3t59 - Revision history

OCA at 16:43, 6 July 2022

OCA — Wed, 06 Jul 2022 16:43:38 GMT

←Older revision		Revision as of 16:43, 6 July 2022
Line 1:		Line 1:

	==C76A/C455S mutant of mouse QSOX1 containing an interdomain disulfide==		==C76A/C455S mutant of mouse QSOX1 containing an interdomain disulfide==
-	<StructureSection load='3t59' size='340' side='right' caption='[[3t59]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='3t59' size='340' side='right'caption='[[3t59]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3t59]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T59 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3T59 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3t59]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T59 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T59 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3llk\|3llk]], [[3lli\|3lli]], [[3q6o\|3q6o]], [[3qcp\|3qcp]], [[3qd9\|3qd9]], [[3t58\|3t58]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3llk\|3llk]], [[3lli\|3lli]], [[3q6o\|3q6o]], [[3qcp\|3qcp]], [[3qd9\|3qd9]], [[3t58\|3t58]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Qscn6, Qsox1, QSOX1b, Sox ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Qscn6, Qsox1, QSOX1b, Sox ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Thiol_oxidase Thiol oxidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.2 1.8.3.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Thiol_oxidase Thiol oxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.2 1.8.3.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3t59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t59 OCA], [~~http~~://pdbe.org/3t59 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3t59 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3t59 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3t59 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t59 OCA], [https://pdbe.org/3t59 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t59 RCSB], [https://www.ebi.ac.uk/pdbsum/3t59 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t59 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/QSOX1_MOUSE QSOX1_MOUSE]] Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins (By similarity).	+	[[https://www.uniprot.org/uniprot/QSOX1_MOUSE QSOX1_MOUSE]] Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:

	==See Also==		==See Also==
-	*[[Sulfhydryl oxidase\|Sulfhydryl oxidase]]	+	*[[Sulfhydryl oxidase 3D structures\|Sulfhydryl oxidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Thiol oxidase]]		[[Category: Thiol oxidase]]

OCA at 03:50, 5 August 2016

OCA — Fri, 05 Aug 2016 03:50:36 GMT

←Older revision		Revision as of 03:50, 5 August 2016
Line 1:		Line 1:
		+
	==C76A/C455S mutant of mouse QSOX1 containing an interdomain disulfide==		==C76A/C455S mutant of mouse QSOX1 containing an interdomain disulfide==
	<StructureSection load='3t59' size='340' side='right' caption='[[3t59]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='3t59' size='340' side='right' caption='[[3t59]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3t59]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3T59 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3t59]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3T59 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3llk\|3llk]], [[3lli\|3lli]], [[3q6o\|3q6o]], [[3qcp\|3qcp]], [[3qd9\|3qd9]], [[3t58\|3t58]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3llk\|3llk]], [[3lli\|3lli]], [[3q6o\|3q6o]], [[3qcp\|3qcp]], [[3qd9\|3qd9]], [[3t58\|3t58]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Qscn6, Qsox1, QSOX1b, Sox ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Qscn6, Qsox1, QSOX1b, Sox ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiol_oxidase Thiol oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.2 1.8.3.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiol_oxidase Thiol oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.2 1.8.3.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3t59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t59 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3t59 RCSB], [http://www.ebi.ac.uk/pdbsum/3t59 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3t59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t59 OCA], [http://pdbe.org/3t59 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3t59 RCSB], [http://www.ebi.ac.uk/pdbsum/3t59 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3t59 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3t59" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Thiol oxidase]]		[[Category: Thiol oxidase]]
	[[Category: Alon, A]]		[[Category: Alon, A]]

OCA at 22:41, 24 December 2014

OCA — Wed, 24 Dec 2014 22:41:26 GMT

←Older revision		Revision as of 22:41, 24 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3t59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t59 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3t59 RCSB], [http://www.ebi.ac.uk/pdbsum/3t59 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3t59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t59 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3t59 RCSB], [http://www.ebi.ac.uk/pdbsum/3t59 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/QSOX1_MOUSE QSOX1_MOUSE]] Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 04:39, 24 November 2014

