3tbm - Revision history

OCA at 08:37, 20 March 2024

OCA — Wed, 20 Mar 2024 08:37:34 GMT

←Older revision		Revision as of 08:37, 20 March 2024
Line 3:		Line 3:
	<StructureSection load='3tbm' size='340' side='right'caption='[[3tbm]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3tbm' size='340' side='right'caption='[[3tbm]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tbm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Pseudomonas_solanacearum Pseudomonas~~ solanacearum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TBM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tbm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ralstonia_solanacearum_GMI1000 Ralstonia solanacearum GMI1000]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TBM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2PE:NONAETHYLENE+GLYCOL'>2PE</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.797Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3tbn\|3tbn]], [[3tbo\|3tbo]], [[2qd0\|2qd0]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2PE:NONAETHYLENE+GLYCOL'>2PE</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RSc2912 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=267608 Pseudomonas solanacearum])</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbm OCA], [https://pdbe.org/3tbm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tbm RCSB], [https://www.ebi.ac.uk/pdbsum/3tbm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tbm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbm OCA], [https://pdbe.org/3tbm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tbm RCSB], [https://www.ebi.ac.uk/pdbsum/3tbm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tbm ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/Q8XVB9_RALSO Q8XVB9_RALSO]
-	The recently discovered CDGSH iron-sulfur domains (CISDs) are classified into seven major types with a wide distribution throughout the three domains of life. The type 1 protein mitoNEET has been shown to fold into a dimer with the signature CDGSH motif binding to a [2Fe-2S] cluster. However, the structures of all other types of CISDs were unknown. Here we report the crystal structures of type 3, 4, and 6 CISDs determined at 1.5 A, 1.8 A and 1.15 A resolution, respectively. The type 3 and 4 CISD each contain one CDGSH motif and adopt a dimeric structure. Although similar to each other, the two structures have permutated topologies, and both are distinct from the type 1 structure. The type 6 CISD contains tandem CDGSH motifs and adopts a monomeric structure with an internal pseudo dyad symmetry. All currently known CISD structures share dual iron-sulfur binding modules and a beta-sandwich for either intermolecular or intramolecular dimerization. The iron-sulfur binding module, the beta-strand N-terminal to the module and a proline motif are conserved among different type structures, but the dimerization module and the interface and orientation between the two iron-sulfur binding modules are divergent. Sequence analysis further shows resemblance between CISD types 4 and 7 and between 1 and 2. Our findings suggest that all CISDs share common ancestry and diverged into three primary folds with a characteristic phylogenetic distribution: a eukaryote-specific fold adopted by types 1 and 2 proteins, a prokaryote-specific fold adopted by types 3, 4 and 7 proteins, and a tandem-motif fold adopted by types 5 and 6 proteins. Our comprehensive structural, sequential and phylogenetic analysis provides significant insight into the assembly principles and evolutionary relationship of CISDs.	+
-		+
-	~~Structure and Molecular Evolution of CDGSH Iron-Sulfur Domains.,Lin J, Zhang L, Lai S, Ye K PLoS One. 2011;6(9):e24790. Epub 2011 Sep 16. PMID:21949752<ref>PMID~~:~~21949752<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®~~/~~PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 3tbm" style="background-color:#fffaf0;"><~~/~~div>~~	+
-	~~== References ==~~	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Pseudomonas~~ solanacearum]]	+	[[Category: Ralstonia solanacearum GMI1000]]
-	[[Category: Lin, J]]	+	[[Category: Lin J]]
-	[[Category: Ye, K]]	+	[[Category: Ye K]]
-	[[Category: Zhang, L]]	+	[[Category: Zhang L]]
-	~~[[Category: Cdgsh]]~~	+
-	~~[[Category: Iron-sulfur]]~~	+
-	~~[[Category: Metal binding protein~~]]	+

