3tic - Revision history

OCA at 17:32, 1 November 2023

OCA — Wed, 01 Nov 2023 17:32:49 GMT

←Older revision		Revision as of 17:32, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3tic' size='340' side='right'caption='[[3tic]], [[Resolution\|resolution]] 1.89Å' scene=''>		<StructureSection load='3tic' size='340' side='right'caption='[[3tic]], [[Resolution\|resolution]] 1.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tic]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Influenza_a_virus_~~(a/ri/5+/1957(~~h2n2~~)) Influenza a virus (a/ri/5+/1957(~~h2n2~~))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TIC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TIC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tic]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/RI/5+/1957(H2N2)) Influenza A virus (A/RI/5+/1957(H2N2))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TIC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TIC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL~~-D-~~GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=~~ZMR~~:~~ZANAMIVIR~~'>~~ZMR~~</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA-D-MANNOSE~~'>~~MAN~~</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.89Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ti3\|3ti3]], [[3ti4\|3ti4]], [[3ti5\|3ti5]], [[3ti6\|3ti6]], [[3ti8\|3ti8]], [[3tia\|3tia]], [[3tib\|3tib]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZMR:ZANAMIVIR'>ZMR</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tic OCA], [https://pdbe.org/3tic PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tic RCSB], [https://www.ebi.ac.uk/pdbsum/3tic PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tic ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tic OCA], [https://pdbe.org/3tic PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tic RCSB], [https://www.ebi.ac.uk/pdbsum/3tic PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tic ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q194T1_9INFA Q194T1_9INFA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Feng, E]]	+	[[Category: Feng E]]
-	[[Category: Gao, F]]	+	[[Category: Gao F]]
-	[[Category: Gao~~, G F~~]]	+	[[Category: Gao GF]]
-	[[Category: He, J]]	+	[[Category: He J]]
-	[[Category: Jiang, H]]	+	[[Category: Jiang H]]
-	[[Category: Li, Q]]	+	[[Category: Li Q]]
-	[[Category: Liu, H]]	+	[[Category: Liu H]]
-	[[Category: Liu, J]]	+	[[Category: Liu J]]
-	[[Category: Liu, Y]]	+	[[Category: Liu Y]]
-	[[Category: Qi, J]]	+	[[Category: Qi J]]
-	[[Category: Vavricka~~, C J~~]]	+	[[Category: Vavricka CJ]]
-	[[Category: Wang, J]]	+	[[Category: Wang J]]
-	[[Category: Wang, M]]	+	[[Category: Wang M]]
-	[[Category: Wu, Y]]	+	[[Category: Wu Y]]
-	~~[[Category: 6-bladed beta-propeller]]~~	+
-	~~[[Category: Antiviral]]~~	+
-	~~[[Category: Calcium binding]]~~	+
-	~~[[Category: Glycosylation]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex~~]]	+

OCA at 16:59, 6 July 2022

OCA — Wed, 06 Jul 2022 16:59:20 GMT

←Older revision		Revision as of 16:59, 6 July 2022
Line 1:		Line 1:

	==Crystal structure of 1957 pandemic H2N2 neuraminidase complexed with zanamivir==		==Crystal structure of 1957 pandemic H2N2 neuraminidase complexed with zanamivir==
-	<StructureSection load='3tic' size='340' side='right' caption='[[3tic]], [[Resolution\|resolution]] 1.89Å' scene=''>	+	<StructureSection load='3tic' size='340' side='right'caption='[[3tic]], [[Resolution\|resolution]] 1.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tic]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Influenza_a_virus_(a/ri/5+/1957(h2n2)) Influenza a virus (a/ri/5+/1957(h2n2))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TIC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3TIC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tic]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_a_virus_(a/ri/5+/1957(h2n2)) Influenza a virus (a/ri/5+/1957(h2n2))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TIC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TIC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA~~-D-~~MANNOSE~~'>~~MAN~~</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL-D-GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=~~ZMR~~:~~ZANAMIVIR~~'>~~ZMR~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZMR:ZANAMIVIR'>ZMR</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ti3\|3ti3]], [[3ti4\|3ti4]], [[3ti5\|3ti5]], [[3ti6\|3ti6]], [[3ti8\|3ti8]], [[3tia\|3tia]], [[3tib\|3tib]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ti3\|3ti3]], [[3ti4\|3ti4]], [[3ti5\|3ti5]], [[3ti6\|3ti6]], [[3ti8\|3ti8]], [[3tia\|3tia]], [[3tib\|3tib]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3tic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tic OCA], [~~http~~://pdbe.org/3tic PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3tic RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3tic PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3tic ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tic OCA], [https://pdbe.org/3tic PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tic RCSB], [https://www.ebi.ac.uk/pdbsum/3tic PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tic ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 19:		Line 19:

	==See Also==		==See Also==
-	*[[Neuraminidase\|Neuraminidase]]	+	*[[Neuraminidase 3D structures\|Neuraminidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Feng, E]]		[[Category: Feng, E]]
	[[Category: Gao, F]]		[[Category: Gao, F]]

OCA at 10:08, 13 February 2019

OCA — Wed, 13 Feb 2019 10:08:52 GMT

←Older revision		Revision as of 10:08, 13 February 2019
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3tic]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/ri/5+/1957(h2n2)) Influenza a virus (a/ri/5+/1957(h2n2))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TIC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TIC FirstGlance]. <br>		<table><tr><td colspan='2'>[[3tic]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/ri/5+/1957(h2n2)) Influenza a virus (a/ri/5+/1957(h2n2))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TIC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TIC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL~~-D-~~GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=~~ZMR~~:~~ZANAMIVIR~~'>~~ZMR~~</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA-D-MANNOSE~~'>~~MAN~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZMR:ZANAMIVIR'>ZMR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ti3\|3ti3]], [[3ti4\|3ti4]], [[3ti5\|3ti5]], [[3ti6\|3ti6]], [[3ti8\|3ti8]], [[3tia\|3tia]], [[3tib\|3tib]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ti3\|3ti3]], [[3ti4\|3ti4]], [[3ti5\|3ti5]], [[3ti6\|3ti6]], [[3ti8\|3ti8]], [[3tia\|3tia]], [[3tib\|3tib]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tic OCA], [http://pdbe.org/3tic PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3tic RCSB], [http://www.ebi.ac.uk/pdbsum/3tic PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3tic ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tic OCA], [http://pdbe.org/3tic PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3tic RCSB], [http://www.ebi.ac.uk/pdbsum/3tic PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3tic ProSAT]</span></td></tr>

OCA at 18:57, 10 December 2016

OCA — Sat, 10 Dec 2016 18:57:56 GMT

←Older revision		Revision as of 18:57, 10 December 2016
Line 1:		Line 1:
		+
	==Crystal structure of 1957 pandemic H2N2 neuraminidase complexed with zanamivir==		==Crystal structure of 1957 pandemic H2N2 neuraminidase complexed with zanamivir==
	<StructureSection load='3tic' size='340' side='right' caption='[[3tic]], [[Resolution\|resolution]] 1.89Å' scene=''>		<StructureSection load='3tic' size='340' side='right' caption='[[3tic]], [[Resolution\|resolution]] 1.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tic]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Influenza_a_virus~~ Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TIC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TIC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tic]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/ri/5+/1957(h2n2)) Influenza a virus (a/ri/5+/1957(h2n2))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TIC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TIC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZMR:ZANAMIVIR'>ZMR</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZMR:ZANAMIVIR'>ZMR</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ti3\|3ti3]], [[3ti4\|3ti4]], [[3ti5\|3ti5]], [[3ti6\|3ti6]], [[3ti8\|3ti8]], [[3tia\|3tia]], [[3tib\|3tib]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ti3\|3ti3]], [[3ti4\|3ti4]], [[3ti5\|3ti5]], [[3ti6\|3ti6]], [[3ti8\|3ti8]], [[3tia\|3tia]], [[3tib\|3tib]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tic OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tic RCSB], [http://www.ebi.ac.uk/pdbsum/3tic PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tic OCA], [http://pdbe.org/3tic PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3tic RCSB], [http://www.ebi.ac.uk/pdbsum/3tic PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3tic ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3tic" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 22:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Influenza a virus]]
	[[Category: Feng, E]]		[[Category: Feng, E]]
	[[Category: Gao, F]]		[[Category: Gao, F]]

