3tbj - Revision history

OCA at 16:51, 6 July 2022

OCA — Wed, 06 Jul 2022 16:51:10 GMT

←Older revision		Revision as of 16:51, 6 July 2022
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	==The 1.7A crystal structure of Actibind a T2 ribonucleases as antitumorigenic agents==		==The 1.7A crystal structure of Actibind a T2 ribonucleases as antitumorigenic agents==
-	<StructureSection load='3tbj' size='340' side='right' caption='[[3tbj]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='3tbj' size='340' side='right'caption='[[3tbj]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tbj]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Aspergillus_niger Aspergillus niger]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3TBJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tbj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_niger Aspergillus niger]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TBJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3d3z\|3d3z]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3d3z\|3d3z]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3tbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbj OCA], [~~http~~://pdbe.org/3tbj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3tbj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3tbj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3tbj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbj OCA], [https://pdbe.org/3tbj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tbj RCSB], [https://www.ebi.ac.uk/pdbsum/3tbj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tbj ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Aspergillus niger]]		[[Category: Aspergillus niger]]
		+	[[Category: Large Structures]]
	[[Category: Almog, O]]		[[Category: Almog, O]]
	[[Category: Gonzalez, A]]		[[Category: Gonzalez, A]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Ribonuclease]]		[[Category: Ribonuclease]]

OCA at 08:33, 11 August 2016

OCA — Thu, 11 Aug 2016 08:33:31 GMT

←Older revision		Revision as of 08:33, 11 August 2016
Line 1:		Line 1:
		+
	==The 1.7A crystal structure of Actibind a T2 ribonucleases as antitumorigenic agents==		==The 1.7A crystal structure of Actibind a T2 ribonucleases as antitumorigenic agents==
	<StructureSection load='3tbj' size='340' side='right' caption='[[3tbj]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3tbj' size='340' side='right' caption='[[3tbj]], [[Resolution\|resolution]] 1.80Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3d3z\|3d3z]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3d3z\|3d3z]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tbj RCSB], [http://www.ebi.ac.uk/pdbsum/3tbj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbj OCA], [http://pdbe.org/3tbj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3tbj RCSB], [http://www.ebi.ac.uk/pdbsum/3tbj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3tbj ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3tbj" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:43, 4 January 2015

OCA — Sun, 04 Jan 2015 10:43:59 GMT

←Older revision		Revision as of 10:43, 4 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3tbj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspergillus_niger Aspergillus niger]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TBJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[3tbj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspergillus_niger Aspergillus niger]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TBJ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3d3z\|3d3z]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3d3z\|3d3z]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tbj RCSB], [http://www.ebi.ac.uk/pdbsum/3tbj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tbj RCSB], [http://www.ebi.ac.uk/pdbsum/3tbj PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Aspergillus niger]]		[[Category: Aspergillus niger]]
-	[[Category: Almog, O.]]	+	[[Category: Almog, O]]
-	[[Category: Gonzalez, A.]]	+	[[Category: Gonzalez, A]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Ribonuclease]]		[[Category: Ribonuclease]]

OCA at 09:08, 11 June 2014

OCA — Wed, 11 Jun 2014 09:08:36 GMT

←Older revision		Revision as of 09:08, 11 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3tbj.~~jpg~~\|~~left~~\|~~200px~~]]	+	==The 1.7A crystal structure of Actibind a T2 ribonucleases as antitumorigenic agents==
		+	<StructureSection load='3tbj' size='340' side='right' caption='[[3tbj]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3tbj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspergillus_niger Aspergillus niger]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TBJ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3d3z\|3d3z]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tbj RCSB], [http://www.ebi.ac.uk/pdbsum/3tbj PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	ACTIBIND and its human homologue RNASET2 are T2 ribonucleases (RNases). RNases are ubiquitous and efficient enzymes that hydrolyze RNA to 3' mononucleotides and also possess antitumorigenic and antiangiogenic activities. Previously, we have shown that ACTIBIND and RNASET2 bind actin and interfere with the cytoskeletal network structure, thereby inhibiting cell motility and invasiveness in cancer and in endothelial cells. We also showed that ACTIBIND binds actin in a molar ratio of 1:2. Here, we further characterize ACTIBIND and determine its crystal structure at 1.8 A resolution, which enables us to propose two structural elements that create binding sites to actin. We suggest that each of these binding sites is composed of one cysteine residue and one conserved amino acid region. These binding sites possibly interfere with the cytoskeleton network structure and as such may be responsible for the antitumorigenic and antiangiogenic activities of ACTIBIND and its human analogue RNASET2.

