3t7n - Revision history

OCA at 13:19, 14 March 2024

OCA — Thu, 14 Mar 2024 13:19:49 GMT

←Older revision		Revision as of 13:19, 14 March 2024
Line 3:		Line 3:
	<StructureSection load='3t7n' size='340' side='right'caption='[[3t7n]], [[Resolution\|resolution]] 1.98Å' scene=''>		<StructureSection load='3t7n' size='340' side='right'caption='[[3t7n]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3t7n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T7N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T7N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3t7n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T7N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T7N FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>~~, ~~<scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.98Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[3qvb\|3qvb]], [[3q4s\|3q4s]], [[3rmw\|3rmw]], [[3rmv\|3rmv]], [[3t7m\|3t7m]], [[3t7o\|3t7o]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>GYG, GYG1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Glycogenin_glucosyltransferase Glycogenin glucosyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.186 2.4.1.186]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t7n OCA], [https://pdbe.org/3t7n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t7n RCSB], [https://www.ebi.ac.uk/pdbsum/3t7n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t7n ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t7n OCA], [https://pdbe.org/3t7n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t7n RCSB], [https://www.ebi.ac.uk/pdbsum/3t7n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t7n ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/GLYG_HUMAN GLYG_HUMAN]] Glycogen storage disease due to glycogenin deficiency. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/GLYG_HUMAN GLYG_HUMAN] Glycogen storage disease due to glycogenin deficiency. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GLYG_HUMAN GLYG_HUMAN]] Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase.	+	[https://www.uniprot.org/uniprot/GLYG_HUMAN GLYG_HUMAN] Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase.
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Glycogenin initiates the synthesis of a maltosaccharide chain covalently attached to itself on Tyr195 via a stepwise glucosylation reaction, priming glycogen synthesis. We have captured crystallographic snapshots of human glycogenin during its reaction cycle, revealing a dynamic conformational switch between ground and active states mediated by the sugar donor UDP-glucose. This switch includes the ordering of a polypeptide stretch containing Tyr195, and major movement of an approximately 30-residue "lid" segment covering the active site. The rearranged lid guides the nascent maltosaccharide chain into the active site in either an intra- or intersubunit mode dependent upon chain length and steric factors and positions the donor and acceptor sugar groups for catalysis. The Thr83Met mutation, which causes glycogen storage disease XV, is conformationally locked in the ground state and catalytically inactive. Our data highlight the conformational plasticity of glycogenin and coexistence of two modes of glucosylation as integral to its catalytic mechanism.	+
-		+
-	Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis.,Chaikuad A, Froese DS, Berridge G, von Delft F, Oppermann U, Yue WW Proc Natl Acad Sci U S A. 2011 Dec 12. PMID:22160680<ref>PMID:22160680</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3t7n" style="background-color:#fffaf0;"></div>~~	+

	==See Also==		==See Also==
	*[[Glycogenin\|Glycogenin]]		*[[Glycogenin\|Glycogenin]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Glycogenin glucosyltransferase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Bountra, C]]	+	[[Category: Bountra C]]
-	[[Category: Chaikuad, A]]	+	[[Category: Chaikuad A]]
-	~~[[Category: Delft, F von~~]]	+	[[Category: Edwards AM]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Froese DS]]
-	[[Category: Froese~~, D S~~]]	+	[[Category: Krysztofinska E]]
-	[[Category: Krysztofinska, E]]	+	[[Category: Oppermann U]]
-	[[Category: Oppermann, U]]	+	[[Category: Weigelt J]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Yue WW]]
-	[[Category: Weigelt, J]]	+	[[Category: Von Delft F]]
-	[[Category: Yue~~, W W~~]]	+
-	[[Category: ~~Glycogen biosynthesis]]~~	+
-	~~[[Category: Glycosylation]]~~	+
-	~~[[Category: Glycosyltransferase]]~~	+
-	~~[[Category: Sgc]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 16:46, 6 July 2022

OCA — Wed, 06 Jul 2022 16:46:31 GMT

←Older revision		Revision as of 16:46, 6 July 2022
Line 1:		Line 1:

	==Crystal Structure of Human Glycogenin-1 (GYG1) complexed with manganese and UDP, in a monoclinic closed form==		==Crystal Structure of Human Glycogenin-1 (GYG1) complexed with manganese and UDP, in a monoclinic closed form==
-	<StructureSection load='3t7n' size='340' side='right' caption='[[3t7n]], [[Resolution\|resolution]] 1.98Å' scene=''>	+	<StructureSection load='3t7n' size='340' side='right'caption='[[3t7n]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3t7n]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T7N OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3T7N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3t7n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T7N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T7N FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qvb\|3qvb]], [[3q4s\|3q4s]], [[3rmw\|3rmw]], [[3rmv\|3rmv]], [[3t7m\|3t7m]], [[3t7o\|3t7o]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3qvb\|3qvb]], [[3q4s\|3q4s]], [[3rmw\|3rmw]], [[3rmv\|3rmv]], [[3t7m\|3t7m]], [[3t7o\|3t7o]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GYG, GYG1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GYG, GYG1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Glycogenin_glucosyltransferase Glycogenin glucosyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.186 2.4.1.186] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glycogenin_glucosyltransferase Glycogenin glucosyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.186 2.4.1.186] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3t7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t7n OCA], [~~http~~://pdbe.org/3t7n PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3t7n RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3t7n PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3t7n ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t7n OCA], [https://pdbe.org/3t7n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t7n RCSB], [https://www.ebi.ac.uk/pdbsum/3t7n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t7n ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/GLYG_HUMAN GLYG_HUMAN]] Glycogen storage disease due to glycogenin deficiency. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.	+	[[https://www.uniprot.org/uniprot/GLYG_HUMAN GLYG_HUMAN]] Glycogen storage disease due to glycogenin deficiency. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GLYG_HUMAN GLYG_HUMAN]] Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase.	+	[[https://www.uniprot.org/uniprot/GLYG_HUMAN GLYG_HUMAN]] Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 32:		Line 32:
	[[Category: Glycogenin glucosyltransferase]]		[[Category: Glycogenin glucosyltransferase]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]

OCA at 11:28, 10 December 2016

OCA — Sat, 10 Dec 2016 11:28:59 GMT

←Older revision		Revision as of 11:28, 10 December 2016
Line 1:		Line 1:
		+
	==Crystal Structure of Human Glycogenin-1 (GYG1) complexed with manganese and UDP, in a monoclinic closed form==		==Crystal Structure of Human Glycogenin-1 (GYG1) complexed with manganese and UDP, in a monoclinic closed form==
	<StructureSection load='3t7n' size='340' side='right' caption='[[3t7n]], [[Resolution\|resolution]] 1.98Å' scene=''>		<StructureSection load='3t7n' size='340' side='right' caption='[[3t7n]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3t7n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T7N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3T7N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3t7n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T7N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3T7N FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qvb\|3qvb]], [[3q4s\|3q4s]], [[3rmw\|3rmw]], [[3rmv\|3rmv]], [[3t7m\|3t7m]], [[3t7o\|3t7o]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qvb\|3qvb]], [[3q4s\|3q4s]], [[3rmw\|3rmw]], [[3rmv\|3rmv]], [[3t7m\|3t7m]], [[3t7o\|3t7o]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GYG, GYG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GYG, GYG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycogenin_glucosyltransferase Glycogenin glucosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.186 2.4.1.186] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycogenin_glucosyltransferase Glycogenin glucosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.186 2.4.1.186] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3t7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t7n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3t7n RCSB], [http://www.ebi.ac.uk/pdbsum/3t7n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3t7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t7n OCA], [http://pdbe.org/3t7n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3t7n RCSB], [http://www.ebi.ac.uk/pdbsum/3t7n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3t7n ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/GLYG_HUMAN GLYG_HUMAN]] Glycogen storage disease due to glycogenin deficiency. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GLYG_HUMAN GLYG_HUMAN]] Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 22:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3t7n" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Glycogenin glucosyltransferase]]		[[Category: Glycogenin glucosyltransferase]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]

