3tjr - Revision history

OCA at 13:31, 14 March 2024

OCA — Thu, 14 Mar 2024 13:31:16 GMT

←Older revision		Revision as of 13:31, 14 March 2024
Line 3:		Line 3:
	<StructureSection load='3tjr' size='340' side='right'caption='[[3tjr]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='3tjr' size='340' side='right'caption='[[3tjr]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tjr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_paratuberculosis"_(bergey_et_al~~.~~_1923)_krasil'nikov_1941 "bacillus~~ paratuberculosis~~" (bergey et al. 1923) krasil'nikov 1941~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TJR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TJR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tjr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_avium_subsp._paratuberculosis Mycobacterium avium subsp. paratuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TJR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TJR FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>MAP_0710c ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1770~~ "~~Bacillus paratuberculosis~~" ~~(Bergey et al. 1923) Krasil~~'~~nikov 1941])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tjr OCA], [https://pdbe.org/3tjr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tjr RCSB], [https://www.ebi.ac.uk/pdbsum/3tjr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tjr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tjr OCA], [https://pdbe.org/3tjr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tjr RCSB], [https://www.ebi.ac.uk/pdbsum/3tjr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tjr ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/Q742X5_MYCPA Q742X5_MYCPA]
-	High-resolution three-dimensional structures of essential Mycobacterium tuberculosis (Mtb) proteins provide templates for TB drug design, but are available for only a small fraction of the Mtb proteome. Here we evaluate an intra-genus "homolog-rescue" strategy to increase the structural information available for TB drug discovery by using mycobacterial homologs with conserved active sites. Of 179 potential TB drug targets selected for x-ray structure determination, only 16 yielded a crystal structure. By adding 1675 homologs from nine other mycobacterial species to the pipeline, structures representing an additional 52 otherwise intractable targets were solved. To determine whether these homolog structures would be useful surrogates in TB drug design, we compared the active sites of 106 pairs of Mtb and non-TB mycobacterial (NTM) enzyme homologs with experimentally determined structures, using three metrics of active site similarity, including superposition of continuous pharmacophoric property distributions. Pair-wise structural comparisons revealed that 19/22 pairs with >55% overall sequence identity had active site Calpha RMSD <1 A, >85% side chain identity, and >/=80% PSAPF (similarity based on pharmacophoric properties) indicating highly conserved active site shape and chemistry. Applying these results to the 52 NTM structures described above, 41 shared >55% sequence identity with the Mtb target, thus increasing the effective structural coverage of the 179 Mtb targets over three-fold (from 9% to 32%). The utility of these structures in TB drug design can be tested by designing inhibitors using the homolog structure and assaying the cognate Mtb enzyme; a promising test case, Mtb cytidylate kinase, is described. The homolog-rescue strategy evaluated here for TB is also generalizable to drug targets for other diseases.	+
-		+
-	Increasing the structural coverage of tuberculosis drug targets.,Baugh L, Phan I, Begley DW, Clifton MC, Armour B, Dranow DM, Taylor BM, Muruthi MM, Abendroth J, Fairman JW, Fox D 3rd, Dieterich SH, Staker BL, Gardberg AS, Choi R, Hewitt SN, Napuli AJ, Myers J, Barrett LK, Zhang Y, Ferrell M, Mundt E, Thompkins K, Tran N, Lyons-Abbott S, Abramov A, Sekar A, Serbzhinskiy D, Lorimer D, Buchko GW, Stacy R, Stewart LJ, Edwards TE, Van Voorhis WC, Myler PJ Tuberculosis (Edinb). 2014 Dec 19. pii: ~~S1472-9792(14)20565-8. doi:, 10.1016~~/~~j.tube.2014.12.003. PMID:25613812<ref>PMID:25613812<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 3tjr" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references~~/>	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Structural genomic]]~~	+	[[Category: Mycobacterium avium subsp. paratuberculosis]]
-	~~[[Category: 5-hydroxy nad]]~~	+
-	~~[[Category: Asymmetric substrate or cofactor recognition]]~~	+
-	~~[[Category: Nad]]~~	+
-	~~[[Category: Nucleotide adenine dinucleotide]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Putative uncharacterized protein]]~~	+
-	~~[[Category: Scd]]~~	+
-	~~[[Category: Ssgcid~~]]	+

OCA at 17:01, 6 July 2022

OCA — Wed, 06 Jul 2022 17:01:15 GMT

←Older revision		Revision as of 17:01, 6 July 2022
Line 1:		Line 1:

	==Crystal structure of a Rv0851c ortholog short chain dehydrogenase from Mycobacterium paratuberculosis==		==Crystal structure of a Rv0851c ortholog short chain dehydrogenase from Mycobacterium paratuberculosis==
-	<StructureSection load='3tjr' size='340' side='right' caption='[[3tjr]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='3tjr' size='340' side='right'caption='[[3tjr]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tjr]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_paratuberculosis"_(bergey_et_al._1923)_krasil'nikov_1941 "bacillus paratuberculosis" (bergey et al. 1923) krasil'nikov 1941]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TJR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3TJR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tjr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_paratuberculosis"_(bergey_et_al._1923)_krasil'nikov_1941 "bacillus paratuberculosis" (bergey et al. 1923) krasil'nikov 1941]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TJR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TJR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAP_0710c ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1770 "Bacillus paratuberculosis" (Bergey et al. 1923) Krasil'nikov 1941])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAP_0710c ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1770 "Bacillus paratuberculosis" (Bergey et al. 1923) Krasil'nikov 1941])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3tjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tjr OCA], [~~http~~://pdbe.org/3tjr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3tjr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3tjr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3tjr ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tjr OCA], [https://pdbe.org/3tjr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tjr RCSB], [https://www.ebi.ac.uk/pdbsum/3tjr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tjr ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: 5-hydroxy nad]]		[[Category: 5-hydroxy nad]]

OCA at 18:52, 1 February 2017

OCA — Wed, 01 Feb 2017 18:52:10 GMT

←Older revision		Revision as of 18:52, 1 February 2017
Line 1:		Line 1:
		+
	==Crystal structure of a Rv0851c ortholog short chain dehydrogenase from Mycobacterium paratuberculosis==		==Crystal structure of a Rv0851c ortholog short chain dehydrogenase from Mycobacterium paratuberculosis==
	<StructureSection load='3tjr' size='340' side='right' caption='[[3tjr]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='3tjr' size='340' side='right' caption='[[3tjr]], [[Resolution\|resolution]] 1.60Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAP_0710c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1770 "Bacillus paratuberculosis" (Bergey et al. 1923) Krasil'nikov 1941])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAP_0710c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1770 "Bacillus paratuberculosis" (Bergey et al. 1923) Krasil'nikov 1941])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tjr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tjr RCSB], [http://www.ebi.ac.uk/pdbsum/3tjr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tjr OCA], [http://pdbe.org/3tjr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3tjr RCSB], [http://www.ebi.ac.uk/pdbsum/3tjr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3tjr ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3tjr" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:24, 22 April 2015

OCA — Wed, 22 Apr 2015 07:24:29 GMT

←Older revision		Revision as of 07:24, 22 April 2015
Line 2:		Line 2:
	<StructureSection load='3tjr' size='340' side='right' caption='[[3tjr]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='3tjr' size='340' side='right' caption='[[3tjr]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tjr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_avium_subsp._paratuberculosis Mycobacterium avium subsp~~. paratuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TJR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tjr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_paratuberculosis"_(bergey_et_al._1923)_krasil'nikov_1941 "bacillus paratuberculosis" (bergey et al. 1923) krasil'nikov 1941]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TJR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAP_0710c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1770 ~~Mycobacterium avium subsp.~~ paratuberculosis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAP_0710c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1770 "Bacillus paratuberculosis" (Bergey et al. 1923) Krasil'nikov 1941])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tjr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tjr RCSB], [http://www.ebi.ac.uk/pdbsum/3tjr PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tjr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tjr RCSB], [http://www.ebi.ac.uk/pdbsum/3tjr PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	High-resolution three-dimensional structures of essential Mycobacterium tuberculosis (Mtb) proteins provide templates for TB drug design, but are available for only a small fraction of the Mtb proteome. Here we evaluate an intra-genus "homolog-rescue" strategy to increase the structural information available for TB drug discovery by using mycobacterial homologs with conserved active sites. Of 179 potential TB drug targets selected for x-ray structure determination, only 16 yielded a crystal structure. By adding 1675 homologs from nine other mycobacterial species to the pipeline, structures representing an additional 52 otherwise intractable targets were solved. To determine whether these homolog structures would be useful surrogates in TB drug design, we compared the active sites of 106 pairs of Mtb and non-TB mycobacterial (NTM) enzyme homologs with experimentally determined structures, using three metrics of active site similarity, including superposition of continuous pharmacophoric property distributions. Pair-wise structural comparisons revealed that 19/22 pairs with >55% overall sequence identity had active site Calpha RMSD <1 A, >85% side chain identity, and >/=80% PSAPF (similarity based on pharmacophoric properties) indicating highly conserved active site shape and chemistry. Applying these results to the 52 NTM structures described above, 41 shared >55% sequence identity with the Mtb target, thus increasing the effective structural coverage of the 179 Mtb targets over three-fold (from 9% to 32%). The utility of these structures in TB drug design can be tested by designing inhibitors using the homolog structure and assaying the cognate Mtb enzyme; a promising test case, Mtb cytidylate kinase, is described. The homolog-rescue strategy evaluated here for TB is also generalizable to drug targets for other diseases.
		+
		+	Increasing the structural coverage of tuberculosis drug targets.,Baugh L, Phan I, Begley DW, Clifton MC, Armour B, Dranow DM, Taylor BM, Muruthi MM, Abendroth J, Fairman JW, Fox D 3rd, Dieterich SH, Staker BL, Gardberg AS, Choi R, Hewitt SN, Napuli AJ, Myers J, Barrett LK, Zhang Y, Ferrell M, Mundt E, Thompkins K, Tran N, Lyons-Abbott S, Abramov A, Sekar A, Serbzhinskiy D, Lorimer D, Buchko GW, Stacy R, Stewart LJ, Edwards TE, Van Voorhis WC, Myler PJ Tuberculosis (Edinb). 2014 Dec 19. pii: S1472-9792(14)20565-8. doi:, 10.1016/j.tube.2014.12.003. PMID:25613812<ref>PMID:25613812</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Mycobacterium avium subsp. paratuberculosis]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: 5-hydroxy nad]]		[[Category: 5-hydroxy nad]]