OCA at 16:51, 6 July 2022

OCA — Wed, 06 Jul 2022 16:51:17 GMT

←Older revision		Revision as of 16:51, 6 July 2022
Line 1:		Line 1:

	==Crystal structure of a type 4 CDGSH iron-sulfur protein.==		==Crystal structure of a type 4 CDGSH iron-sulfur protein.==
-	<StructureSection load='3tbm' size='340' side='right' caption='[[3tbm]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='3tbm' size='340' side='right'caption='[[3tbm]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tbm]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Pseudomonas_solanacearum Pseudomonas solanacearum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3TBM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tbm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_solanacearum Pseudomonas solanacearum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TBM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2PE:NONAETHYLENE+GLYCOL'>2PE</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2PE:NONAETHYLENE+GLYCOL'>2PE</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tbn\|3tbn]], [[3tbo\|3tbo]], [[2qd0\|2qd0]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3tbn\|3tbn]], [[3tbo\|3tbo]], [[2qd0\|2qd0]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RSc2912 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=267608 Pseudomonas solanacearum])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RSc2912 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=267608 Pseudomonas solanacearum])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3tbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbm OCA], [~~http~~://pdbe.org/3tbm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3tbm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3tbm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3tbm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbm OCA], [https://pdbe.org/3tbm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tbm RCSB], [https://www.ebi.ac.uk/pdbsum/3tbm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tbm ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Pseudomonas solanacearum]]		[[Category: Pseudomonas solanacearum]]
	[[Category: Lin, J]]		[[Category: Lin, J]]

OCA at 10:39, 11 August 2016

OCA — Thu, 11 Aug 2016 10:39:42 GMT

←Older revision		Revision as of 10:39, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of a type 4 CDGSH iron-sulfur protein.==		==Crystal structure of a type 4 CDGSH iron-sulfur protein.==
	<StructureSection load='3tbm' size='340' side='right' caption='[[3tbm]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3tbm' size='340' side='right' caption='[[3tbm]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tbm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Ralstonia_solanacearum Ralstonia~~ solanacearum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TBM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tbm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_solanacearum Pseudomonas solanacearum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TBM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2PE:NONAETHYLENE+GLYCOL'>2PE</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2PE:NONAETHYLENE+GLYCOL'>2PE</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tbn\|3tbn]], [[3tbo\|3tbo]], [[2qd0\|2qd0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tbn\|3tbn]], [[3tbo\|3tbo]], [[2qd0\|2qd0]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RSc2912 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~305 Ralstonia~~ solanacearum])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RSc2912 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=267608 Pseudomonas solanacearum])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tbm RCSB], [http://www.ebi.ac.uk/pdbsum/3tbm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbm OCA], [http://pdbe.org/3tbm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3tbm RCSB], [http://www.ebi.ac.uk/pdbsum/3tbm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3tbm ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3tbm" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ralstonia~~ solanacearum]]	+	[[Category: Pseudomonas solanacearum]]
	[[Category: Lin, J]]		[[Category: Lin, J]]
	[[Category: Ye, K]]		[[Category: Ye, K]]

