrnv Pyrnv~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T2G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T2G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3t2g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrobaculum_neutrophilum_V24Sta Pyrobaculum neutrophilum V24Sta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T2G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T2G FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=13P:1~~,3~~-DIHYDROXYACETONEPHOSPHATE'>13P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[3t2b\|3t2b]], [[3t2c\|3t2c]], [[3t2d\|3t2d]], [[3t2e\|3t2e]], [[3t2f\|3t2f]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=13P:1,3-DIHYDROXYACETONEPHOSPHATE'>13P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">Tneu_0133 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=444157 PYRNV])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t2g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t2g OCA], [https://pdbe.org/3t2g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t2g RCSB], [https://www.ebi.ac.uk/pdbsum/3t2g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t2g ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t2g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t2g OCA], [https://pdbe.org/3t2g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t2g RCSB], [https://www.ebi.ac.uk/pdbsum/3t2g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t2g ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/FBPAP_PYRNV FBPAP_PYRNV] Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).<ref>PMID:20348906</ref> <ref>PMID:21983965</ref>
-	~~Fructose-1,6-bisphosphate (FBP) aldolase~~/~~phosphatase is a bifunctional, thermostable enzyme that catalyses~~ two subsequent steps in gluconeogenesis ~~in most archaea and in deeply branching bacterial lineages. It mediates~~ the aldol condensation of ~~heat-labile~~ dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (~~GAP~~) to ~~FBP, as well as the subsequent, irreversible hydrolysis of the product to yield the stable~~ fructose-6-~~phosphate~~ (~~F6P~~) and inorganic phosphate; no reaction intermediates are released. Here we present a series of structural snapshots of the reaction that reveal a substantial remodelling of the active site through the movement of loop regions that create different catalytic functionalities at the same location. We have solved the three-dimensional structures of FBP aldolase/phosphatase from thermophilic Thermoproteus neutrophilus in a ligand-free state as well as in complex with the substrates DHAP and FBP and the product F6P to resolutions up to 1.3 A. In conjunction with mutagenesis data, ~~this pinpoints the residues required for the two reaction steps~~ and ~~shows that~~ the ~~sequential binding~~ of ~~additional Mg(2+) cations reversibly facilitates the reaction.~~ FBP aldolase/phosphatase is an ancestral gluconeogenic enzyme optimized for high ambient temperatures, and our work resolves how consecutive structural rearrangements reorganize the catalytic centre of the protein to ~~carry out two canonical reactions in a very non-canonical type of bifunctionality.~~	+
-		+
-	~~Active-site remodelling in the bifunctional~~ fructose-1,6-~~bisphosphate aldolase/phosphatase~~.~~,Du J, Say RF, Lu W, Fuchs G, Einsle O Nature. 2011 Oct 9. doi: 10.1038/nature10458. PMID:21983965~~<ref>PMID:~~21983965~~</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.~~<br>	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3t2g" style="background-color~~:~~#fffaf0;">~~</~~div~~>	+

	==See Also==		==See Also==
Line 26:		Line 18:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Pyrnv~~]]	+	[[Category: Pyrobaculum neutrophilum V24Sta]]
-	[[Category: Du, J]]	+	[[Category: Du J]]
-	[[Category: Einsle, O]]	+	[[Category: Einsle O]]
-	[[Category: Fuchs, G]]	+	[[Category: Fuchs G]]
-	[[Category: Lue, W]]	+	[[Category: Lue W]]
-	[[Category: Say, R]]	+	[[Category: Say R]]
-	~~[[Category: Dhap]]~~	+
-	~~[[Category: F6p]]~~	+
-	~~[[Category: Fbp]]~~	+
-	~~[[Category: Gap]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Phosphorylation~~]]	+

OCA at 16:40, 6 July 2022

OCA — Wed, 06 Jul 2022 16:40:15 GMT

←Older revision		Revision as of 16:40, 6 July 2022
Line 1:		Line 1:

	==Fructose-1,6-bisphosphate aldolase/phosphatase from Thermoproteus neutrophilus, Y229F variant with DHAP==		==Fructose-1,6-bisphosphate aldolase/phosphatase from Thermoproteus neutrophilus, Y229F variant with DHAP==
-	<StructureSection load='3t2g' size='340' side='right' caption='[[3t2g]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='3t2g' size='340' side='right'caption='[[3t2g]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3t2g]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Pyrnv Pyrnv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T2G OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3T2G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3t2g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrnv Pyrnv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T2G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T2G FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=13P:1,3-DIHYDROXYACETONEPHOSPHATE'>13P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=13P:1,3-DIHYDROXYACETONEPHOSPHATE'>13P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3t2b\|3t2b]], [[3t2c\|3t2c]], [[3t2d\|3t2d]], [[3t2e\|3t2e]], [[3t2f\|3t2f]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3t2b\|3t2b]], [[3t2c\|3t2c]], [[3t2d\|3t2d]], [[3t2e\|3t2e]], [[3t2f\|3t2f]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tneu_0133 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=444157 PYRNV])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tneu_0133 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=444157 PYRNV])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3t2g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t2g OCA], [~~http~~://pdbe.org/3t2g PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3t2g RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3t2g PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3t2g ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t2g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t2g OCA], [https://pdbe.org/3t2g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t2g RCSB], [https://www.ebi.ac.uk/pdbsum/3t2g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t2g ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Aldolase\|Aldolase]]	+	*[[Aldolase 3D structures\|Aldolase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Pyrnv]]		[[Category: Pyrnv]]
	[[Category: Du, J]]		[[Category: Du, J]]

OCA at 11:19, 10 December 2016

OCA — Sat, 10 Dec 2016 11:19:20 GMT

←Older revision		Revision as of 11:19, 10 December 2016
Line 1:		Line 1:
		+
	==Fructose-1,6-bisphosphate aldolase/phosphatase from Thermoproteus neutrophilus, Y229F variant with DHAP==		==Fructose-1,6-bisphosphate aldolase/phosphatase from Thermoproteus neutrophilus, Y229F variant with DHAP==
	<StructureSection load='3t2g' size='340' side='right' caption='[[3t2g]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='3t2g' size='340' side='right' caption='[[3t2g]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3t2g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Thermoproteus_neutrophilus Thermoproteus neutrophilus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T2G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3T2G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3t2g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrnv Pyrnv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T2G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3T2G FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=13P:1,3-DIHYDROXYACETONEPHOSPHATE'>13P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=13P:1,3-DIHYDROXYACETONEPHOSPHATE'>13P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3t2b\|3t2b]], [[3t2c\|3t2c]], [[3t2d\|3t2d]], [[3t2e\|3t2e]], [[3t2f\|3t2f]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3t2b\|3t2b]], [[3t2c\|3t2c]], [[3t2d\|3t2d]], [[3t2e\|3t2e]], [[3t2f\|3t2f]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tneu_0133 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~70771 Thermoproteus neutrophilus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tneu_0133 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=444157 PYRNV])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3t2g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t2g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3t2g RCSB], [http://www.ebi.ac.uk/pdbsum/3t2g PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3t2g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t2g OCA], [http://pdbe.org/3t2g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3t2g RCSB], [http://www.ebi.ac.uk/pdbsum/3t2g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3t2g ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3t2g" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 23:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Thermoproteus neutrophilus~~]]	+	[[Category: Pyrnv]]
	[[Category: Du, J]]		[[Category: Du, J]]
	[[Category: Einsle, O]]		[[Category: Einsle, O]]

