3tfn - Revision history

OCA at 13:26, 14 March 2024

OCA — Thu, 14 Mar 2024 13:26:50 GMT

←Older revision		Revision as of 13:26, 14 March 2024
Line 3:		Line 3:
	<StructureSection load='3tfn' size='340' side='right'caption='[[3tfn]], [[Resolution\|resolution]] 2.07Å' scene=''>		<StructureSection load='3tfn' size='340' side='right'caption='[[3tfn]], [[Resolution\|resolution]] 2.07Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tfn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus~~ aureus~~" (rosenbach 1884) zopf 1885~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TFN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TFN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tfn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TFN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TFN FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=2CJ:(1-{2~~-[~~4-(DIPHENYLMETHYL)PIPERAZIN-1-YL~~]-2~~-OXOETHYL}CYCLOPENTYL)ACETIC+ACID'>2CJ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.07Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;'>~~[~~[3tfp\|3tfp~~]~~], [[3tfv\|3tfv]]</div~~></td><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2CJ:(1-{2-[4-(DIPHENYLMETHYL)PIPERAZIN-1-YL]-2-OXOETHYL}CYCLOPENTYL)ACETIC+ACID'>2CJ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">crtM ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tfn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tfn OCA], [https://pdbe.org/3tfn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tfn RCSB], [https://www.ebi.ac.uk/pdbsum/3tfn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tfn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tfn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tfn OCA], [https://pdbe.org/3tfn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tfn RCSB], [https://www.ebi.ac.uk/pdbsum/3tfn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tfn ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/CRTM_STAAU CRTM_STAAU]
-	Double whammy! Small molecules that inhibit Staphylococcus aureus dehydrosqualene synthase (CrtM) or host squalene synthase (SQS) are of interest as novel, innate immunity-based therapeutics, blocking virulence or stimulating antibacterial neutrophil extracellular trap (NET) formation. The discovery of leads that do both represents a new route to treating staph infections.	+
-		+
-	~~Dual dehydrosqualene/squalene synthase inhibitors~~: ~~leads for innate immune system-based therapeutics.,Lin FY, Zhang Y, Hensler M, Liu YL, Chow OA, Zhu W, Wang K, Pang R, Thienphrapa W, Nizet V, Oldfield E ChemMedChem. 2012 Apr;7(4):561-4. doi: 10.1002~~/~~cmdc.201100589. Epub 2012 Jan 30. PMID:22290830<ref>PMID:22290830<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 3tfn" style="background-color:#fffaf0;"><~~/~~div>~~	+

	==See Also==		==See Also==
	*[[Squalene synthase\|Squalene synthase]]		*[[Squalene synthase\|Squalene synthase]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Lin, F Y]]	+	[[Category: Staphylococcus aureus]]
-	[[Category: Liu, Y L]]	+	[[Category: Lin F-Y]]
-	[[Category: Oldfield, E]]	+	[[Category: Liu Y-L]]
-	~~[[Category: Head to head prenyl synthase]]~~	+	[[Category: Oldfield E]]
-	~~[[Category: Transferase-transferase inhibitor complex~~]]	+

OCA at 16:55, 6 July 2022

OCA — Wed, 06 Jul 2022 16:55:59 GMT

←Older revision		Revision as of 16:55, 6 July 2022
Line 1:		Line 1:

	==Crystal structure of dehydrosqualene synthase (crtm) from s. aureus complexed with bph-1183==		==Crystal structure of dehydrosqualene synthase (crtm) from s. aureus complexed with bph-1183==
-	<StructureSection load='3tfn' size='340' side='right' caption='[[3tfn]], [[Resolution\|resolution]] 2.07Å' scene=''>	+	<StructureSection load='3tfn' size='340' side='right'caption='[[3tfn]], [[Resolution\|resolution]] 2.07Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tfn]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TFN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3TFN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tfn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TFN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TFN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CJ:(1-{2-[4-(DIPHENYLMETHYL)PIPERAZIN-1-YL]-2-OXOETHYL}CYCLOPENTYL)ACETIC+ACID'>2CJ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2CJ:(1-{2-[4-(DIPHENYLMETHYL)PIPERAZIN-1-YL]-2-OXOETHYL}CYCLOPENTYL)ACETIC+ACID'>2CJ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tfp\|3tfp]], [[3tfv\|3tfv]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3tfp\|3tfp]], [[3tfv\|3tfv]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">crtM ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">crtM ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3tfn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tfn OCA], [~~http~~://pdbe.org/3tfn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3tfn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3tfn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3tfn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tfn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tfn OCA], [https://pdbe.org/3tfn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tfn RCSB], [https://www.ebi.ac.uk/pdbsum/3tfn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tfn ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 3tfn" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3tfn" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Squalene synthase\|Squalene synthase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lin, F Y]]		[[Category: Lin, F Y]]
	[[Category: Liu, Y L]]		[[Category: Liu, Y L]]