OCA at 11:08, 4 January 2015

OCA — Sun, 04 Jan 2015 11:08:46 GMT

←Older revision		Revision as of 11:08, 4 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3tbm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ralstonia_solanacearum Ralstonia solanacearum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TBM FirstGlance]. <br>		<table><tr><td colspan='2'>[[3tbm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ralstonia_solanacearum Ralstonia solanacearum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TBM FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2PE:NONAETHYLENE+GLYCOL'>2PE</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2PE:NONAETHYLENE+GLYCOL'>2PE</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tbn\|3tbn]], [[3tbo\|3tbo]], [[2qd0\|2qd0]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tbn\|3tbn]], [[3tbo\|3tbo]], [[2qd0\|2qd0]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RSc2912 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=305 Ralstonia solanacearum])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RSc2912 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=305 Ralstonia solanacearum])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tbm RCSB], [http://www.ebi.ac.uk/pdbsum/3tbm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tbm RCSB], [http://www.ebi.ac.uk/pdbsum/3tbm PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 14:
	Structure and Molecular Evolution of CDGSH Iron-Sulfur Domains.,Lin J, Zhang L, Lai S, Ye K PLoS One. 2011;6(9):e24790. Epub 2011 Sep 16. PMID:21949752<ref>PMID:21949752</ref>		Structure and Molecular Evolution of CDGSH Iron-Sulfur Domains.,Lin J, Zhang L, Lai S, Ye K PLoS One. 2011;6(9):e24790. Epub 2011 Sep 16. PMID:21949752<ref>PMID:21949752</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Ralstonia solanacearum]]		[[Category: Ralstonia solanacearum]]
-	[[Category: Lin, J.]]	+	[[Category: Lin, J]]
-	[[Category: Ye, K.]]	+	[[Category: Ye, K]]
-	[[Category: Zhang, L.]]	+	[[Category: Zhang, L]]
	[[Category: Cdgsh]]		[[Category: Cdgsh]]
	[[Category: Iron-sulfur]]		[[Category: Iron-sulfur]]
	[[Category: Metal binding protein]]		[[Category: Metal binding protein]]

OCA at 06:45, 5 June 2014

OCA — Thu, 05 Jun 2014 06:45:40 GMT

←Older revision		Revision as of 06:45, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3tbm.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of a type 4 CDGSH iron-sulfur protein.==
		+	<StructureSection load='3tbm' size='340' side='right' caption='[[3tbm]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3tbm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ralstonia_solanacearum Ralstonia solanacearum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TBM FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2PE:NONAETHYLENE+GLYCOL'>2PE</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tbn\|3tbn]], [[3tbo\|3tbo]], [[2qd0\|2qd0]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RSc2912 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=305 Ralstonia solanacearum])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tbm RCSB], [http://www.ebi.ac.uk/pdbsum/3tbm PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The recently discovered CDGSH iron-sulfur domains (CISDs) are classified into seven major types with a wide distribution throughout the three domains of life. The type 1 protein mitoNEET has been shown to fold into a dimer with the signature CDGSH motif binding to a [2Fe-2S] cluster. However, the structures of all other types of CISDs were unknown. Here we report the crystal structures of type 3, 4, and 6 CISDs determined at 1.5 A, 1.8 A and 1.15 A resolution, respectively. The type 3 and 4 CISD each contain one CDGSH motif and adopt a dimeric structure. Although similar to each other, the two structures have permutated topologies, and both are distinct from the type 1 structure. The type 6 CISD contains tandem CDGSH motifs and adopts a monomeric structure with an internal pseudo dyad symmetry. All currently known CISD structures share dual iron-sulfur binding modules and a beta-sandwich for either intermolecular or intramolecular dimerization. The iron-sulfur binding module, the beta-strand N-terminal to the module and a proline motif are conserved among different type structures, but the dimerization module and the interface and orientation between the two iron-sulfur binding modules are divergent. Sequence analysis further shows resemblance between CISD types 4 and 7 and between 1 and 2. Our findings suggest that all CISDs share common ancestry and diverged into three primary folds with a characteristic phylogenetic distribution: a eukaryote-specific fold adopted by types 1 and 2 proteins, a prokaryote-specific fold adopted by types 3, 4 and 7 proteins, and a tandem-motif fold adopted by types 5 and 6 proteins. Our comprehensive structural, sequential and phylogenetic analysis provides significant insight into the assembly principles and evolutionary relationship of CISDs.