OCA at 12:10, 9 December 2014

OCA — Tue, 09 Dec 2014 12:10:04 GMT

←Older revision		Revision as of 12:10, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3t7n.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal Structure of Human Glycogenin-1 (GYG1) complexed with manganese and UDP, in a monoclinic closed form==
		+	<StructureSection load='3t7n' size='340' side='right' caption='[[3t7n]], [[Resolution\|resolution]] 1.98Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3t7n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T7N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3T7N FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qvb\|3qvb]], [[3q4s\|3q4s]], [[3rmw\|3rmw]], [[3rmv\|3rmv]], [[3t7m\|3t7m]], [[3t7o\|3t7o]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GYG, GYG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycogenin_glucosyltransferase Glycogenin glucosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.186 2.4.1.186] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3t7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t7n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3t7n RCSB], [http://www.ebi.ac.uk/pdbsum/3t7n PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Glycogenin initiates the synthesis of a maltosaccharide chain covalently attached to itself on Tyr195 via a stepwise glucosylation reaction, priming glycogen synthesis. We have captured crystallographic snapshots of human glycogenin during its reaction cycle, revealing a dynamic conformational switch between ground and active states mediated by the sugar donor UDP-glucose. This switch includes the ordering of a polypeptide stretch containing Tyr195, and major movement of an approximately 30-residue "lid" segment covering the active site. The rearranged lid guides the nascent maltosaccharide chain into the active site in either an intra- or intersubunit mode dependent upon chain length and steric factors and positions the donor and acceptor sugar groups for catalysis. The Thr83Met mutation, which causes glycogen storage disease XV, is conformationally locked in the ground state and catalytically inactive. Our data highlight the conformational plasticity of glycogenin and coexistence of two modes of glucosylation as integral to its catalytic mechanism.

-	~~{{STRUCTURE_3t7n\| PDB=3t7n \| SCENE= }}~~	+	Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis.,Chaikuad A, Froese DS, Berridge G, von Delft F, Oppermann U, Yue WW Proc Natl Acad Sci U S A. 2011 Dec 12. PMID:22160680<ref>PMID:22160680</ref>

-	~~===Crystal Structure of Human Glycogenin-1 (GYG1) complexed with manganese and UDP~~, in a ~~monoclinic closed form===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22160680}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3t7n]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3T7N OCA].~~	+

	==See Also==		==See Also==
	*[[Glycogenin\|Glycogenin]]		*[[Glycogenin\|Glycogenin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:022160680<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Glycogenin glucosyltransferase]]		[[Category: Glycogenin glucosyltransferase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Bountra, C.]]	+	[[Category: Bountra, C]]
-	[[Category: Chaikuad, A.]]	+	[[Category: Chaikuad, A]]
-	[[Category: Delft, F von.]]	+	[[Category: Delft, F von]]
-	[[Category: Edwards, A M.]]	+	[[Category: Edwards, A M]]
-	[[Category: Froese, D S.]]	+	[[Category: Froese, D S]]
-	[[Category: Krysztofinska, E.]]	+	[[Category: Krysztofinska, E]]
-	[[Category: Oppermann, U.]]	+	[[Category: Oppermann, U]]
-	[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Weigelt, J.]]	+	[[Category: Weigelt, J]]
-	[[Category: Yue, W W.]]	+	[[Category: Yue, W W]]
	[[Category: Glycogen biosynthesis]]		[[Category: Glycogen biosynthesis]]
	[[Category: Glycosylation]]		[[Category: Glycosylation]]
	[[Category: Glycosyltransferase]]		[[Category: Glycosyltransferase]]
	[[Category: Sgc]]		[[Category: Sgc]]
-	[[Category: Structural genomic]]
-	[[Category: Structural genomics consortium]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 15:10, 20 October 2012

OCA — Sat, 20 Oct 2012 15:10:04 GMT

←Older revision		Revision as of 15:10, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3t7n]] is a 2 chain structure ~~of [[Glycogenin]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T7N OCA].	+	[[3t7n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T7N OCA].