OCA at 09:14, 5 August 2016

OCA — Fri, 05 Aug 2016 09:14:14 GMT

←Older revision		Revision as of 09:14, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of dehydrosqualene synthase (crtm) from s. aureus complexed with bph-1183==		==Crystal structure of dehydrosqualene synthase (crtm) from s. aureus complexed with bph-1183==
	<StructureSection load='3tfn' size='340' side='right' caption='[[3tfn]], [[Resolution\|resolution]] 2.07Å' scene=''>		<StructureSection load='3tfn' size='340' side='right' caption='[[3tfn]], [[Resolution\|resolution]] 2.07Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tfn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Staphylococcus_aureus Staphylococcus~~ aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TFN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TFN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tfn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TFN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TFN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CJ:(1-{2-[4-(DIPHENYLMETHYL)PIPERAZIN-1-YL]-2-OXOETHYL}CYCLOPENTYL)ACETIC+ACID'>2CJ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CJ:(1-{2-[4-(DIPHENYLMETHYL)PIPERAZIN-1-YL]-2-OXOETHYL}CYCLOPENTYL)ACETIC+ACID'>2CJ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tfp\|3tfp]], [[3tfv\|3tfv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tfp\|3tfp]], [[3tfv\|3tfv]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">crtM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 ~~Staphylococcus~~ aureus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">crtM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tfn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tfn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tfn RCSB], [http://www.ebi.ac.uk/pdbsum/3tfn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tfn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tfn OCA], [http://pdbe.org/3tfn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3tfn RCSB], [http://www.ebi.ac.uk/pdbsum/3tfn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3tfn ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3tfn" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Staphylococcus aureus]]
	[[Category: Lin, F Y]]		[[Category: Lin, F Y]]
	[[Category: Liu, Y L]]		[[Category: Liu, Y L]]

OCA at 01:05, 25 December 2014

OCA — Thu, 25 Dec 2014 01:05:13 GMT

←Older revision		Revision as of 01:05, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3tfn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TFN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TFN FirstGlance]. <br>		<table><tr><td colspan='2'>[[3tfn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TFN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TFN FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CJ:(1-{2-[4-(DIPHENYLMETHYL)PIPERAZIN-1-YL]-2-OXOETHYL}CYCLOPENTYL)ACETIC+ACID'>2CJ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CJ:(1-{2-[4-(DIPHENYLMETHYL)PIPERAZIN-1-YL]-2-OXOETHYL}CYCLOPENTYL)ACETIC+ACID'>2CJ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tfp\|3tfp]], [[3tfv\|3tfv]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tfp\|3tfp]], [[3tfv\|3tfv]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">crtM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">crtM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tfn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tfn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tfn RCSB], [http://www.ebi.ac.uk/pdbsum/3tfn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tfn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tfn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tfn RCSB], [http://www.ebi.ac.uk/pdbsum/3tfn PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 14:
	Dual dehydrosqualene/squalene synthase inhibitors: leads for innate immune system-based therapeutics.,Lin FY, Zhang Y, Hensler M, Liu YL, Chow OA, Zhu W, Wang K, Pang R, Thienphrapa W, Nizet V, Oldfield E ChemMedChem. 2012 Apr;7(4):561-4. doi: 10.1002/cmdc.201100589. Epub 2012 Jan 30. PMID:22290830<ref>PMID:22290830</ref>		Dual dehydrosqualene/squalene synthase inhibitors: leads for innate immune system-based therapeutics.,Lin FY, Zhang Y, Hensler M, Liu YL, Chow OA, Zhu W, Wang K, Pang R, Thienphrapa W, Nizet V, Oldfield E ChemMedChem. 2012 Apr;7(4):561-4. doi: 10.1002/cmdc.201100589. Epub 2012 Jan 30. PMID:22290830<ref>PMID:22290830</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
-	[[Category: Lin, F Y.]]	+	[[Category: Lin, F Y]]
-	[[Category: Liu, Y L.]]	+	[[Category: Liu, Y L]]
-	[[Category: Oldfield, E.]]	+	[[Category: Oldfield, E]]
	[[Category: Head to head prenyl synthase]]		[[Category: Head to head prenyl synthase]]
	[[Category: Transferase-transferase inhibitor complex]]		[[Category: Transferase-transferase inhibitor complex]]