-	<!--	+	Structure and Molecular Evolution of CDGSH Iron-Sulfur Domains.,Lin J, Zhang L, Lai S, Ye K PLoS One. 2011;6(9):e24790. Epub 2011 Sep 16. PMID:21949752<ref>PMID:21949752</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3tbm"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_3tbm\| PDB=3tbm \| SCENE= }}~~	+

-	~~===Crystal structure~~ of ~~a type 4 CDGSH iron-sulfur protein.===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21949752}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21949752 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_21949752}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3tbm]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Ralstonia_solanacearum Ralstonia solanacearum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBM OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021949752<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Ralstonia solanacearum]]		[[Category: Ralstonia solanacearum]]
	[[Category: Lin, J.]]		[[Category: Lin, J.]]

OCA at 08:22, 30 October 2011

OCA — Sun, 30 Oct 2011 08:22:19 GMT

←Older revision		Revision as of 08:22, 30 October 2011
Line 1:		Line 1:
-	[[Image:3tbm.~~jpg~~\|left\|200px]]	+	[[Image:3tbm.png\|left\|200px]]

	<!--		<!--
Line 11:		Line 11:
	===Crystal structure of a type 4 CDGSH iron-sulfur protein.===		===Crystal structure of a type 4 CDGSH iron-sulfur protein.===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21949752}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21949752 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21949752}}

	==About this Structure==		==About this Structure==
	[[3tbm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ralstonia_solanacearum Ralstonia solanacearum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBM OCA].		[[3tbm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ralstonia_solanacearum Ralstonia solanacearum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBM OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021949752</ref><references group="xtra"/>
	[[Category: Ralstonia solanacearum]]		[[Category: Ralstonia solanacearum]]
	[[Category: Lin, J.]]		[[Category: Lin, J.]]

OCA at 06:48, 5 October 2011

OCA — Wed, 05 Oct 2011 06:48:20 GMT

←Older revision		Revision as of 06:48, 5 October 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3tbm.jpg\|left\|200px]]

-	The ~~entry 3tbm~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3tbm", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3tbm\| PDB=3tbm \| SCENE= }}

-	~~Authors: Lin, J., Zhang, L., Ye, K~~.	+	===Crystal structure of a type 4 CDGSH iron-sulfur protein.===

-	~~Description: Crystal structure of~~ a ~~type 4 CDGSH iron~~-sulfur protein.	+
		+	==About this Structure==
		+	[[3tbm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ralstonia_solanacearum Ralstonia solanacearum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBM OCA].
		+	[[Category: Ralstonia solanacearum]]
		+	[[Category: Lin, J.]]
		+	[[Category: Ye, K.]]
		+	[[Category: Zhang, L.]]
		+	[[Category: Cdgsh]]
		+	[[Category: Iron-sulfur]]
		+	[[Category: Metal binding protein]]

OCA at 05:29, 21 September 2011

OCA — Wed, 21 Sep 2011 05:29:39 GMT

←Older revision		Revision as of 05:29, 21 September 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3tbm is ON HOLD	+	The entry 3tbm is ON HOLD until Paper Publication

	Authors: Lin, J., Zhang, L., Ye, K.		Authors: Lin, J., Zhang, L., Ye, K.

	Description: Crystal structure of a type 4 CDGSH iron-sulfur protein.		Description: Crystal structure of a type 4 CDGSH iron-sulfur protein.

OCA: Protected "3tbm" [edit=sysop:move=sysop]

OCA — Wed, 17 Aug 2011 05:56:12 GMT

Protected "3tbm" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:56, 17 August 2011

OCA: New page: '''Unreleased structure''' The entry 3tbm is ON HOLD Authors: Lin, J., Zhang, L., Ye, K. Description: Crystal structure of a type 4 CDGSH iron-sulfur protein.

OCA — Wed, 17 Aug 2011 05:56:11 GMT

New page: '''Unreleased structure''' The entry 3tbm is ON HOLD Authors: Lin, J., Zhang, L., Ye, K. Description: Crystal structure of a type 4 CDGSH iron-sulfur protein.

New page

'''Unreleased structure'''

The entry 3tbm is ON HOLD

Authors: Lin, J., Zhang, L., Ye, K.

Description: Crystal structure of a type 4 CDGSH iron-sulfur protein.