	==See Also==		==See Also==

OCA at 17:30, 26 July 2012

OCA — Thu, 26 Jul 2012 17:30:51 GMT

←Older revision		Revision as of 17:30, 26 July 2012
Line 1:		Line 1:
	[[Image:3t7n.png\|left\|200px]]		[[Image:3t7n.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3t7n", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3t7n\| PDB=3t7n \| SCENE= }}		{{STRUCTURE_3t7n\| PDB=3t7n \| SCENE= }}

	===Crystal Structure of Human Glycogenin-1 (GYG1) complexed with manganese and UDP, in a monoclinic closed form===		===Crystal Structure of Human Glycogenin-1 (GYG1) complexed with manganese and UDP, in a monoclinic closed form===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_22160680}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 22160680 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_22160680}}		{{ABSTRACT_PUBMED_22160680}}

Line 22:		Line 11:

	==See Also==		==See Also==
-	*[[Glycogenin]]	+	*[[Glycogenin\|Glycogenin]]

	==Reference==		==Reference==

OCA at 06:14, 28 December 2011

OCA — Wed, 28 Dec 2011 06:14:21 GMT

←Older revision		Revision as of 06:14, 28 December 2011
Line 11:		Line 11:
	===Crystal Structure of Human Glycogenin-1 (GYG1) complexed with manganese and UDP, in a monoclinic closed form===		===Crystal Structure of Human Glycogenin-1 (GYG1) complexed with manganese and UDP, in a monoclinic closed form===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22160680}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22160680 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22160680}}

	==About this Structure==		==About this Structure==
Line 17:		Line 23:
	==See Also==		==See Also==
	*[[Glycogenin]]		*[[Glycogenin]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022160680</ref><references group="xtra"/>
	[[Category: Glycogenin glucosyltransferase]]		[[Category: Glycogenin glucosyltransferase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 10:47, 14 December 2011

OCA — Wed, 14 Dec 2011 10:47:22 GMT

←Older revision		Revision as of 10:47, 14 December 2011
Line 1:		Line 1:
-	[[Image:3t7n.~~jpg~~\|left\|200px]]	+	[[Image:3t7n.png\|left\|200px]]

	<!--		<!--
Line 13:		Line 13:

	==About this Structure==		==About this Structure==
-	[[3t7n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T7N OCA].	+	[[3t7n]] is a 2 chain structure of [[Glycogenin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T7N OCA].
		+
		+	==See Also==
		+	*[[Glycogenin]]
	[[Category: Glycogenin glucosyltransferase]]		[[Category: Glycogenin glucosyltransferase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 07:02, 31 August 2011

OCA — Wed, 31 Aug 2011 07:02:30 GMT

←Older revision		Revision as of 07:02, 31 August 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3t7n.jpg\|left\|200px]]

-	The ~~entry 3t7n~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3t7n", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3t7n\| PDB=3t7n \| SCENE= }}

-	~~Authors: Chaikuad, A., Froese, D.S., Krysztofinska, E., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Oppermann, U., Yue, W.W., Structural Genomics Consortium~~ (~~SGC~~)	+	===Crystal Structure of Human Glycogenin-1 (GYG1) complexed with manganese and UDP, in a monoclinic closed form===

-	~~Description: Crystal~~ Structure ~~of Human Glycogenin-1 (GYG1) complexed~~ with ~~manganese and UDP~~, ~~in a monoclinic closed form~~	+
		+	==About this Structure==
		+	[[3t7n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T7N OCA].
		+	[[Category: Glycogenin glucosyltransferase]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Arrowsmith, C H.]]
		+	[[Category: Bountra, C.]]
		+	[[Category: Chaikuad, A.]]
		+	[[Category: Delft, F von.]]
		+	[[Category: Edwards, A M.]]
		+	[[Category: Froese, D S.]]
		+	[[Category: Krysztofinska, E.]]
		+	[[Category: Oppermann, U.]]
		+	[[Category: SGC, Structural Genomics Consortium.]]
		+	[[Category: Weigelt, J.]]
		+	[[Category: Yue, W W.]]
		+	[[Category: Glycogen biosynthesis]]
		+	[[Category: Glycosylation]]
		+	[[Category: Glycosyltransferase]]
		+	[[Category: Sgc]]
		+	[[Category: Structural genomic]]
		+	[[Category: Structural genomics consortium]]
		+	[[Category: Transferase]]

OCA: Protected "3t7n" [edit=sysop:move=sysop]

OCA — Wed, 10 Aug 2011 05:36:11 GMT

Protected "3t7n" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:36, 10 August 2011