OCA at 09:38, 4 January 2015

OCA — Sun, 04 Jan 2015 09:38:34 GMT

←Older revision		Revision as of 09:38, 4 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3tjr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_avium_subsp._paratuberculosis Mycobacterium avium subsp. paratuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TJR FirstGlance]. <br>		<table><tr><td colspan='2'>[[3tjr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_avium_subsp._paratuberculosis Mycobacterium avium subsp. paratuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TJR FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAP_0710c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1770 Mycobacterium avium subsp. paratuberculosis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAP_0710c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1770 Mycobacterium avium subsp. paratuberculosis])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tjr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tjr RCSB], [http://www.ebi.ac.uk/pdbsum/3tjr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tjr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tjr RCSB], [http://www.ebi.ac.uk/pdbsum/3tjr PDBsum]</span></td></tr>
-	<table>	+	</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Mycobacterium avium subsp. paratuberculosis]]		[[Category: Mycobacterium avium subsp. paratuberculosis]]
-	[[Category: ~~SSGCID, Seattle~~ Structural ~~Genomics Center for Infectious Disease.~~]]	+	[[Category: Structural genomic]]
	[[Category: 5-hydroxy nad]]		[[Category: 5-hydroxy nad]]
	[[Category: Asymmetric substrate or cofactor recognition]]		[[Category: Asymmetric substrate or cofactor recognition]]
Line 18:		Line 18:
	[[Category: Putative uncharacterized protein]]		[[Category: Putative uncharacterized protein]]
	[[Category: Scd]]		[[Category: Scd]]
-	[[Category: Seattle structural genomics center for infectious disease]]
	[[Category: Ssgcid]]		[[Category: Ssgcid]]
-	[[Category: Structural genomic]]

OCA at 06:13, 5 June 2014

OCA — Thu, 05 Jun 2014 06:13:25 GMT

←Older revision		Revision as of 06:13, 5 June 2014
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-	~~[[Image:3tjr.jpg\|left\|200px]]~~	+	==Crystal structure of a Rv0851c ortholog short chain dehydrogenase from Mycobacterium paratuberculosis==
-		+	<StructureSection load='3tjr' size='340' side='right' caption='[[3tjr]], [[Resolution\|resolution]] 1.60Å' scene=''>
-	~~<!--~~	+	== Structural highlights ==
-	~~The line below this paragraph, containing "STRUCTURE_3tjr", creates the "Structure Box" on the page.~~	+	<table><tr><td colspan='2'>[[3tjr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_avium_subsp._paratuberculosis Mycobacterium avium subsp. paratuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TJR FirstGlance]. <br>
-	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene><br>
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAP_0710c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1770 Mycobacterium avium subsp. paratuberculosis])</td></tr>
-	~~or leave the SCENE parameter empty for the default display.~~	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tjr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tjr RCSB], [http://www.ebi.ac.uk/pdbsum/3tjr PDBsum]</span></td></tr>
-	~~-->~~	+	<table>
-	~~{{STRUCTURE_3tjr\| PDB=3tjr \| SCENE= }}~~	+	__TOC__
-		+	</StructureSection>
-	===Crystal structure of a Rv0851c ortholog short chain dehydrogenase from Mycobacterium paratuberculosis===	+
-		+
-		+
-	==~~About this Structure~~==	+
-	[[3tjr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_avium_subsp._paratuberculosis Mycobacterium avium subsp. paratuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TJR OCA].	+
	[[Category: Mycobacterium avium subsp. paratuberculosis]]		[[Category: Mycobacterium avium subsp. paratuberculosis]]
	[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]		[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]

OCA: Protected "3tjr" [edit=sysop:move=sysop]

OCA — Wed, 31 Aug 2011 07:06:12 GMT

Protected "3tjr" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:06, 31 August 2011