3tbs - Revision history

OCA at 13:23, 14 March 2024

OCA — Thu, 14 Mar 2024 13:23:16 GMT

←Older revision		Revision as of 13:23, 14 March 2024
Line 3:		Line 3:
	<StructureSection load='3tbs' size='340' side='right'caption='[[3tbs]], [[Resolution\|resolution]] 2.49Å' scene=''>		<StructureSection load='3tbs' size='340' side='right'caption='[[3tbs]], [[Resolution\|resolution]] 2.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tbs]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TBS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tbs]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Lymphocytic_choriomeningitis_virus_(strain_WE) Lymphocytic choriomeningitis virus (strain WE)] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TBS FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.49Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1s7u\|1s7u]], [[1s7v\|1s7v]], [[1s7w\|1s7w]], [[1s7x\|1s7x]], [[3qul\|3qul]], [[3quk\|3quk]], [[3tbt\|3tbt]], [[3tbv\|3tbv]], [[3tbw\|3tbw]], [[3tbx\|3tbx]], [[3tby\|3tby]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td><td class="sblockDat">H2-D1, H2-DB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), B2m ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbs OCA], [https://pdbe.org/3tbs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tbs RCSB], [https://www.ebi.ac.uk/pdbsum/3tbs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tbs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbs OCA], [https://pdbe.org/3tbs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tbs RCSB], [https://www.ebi.ac.uk/pdbsum/3tbs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tbs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE]] Involved in the presentation of foreign antigens to the immune system. [[https://www.uniprot.org/uniprot/GLYC_LYCVW GLYC_LYCVW]] The stable signal peptide (SSP) is cleaved and functions as a signal peptide. In addition, it is apparently retained as the third component of the GP complex. The SSP is required for efficient glycoprotein expression, post-translational maturation cleavage of GP1 and GP2, glycoprotein transport to the cell surface plasma membrane, formation of infectious virus particles, and acid pH-dependent glycoprotein-mediated cell fusion (By similarity). Glycoprotein G1 mediates virus attachment to host receptor alpha-dystroglycan DAG1. This attachment induces virion internalization predominantly through clathrin- and caveolin-independent endocytosis (By similarity). Glycoprotein G2 is a viral fusion protein. Membrane fusion is mediated by conformational changes induced upon acidification in the endosome (Potential). [[https://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	+	[https://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE] Involved in the presentation of foreign antigens to the immune system.

	==See Also==		==See Also==
	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]		*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
	*[[MHC 3D structures\|MHC 3D structures]]		*[[MHC 3D structures\|MHC 3D structures]]
		+	*[[MHC I 3D structures\|MHC I 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Achour, A]]	+	[[Category: Achour A]]
-	[[Category: Allerbring~~, E B~~]]	+	[[Category: Allerbring EB]]
-	[[Category: Badia-Martinez, D]]	+	[[Category: Badia-Martinez D]]
-	[[Category: Duru~~, A D~~]]	+	[[Category: Duru AD]]
-	[[Category: Madhurantakam, C]]	+	[[Category: Madhurantakam C]]
-	[[Category: Mazumdar~~, P A~~]]	+	[[Category: Mazumdar PA]]
-	[[Category: Nygren, P]]	+	[[Category: Nygren P]]
-	[[Category: Sandalova, T]]	+	[[Category: Sandalova T]]
-	[[Category: Uchtenhagen, H]]	+	[[Category: Uchtenhagen H]]
-	~~[[Category: Agonism]]~~	+
-	~~[[Category: Altered peptide ligand]]~~	+
-	~~[[Category: Antagonism]]~~	+
-	~~[[Category: Antigen presentation]]~~	+
-	~~[[Category: Beta2-microglobulin]]~~	+
-	~~[[Category: Cd8]]~~	+
-	~~[[Category: Cell surface]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immune system-agonist complex]]~~	+
-	~~[[Category: Lcmv]]~~	+
-	~~[[Category: Murine mhc]]~~	+
-	~~[[Category: Receptor binding]]~~	+
-	~~[[Category: T cell receptor]]~~	+
-	~~[[Category: T cell recognition~~]]	+

