3tgh - Revision history

OCA at 13:27, 14 March 2024

OCA — Thu, 14 Mar 2024 13:27:50 GMT

←Older revision		Revision as of 13:27, 14 March 2024
Line 3:		Line 3:
	<StructureSection load='3tgh' size='340' side='right'caption='[[3tgh]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='3tgh' size='340' side='right'caption='[[3tgh]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tgh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Plaf7 Plaf7~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TGH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TGH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tgh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TGH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TGH FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>~~, ~~<scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~GAP50, PFI0880c ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=36329 PLAF7]~~)~~</td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<~~tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Acid_phosphatase Acid phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.2 3.1.3.2]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tgh OCA], [https://pdbe.org/3tgh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tgh RCSB], [https://www.ebi.ac.uk/pdbsum/3tgh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tgh ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tgh OCA], [https://pdbe.org/3tgh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tgh RCSB], [https://www.ebi.ac.uk/pdbsum/3tgh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tgh ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/Q8I2X3_PLAF7 Q8I2X3_PLAF7]
-	The glideosome associated protein GAP50 is an essential protein in apicomplexan parasites such as Plasmodium, Toxoplasma and Cryptosporidium, several species of which are important human pathogens. The 44.6kDa protein is part of a multi-protein complex known as the invasion machinery or glideosome, which is required for cell invasion and substrate gliding motility empowered by an actin-myosin motor. GAP50 is anchored through its C-terminal transmembrane helix into the inner membrane complex and interacts via a short six residue C-terminal tail with other proteins of the invasion machinery in the pellicle of the parasite. In this paper we describe the 1.7A resolution crystal structure of the soluble GAP50 domain from the malaria parasite Plasmodium falciparum. The structure shows an alphassssalpha fold with overall similarity to purple acid phosphatases with, however, little homology regarding the nature of the residues in the active site region of the latter enzyme. While purple acid phosphatases contain a phosphate bridged binuclear Fe-site coordinated by seven side chains with the Fe-ions 3.2A apart, GAP50 in our crystals contains two cobalt ions each with one protein ligand and a distance between the Co(2+) ions of 18A.	+
-		+
-	~~Crystal structure of GAP50, the anchor of the invasion machinery in the inner membrane complex of Plasmodium falciparum.,Bosch J, Paige MH, Vaidya AB, Bergman LW, Hol WG J Struct Biol. 2012 Apr;178(1)~~:~~61-73. Epub 2012 Feb 22. PMID:22387043<ref>PMID:22387043<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®~~/~~PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 3tgh" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references~~/>	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Acid phosphatase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Plaf7~~]]	+	[[Category: Plasmodium falciparum 3D7]]
-	[[Category: Bergman, L]]	+	[[Category: Bergman L]]
-	[[Category: Bosch, J]]	+	[[Category: Bosch J]]
-	[[Category: Hol~~, W G.J~~]]	+	[[Category: Hol WGJ]]
-	[[Category: Paige~~, M H~~]]	+	[[Category: Paige MH]]
-	[[Category: Vaidya, A]]	+	[[Category: Vaidya A]]
-	~~[[Category: Cell invasion]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Motor protein]]~~	+
-	~~[[Category: Not a phosphatase]]~~	+
-	~~[[Category: Phosphatase fold]]~~	+
-	~~[[Category: Structural protein~~]]	+

OCA at 16:57, 6 July 2022

OCA — Wed, 06 Jul 2022 16:57:05 GMT

←Older revision		Revision as of 16:57, 6 July 2022
Line 1:		Line 1:

	==GAP50 the anchor in the inner membrane complex of Plasmodium==		==GAP50 the anchor in the inner membrane complex of Plasmodium==
-	<StructureSection load='3tgh' size='340' side='right' caption='[[3tgh]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='3tgh' size='340' side='right'caption='[[3tgh]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tgh]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TGH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3TGH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tgh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TGH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TGH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GAP50, PFI0880c ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GAP50, PFI0880c ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Acid_phosphatase Acid phosphatase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.2 3.1.3.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Acid_phosphatase Acid phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.2 3.1.3.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3tgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tgh OCA], [~~http~~://pdbe.org/3tgh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3tgh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3tgh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3tgh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tgh OCA], [https://pdbe.org/3tgh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tgh RCSB], [https://www.ebi.ac.uk/pdbsum/3tgh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tgh ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Acid phosphatase]]		[[Category: Acid phosphatase]]
		+	[[Category: Large Structures]]
	[[Category: Plaf7]]		[[Category: Plaf7]]
	[[Category: Bergman, L]]		[[Category: Bergman, L]]