OCA — Mon, 24 Nov 2014 04:39:10 GMT

←Older revision		Revision as of 04:39, 24 November 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3t59]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3T59 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3t59]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3T59 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3llk\|3llk]], [[3lli\|3lli]], [[3q6o\|3q6o]], [[3qcp\|3qcp]], [[3qd9\|3qd9]], [[3t58\|3t58]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3llk\|3llk]], [[3lli\|3lli]], [[3q6o\|3q6o]], [[3qcp\|3qcp]], [[3qd9\|3qd9]], [[3t58\|3t58]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Qscn6, Qsox1, QSOX1b, Sox ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Qscn6, Qsox1, QSOX1b, Sox ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiol_oxidase Thiol oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.2 1.8.3.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiol_oxidase Thiol oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.2 1.8.3.2] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3t59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t59 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3t59 RCSB], [http://www.ebi.ac.uk/pdbsum/3t59 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3t59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t59 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3t59 RCSB], [http://www.ebi.ac.uk/pdbsum/3t59 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Thiol oxidase]]		[[Category: Thiol oxidase]]
-	[[Category: Alon, A.]]	+	[[Category: Alon, A]]
-	[[Category: Fass, D.]]	+	[[Category: Fass, D]]
-	[[Category: Gat, Y.]]	+	[[Category: Gat, Y]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 09:27, 11 June 2014

OCA — Wed, 11 Jun 2014 09:27:58 GMT

←Older revision		Revision as of 09:27, 11 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3t59.~~png~~\|~~left~~\|~~200px~~]]	+	==C76A/C455S mutant of mouse QSOX1 containing an interdomain disulfide==
		+	<StructureSection load='3t59' size='340' side='right' caption='[[3t59]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3t59]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3T59 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3llk\|3llk]], [[3lli\|3lli]], [[3q6o\|3q6o]], [[3qcp\|3qcp]], [[3qd9\|3qd9]], [[3t58\|3t58]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Qscn6, Qsox1, QSOX1b, Sox ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiol_oxidase Thiol oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.2 1.8.3.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3t59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t59 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3t59 RCSB], [http://www.ebi.ac.uk/pdbsum/3t59 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Protein stability, assembly, localization and regulation often depend on the formation of disulphide crosslinks between cysteine side chains. Enzymes known as sulphydryl oxidases catalyse de novo disulphide formation and initiate intra- and intermolecular dithiol/disulphide relays to deliver the disulphides to substrate proteins. Quiescin sulphydryl oxidase (QSOX) is a unique, multi-domain disulphide catalyst that is localized primarily to the Golgi apparatus and secreted fluids and has attracted attention owing to its overproduction in tumours. In addition to its physiological importance, QSOX is a mechanistically intriguing enzyme, encompassing functions typically carried out by a series of proteins in other disulphide-formation pathways. How disulphides are relayed through the multiple redox-active sites of QSOX and whether there is a functional benefit to concatenating these sites on a single polypeptide are open questions. Here we present the first crystal structure of an intact QSOX enzyme, derived from a trypanosome parasite. Notably, sequential sites in the disulphide relay were found more than 40 A apart in this structure, too far for direct disulphide transfer. To resolve this puzzle, we trapped and crystallized an intermediate in the disulphide hand-off, which showed a 165 degrees domain rotation relative to the original structure, bringing the two active sites within disulphide-bonding distance. The comparable structure of a mammalian QSOX enzyme, also presented here, shows further biochemical features that facilitate disulphide transfer in metazoan orthologues. Finally, we quantified the contribution of concatenation to QSOX activity, providing general lessons for the understanding of multi-domain enzymes and the design of new catalytic relays.