OCA at 16:51, 6 July 2022

OCA — Wed, 06 Jul 2022 16:51:19 GMT

←Older revision		Revision as of 16:51, 6 July 2022
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF THE MURINE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX H-2DB IN COMPLEX THE WITH LCMV-DERIVED GP33 ALTERED PEPTIDE ligand (V3P,Y4A)==		==CRYSTAL STRUCTURE OF THE MURINE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX H-2DB IN COMPLEX THE WITH LCMV-DERIVED GP33 ALTERED PEPTIDE ligand (V3P,Y4A)==
-	<StructureSection load='3tbs' size='340' side='right' caption='[[3tbs]], [[Resolution\|resolution]] 2.49Å' scene=''>	+	<StructureSection load='3tbs' size='340' side='right'caption='[[3tbs]], [[Resolution\|resolution]] 2.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tbs]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3TBS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tbs]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TBS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s7u\|1s7u]], [[1s7v\|1s7v]], [[1s7w\|1s7w]], [[1s7x\|1s7x]], [[3qul\|3qul]], [[3quk\|3quk]], [[3tbt\|3tbt]], [[3tbv\|3tbv]], [[3tbw\|3tbw]], [[3tbx\|3tbx]], [[3tby\|3tby]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1s7u\|1s7u]], [[1s7v\|1s7v]], [[1s7w\|1s7w]], [[1s7x\|1s7x]], [[3qul\|3qul]], [[3quk\|3quk]], [[3tbt\|3tbt]], [[3tbv\|3tbv]], [[3tbw\|3tbw]], [[3tbx\|3tbx]], [[3tby\|3tby]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-D1, H2-DB ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), B2m ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-D1, H2-DB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), B2m ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3tbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbs OCA], [~~http~~://pdbe.org/3tbs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3tbs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3tbs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3tbs ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbs OCA], [https://pdbe.org/3tbs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tbs RCSB], [https://www.ebi.ac.uk/pdbsum/3tbs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tbs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE]] Involved in the presentation of foreign antigens to the immune system. [[~~http~~://www.uniprot.org/uniprot/GLYC_LYCVW GLYC_LYCVW]] The stable signal peptide (SSP) is cleaved and functions as a signal peptide. In addition, it is apparently retained as the third component of the GP complex. The SSP is required for efficient glycoprotein expression, post-translational maturation cleavage of GP1 and GP2, glycoprotein transport to the cell surface plasma membrane, formation of infectious virus particles, and acid pH-dependent glycoprotein-mediated cell fusion (By similarity). Glycoprotein G1 mediates virus attachment to host receptor alpha-dystroglycan DAG1. This attachment induces virion internalization predominantly through clathrin- and caveolin-independent endocytosis (By similarity). Glycoprotein G2 is a viral fusion protein. Membrane fusion is mediated by conformational changes induced upon acidification in the endosome (Potential). [[~~http~~://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	+	[[https://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE]] Involved in the presentation of foreign antigens to the immune system. [[https://www.uniprot.org/uniprot/GLYC_LYCVW GLYC_LYCVW]] The stable signal peptide (SSP) is cleaved and functions as a signal peptide. In addition, it is apparently retained as the third component of the GP complex. The SSP is required for efficient glycoprotein expression, post-translational maturation cleavage of GP1 and GP2, glycoprotein transport to the cell surface plasma membrane, formation of infectious virus particles, and acid pH-dependent glycoprotein-mediated cell fusion (By similarity). Glycoprotein G1 mediates virus attachment to host receptor alpha-dystroglycan DAG1. This attachment induces virion internalization predominantly through clathrin- and caveolin-independent endocytosis (By similarity). Glycoprotein G2 is a viral fusion protein. Membrane fusion is mediated by conformational changes induced upon acidification in the endosome (Potential). [[https://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

	==See Also==		==See Also==
-	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]	+	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
-	*[[~~Major histocompatibility complex~~\|~~Major histocompatibility complex~~]]	+	*[[MHC 3D structures\|MHC 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Achour, A]]		[[Category: Achour, A]]

OCA at 10:48, 13 February 2019

OCA — Wed, 13 Feb 2019 10:48:36 GMT

←Older revision		Revision as of 10:48, 13 February 2019
Line 3:		Line 3:
	<StructureSection load='3tbs' size='340' side='right' caption='[[3tbs]], [[Resolution\|resolution]] 2.49Å' scene=''>		<StructureSection load='3tbs' size='340' side='right' caption='[[3tbs]], [[Resolution\|resolution]] 2.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tbs]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TBS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tbs]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TBS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s7u\|1s7u]], [[1s7v\|1s7v]], [[1s7w\|1s7w]], [[1s7x\|1s7x]], [[3qul\|3qul]], [[3quk\|3quk]], [[3tbt\|3tbt]], [[3tbv\|3tbv]], [[3tbw\|3tbw]], [[3tbx\|3tbx]], [[3tby\|3tby]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s7u\|1s7u]], [[1s7v\|1s7v]], [[1s7w\|1s7w]], [[1s7x\|1s7x]], [[3qul\|3qul]], [[3quk\|3quk]], [[3tbt\|3tbt]], [[3tbv\|3tbv]], [[3tbw\|3tbw]], [[3tbx\|3tbx]], [[3tby\|3tby]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-D1, H2-DB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), B2m ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbs OCA], [http://pdbe.org/3tbs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3tbs RCSB], [http://www.ebi.ac.uk/pdbsum/3tbs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3tbs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbs OCA], [http://pdbe.org/3tbs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3tbs RCSB], [http://www.ebi.ac.uk/pdbsum/3tbs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3tbs ProSAT]</span></td></tr>
	</table>		</table>
Line 16:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Achour, A]]		[[Category: Achour, A]]
	[[Category: Allerbring, E B]]		[[Category: Allerbring, E B]]