OCA at 05:39, 5 June 2014

OCA — Thu, 05 Jun 2014 05:39:33 GMT

←Older revision		Revision as of 05:39, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3tfn.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of dehydrosqualene synthase (crtm) from s. aureus complexed with bph-1183==
		+	<StructureSection load='3tfn' size='340' side='right' caption='[[3tfn]], [[Resolution\|resolution]] 2.07Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3tfn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TFN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TFN FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CJ:(1-{2-[4-(DIPHENYLMETHYL)PIPERAZIN-1-YL]-2-OXOETHYL}CYCLOPENTYL)ACETIC+ACID'>2CJ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3tfp\|3tfp]], [[3tfv\|3tfv]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">crtM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tfn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tfn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tfn RCSB], [http://www.ebi.ac.uk/pdbsum/3tfn PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Double whammy! Small molecules that inhibit Staphylococcus aureus dehydrosqualene synthase (CrtM) or host squalene synthase (SQS) are of interest as novel, innate immunity-based therapeutics, blocking virulence or stimulating antibacterial neutrophil extracellular trap (NET) formation. The discovery of leads that do both represents a new route to treating staph infections.

-	<!--	+	Dual dehydrosqualene/squalene synthase inhibitors: leads for innate immune system-based therapeutics.,Lin FY, Zhang Y, Hensler M, Liu YL, Chow OA, Zhu W, Wang K, Pang R, Thienphrapa W, Nizet V, Oldfield E ChemMedChem. 2012 Apr;7(4):561-4. doi: 10.1002/cmdc.201100589. Epub 2012 Jan 30. PMID:22290830<ref>PMID:22290830</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3tfn"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_3tfn\| PDB=3tfn \| SCENE= }}~~	+

-	~~===Crystal structure~~ of ~~dehydrosqualene synthase (crtm) from s. aureus complexed with bph-1183===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_22290830}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22290830 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_22290830}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3tfn]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TFN OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022290830<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Lin, F Y.]]		[[Category: Lin, F Y.]]

OCA at 04:57, 23 May 2012

OCA — Wed, 23 May 2012 04:57:47 GMT

←Older revision		Revision as of 04:57, 23 May 2012
Line 1:		Line 1:
-	[[Image:3tfn.~~jpg~~\|left\|200px]]	+	[[Image:3tfn.png\|left\|200px]]

	<!--		<!--

OCA at 06:04, 4 April 2012

OCA — Wed, 04 Apr 2012 06:04:08 GMT

←Older revision		Revision as of 06:04, 4 April 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3tfn.jpg\|left\|200px]]

-	The ~~entry 3tfn~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3tfn", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3tfn\| PDB=3tfn \| SCENE= }}

-	~~Authors: Lin, F~~.-~~Y., Liu, Y.-L., Oldfield, E.~~	+	===Crystal structure of dehydrosqualene synthase (crtm) from s. aureus complexed with bph-1183===

-	~~Description: Crystal structure of dehydrosqualene synthase~~ (~~crtm~~) from s. aureus ~~complexed with bph~~-~~1183~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22290830}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22290830 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22290830}}
		+
		+	==About this Structure==
		+	[[3tfn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TFN OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022290830</ref><references group="xtra"/>
		+	[[Category: Staphylococcus aureus]]
		+	[[Category: Lin, F Y.]]
		+	[[Category: Liu, Y L.]]
		+	[[Category: Oldfield, E.]]
		+	[[Category: Head to head prenyl synthase]]
		+	[[Category: Transferase-transferase inhibitor complex]]

OCA at 05:47, 7 September 2011

OCA — Wed, 07 Sep 2011 05:47:15 GMT

←Older revision		Revision as of 05:47, 7 September 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3tfn is ON HOLD	+	The entry 3tfn is ON HOLD until Paper Publication

	Authors: Lin, F.-Y., Liu, Y.-L., Oldfield, E.		Authors: Lin, F.-Y., Liu, Y.-L., Oldfield, E.

	Description: Crystal structure of dehydrosqualene synthase (crtm) from s. aureus complexed with bph-1183		Description: Crystal structure of dehydrosqualene synthase (crtm) from s. aureus complexed with bph-1183

OCA: Protected "3tfn" [edit=sysop:move=sysop]

OCA — Wed, 24 Aug 2011 07:12:23 GMT

Protected "3tfn" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:12, 24 August 2011

OCA: New page: '''Unreleased structure''' The entry 3tfn is ON HOLD Authors: Lin, F.-Y., Liu, Y.-L., Oldfield, E. Description: Crystal structure of dehydrosqualene synthase (crtm) from s. aureus comp...

OCA — Wed, 24 Aug 2011 07:12:21 GMT

New page: '''Unreleased structure''' The entry 3tfn is ON HOLD Authors: Lin, F.-Y., Liu, Y.-L., Oldfield, E. Description: Crystal structure of dehydrosqualene synthase (crtm) from s. aureus comp...

New page

'''Unreleased structure'''

The entry 3tfn is ON HOLD

Authors: Lin, F.-Y., Liu, Y.-L., Oldfield, E.

Description: Crystal structure of dehydrosqualene synthase (crtm) from s. aureus complexed with bph-1183