-	~~{{STRUCTURE_3t59\| PDB=3t59 \| SCENE= }}~~	+	The dynamic disulphide relay of quiescin sulphydryl oxidase.,Alon A, Grossman I, Gat Y, Kodali VK, DiMaio F, Mehlman T, Haran G, Baker D, Thorpe C, Fass D Nature. 2012 Aug 16;488(7411):414-8. PMID:22801504<ref>PMID:22801504</ref>

-	~~===C76A~~/~~C455S mutant~~ of ~~mouse QSOX1 containing an interdomain disulfide===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_22801504}}~~	+	==See Also==
-		+	*[[Sulfhydryl oxidase\|Sulfhydryl oxidase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~3t59~~]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T59 OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:022801504<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Thiol oxidase]]		[[Category: Thiol oxidase]]

OCA at 05:12, 22 August 2012

OCA — Wed, 22 Aug 2012 05:12:50 GMT

←Older revision		Revision as of 05:12, 22 August 2012
Line 1:		Line 1:
-	[[Image:3t59.~~jpg~~\|left\|200px]]	+	[[Image:3t59.png\|left\|200px]]

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	{{STRUCTURE_3t59\| PDB=3t59 \| SCENE= }}		{{STRUCTURE_3t59\| PDB=3t59 \| SCENE= }}

	===C76A/C455S mutant of mouse QSOX1 containing an interdomain disulfide===		===C76A/C455S mutant of mouse QSOX1 containing an interdomain disulfide===

		+	{{ABSTRACT_PUBMED_22801504}}

	==About this Structure==		==About this Structure==
	[[3t59]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T59 OCA].		[[3t59]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T59 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022801504</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Thiol oxidase]]		[[Category: Thiol oxidase]]

OCA at 06:00, 30 May 2012

OCA — Wed, 30 May 2012 06:00:13 GMT

←Older revision		Revision as of 06:00, 30 May 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3t59.jpg\|left\|200px]]

-	The ~~entry 3t59~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3t59", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3t59\| PDB=3t59 \| SCENE= }}

-	~~Authors: Fass, D., Alon, A., Gat, Y.~~	+	===C76A/C455S mutant of mouse QSOX1 containing an interdomain disulfide===

-	~~Description~~: ~~C76A~~/~~C455S mutant of mouse QSOX1 containing an interdomain disulfide~~	+
		+	==About this Structure==
		+	[[3t59]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T59 OCA].
		+	[[Category: Mus musculus]]
		+	[[Category: Thiol oxidase]]
		+	[[Category: Alon, A.]]
		+	[[Category: Fass, D.]]
		+	[[Category: Gat, Y.]]
		+	[[Category: Oxidoreductase]]

OCA at 05:26, 23 May 2012

OCA — Wed, 23 May 2012 05:26:32 GMT

←Older revision		Revision as of 05:26, 23 May 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3t59 is ON HOLD ~~until Paper Publication~~	+	The entry 3t59 is ON HOLD

	Authors: Fass, D., Alon, A., Gat, Y.		Authors: Fass, D., Alon, A., Gat, Y.

	Description: C76A/C455S mutant of mouse QSOX1 containing an interdomain disulfide		Description: C76A/C455S mutant of mouse QSOX1 containing an interdomain disulfide

OCA at 05:53, 17 August 2011

OCA — Wed, 17 Aug 2011 05:53:56 GMT

←Older revision		Revision as of 05:53, 17 August 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3t59 is ON HOLD	+	The entry 3t59 is ON HOLD until Paper Publication

	Authors: Fass, D., Alon, A., Gat, Y.		Authors: Fass, D., Alon, A., Gat, Y.

	Description: C76A/C455S mutant of mouse QSOX1 containing an interdomain disulfide		Description: C76A/C455S mutant of mouse QSOX1 containing an interdomain disulfide

OCA at 05:34, 10 August 2011

OCA — Wed, 10 Aug 2011 05:34:32 GMT

←Older revision		Revision as of 05:34, 10 August 2011
Line 3:		Line 3:
	The entry 3t59 is ON HOLD		The entry 3t59 is ON HOLD

-	Authors: Fass, D, Alon, A, Gat, Y	+	Authors: Fass, D., Alon, A., Gat, Y.

	Description: C76A/C455S mutant of mouse QSOX1 containing an interdomain disulfide		Description: C76A/C455S mutant of mouse QSOX1 containing an interdomain disulfide