OCA at 06:22, 19 April 2017

OCA — Wed, 19 Apr 2017 06:22:30 GMT

←Older revision		Revision as of 06:22, 19 April 2017
Line 3:		Line 3:
	<StructureSection load='3tbs' size='340' side='right' caption='[[3tbs]], [[Resolution\|resolution]] 2.49Å' scene=''>		<StructureSection load='3tbs' size='340' side='right' caption='[[3tbs]], [[Resolution\|resolution]] 2.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tbs]] is a 6 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TBS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tbs]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TBS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s7u\|1s7u]], [[1s7v\|1s7v]], [[1s7w\|1s7w]], [[1s7x\|1s7x]], [[3qul\|3qul]], [[3quk\|3quk]], [[3tbt\|3tbt]], [[3tbv\|3tbv]], [[3tbw\|3tbw]], [[3tbx\|3tbx]], [[3tby\|3tby]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s7u\|1s7u]], [[1s7v\|1s7v]], [[1s7w\|1s7w]], [[1s7x\|1s7x]], [[3qul\|3qul]], [[3quk\|3quk]], [[3tbt\|3tbt]], [[3tbv\|3tbv]], [[3tbw\|3tbw]], [[3tbx\|3tbx]], [[3tby\|3tby]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-D1, H2-DB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), B2m ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbs OCA], [http://pdbe.org/3tbs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3tbs RCSB], [http://www.ebi.ac.uk/pdbsum/3tbs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3tbs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbs OCA], [http://pdbe.org/3tbs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3tbs RCSB], [http://www.ebi.ac.uk/pdbsum/3tbs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3tbs ProSAT]</span></td></tr>
	</table>		</table>
Line 17:		Line 16:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Lk3 transgenic mice]]
	[[Category: Achour, A]]		[[Category: Achour, A]]
	[[Category: Allerbring, E B]]		[[Category: Allerbring, E B]]

OCA at 23:18, 5 August 2016

OCA — Fri, 05 Aug 2016 23:18:20 GMT

←Older revision		Revision as of 23:18, 5 August 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF THE MURINE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX H-2DB IN COMPLEX THE WITH LCMV-DERIVED GP33 ALTERED PEPTIDE ligand (V3P,Y4A)==		==CRYSTAL STRUCTURE OF THE MURINE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX H-2DB IN COMPLEX THE WITH LCMV-DERIVED GP33 ALTERED PEPTIDE ligand (V3P,Y4A)==
	<StructureSection load='3tbs' size='340' side='right' caption='[[3tbs]], [[Resolution\|resolution]] 2.49Å' scene=''>		<StructureSection load='3tbs' size='340' side='right' caption='[[3tbs]], [[Resolution\|resolution]] 2.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tbs]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TBS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tbs]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TBS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s7u\|1s7u]], [[1s7v\|1s7v]], [[1s7w\|1s7w]], [[1s7x\|1s7x]], [[3qul\|3qul]], [[3quk\|3quk]], [[3tbt\|3tbt]], [[3tbv\|3tbv]], [[3tbw\|3tbw]], [[3tbx\|3tbx]], [[3tby\|3tby]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s7u\|1s7u]], [[1s7v\|1s7v]], [[1s7w\|1s7w]], [[1s7x\|1s7x]], [[3qul\|3qul]], [[3quk\|3quk]], [[3tbt\|3tbt]], [[3tbv\|3tbv]], [[3tbw\|3tbw]], [[3tbx\|3tbx]], [[3tby\|3tby]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-D1, H2-DB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~]), B2m ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-D1, H2-DB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), B2m ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tbs RCSB], [http://www.ebi.ac.uk/pdbsum/3tbs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbs OCA], [http://pdbe.org/3tbs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3tbs RCSB], [http://www.ebi.ac.uk/pdbsum/3tbs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3tbs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Achour, A]]		[[Category: Achour, A]]
	[[Category: Allerbring, E B]]		[[Category: Allerbring, E B]]