OCA at 17:21, 11 August 2016

OCA — Thu, 11 Aug 2016 17:21:07 GMT

←Older revision		Revision as of 17:21, 11 August 2016
Line 1:		Line 1:
		+
	==GAP50 the anchor in the inner membrane complex of Plasmodium==		==GAP50 the anchor in the inner membrane complex of Plasmodium==
	<StructureSection load='3tgh' size='340' side='right' caption='[[3tgh]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='3tgh' size='340' side='right' caption='[[3tgh]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tgh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TGH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TGH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tgh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TGH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TGH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GAP50, PFI0880c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 ~~Plasmodium falciparum 3D7~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GAP50, PFI0880c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acid_phosphatase Acid phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.2 3.1.3.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acid_phosphatase Acid phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.2 3.1.3.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tgh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tgh RCSB], [http://www.ebi.ac.uk/pdbsum/3tgh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tgh OCA], [http://pdbe.org/3tgh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3tgh RCSB], [http://www.ebi.ac.uk/pdbsum/3tgh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3tgh ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3tgh" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 21:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Acid phosphatase]]		[[Category: Acid phosphatase]]
-	[[Category: ~~Plasmodium falciparum 3d7~~]]	+	[[Category: Plaf7]]
	[[Category: Bergman, L]]		[[Category: Bergman, L]]
	[[Category: Bosch, J]]		[[Category: Bosch, J]]

OCA at 10:51, 4 January 2015

OCA — Sun, 04 Jan 2015 10:51:43 GMT

←Older revision		Revision as of 10:51, 4 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3tgh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TGH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TGH FirstGlance]. <br>		<table><tr><td colspan='2'>[[3tgh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TGH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TGH FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GAP50, PFI0880c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 Plasmodium falciparum 3D7])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GAP50, PFI0880c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 Plasmodium falciparum 3D7])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acid_phosphatase Acid phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.2 3.1.3.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acid_phosphatase Acid phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.2 3.1.3.2] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tgh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tgh RCSB], [http://www.ebi.ac.uk/pdbsum/3tgh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tgh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tgh RCSB], [http://www.ebi.ac.uk/pdbsum/3tgh PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 14:
	Crystal structure of GAP50, the anchor of the invasion machinery in the inner membrane complex of Plasmodium falciparum.,Bosch J, Paige MH, Vaidya AB, Bergman LW, Hol WG J Struct Biol. 2012 Apr;178(1):61-73. Epub 2012 Feb 22. PMID:22387043<ref>PMID:22387043</ref>		Crystal structure of GAP50, the anchor of the invasion machinery in the inner membrane complex of Plasmodium falciparum.,Bosch J, Paige MH, Vaidya AB, Bergman LW, Hol WG J Struct Biol. 2012 Apr;178(1):61-73. Epub 2012 Feb 22. PMID:22387043<ref>PMID:22387043</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 22:		Line 22:
	[[Category: Acid phosphatase]]		[[Category: Acid phosphatase]]
	[[Category: Plasmodium falciparum 3d7]]		[[Category: Plasmodium falciparum 3d7]]
-	[[Category: Bergman, L.]]	+	[[Category: Bergman, L]]
-	[[Category: Bosch, J.]]	+	[[Category: Bosch, J]]
-	[[Category: Hol, W G.J.]]	+	[[Category: Hol, W G.J]]
-	[[Category: Paige, M H.]]	+	[[Category: Paige, M H]]
-	[[Category: Vaidya, A.]]	+	[[Category: Vaidya, A]]
	[[Category: Cell invasion]]		[[Category: Cell invasion]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]

OCA at 06:29, 5 June 2014

OCA — Thu, 05 Jun 2014 06:29:41 GMT

←Older revision		Revision as of 06:29, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3tgh.~~png~~\|~~left~~\|~~200px~~]]	+	==GAP50 the anchor in the inner membrane complex of Plasmodium==
		+	<StructureSection load='3tgh' size='340' side='right' caption='[[3tgh]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3tgh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TGH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TGH FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GAP50, PFI0880c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 Plasmodium falciparum 3D7])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acid_phosphatase Acid phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.2 3.1.3.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tgh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tgh RCSB], [http://www.ebi.ac.uk/pdbsum/3tgh PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The glideosome associated protein GAP50 is an essential protein in apicomplexan parasites such as Plasmodium, Toxoplasma and Cryptosporidium, several species of which are important human pathogens. The 44.6kDa protein is part of a multi-protein complex known as the invasion machinery or glideosome, which is required for cell invasion and substrate gliding motility empowered by an actin-myosin motor. GAP50 is anchored through its C-terminal transmembrane helix into the inner membrane complex and interacts via a short six residue C-terminal tail with other proteins of the invasion machinery in the pellicle of the parasite. In this paper we describe the 1.7A resolution crystal structure of the soluble GAP50 domain from the malaria parasite Plasmodium falciparum. The structure shows an alphassssalpha fold with overall similarity to purple acid phosphatases with, however, little homology regarding the nature of the residues in the active site region of the latter enzyme. While purple acid phosphatases contain a phosphate bridged binuclear Fe-site coordinated by seven side chains with the Fe-ions 3.2A apart, GAP50 in our crystals contains two cobalt ions each with one protein ligand and a distance between the Co(2+) ions of 18A.