OCA at 10:49, 9 December 2014

OCA — Tue, 09 Dec 2014 10:49:18 GMT

←Older revision		Revision as of 10:49, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3t2g.~~png~~\|~~left~~\|~~200px~~]]	+	==Fructose-1,6-bisphosphate aldolase/phosphatase from Thermoproteus neutrophilus, Y229F variant with DHAP==
		+	<StructureSection load='3t2g' size='340' side='right' caption='[[3t2g]], [[Resolution\|resolution]] 3.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3t2g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermoproteus_neutrophilus Thermoproteus neutrophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T2G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3T2G FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=13P:1,3-DIHYDROXYACETONEPHOSPHATE'>13P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3t2b\|3t2b]], [[3t2c\|3t2c]], [[3t2d\|3t2d]], [[3t2e\|3t2e]], [[3t2f\|3t2f]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tneu_0133 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=70771 Thermoproteus neutrophilus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3t2g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t2g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3t2g RCSB], [http://www.ebi.ac.uk/pdbsum/3t2g PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Fructose-1,6-bisphosphate (FBP) aldolase/phosphatase is a bifunctional, thermostable enzyme that catalyses two subsequent steps in gluconeogenesis in most archaea and in deeply branching bacterial lineages. It mediates the aldol condensation of heat-labile dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GAP) to FBP, as well as the subsequent, irreversible hydrolysis of the product to yield the stable fructose-6-phosphate (F6P) and inorganic phosphate; no reaction intermediates are released. Here we present a series of structural snapshots of the reaction that reveal a substantial remodelling of the active site through the movement of loop regions that create different catalytic functionalities at the same location. We have solved the three-dimensional structures of FBP aldolase/phosphatase from thermophilic Thermoproteus neutrophilus in a ligand-free state as well as in complex with the substrates DHAP and FBP and the product F6P to resolutions up to 1.3 A. In conjunction with mutagenesis data, this pinpoints the residues required for the two reaction steps and shows that the sequential binding of additional Mg(2+) cations reversibly facilitates the reaction. FBP aldolase/phosphatase is an ancestral gluconeogenic enzyme optimized for high ambient temperatures, and our work resolves how consecutive structural rearrangements reorganize the catalytic centre of the protein to carry out two canonical reactions in a very non-canonical type of bifunctionality.

-	~~{{STRUCTURE_3t2g\| PDB=3t2g \| SCENE= }}~~	+	Active-site remodelling in the bifunctional fructose-1,6-bisphosphate aldolase/phosphatase.,Du J, Say RF, Lu W, Fuchs G, Einsle O Nature. 2011 Oct 9. doi: 10.1038/nature10458. PMID:21983965<ref>PMID:21983965</ref>

-	~~===Fructose-1,6-bisphosphate aldolase~~/~~phosphatase from Thermoproteus neutrophilus~~, ~~Y229F variant with DHAP===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21983965}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3t2g]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Thermoproteus_neutrophilus Thermoproteus neutrophilus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3T2G OCA].~~	+

	==See Also==		==See Also==
	*[[Aldolase\|Aldolase]]		*[[Aldolase\|Aldolase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021983965<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Thermoproteus neutrophilus]]		[[Category: Thermoproteus neutrophilus]]
-	[[Category: Du, J.]]	+	[[Category: Du, J]]
-	[[Category: Einsle, O.]]	+	[[Category: Einsle, O]]
-	[[Category: Fuchs, G.]]	+	[[Category: Fuchs, G]]
-	[[Category: Lue, W.]]	+	[[Category: Lue, W]]
-	[[Category: Say, R.]]	+	[[Category: Say, R]]
	[[Category: Dhap]]		[[Category: Dhap]]
	[[Category: F6p]]		[[Category: F6p]]

OCA at 16:01, 20 October 2012

OCA — Sat, 20 Oct 2012 16:01:32 GMT

←Older revision		Revision as of 16:01, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3t2g]] is a 1 chain structure ~~of [[Aldolase]]~~ with sequence from [http://en.wikipedia.org/wiki/Thermoproteus_neutrophilus Thermoproteus neutrophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T2G OCA].	+	[[3t2g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermoproteus_neutrophilus Thermoproteus neutrophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T2G OCA].