OCA at 06:44, 25 December 2014

OCA — Thu, 25 Dec 2014 06:44:03 GMT

←Older revision		Revision as of 06:44, 25 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3tbs.~~jpg~~\|~~left~~\|~~200px~~]]	+	==CRYSTAL STRUCTURE OF THE MURINE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX H-2DB IN COMPLEX THE WITH LCMV-DERIVED GP33 ALTERED PEPTIDE ligand (V3P,Y4A)==
		+	<StructureSection load='3tbs' size='340' side='right' caption='[[3tbs]], [[Resolution\|resolution]] 2.49Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3tbs]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TBS FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s7u\|1s7u]], [[1s7v\|1s7v]], [[1s7w\|1s7w]], [[1s7x\|1s7x]], [[3qul\|3qul]], [[3quk\|3quk]], [[3tbt\|3tbt]], [[3tbv\|3tbv]], [[3tbw\|3tbw]], [[3tbx\|3tbx]], [[3tby\|3tby]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-D1, H2-DB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), B2m ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tbs RCSB], [http://www.ebi.ac.uk/pdbsum/3tbs PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/GLYC_LYCVW GLYC_LYCVW]] The stable signal peptide (SSP) is cleaved and functions as a signal peptide. In addition, it is apparently retained as the third component of the GP complex. The SSP is required for efficient glycoprotein expression, post-translational maturation cleavage of GP1 and GP2, glycoprotein transport to the cell surface plasma membrane, formation of infectious virus particles, and acid pH-dependent glycoprotein-mediated cell fusion (By similarity). Glycoprotein G1 mediates virus attachment to host receptor alpha-dystroglycan DAG1. This attachment induces virion internalization predominantly through clathrin- and caveolin-independent endocytosis (By similarity). Glycoprotein G2 is a viral fusion protein. Membrane fusion is mediated by conformational changes induced upon acidification in the endosome (Potential). [[http://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

-	~~{{STRUCTURE_3tbs\| PDB~~=~~3tbs \| SCENE~~= }}	+	==See Also==
-		+	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]
-	==~~=CRYSTAL STRUCTURE OF THE MURINE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX H~~-~~2DB IN COMPLEX THE WITH LCMV~~-~~DERIVED GP33 ALTERED PEPTIDE ligand (V3P,Y4A)===~~	+	*[[Major histocompatibility complex\|Major histocompatibility complex]]
-		+	__TOC__
-		+	</StructureSection>
-	~~==About this Structure==~~	+
-	[[~~3tbs~~]] ~~is a 6 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBS OCA].~~	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Achour, A.]]	+	[[Category: Achour, A]]
-	[[Category: Allerbring, E B.]]	+	[[Category: Allerbring, E B]]
-	[[Category: Badia-Martinez, D.]]	+	[[Category: Badia-Martinez, D]]
-	[[Category: Duru, A D.]]	+	[[Category: Duru, A D]]
-	[[Category: Madhurantakam, C.]]	+	[[Category: Madhurantakam, C]]
-	[[Category: Mazumdar, P A.]]	+	[[Category: Mazumdar, P A]]
-	[[Category: Nygren, P.]]	+	[[Category: Nygren, P]]
-	[[Category: Sandalova, T.]]	+	[[Category: Sandalova, T]]
-	[[Category: Uchtenhagen, H.]]	+	[[Category: Uchtenhagen, H]]
	[[Category: Agonism]]		[[Category: Agonism]]
	[[Category: Altered peptide ligand]]		[[Category: Altered peptide ligand]]

OCA at 05:28, 8 August 2012

OCA — Wed, 08 Aug 2012 05:28:35 GMT

←Older revision		Revision as of 05:28, 8 August 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3tbs.jpg\|left\|200px]]

-	~~The entry~~ 3tbs ~~is ON HOLD~~ ~~until Aug 08 2013~~	+	{{STRUCTURE_3tbs\| PDB=3tbs \| SCENE= }}

-	~~Authors: Duru, A.D., Allerbring, E.B., Uchtenhagen,~~ H~~., Mazumdar, P.A., Badia~~-~~Martinez, D., Madhurantakam, C., Sandalova, T., Nygren, P., Achour~~, A.	+	===CRYSTAL STRUCTURE OF THE MURINE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX H-2DB IN COMPLEX THE WITH LCMV-DERIVED GP33 ALTERED PEPTIDE ligand (V3P,Y4A)===