-	~~<!--~~	+	Crystal structure of GAP50, the anchor of the invasion machinery in the inner membrane complex of Plasmodium falciparum.,Bosch J, Paige MH, Vaidya AB, Bergman LW, Hol WG J Struct Biol. 2012 Apr;178(1):61-73. Epub 2012 Feb 22. PMID:22387043<ref>PMID:22387043</ref>
-	~~The line below this paragraph, containing "STRUCTURE_3tgh"~~, ~~creates~~ the ~~"Structure Box" on~~ the ~~page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_3tgh\| PDB=3tgh \| SCENE= }}~~	+

-	~~===GAP50 the anchor in the inner membrane complex~~ of ~~Plasmodium===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_22387043}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22387043 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_22387043}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3tgh]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TGH OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022387043<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Acid phosphatase]]		[[Category: Acid phosphatase]]
	[[Category: Plasmodium falciparum 3d7]]		[[Category: Plasmodium falciparum 3d7]]

OCA at 08:23, 25 April 2012

OCA — Wed, 25 Apr 2012 08:23:28 GMT

←Older revision		Revision as of 08:23, 25 April 2012
Line 1:		Line 1:
-	[[Image:3tgh.~~jpg~~\|left\|200px]]	+	[[Image:3tgh.png\|left\|200px]]

	<!--		<!--
Line 11:		Line 11:
	===GAP50 the anchor in the inner membrane complex of Plasmodium===		===GAP50 the anchor in the inner membrane complex of Plasmodium===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22387043}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22387043 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22387043}}

	==About this Structure==		==About this Structure==
	[[3tgh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TGH OCA].		[[3tgh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TGH OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022387043</ref><references group="xtra"/>
	[[Category: Acid phosphatase]]		[[Category: Acid phosphatase]]
	[[Category: Plasmodium falciparum 3d7]]		[[Category: Plasmodium falciparum 3d7]]

OCA at 05:55, 8 March 2012

OCA — Thu, 08 Mar 2012 05:55:08 GMT

←Older revision		Revision as of 05:55, 8 March 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3tgh.jpg\|left\|200px]]

-	The ~~entry 3tgh~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3tgh", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3tgh\| PDB=3tgh \| SCENE= }}

-	~~Authors: Bosch, J., Paige, M.H., Vaidya, A., Bergman, L., Hol, W.G.J.~~	+	===GAP50 the anchor in the inner membrane complex of Plasmodium===

-	~~Description~~: ~~GAP50 the anchor in the inner membrane complex of~~ Plasmodium	+
		+	==About this Structure==
		+	[[3tgh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TGH OCA].
		+	[[Category: Acid phosphatase]]
		+	[[Category: Plasmodium falciparum 3d7]]
		+	[[Category: Bergman, L.]]
		+	[[Category: Bosch, J.]]
		+	[[Category: Hol, W G.J.]]
		+	[[Category: Paige, M H.]]
		+	[[Category: Vaidya, A.]]
		+	[[Category: Cell invasion]]
		+	[[Category: Membrane protein]]
		+	[[Category: Motor protein]]
		+	[[Category: Not a phosphatase]]
		+	[[Category: Phosphatase fold]]
		+	[[Category: Structural protein]]

OCA at 11:11, 9 November 2011

OCA — Wed, 09 Nov 2011 11:11:43 GMT

←Older revision		Revision as of 11:11, 9 November 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3tgh is ON HOLD	+	The entry 3tgh is ON HOLD until Paper Publication

	Authors: Bosch, J., Paige, M.H., Vaidya, A., Bergman, L., Hol, W.G.J.		Authors: Bosch, J., Paige, M.H., Vaidya, A., Bergman, L., Hol, W.G.J.

	Description: GAP50 the anchor in the inner membrane complex of Plasmodium		Description: GAP50 the anchor in the inner membrane complex of Plasmodium

OCA at 06:24, 31 August 2011

OCA — Wed, 31 Aug 2011 06:24:32 GMT

←Older revision		Revision as of 06:24, 31 August 2011
Line 3:		Line 3:
	The entry 3tgh is ON HOLD		The entry 3tgh is ON HOLD

-	Authors: Bosch, J, Paige, M.H, Vaidya, A., Bergman, L., Hol, W.G.J.	+	Authors: Bosch, J., Paige, M.H., Vaidya, A., Bergman, L., Hol, W.G.J.

	Description: GAP50 the anchor in the inner membrane complex of Plasmodium		Description: GAP50 the anchor in the inner membrane complex of Plasmodium

OCA: Protected "3tgh" [edit=sysop:move=sysop]

OCA — Wed, 24 Aug 2011 07:13:13 GMT

Protected "3tgh" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:13, 24 August 2011