OCA at 16:31, 9 December 2014

OCA — Tue, 09 Dec 2014 16:31:46 GMT

←Older revision		Revision as of 16:31, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3tic.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of 1957 pandemic H2N2 neuraminidase complexed with zanamivir==
		+	<StructureSection load='3tic' size='340' side='right' caption='[[3tic]], [[Resolution\|resolution]] 1.89Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3tic]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TIC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TIC FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZMR:ZANAMIVIR'>ZMR</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ti3\|3ti3]], [[3ti4\|3ti4]], [[3ti5\|3ti5]], [[3ti6\|3ti6]], [[3ti8\|3ti8]], [[3tia\|3tia]], [[3tib\|3tib]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tic OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tic RCSB], [http://www.ebi.ac.uk/pdbsum/3tic PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The 2009 H1N1 influenza pandemic (pH1N1) led to record sales of neuraminidase (NA) inhibitors, which has contributed significantly to the recent increase in oseltamivir-resistant viruses. Therefore, development and careful evaluation of novel NA inhibitors is of great interest. Recently, a highly potent NA inhibitor, laninamivir, has been approved for use in Japan. Laninamivir is effective using a single inhaled dose via its octanoate prodrug (CS-8958) and has been demonstrated to be effective against oseltamivir-resistant NA in vitro. However, effectiveness of laninamivir octanoate prodrug against oseltamivir-resistant influenza infection in adults has not been demonstrated. NA is classified into 2 groups based upon phylogenetic analysis and it is becoming clear that each group has some distinct structural features. Recently, we found that pH1N1 N1 NA (p09N1) is an atypical group 1 NA with some group 2-like features in its active site (lack of a 150-cavity). Furthermore, it has been reported that certain oseltamivir-resistant substitutions in the NA active site are group 1 specific. In order to comprehensively evaluate the effectiveness of laninamivir, we utilized recombinant N5 (typical group 1), p09N1 (atypical group 1) and N2 from the 1957 pandemic H2N2 (p57N2) (typical group 2) to carry out in vitro inhibition assays. We found that laninamivir and its octanoate prodrug display group specific preferences to different influenza NAs and provide the structural basis of their specific action based upon their novel complex crystal structures. Our results indicate that laninamivir and zanamivir are more effective against group 1 NA with a 150-cavity than group 2 NA with no 150-cavity. Furthermore, we have found that the laninamivir octanoate prodrug has a unique binding mode in p09N1 that is different from that of group 2 p57N2, but with some similarities to NA-oseltamivir binding, which provides additional insight into group specific differences of oseltamivir binding and resistance.

-	~~{{STRUCTURE_3tic\| PDB=3tic \| SCENE= }}~~	+	Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza na inhibition.,Vavricka CJ, Li Q, Wu Y, Qi J, Wang M, Liu Y, Gao F, Liu J, Feng E, He J, Wang J, Liu H, Jiang H, Gao GF PLoS Pathog. 2011 Oct;7(10):e1002249. Epub 2011 Oct 20. PMID:22028647<ref>PMID:22028647</ref>

-	~~===Crystal structure of 1957 pandemic H2N2 neuraminidase complexed with zanamivir===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22028647}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3tic]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki~~/~~Influenza_a_virus Influenza~~ a ~~virus]~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=3TIC OCA].~~	+

	==See Also==		==See Also==
	*[[Neuraminidase\|Neuraminidase]]		*[[Neuraminidase\|Neuraminidase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:022028647<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Influenza a virus]]		[[Category: Influenza a virus]]
-	[[Category: Feng, E.]]	+	[[Category: Feng, E]]
-	[[Category: Gao, F.]]	+	[[Category: Gao, F]]
-	[[Category: Gao, G F.]]	+	[[Category: Gao, G F]]
-	[[Category: He, J.]]	+	[[Category: He, J]]
-	[[Category: Jiang, H.]]	+	[[Category: Jiang, H]]
-	[[Category: Li, Q.]]	+	[[Category: Li, Q]]
-	[[Category: Liu, H.]]	+	[[Category: Liu, H]]
-	[[Category: Liu, J.]]	+	[[Category: Liu, J]]
-	[[Category: Liu, Y.]]	+	[[Category: Liu, Y]]
-	[[Category: Qi, J.]]	+	[[Category: Qi, J]]
-	[[Category: Vavricka, C J.]]	+	[[Category: Vavricka, C J]]
-	[[Category: Wang, J.]]	+	[[Category: Wang, J]]
-	[[Category: Wang, M.]]	+	[[Category: Wang, M]]
-	[[Category: Wu, Y.]]	+	[[Category: Wu, Y]]
	[[Category: 6-bladed beta-propeller]]		[[Category: 6-bladed beta-propeller]]
	[[Category: Antiviral]]		[[Category: Antiviral]]

OCA at 13:05, 20 October 2012

OCA — Sat, 20 Oct 2012 13:05:23 GMT

←Older revision		Revision as of 13:05, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3tic]] is a 4 chain structure ~~of [[Neuraminidase]]~~ with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TIC OCA].	+	[[3tic]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TIC OCA].