-	~~Description~~: ~~CRYSTAL STRUCTURE OF THE MURINE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX H~~-~~2DB IN COMPLEX THE WITH LCMV~~-~~DERIVED GP33 ALTERED PEPTIDE ligand (V3P~~,~~Y4A)~~	+
		+	==About this Structure==
		+	[[3tbs]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBS OCA].
		+	[[Category: Mus musculus]]
		+	[[Category: Achour, A.]]
		+	[[Category: Allerbring, E B.]]
		+	[[Category: Badia-Martinez, D.]]
		+	[[Category: Duru, A D.]]
		+	[[Category: Madhurantakam, C.]]
		+	[[Category: Mazumdar, P A.]]
		+	[[Category: Nygren, P.]]
		+	[[Category: Sandalova, T.]]
		+	[[Category: Uchtenhagen, H.]]
		+	[[Category: Agonism]]
		+	[[Category: Altered peptide ligand]]
		+	[[Category: Antagonism]]
		+	[[Category: Antigen presentation]]
		+	[[Category: Beta2-microglobulin]]
		+	[[Category: Cd8]]
		+	[[Category: Cell surface]]
		+	[[Category: Immune system]]
		+	[[Category: Immune system-agonist complex]]
		+	[[Category: Lcmv]]
		+	[[Category: Murine mhc]]
		+	[[Category: Receptor binding]]
		+	[[Category: T cell receptor]]
		+	[[Category: T cell recognition]]

OCA at 04:48, 18 July 2012

OCA — Wed, 18 Jul 2012 04:48:06 GMT

←Older revision		Revision as of 04:48, 18 July 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3tbs is ON HOLD until ~~Paper Publication~~	+	The entry 3tbs is ON HOLD until Aug 08 2013

	Authors: Duru, A.D., Allerbring, E.B., Uchtenhagen, H., Mazumdar, P.A., Badia-Martinez, D., Madhurantakam, C., Sandalova, T., Nygren, P., Achour, A.		Authors: Duru, A.D., Allerbring, E.B., Uchtenhagen, H., Mazumdar, P.A., Badia-Martinez, D., Madhurantakam, C., Sandalova, T., Nygren, P., Achour, A.

	Description: CRYSTAL STRUCTURE OF THE MURINE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX H-2DB IN COMPLEX THE WITH LCMV-DERIVED GP33 ALTERED PEPTIDE ligand (V3P,Y4A)		Description: CRYSTAL STRUCTURE OF THE MURINE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX H-2DB IN COMPLEX THE WITH LCMV-DERIVED GP33 ALTERED PEPTIDE ligand (V3P,Y4A)

OCA at 06:07, 5 October 2011

OCA — Wed, 05 Oct 2011 06:07:56 GMT

←Older revision		Revision as of 06:07, 5 October 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3tbs is ON HOLD	+	The entry 3tbs is ON HOLD until Paper Publication

	Authors: Duru, A.D., Allerbring, E.B., Uchtenhagen, H., Mazumdar, P.A., Badia-Martinez, D., Madhurantakam, C., Sandalova, T., Nygren, P., Achour, A.		Authors: Duru, A.D., Allerbring, E.B., Uchtenhagen, H., Mazumdar, P.A., Badia-Martinez, D., Madhurantakam, C., Sandalova, T., Nygren, P., Achour, A.

	Description: CRYSTAL STRUCTURE OF THE MURINE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX H-2DB IN COMPLEX THE WITH LCMV-DERIVED GP33 ALTERED PEPTIDE ligand (V3P,Y4A)		Description: CRYSTAL STRUCTURE OF THE MURINE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX H-2DB IN COMPLEX THE WITH LCMV-DERIVED GP33 ALTERED PEPTIDE ligand (V3P,Y4A)

OCA at 07:10, 24 August 2011

OCA — Wed, 24 Aug 2011 07:10:10 GMT

←Older revision		Revision as of 07:10, 24 August 2011
Line 5:		Line 5:
	Authors: Duru, A.D., Allerbring, E.B., Uchtenhagen, H., Mazumdar, P.A., Badia-Martinez, D., Madhurantakam, C., Sandalova, T., Nygren, P., Achour, A.		Authors: Duru, A.D., Allerbring, E.B., Uchtenhagen, H., Mazumdar, P.A., Badia-Martinez, D., Madhurantakam, C., Sandalova, T., Nygren, P., Achour, A.

-	Description: CRYSTAL STRUCTURE OF THE MURINE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX H-2DB IN COMPLEX THE WITH LCMV-DERIVED GP33 ALTERED PEPTIDE ~~LIGAND~~ (V3P,Y4A)	+	Description: CRYSTAL STRUCTURE OF THE MURINE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX H-2DB IN COMPLEX THE WITH LCMV-DERIVED GP33 ALTERED PEPTIDE ligand (V3P,Y4A)