	==See Also==		==See Also==

OCA at 20:20, 26 July 2012

OCA — Thu, 26 Jul 2012 20:20:36 GMT

←Older revision		Revision as of 20:20, 26 July 2012
Line 1:		Line 1:
	[[Image:3t2g.png\|left\|200px]]		[[Image:3t2g.png\|left\|200px]]

-	<!--
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-	-->
	{{STRUCTURE_3t2g\| PDB=3t2g \| SCENE= }}		{{STRUCTURE_3t2g\| PDB=3t2g \| SCENE= }}

	===Fructose-1,6-bisphosphate aldolase/phosphatase from Thermoproteus neutrophilus, Y229F variant with DHAP===		===Fructose-1,6-bisphosphate aldolase/phosphatase from Thermoproteus neutrophilus, Y229F variant with DHAP===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21983965}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21983965 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21983965}}		{{ABSTRACT_PUBMED_21983965}}

Line 22:		Line 11:

	==See Also==		==See Also==
-	*[[Aldolase]]	+	*[[Aldolase\|Aldolase]]

	==Reference==		==Reference==

OCA at 10:54, 9 November 2011

OCA — Wed, 09 Nov 2011 10:54:15 GMT

←Older revision		Revision as of 10:54, 9 November 2011
Line 19:		Line 19:

	==About this Structure==		==About this Structure==
-	[[3t2g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermoproteus_neutrophilus Thermoproteus neutrophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T2G OCA].	+	[[3t2g]] is a 1 chain structure of [[Aldolase]] with sequence from [http://en.wikipedia.org/wiki/Thermoproteus_neutrophilus Thermoproteus neutrophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T2G OCA].
		+
		+	==See Also==
		+	*[[Aldolase]]

	==Reference==		==Reference==

OCA at 09:22, 30 October 2011

OCA — Sun, 30 Oct 2011 09:22:48 GMT

←Older revision		Revision as of 09:22, 30 October 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3t2g.png\|left\|200px]]

-	The ~~entry 3t2g~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3t2g", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3t2g\| PDB=3t2g \| SCENE= }}

-	~~Authors: Du~~, J., ~~Say, R., Lue, W., Fuchs, G., Einsle, O.~~	+	===Fructose-1,6-bisphosphate aldolase/phosphatase from Thermoproteus neutrophilus, Y229F variant with DHAP===

-	~~Description: Fructose~~-1,6-~~bisphosphate aldolase~~/~~phosphatase~~ from Thermoproteus neutrophilus, ~~Y229F variant with DHAP~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21983965}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21983965 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21983965}}
		+
		+	==About this Structure==
		+	[[3t2g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermoproteus_neutrophilus Thermoproteus neutrophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T2G OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021983965</ref><references group="xtra"/>
		+	[[Category: Thermoproteus neutrophilus]]
		+	[[Category: Du, J.]]
		+	[[Category: Einsle, O.]]
		+	[[Category: Fuchs, G.]]
		+	[[Category: Lue, W.]]
		+	[[Category: Say, R.]]
		+	[[Category: Dhap]]
		+	[[Category: F6p]]
		+	[[Category: Fbp]]
		+	[[Category: Gap]]
		+	[[Category: Hydrolase]]
		+	[[Category: Lyase]]
		+	[[Category: Phosphorylation]]

OCA at 06:20, 31 August 2011

OCA — Wed, 31 Aug 2011 06:20:31 GMT

←Older revision		Revision as of 06:20, 31 August 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3t2g is ON HOLD	+	The entry 3t2g is ON HOLD until Paper Publication

	Authors: Du, J., Say, R., Lue, W., Fuchs, G., Einsle, O.		Authors: Du, J., Say, R., Lue, W., Fuchs, G., Einsle, O.

	Description: Fructose-1,6-bisphosphate aldolase/phosphatase from Thermoproteus neutrophilus, Y229F variant with DHAP		Description: Fructose-1,6-bisphosphate aldolase/phosphatase from Thermoproteus neutrophilus, Y229F variant with DHAP

OCA: Protected "3t2g" [edit=sysop:move=sysop]

OCA — Wed, 03 Aug 2011 08:24:15 GMT

Protected "3t2g" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:24, 3 August 2011