	==See Also==		==See Also==

OCA at 10:52, 26 July 2012

OCA — Thu, 26 Jul 2012 10:52:22 GMT

←Older revision		Revision as of 10:52, 26 July 2012
Line 1:		Line 1:
-	[[Image:3tic.~~jpg~~\|left\|200px]]	+	[[Image:3tic.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3tic", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3tic\| PDB=3tic \| SCENE= }}		{{STRUCTURE_3tic\| PDB=3tic \| SCENE= }}

	===Crystal structure of 1957 pandemic H2N2 neuraminidase complexed with zanamivir===		===Crystal structure of 1957 pandemic H2N2 neuraminidase complexed with zanamivir===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_22028647}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 22028647 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_22028647}}		{{ABSTRACT_PUBMED_22028647}}

	==About this Structure==		==About this Structure==
-	[[3tic]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TIC OCA].	+	[[3tic]] is a 4 chain structure of [[Neuraminidase]] with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TIC OCA].
		+
		+	==See Also==
		+	*[[Neuraminidase\|Neuraminidase]]

	==Reference==		==Reference==

OCA at 12:18, 16 November 2011

OCA — Wed, 16 Nov 2011 12:18:34 GMT

←Older revision		Revision as of 12:18, 16 November 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3tic.jpg\|left\|200px]]

-	The ~~entry 3tic~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3tic", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3tic\| PDB=3tic \| SCENE= }}

-	~~Authors: Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.~~	+	===Crystal structure of 1957 pandemic H2N2 neuraminidase complexed with zanamivir===

-	~~Description~~: ~~Crystal~~ structure ~~of 1957 pandemic H2N2 neuraminidase complexed~~ with ~~zanamivir~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22028647}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22028647 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22028647}}
		+
		+	==About this Structure==
		+	[[3tic]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TIC OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022028647</ref><references group="xtra"/>
		+	[[Category: Influenza a virus]]
		+	[[Category: Feng, E.]]
		+	[[Category: Gao, F.]]
		+	[[Category: Gao, G F.]]
		+	[[Category: He, J.]]
		+	[[Category: Jiang, H.]]
		+	[[Category: Li, Q.]]
		+	[[Category: Liu, H.]]
		+	[[Category: Liu, J.]]
		+	[[Category: Liu, Y.]]
		+	[[Category: Qi, J.]]
		+	[[Category: Vavricka, C J.]]
		+	[[Category: Wang, J.]]
		+	[[Category: Wang, M.]]
		+	[[Category: Wu, Y.]]
		+	[[Category: 6-bladed beta-propeller]]
		+	[[Category: Antiviral]]
		+	[[Category: Calcium binding]]
		+	[[Category: Glycosylation]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 05:14, 28 September 2011

OCA — Wed, 28 Sep 2011 05:14:59 GMT

←Older revision		Revision as of 05:14, 28 September 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3tic is ON HOLD	+	The entry 3tic is ON HOLD until Paper Publication

	Authors: Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.		Authors: Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.

	Description: Crystal structure of 1957 pandemic H2N2 neuraminidase complexed with zanamivir		Description: Crystal structure of 1957 pandemic H2N2 neuraminidase complexed with zanamivir

OCA at 06:04, 14 September 2011

OCA — Wed, 14 Sep 2011 06:04:10 GMT

←Older revision		Revision as of 06:04, 14 September 2011
Line 3:		Line 3:
	The entry 3tic is ON HOLD		The entry 3tic is ON HOLD

-	Authors: Vavricka. C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.	+	Authors: Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.

	Description: Crystal structure of 1957 pandemic H2N2 neuraminidase complexed with zanamivir		Description: Crystal structure of 1957 pandemic H2N2 neuraminidase complexed with zanamivir