-	~~{{STRUCTURE_3tbj\| PDB=3tbj \| SCENE= }}~~	+	The 1.8 A crystal structure of ACTIBIND suggests a mode of action for T2 ribonucleases as antitumorigenic agents.,de Leeuw M, Gonzalez A, Lanir A, Roiz L, Smirnoff P, Schwartz B, Shoseyov O, Almog O J Med Chem. 2012 Feb 9;55(3):1013-20. Epub 2012 Jan 31. PMID:22216760<ref>PMID:22216760</ref>

-	~~===The 1.7A crystal structure~~ of ~~Actibind a T2 ribonucleases as antitumorigenic agents===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22216760}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3tbj]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Aspergillus_niger Aspergillus niger]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3TBJ OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022216760<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Aspergillus niger]]		[[Category: Aspergillus niger]]
	[[Category: Almog, O.]]		[[Category: Almog, O.]]

OCA at 05:53, 22 August 2012

OCA — Wed, 22 Aug 2012 05:53:15 GMT

←Older revision		Revision as of 05:53, 22 August 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3tbj.jpg\|left\|200px]]

-	~~The entry~~ 3tbj ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_3tbj\| PDB=3tbj \| SCENE= }}

-	~~Authors: Almog, O., Gonzalez, A~~.	+	===The 1.7A crystal structure of Actibind a T2 ribonucleases as antitumorigenic agents===

-	~~Description: The~~ 1~~.7A crystal~~ structure ~~of Actibind a T2 ribonucleases as antitumorigenic agents~~	+	{{ABSTRACT_PUBMED_22216760}}
		+
		+	==About this Structure==
		+	[[3tbj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspergillus_niger Aspergillus niger]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBJ OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022216760</ref><references group="xtra"/>
		+	[[Category: Aspergillus niger]]
		+	[[Category: Almog, O.]]
		+	[[Category: Gonzalez, A.]]
		+	[[Category: Hydrolase]]
		+	[[Category: Ribonuclease]]

OCA at 06:00, 14 March 2012

OCA — Wed, 14 Mar 2012 06:00:26 GMT

←Older revision		Revision as of 06:00, 14 March 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3tbj is ON HOLD	+	The entry 3tbj is ON HOLD until Paper Publication

	Authors: Almog, O., Gonzalez, A.		Authors: Almog, O., Gonzalez, A.

	Description: The 1.7A crystal structure of Actibind a T2 ribonucleases as antitumorigenic agents		Description: The 1.7A crystal structure of Actibind a T2 ribonucleases as antitumorigenic agents

OCA at 07:10, 24 August 2011

OCA — Wed, 24 Aug 2011 07:10:05 GMT

←Older revision		Revision as of 07:10, 24 August 2011
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	Authors: Almog, O., Gonzalez, A.		Authors: Almog, O., Gonzalez, A.

-	Description: The 1.7 crystal structure of ~~ACTIBIND~~ a T2 ribonucleases as antitumorigenic agents	+	Description: The 1.7A crystal structure of Actibind a T2 ribonucleases as antitumorigenic agents

OCA: Protected "3tbj" [edit=sysop:move=sysop]

OCA — Wed, 17 Aug 2011 05:56:06 GMT

Protected "3tbj" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:56, 17 August 2011

OCA: New page: '''Unreleased structure''' The entry 3tbj is ON HOLD Authors: Almog, O., Gonzalez, A. Description: The 1.7 crystal structure of ACTIBIND a T2 ribonucleases as antitumorigenic agents

OCA — Wed, 17 Aug 2011 05:56:05 GMT

New page: '''Unreleased structure''' The entry 3tbj is ON HOLD Authors: Almog, O., Gonzalez, A. Description: The 1.7 crystal structure of ACTIBIND a T2 ribonucleases as antitumorigenic agents

New page

'''Unreleased structure'''

The entry 3tbj is ON HOLD

Authors: Almog, O., Gonzalez, A.

Description: The 1.7 crystal structure of ACTIBIND a T2 ribonucleases as antitumorigenic agents